EKS-GAA-00349

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-GAA-00349

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	364.8	4.1E-109	183	481	299

Status

Unreviewed

Ensembl Protein

ENSGACP00000018245

UniProt Accession

G3PKW5;

Protein Name

Protein Synonyms/Alias

Gene Name

BMPR2 (1 of 2)

Gene Synonyms/Alias

BMPR2 (1 of 2);

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGACG00000013817	ENSGACP00000018245	ENSGACT00000018280

Organism

Gasterosteus aculeatus

Functional Description

Protein Length

997

Protein Sequence
(FASTA)

AAQGEKRKCA AAFQQWEVNQ VAGDEGLISP ENTTVECNEG NHCYGLWEKS LPGEVRLVKQ 60

GCWPHLGDHQ GCRDDRCVVT NLPPQIQNGT YHFCCCGSDM CNVNFTEDFP LPSPTTAQTP 120

HLRPLRHEET IIIALATLSV LAVVAVAAFF GYRMMRGDGK QGLHNLNMME AASSESSLDL 180

DNLKLLELIG RGRYGAVYGG SLDERPVAVK VFTAANRQNF LNECSIYRLP LLEHDNIARF 240

VAADERTGPE GRTEYLLVME YYPHGSLSRY LGVQTNDWVN SCRLAHSVTR GLAYLHTELF 300

KGDLYKPAVS HRDLNSRNVL VKADGACVII DFGLSMKLTG NRPARHGEEE STAISEVGTI 360

RYMAPEVLEG AVNLRDCESA LKQVDMYALG LIYWETFMRC TDLFPGESVP EYQMAFQAEA 420

GNHPTFEDMQ VLVSREKQRP KFPEAWKENS LAVRSLKETM EDCWDQDAEA RLTAQCAEER 480

LAELLLIWDR SKSVSPTLNP MSTTLHNERN RMTPRSGPYA DQTSTYIEEN EGVGKNPQAG 540

TGERNRNSIN QERQQQAHTR LPSPEGSSTS TGLRGSPSAS TTTTTIVSDS EGPAGTPAVP 600

VCLHLTQEDL ETTKLDPKEV DKNLKESSDE NLMEHSQKQF CSPDALSPGS SSLLYPLIKM 660

ASEAAGASDA AADPLPTAIF PLPKQQNLPK RPSSLPLRTK PAKKESSSSS SLRFKFGRSG 720

KSNLRKVEGT KMNIAAAAAA NAEPEAHGGA GTNNAAALRN AHVNGHGRAG VSAVVAGGAT 780

GFGGSSATES GSGAPRPDDG RLSLGVITAS PDEHEPLLSR ERERPDPREA GPGSAAALRS 840

ARTNTNNNNS NDAGSREAVA AAAESSGTGS GFAAPPQREA PAAMRGEALL RQPRARRPER 900

PNSLDLSFTT QDLSSLGEGL VQPDGAFGPG GDKIKKRVKT PYSLKKWRPT TWVISTDARG 960

PEVNNNNNNG SSRAPAPHGQ SRPKSSSAIY LRGGGLA 997

Nucleotide Sequence
(FASTA)

GCGGCGCAGG GCGAGAAGAG GAAGTGCGCC GCCGCCTTCC AGCAGTGGGA GGTGAACCAG 60

GTTGCGGGGG ACGAAGGTCT CATCTCCCCG GAGAACACCA CCGTCGAGTG CAATGAGGGG 120

AACCACTGCT ACGGCCTGTG GGAGAAGAGT CTTCCGGGCG AGGTGCGACT GGTCAAACAA 180

GGCTGCTGGC CCCACCTGGG TGACCACCAG GGTTGCCGCG ACGACCGCTG CGTGGTGACC 240

AACCTCCCGC CGCAGATCCA GAATGGGACG TACCACTTCT GCTGCTGCGG CAGCGACATG 300

TGCAACGTCA ACTTCACGGA GGACTTCCCC CTGCCGAGCC CCACTACGGC GCAGACGCCT 360

CACCTGCGCC CACTGCGCCA CGAGGAGACA ATAATCATCG CCCTGGCAAC CCTCTCCGTA 420

CTGGCTGTGG TTGCCGTGGC AGCCTTCTTC GGTTACCGCA TGATGCGTGG AGATGGTAAG 480

CAAGGCCTTC ACAACCTGAA TATGATGGAG GCCGCCAGCT CCGAGAGCTC TCTGGATCTG 540

GACAATTTGA AGCTCCTGGA GCTGATCGGG CGCGGCAGAT ACGGCGCCGT CTACGGCGGC 600

TCTCTGGACG AGCGGCCCGT GGCGGTGAAG GTGTTCACAG CGGCCAACCG GCAGAACTTC 660

CTCAACGAGT GCTCCATCTA CCGGCTGCCG CTGCTGGAGC ACGACAACAT CGCCCGCTTC 720

GTCGCCGCGG ACGAGCGGAC GGGCCCGGAG GGACGCACGG AGTACCTGCT GGTCATGGAA 780

TACTACCCGC ATGGCTCTCT GAGTCGCTAC CTGGGAGTCC AGACCAACGA CTGGGTCAAC 840

AGCTGCCGCC TCGCTCATTC CGTCACCCGC GGCCTGGCGT ACCTGCACAC GGAGCTCTTC 900

AAAGGAGACC TGTACAAGCC GGCGGTGTCC CACAGGGACC TGAACAGCCG CAACGTCCTG 960

GTCAAGGCGG ACGGCGCGTG CGTCATCATC GACTTTGGCC TGTCCATGAA GCTGACGGGG 1020

AACCGGCCGG CGCGCCACGG CGAGGAGGAG AGCACGGCCA TCAGCGAGGT GGGGACGATC 1080

CGCTACATGG CCCCGGAGGT GCTGGAGGGG GCGGTGAACC TGAGGGACTG CGAGTCGGCG 1140

CTGAAGCAGG TGGACATGTA CGCCCTGGGC CTGATCTACT GGGAGACCTT CATGAGGTGC 1200

ACCGACCTCT TCCCTGGAGA GTCGGTGCCA GAGTACCAGA TGGCATTCCA GGCGGAGGCA 1260

GGGAACCACC CAACGTTTGA GGACATGCAG GTCCTGGTTT CTAGGGAGAA GCAGCGGCCC 1320

AAATTCCCTG AGGCCTGGAA AGAGAACAGT TTGGCGGTCC GCTCTCTGAA AGAGACCATG 1380

GAGGACTGCT GGGACCAGGA CGCCGAGGCC CGTCTCACGG CCCAGTGTGC CGAGGAGCGC 1440

CTGGCCGAGC TGCTGCTCAT ATGGGACCGC TCCAAGTCGG TCAGCCCCAC GCTGAACCCC 1500

ATGTCCACCA CGCTGCACAA CGAGCGGAAC CGCATGACGC CGCGGTCGGG CCCGTACGCG 1560

GACCAGACGT CCACCTACAT CGAGGAGAAC GAGGGCGTCG GCAAGAACCC GCAGGCCGGA 1620

ACCGGGGAGA GGAACCGGAA CTCCATCAAC CAGGAGCGGC AGCAGCAGGC CCACACCCGC 1680

CTGCCCAGCC CAGAGGGCAG CAGCACCAGC ACCGGCCTCA GGGGAAGCCC CTCGGCCTCC 1740

ACCACGACCA CCACCATCGT CTCCGACTCA GAGGGCCCTG CGGGGACTCC CGCCGTGCCC 1800

GTCTGCCTCC ACCTGACCCA GGAGGACCTG GAGACTACCA AGCTGGACCC GAAGGAGGTC 1860

GACAAGAACC TGAAGGAGAG CTCCGACGAG AACCTGATGG AGCACTCGCA GAAGCAGTTC 1920

TGCTCCCCGG ACGCGCTGAG CCCCGGCAGC TCCAGCCTCC TCTACCCGCT CATCAAGATG 1980

GCGAGCGAGG CCGCAGGCGC TTCTGACGCC GCCGCCGACC CCCTGCCCAC CGCCATCTTC 2040

CCTCTCCCCA AGCAGCAGAA CTTGCCCAAG AGGCCGTCCA GCCTGCCGCT GCGCACCAAG 2100

CCCGCCAAGA AAGAGTCGTC CTCGTCGTCC TCGCTGAGGT TCAAGTTTGG CCGCTCGGGG 2160

AAGTCCAACC TGCGGAAGGT GGAGGGGACA AAGATGAACA TTGCCGCGGC GGCGGCCGCC 2220

AACGCGGAGC CAGAGGCTCA CGGGGGCGCC GGCACGAACA ACGCGGCCGC CCTCCGGAAT 2280

GCGCACGTCA ACGGCCATGG GCGCGCCGGC GTCTCGGCCG TGGTTGCGGG CGGGGCGACG 2340

GGTTTCGGAG GGTCCAGCGC GACCGAGAGC GGGTCGGGGG CGCCGCGGCC CGACGACGGC 2400

CGCCTGAGCC TCGGCGTCAT CACGGCCAGC CCCGACGAGC ACGAGCCGCT CCTGAGCCGC 2460

GAGCGGGAGC GGCCCGACCC GAGGGAGGCG GGGCCGGGGA GCGCCGCGGC CCTCCGCTCG 2520

GCCCGCACCA ACACGAACAA CAACAACAGC AACGACGCCG GGAGCAGGGA GGCGGTGGCG 2580

GCGGCGGCGG AGAGTTCTGG GACGGGTTCC GGCTTTGCCG CGCCCCCCCA GCGTGAAGCT 2640

CCGGCTGCCA TGAGAGGGGA GGCGCTGCTC AGGCAGCCCA GAGCCCGCCG GCCGGAGAGA 2700

CCCAACTCGC TGGACCTGTC CTTCACCACG CAGGACCTGA GCTCACTGGG GGAGGGCTTG 2760

GTCCAGCCGG ACGGCGCCTT CGGGCCGGGC GGCGACAAGA TCAAGAAGCG CGTCAAAACG 2820

CCGTACTCCC TGAAGAAGTG GCGCCCCACC ACGTGGGTCA TCTCCACGGA CGCCAGGGGG 2880

CCGGAGGTCA ACAACAACAA CAACAACGGG TCGTCCCGCG CGCCGGCCCC TCACGGCCAG 2940

AGCCGGCCCA AGTCCAGTTC GGCCATCTAC CTGCGGGGGG GCGGCTTGGC C 2991

Domain Profile

S: 1     lklleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfia  60

         lkllelig+Gryg+V+ ++l+++ vAvK+f++++++++ +E  iy+++ll+h+ni +f+a

Q: 183   LKLLELIGRGRYGAVYGGSLDERPVAVKVFTAANRQNFLNECSIYRLPLLEHDNIARFVA  242

         6899********************************************************

S: 61    adk.keedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgt  119

         ad+ +  + +te+llv+ey+++gsLs yL  +t d+ +++rla+s+++Gla+LH+e+++

Q: 243   ADErTGPEGRTEYLLVMEYYPHGSLSRYLGVQTNDWVNSCRLAHSVTRGLAYLHTELFKG  302

         ***88899************************************************8755

S: 120   kgkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekee....ldlaansqvGtkR  175

          + +Kpa++HRDl+s+N+lvk d++c+i D+GL++kl+ ++ +    ++ +a+s+vGt R

Q: 303   -DLYKPAVSHRDLNSRNVLVKADGACVIIDFGLSMKLTGNRPArhgeEESTAISEVGTIR  361

         .57**********************************9998876776778899*******

S: 176   YmaPEvleealnlkdfe.afkraDvYslgLvlWEvasRcee..vdeeveeyklpfeevvg  232

         YmaPEvle+a+nl+d+e a+k++D+Y+lgL++WE ++Rc++  ++e+v+ey+++f+++ g

Q: 362   YMAPEVLEGAVNLRDCEsALKQVDMYALGLIYWETFMRCTDlfPGESVPEYQMAFQAEAG  421

         *****************99*****************************************

S: 233   sdPsleemkevvvekklrPkipeawkkke.alkelsklleecWdadpeaRltalrvkkrl  291

         ++P++e+m+ +v ++k+rPk+peawk+++ a+++l++++e+cWd+d+eaRlta++ ++rl

Q: 422   NHPTFEDMQVLVSREKQRPKFPEAWKENSlAVRSLKETMEDCWDQDAEARLTAQCAEERL  481

         ***************************9999*************************9986

Domain Sequence
(FASTA)

LKLLELIGRG RYGAVYGGSL DERPVAVKVF TAANRQNFLN ECSIYRLPLL EHDNIARFVA 60

ADERTGPEGR TEYLLVMEYY PHGSLSRYLG VQTNDWVNSC RLAHSVTRGL AYLHTELFKG 120

DLYKPAVSHR DLNSRNVLVK ADGACVIIDF GLSMKLTGNR PARHGEEEST AISEVGTIRY 180

MAPEVLEGAV NLRDCESALK QVDMYALGLI YWETFMRCTD LFPGESVPEY QMAFQAEAGN 240

HPTFEDMQVL VSREKQRPKF PEAWKENSLA VRSLKETMED CWDQDAEARL TAQCAEERL 299

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016020	; C:membrane
GO:0005524	; F:ATP binding
GO:0005024	; F:transforming growth factor beta-activated receptor activity
GO:0007178	; P:transmembrane receptor protein serine/threonine kinase signaling pathway

KEGG

InterPros

IPR000472	; Activin_rcpt.
IPR015770	; BMPRII.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.

Pfam

PF01064	; Activin_recp; 1.
PF00069	; Pkinase; 1.

SMARTs

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.

Prints

Created Date

20-Feb-2013