EKS-GAA-00490
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-GAA-00490
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/PDGFR552.84.7E-166567909343
StatusUnreviewed
Ensembl ProteinENSGACP00000018838
UniProt AccessionG3PMK6;
Protein NameTyrosine-protein kinase receptor
Protein Synonyms/Alias
Gene NamePDGFRA
Gene Synonyms/Alias PDGFRA;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSGACG00000014259ENSGACP00000018837ENSGACT00000018875
ENSGACG00000014259ENSGACP00000018838ENSGACT00000018876
OrganismGasterosteus aculeatus
Functional Description
Protein Length1050
Protein Sequence
(FASTA)
MFPRSSAPVL LPRSEELVVP LHAPFTLTCQ GDAKLAWVTP PDVRQQMRED NSGLFVTTVT 60
VDSATAMHTG YYTCSYSNAT EEEEAEDSSI YVYVPDPDVP FVPSLVPFGN HILYEHEDME 120
IQCRVSDPSA NVTLVNMETQ QPVASVYDSK RGAVGVFTAG TYVCKALVNG EEHHSGEYIV 180
HGWPGGAPLH VELSAERTAL LVGDAVTVTC VARGSEILED HWKYPGKLAN RGIKAVEDIQ 240
KLQEIRYTLT IPQASVKDSG IYSCSITDIV SGESQTKEVA VRVFASEFLS VWPQFGEDES 300
AELDEVREFR AEISAFPAAR VTWLKDGVAL SDVTAEIGLR QLSETSYMSV LTLIRAKEED 360
SGNYTMRVEN GDQRRDVGLM LQVKVPAVIV DLMDIHHGAA TGQSVVCITR GEPLPLVEWF 420
VCKNIKHCAN DSLAWEPLPA NSTGVTAESH VNEDGNLESQ VMFGHLESTL AVRCLSRNGM 480
AAVSREVKLV SSGGPHPELT VAAAVLVLLV IVIISLIVLV VIWKQKPRYE IRWRVIESVS 540
PDGHEYIYVD PMQLPYDSRW EFPRDRLVLG RILGSGAFGK VVEGTAYGLG RSQPVMKVAV 600
KMLKPTARSS EKQALMSELK IMTHLGPHLN IVNLLGACTK SGPIYIITEY CFYGDLVNYL 660
HKNRENFLSL NPEKTKKEVD IFGINPADES SRSYVILSLE SKADYMDMKQ GDGTQYVPLL 720
EMRDASKYSD IQRSEYDPPP SQKGTLTPED ELLSDDVNEG LSTTDLLSFT YQVAKGMEFL 780
ASKNCVHRDL AARNVLLSQG KMVKICDFGL ARDIMHDSNY VSKGSTFLPV KWMAPESIFD 840
NMYTTLSDVW SYGILLWEIF SLGGTPYPGM VVDSSFYNKI KSGYRMSKPE LAPDDVYEMM 900
MKCWNSECEL DRTCAYLLEG DFTRHYERVN REFLKSDHPA VTRVCAESDD VYVGISSKNK 960
KLKDRESGFD EQRLSSDSGY IIPLPDLEPP SDDEYGKRNR HGSQTSEESA IETGSSSSTY 1020
AKREGETLED ITLLDEMCLD CSDLGEDSFL 1050
Nucleotide Sequence
(FASTA)
ATGTTCCCCC GGTCCTCCGC CCCCGTGCTG CTCCCGCGGA GCGAGGAGCT GGTGGTGCCC 60
CTCCACGCCC CTTTCACGCT GACCTGTCAG GGGGACGCCA AACTCGCCTG GGTGACGCCG 120
CCTGACGTGC GCCAGCAAAT GCGGGAGGAC AACAGCGGCC TGTTCGTCAC CACGGTTACC 180
GTGGACTCCG CCACGGCGAT GCACACGGGC TACTACACCT GCTCTTACAG CAACGCCACG 240
GAGGAGGAGG AGGCGGAGGA CAGCAGCATC TATGTCTACG TGCCAGACCC GGATGTCCCC 300
TTCGTGCCCT CGCTGGTGCC CTTCGGCAAC CACATCCTGT ATGAGCACGA GGACATGGAG 360
ATCCAGTGCC GGGTGTCCGA CCCCAGCGCC AACGTCACCC TGGTCAACAT GGAGACCCAG 420
CAGCCCGTCG CCAGCGTGTA CGACAGCAAG CGGGGCGCCG TGGGGGTGTT CACCGCCGGC 480
ACCTACGTCT GCAAGGCGCT CGTCAACGGA GAGGAGCACC ACAGCGGGGA GTACATCGTC 540
CACGGCTGGC CAGGCGGCGC CCCGCTGCAC GTGGAGCTGA GCGCAGAGCG GACCGCTCTG 600
CTGGTGGGAG ACGCCGTCAC CGTCACCTGT GTGGCTCGGG GGTCCGAGAT TCTGGAGGAC 660
CACTGGAAAT ACCCTGGAAA ACTGGCGAAT CGCGGGATCA AAGCGGTGGA AGACATCCAG 720
AAGCTTCAGG AGATCCGCTA CACCCTGACC ATCCCGCAGG CCTCCGTCAA GGACAGCGGC 780
ATCTACTCGT GCTCCATCAC CGACATCGTC AGCGGCGAGA GCCAGACCAA GGAGGTGGCC 840
GTTCGAGTGT TCGCGAGCGA GTTCCTGTCC GTCTGGCCGC AGTTCGGAGA AGACGAGTCG 900
GCGGAGCTGG ACGAGGTCCG GGAGTTCAGG GCCGAGATCA GCGCCTTCCC CGCCGCTCGC 960
GTCACCTGGC TCAAGGACGG CGTCGCGCTC AGCGACGTGA CGGCGGAGAT CGGCCTCCGT 1020
CAGCTCAGCG AAACCAGCTA CATGAGCGTT CTCACCCTGA TCCGGGCCAA GGAGGAGGAC 1080
AGCGGGAACT ACACCATGCG GGTGGAGAAC GGAGACCAGA GACGCGACGT CGGCCTGATG 1140
CTGCAGGTCA AAGTGCCCGC AGTCATCGTG GACCTGATGG ACATCCACCA CGGCGCCGCC 1200
ACCGGCCAGT CGGTGGTGTG CATCACCCGA GGGGAGCCCC TCCCGCTGGT GGAGTGGTTC 1260
GTCTGCAAGA ACATCAAACA TTGTGCCAAC GACTCGTTGG CTTGGGAGCC GCTTCCCGCC 1320
AACTCCACGG GGGTCACGGC GGAGTCGCAC GTCAACGAGG ACGGCAACCT GGAGAGCCAG 1380
GTCATGTTCG GCCACCTGGA GAGCACGCTG GCCGTGCGCT GCCTGTCCCG CAACGGCATG 1440
GCCGCCGTCA GCAGGGAGGT CAAGCTGGTG TCCAGTGGTG GGCCTCACCC GGAGCTGACT 1500
GTCGCCGCCG CCGTGCTGGT GCTGCTGGTC ATTGTCATCA TCTCACTCAT TGTGTTGGTT 1560
GTTATCTGGA AGCAGAAGCC GCGCTATGAG ATCCGCTGGA GGGTCATTGA GTCGGTGAGT 1620
CCCGACGGAC ACGAGTACAT CTACGTGGAT CCCATGCAGC TTCCCTACGA CTCCCGGTGG 1680
GAGTTCCCCC GAGACCGGCT GGTGCTCGGT CGCATCCTGG GCTCCGGAGC CTTCGGGAAG 1740
GTGGTGGAGG GCACCGCCTA CGGGCTCGGC CGCTCGCAGC CCGTCATGAA GGTGGCCGTG 1800
AAGATGCTGA AACCCACAGC GCGCTCGAGT GAGAAGCAGG CGCTGATGTC AGAACTGAAG 1860
ATCATGACCC ATCTCGGGCC GCACCTCAAC ATCGTTAACC TCCTGGGAGC CTGCACCAAA 1920
TCAGGGCCCA TCTACATCAT CACGGAGTAC TGCTTCTACG GGGACCTGGT CAACTACCTG 1980
CACAAGAACA GGGAGAACTT CCTCAGCCTG AACCCGGAGA AGACCAAGAA AGAGGTGGAC 2040
ATCTTTGGGA TCAACCCTGC AGATGAGAGC AGCAGGAGCT ACGTCATCCT GTCTTTGGAG 2100
AGCAAAGCCG ACTACATGGA CATGAAGCAA GGCGACGGCA CGCAATACGT CCCCCTGCTG 2160
GAGATGAGGG ACGCCTCCAA GTATTCCGAC ATCCAGAGGT CCGAGTACGA CCCCCCCCCC 2220
TCCCAAAAAG GTACGCTTAC ACCAGAGGAC GAGCTGCTGT CAGACGACGT GAACGAGGGC 2280
CTCAGCACCA CCGACCTGCT CAGCTTCACC TACCAGGTGG CCAAAGGCAT GGAGTTCCTG 2340
GCCTCCAAGA ATTGCGTCCA TCGGGACCTG GCCGCCAGGA ATGTCCTCCT CTCTCAGGGC 2400
AAGATGGTGA AGATCTGTGA CTTCGGACTG GCCCGGGACA TCATGCACGA CAGCAACTAC 2460
GTCTCCAAAG GGAGCACGTT CCTGCCCGTG AAGTGGATGG CCCCCGAGAG CATCTTTGAC 2520
AACATGTACA CCACCCTGAG TGACGTGTGG TCCTACGGCA TCCTGCTGTG GGAGATCTTC 2580
TCGTTGGGTG GAACCCCGTA CCCGGGGATG GTCGTGGACT CCAGCTTCTA CAACAAGATC 2640
AAGAGTGGAT ACAGGATGTC CAAACCGGAG CTGGCCCCCG ACGACGTGTA CGAGATGATG 2700
ATGAAGTGCT GGAACAGCGA GTGTGAATTA GACCGCACTT GTGCATATCT TTTAGAAGGT 2760
GATTTCACAA GACACTACGA GCGGGTGAAC CGCGAGTTCC TGAAGAGCGA CCACCCCGCC 2820
GTCACCCGGG TGTGCGCGGA GAGCGACGAC GTCTACGTCG GCATCAGCAG CAAGAACAAG 2880
AAGCTGAAGG ATCGAGAGAG CGGCTTCGAC GAGCAGCGGC TGAGCTCCGA CAGCGGCTAC 2940
ATCATCCCGC TGCCCGACCT GGAGCCGCCC TCCGACGACG AGTACGGGAA GAGGAACCGG 3000
CACGGCTCTC AGACGTCGGA GGAGAGCGCC ATCGAGACGG GCTCCAGCAG CTCCACCTAC 3060
GCCAAGCGCG AGGGGGAGAC CCTGGAGGAC ATCACGCTGC TGGACGAGAT GTGTCTGGAC 3120
TGCAGCGACC TGGGGGAGGA CAGCTTCCTG TGA 3153
Domain Profile
S: 1     lelGkvlGsGafGkvveatayGlsksdavlkvavkmlkstarssekealmselkilshlG  60
         l+lG++lGsGafGkvve+tayGl++s++v+kvavkmlk+tarssek+almselki++hlG
Q: 567   LVLGRILGSGAFGKVVEGTAYGLGRSQPVMKVAVKMLKPTARSSEKQALMSELKIMTHLG  626
         78**********************************************************
S: 61    ehenivnllGactkgGpiyviteyccyGdllnylrrkresflkkslekkkekeeeldska  120
         +h+nivnllGactk+Gpiy+iteyc+yGdl+nyl+++re+fl+   ek   +++e+d+++
Q: 627   PHLNIVNLLGACTKSGPIYIITEYCFYGDLVNYLHKNRENFLSLNPEK---TKKEVDIFG  683
         ******************************************888887...678889999
S: 121   l.ladkslrsksslssesseeyvdlkkd................vsdvssskadklasek  163
         + +ad+s rs+++ls es+ +y+d+k++                +sd+++s++d + s+k
Q: 684   InPADESSRSYVILSLESKADYMDMKQGdgtqyvpllemrdaskYSDIQRSEYDPPPSQK  743
         989************************99******************************9
S: 164   kksalerevkaaleeedsevleledllsfsyqvakGmeflaskncvhrdlaarnvllteG  223
          + + e e    l+++ +e+l+ +dllsf+yqvakGmeflaskncvhrdlaarnvll++G
Q: 744   GTLTPEDEL---LSDDVNEGLSTTDLLSFTYQVAKGMEFLASKNCVHRDLAARNVLLSQG  800
         877777665...6888899*****************************************
S: 224   kvvkicdfGlardimkdsnyvvkGnarlpvkwmapesifdslytvksdvwsyGillweif  283
         k+vkicdfGlardim+dsnyv+kG+++lpvkwmapesifd++yt+ sdvwsyGillweif
Q: 801   KMVKICDFGLARDIMHDSNYVSKGSTFLPVKWMAPESIFDNMYTTLSDVWSYGILLWEIF  860
         ************************************************************
S: 284   slGstpypgllvdskfyklikeGyrmaqpayateeiyeimqkcweaepe  332
         slG+tpypg++vds fy++ik+Gyrm++p+ a++++ye+m kcw++e e
Q: 861   SLGGTPYPGMVVDSSFYNKIKSGYRMSKPELAPDDVYEMMMKCWNSECE  909
         *********************************************9976
Domain Sequence
(FASTA)
LVLGRILGSG AFGKVVEGTA YGLGRSQPVM KVAVKMLKPT ARSSEKQALM SELKIMTHLG 60
PHLNIVNLLG ACTKSGPIYI ITEYCFYGDL VNYLHKNREN FLSLNPEKTK KEVDIFGINP 120
ADESSRSYVI LSLESKADYM DMKQGDGTQY VPLLEMRDAS KYSDIQRSEY DPPPSQKGTL 180
TPEDELLSDD VNEGLSTTDL LSFTYQVAKG MEFLASKNCV HRDLAARNVL LSQGKMVKIC 240
DFGLARDIMH DSNYVSKGST FLPVKWMAPE SIFDNMYTTL SDVWSYGILL WEIFSLGGTP 300
YPGMVVDSSF YNKIKSGYRM SKPELAPDDV YEMMMKCWNS ECE 343
KeywordATP-binding; Complete proteome; Disulfide bond; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>
EKS-AIM-00373
EKS-ANC-00388
EKS-BOT-00401
EKS-CAJ-00405
EKS-CAF-00401
EKS-CAP-00430
EKS-EQC-00393
EKS-FEC-00385
EKS-GAG-00339
EKS-GOG-00393
EKS-HOS-00407
EKS-ICT-00380
EKS-LAC-00417
EKS-LOA-00410
EKS-MAM-00400
EKS-MEG-00333
EKS-MOD-00390
EKS-MUM-00433
EKS-MUP-00395
EKS-MYL-00396
EKS-NOL-00366
EKS-ORN-00512
EKS-ORA-00350
EKS-ORC-00376
EKS-ORL-00470
EKS-OTG-00403
EKS-PAT-00380
EKS-PES-00356
EKS-POA-00392
EKS-RAN-00416
EKS-SAH-00370
EKS-TAG-00476
EKS-TAR-00508
EKS-TEN-00509
EKS-TUT-00117
EKS-XET-00512
Gene Ontology
GO:0005887; C:integral to plasma membrane
GO:0005524; F:ATP binding
GO:0005021; F:vascular endothelial growth factor-activated receptor activity
GO:0048010; P:vascular endothelial growth factor receptor signaling pathway
GO:0038084; P:vascular endothelial growth factor signaling pathway
KEGG
InterPros
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR013098; Ig_I-set.
IPR003599; Ig_sub.
IPR003598; Ig_sub2.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016243; Tyr_kinase_CSF1/PDGF_rcpt.
IPR001824; Tyr_kinase_rcpt_3_CS.
IPR009134; Tyr_kinase_VEGFR_rcpt_N.
Pfam
PF07679; I-set; 2.
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00409; IG; 2.
SM00408; IGc2; 1.
SM00219; TyrKc; 1.
Prosites
PS50835; IG_LIKE; 2.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00240; RECEPTOR_TYR_KIN_III; 1.
Prints
PR01832; VEGFRECEPTOR.
Created Date20-Feb-2013