EPS-GAA-00065

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-GAA-00065

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PPP/PP7	467.3	2.7E-140	126	461	336

Status

Unreviewed

Ensembl Protein

ENSGACP00000018241

UniProt Accession

G3PKW4;

Protein Name

Serine/threonine-protein phosphatase

Protein Synonyms/Alias

Gene Name

PPEF2 (1 of 2)

Gene Synonyms/Alias

PPEF2 (1 of 2);

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGACG00000013810	ENSGACP00000018241	ENSGACT00000018276
ENSGACG00000013810	ENSGACP00000018244	ENSGACT00000018279

Organism

Gasterosteus aculeatus

Functional Description

Protein Length

662

Protein Sequence
(FASTA)

MGCGVSKSDQ FHKGSRKAIR SAVLIQRWYR QYIARTEMKR RYTWHIFQSI EYSGEQAQIK 60

LYNFLGYLMD NFTPASNEHS HLTNRAAEGL PESSCRIPLQ KNIEVPEIYS GPHLTFPLTV 120

EQAVGLVEAF RNKKQQLHSR YVLQLLLETW RQLRMLPNIN RISTCQSKEI TICGDLHGQL 180

DDLLLIFYKN DMPSLENPYV FNGDFVDRGK DSIEILLILF SFLLVYPSEV HLNRGNHEDH 240

IINLRYGFTK EVLTKYKLHG KRILKLLQKI FSWLPLATVI DQKVLVLHGG ISDTTDLAIL 300

ARVDRHNYVS ALRPPKKRHQ SSAGMSIDSD MDLDTSCRQN ERTAAASSES LNSLTVVDEW 360

KQILDLLWSD PMTQDGCVPN EVRGGGCYWG PDVTEDFLNR HNLQLIIRSH ECKQEGYEFC 420

HNRKVLTLFS ASNYYDVGSN RGAYVKLGPD LVPYLIQYQA SSMIRELTVR QSAGRTERSA 480

LKVLREQVFA HKSDLLCAIK RFDRNNTGLV CVSDWASAVE SVMHLGLPWR MLRSQLVPGK 540

IHGGMIDYHE WFNELAIKGV NADHIDQSLL ETLYRHRSTL ETIFRIVDYD NSGFISIEDF 600

QQTWKLLSVY LKMEITDDTI ADLIVTIDRN QDGSIDIEEF MEAFRLTDKK SRLERGRSMF 660

MG 662

Nucleotide Sequence
(FASTA)

ATGGGATGTG GCGTCTCAAA ATCCGACCAG TTCCACAAAG GCTCCAGAAA AGCCATCAGA 60

TCCGCCGTCC TGATTCAGCG ATGGTACCGT CAGTACATTG CTCGCACGGA GATGAAACGC 120

AGATACACCT GGCACATCTT CCAGTCCATC GAATACTCTG GAGAACAGGC GCAGATAAAG 180

CTTTATAACT TCCTCGGCTA CCTCATGGAC AACTTCACGC CCGCAAGCAA TGAACATTCT 240

CACCTGACAA ACCGTGCCGC TGAGGGACTT CCCGAATCTT CATGTCGGAT TCCCCTGCAG 300

AAGAACATCG AGGTGCCAGA GATCTACTCG GGACCTCACC TCACTTTCCC CTTGACGGTG 360

GAGCAGGCGG TCGGGCTGGT GGAGGCCTTC AGGAACAAGA AGCAGCAGCT GCACTCGCGC 420

TACGTCCTCC AGCTGTTGCT TGAGACGTGG AGACAGCTCC GGATGTTGCC AAATATCAAC 480

CGCATCTCCA CCTGTCAGAG CAAAGAAATC ACTATTTGTG GGGATTTGCA CGGACAACTG 540

GATGACCTGC TGCTGATTTT CTACAAGAAT GACATGCCGT CCTTGGAGAA CCCCTACGTG 600

TTTAACGGAG ACTTCGTAGA CCGAGGCAAA GACTCCATTG AGATCCTCCT CATCCTGTTT 660

TCCTTCCTGC TCGTCTACCC GAGTGAAGTC CACCTCAACA GAGGAAACCA CGAGGACCAT 720

ATCATCAACC TGAGGTATGG CTTCACCAAG GAGGTGCTGA CTAAATACAA GTTGCACGGC 780

AAACGGATCC TGAAGCTGCT GCAGAAGATA TTCAGCTGGT TGCCGTTAGC GACAGTGATC 840

GACCAGAAGG TGCTGGTGCT CCACGGCGGG ATCTCCGACA CCACGGACCT CGCCATCCTC 900

GCCAGAGTGG ACAGACACAA TTACGTTTCA GCGCTGAGGC CCCCGAAGAA AAGGCACCAG 960

AGCTCGGCGG GGATGTCCAT CGACTCGGAC ATGGACTTGG ACACCTCGTG CCGCCAGAAC 1020

GAGAGGACCG CGGCCGCGTC CTCCGAGTCC CTCAACAGTC TGACTGTGGT TGACGAGTGG 1080

AAACAGATCC TGGACCTGCT GTGGAGCGAC CCGATGACCC AGGACGGCTG CGTGCCCAAT 1140

GAGGTGCGGG GCGGCGGCTG CTACTGGGGC CCCGACGTCA CGGAGGACTT CCTGAACAGA 1200

CACAACCTGC AGCTCATCAT CCGCTCCCAC GAGTGCAAAC AGGAAGGTTA CGAGTTCTGC 1260

CACAACCGCA AGGTCCTCAC GCTGTTCTCT GCCTCCAATT ACTACGACGT GGGCAGCAAC 1320

AGGGGGGCCT ACGTGAAGCT GGGTCCAGAC CTCGTGCCTT ATTTGATTCA ATACCAGGCC 1380

AGCAGCATGA TCAGAGAGCT CACCGTCAGG CAAAGTGCCG GGCGGACCGA GCGCTCAGCG 1440

CTCAAAGTCC TGCGGGAGCA GGTGTTTGCG CACAAATCTG ACCTCCTATG TGCCATCAAA 1500

CGGTTCGACA GAAACAACAC AGGTCTCGTG TGTGTGAGCG ACTGGGCGTC GGCGGTGGAG 1560

AGCGTGATGC ACCTCGGCCT CCCCTGGAGG ATGCTGCGCT CCCAGCTGGT CCCGGGCAAG 1620

ATCCACGGCG GCATGATCGA CTACCACGAG TGGTTCAACG AGCTCGCCAT CAAAGGAGTC 1680

AACGCCGATC ACATCGACCA GAGTCTGCTC GAGACTTTGT ATCGTCACCG CTCCACCTTG 1740

GAGACCATCT TCAGAATCGT TGACTACGAC AACTCGGGCT TTATCAGCAT CGAGGACTTC 1800

CAGCAGACCT GGAAGCTGCT CAGCGTCTAC CTGAAGATGG AGATCACGGA CGACACCATC 1860

GCCGACCTGA TCGTCACCAT CGACCGCAAC CAGGACGGCA GCATCGACAT CGAGGAGTTC 1920

ATGGAGGCCT TCCGGCTCAC GGACAAGAAG AGCCGGCTGG AGCGAGGGCG CAGCATGTTC 1980

ATGGGG 1986

Domain Profile

S: 4     llevfkkkr.ilhakyvlevlfeakkvlkqlpnishvstavskevtvvGdlhGklddlll  62

         l+e+f++k+ +lh++yvl++l e+ + l+ lpni+++st+ ske+t++GdlhG+lddlll

Q: 126   LVEAFRNKKqQLHSRYVLQLLLETWRQLRMLPNINRISTCQSKEITICGDLHGQLDDLLL  185

         799**987659*************************************************

S: 63    vlkknGlPsernpyvfnGdfvdrGkrglevllvllslflvfPnavylnrGnhedkvmnar  122

         +++kn +Ps +npyvfnGdfvdrGk ++e+ll+l s+ lv+P +v+lnrGnhed+++n+r

Q: 186   IFYKNDMPSLENPYVFNGDFVDRGKDSIEILLILFSFLLVYPSEVHLNRGNHEDHIINLR  245

         ************************************************************

S: 123   yGfekevlskykrkgkrilrileevyewlPlgsivdsrvlvvhGGlsestsldllksver  182

         yGf+kevl+kyk +gkril++l++++ wlPl++++d++vlv+hGG+s++t+l  l +v+r

Q: 246   YGFTKEVLTKYKLHGKRILKLLQKIFSWLPLATVIDQKVLVLHGGISDTTDLAILARVDR  305

         ************************************************************

S: 183   kkrksvllpPeessrd...................lgrldtdgepreslt.eteweqiid  222

         ++++s l+pP++  +                      +     e+ +slt   ew+qi+d

Q: 306   HNYVSALRPPKKRHQSsagmsidsdmdldtscrqnERTAAASSESLNSLTvVDEWKQILD  365

         ***********87777999**********9987764444445555556552479******

S: 223   ilwsdPratnGlvPntlrGaGvyfGPdvtedflkkyelklvirsheckpegyeilhdgkv  282

         +lwsdP ++ G+vPn++rG+G+y+GPdvtedfl++++l+l+irsheck egye++h+ kv

Q: 366   LLWSDPMTQDGCVPNEVRGGGCYWGPDVTEDFLNRHNLQLIIRSHECKQEGYEFCHNRKV  425

         ************************************************************

S: 283   vtifsasnyyeegsnkgayiklnsqltprfvqyiva  318

         +t+fsasnyy++gsn+gay+kl  +l+p ++qy+++

Q: 426   LTLFSASNYYDVGSNRGAYVKLGPDLVPYLIQYQAS  461

         *********************************975

Domain Sequence
(FASTA)

LVEAFRNKKQ QLHSRYVLQL LLETWRQLRM LPNINRISTC QSKEITICGD LHGQLDDLLL 60

IFYKNDMPSL ENPYVFNGDF VDRGKDSIEI LLILFSFLLV YPSEVHLNRG NHEDHIINLR 120

YGFTKEVLTK YKLHGKRILK LLQKIFSWLP LATVIDQKVL VLHGGISDTT DLAILARVDR 180

HNYVSALRPP KKRHQSSAGM SIDSDMDLDT SCRQNERTAA ASSESLNSLT VVDEWKQILD 240

LLWSDPMTQD GCVPNEVRGG GCYWGPDVTE DFLNRHNLQL IIRSHECKQE GYEFCHNRKV 300

LTLFSASNYY DVGSNRGAYV KLGPDLVPYL IQYQAS 336

Keyword

Calcium; Complete proteome; Hydrolase; Iron; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Danio rerio"; ?>Felis catus"; ?>Oreochromis niloticus"; ?>Oryzias latipes"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>

Gene Ontology

GO:0005509	; F:calcium ion binding
GO:0004721	; F:phosphoprotein phosphatase activity

KEGG

InterPros

IPR011992	; EF-hand-like_dom.
IPR018247	; EF_Hand_1_Ca_BS.
IPR018249	; EF_HAND_2.
IPR002048	; EF_hand_Ca-bd.
IPR000048	; IQ_motif_EF-hand-BS.
IPR004843	; Metallo_PEstase_dom.
IPR006186	; Ser/Thr-sp_prot-phosphatase.

Pfam

PF00149

; Metallophos; 1.

SMARTs

SM00054	; EFh; 3.
SM00015	; IQ; 1.
SM00156	; PP2Ac; 1.

Prosites

PS00018	; EF_HAND_1; 3.
PS50222	; EF_HAND_2; 3.
PS50096	; IQ; 1.
PS00125	; SER_THR_PHOSPHATASE; 1.

Prints

PR00114

; STPHPHTASE.

Created Date

20-Feb-2013