EKS-GAA-00558
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-GAA-00558
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
CMGC/MAPK426.46.6E-12834322289
StatusUnreviewed
Ensembl ProteinENSGACP00000019049
UniProt AccessionG3PN66;
Protein Name
Protein Synonyms/Alias
Gene NameMAPK1
Gene Synonyms/Alias MAPK1;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSGACG00000014421ENSGACP00000019049ENSGACT00000019087
ENSGACG00000014421ENSGACP00000019034ENSGACT00000019072
OrganismGasterosteus aculeatus
Functional Description
Protein Length369
Protein Sequence
(FASTA)
MATATVSLPA GCGPSPGSGT ELVRGQAFDV GPRYSNLSYI GEGAYGMVCS AYDRDNKVRV 60
AIKKISPFEH QTYCQRTLRE IKILLRFKHE NIIGINDIIR TPTIDLMKDV YIVQDLMETD 120
LYKLLKTQHL SNDHICYFLY QILRGLKYIH SANVLHRDLK PSNLLLNTTC DLKICDFGLA 180
RVADPDHDHT GFLTEYVATR WYRAPEIMLN SKGYTKSIDI WSVGCILAEM LSNRPIFPGK 240
HYLDQLNHIL GILGSPSQED LNCIINIKAR NYLLSLPLRC KVPWNRLFPN ADPKALDLLD 300
KMLTFNPHKR IEVEEALAHP YLEQYYDPTD EPVAEAPFKF DMELDDLPKE TLKELIFAET 360
SRFQTAFRS 369
Nucleotide Sequence
(FASTA)
ATGGCGACAG CTACGGTGTC TCTCCCCGCG GGCTGCGGCC CGAGCCCCGG GTCGGGGACG 60
GAGCTGGTCC GCGGGCAGGC CTTCGACGTC GGGCCTCGGT ACAGCAACCT CTCCTACATC 120
GGGGAGGGAG CCTACGGGAT GGTGTGCTCT GCCTATGACC GGGACAACAA GGTACGCGTG 180
GCCATCAAGA AGATCAGCCC GTTCGAGCAC CAGACGTACT GCCAGCGCAC CCTGAGGGAG 240
ATCAAAATCC TGCTGCGCTT CAAACATGAG AACATCATCG GCATCAACGA CATCATCCGC 300
ACGCCGACCA TCGACCTGAT GAAGGACGTA TACATCGTCC AGGATCTCAT GGAGACGGAC 360
CTCTACAAGC TCCTGAAGAC TCAACACCTG AGCAACGACC ACATCTGCTA CTTCCTCTAC 420
CAGATCCTCC GAGGGCTCAA GTACATCCAC TCCGCCAACG TCCTGCACCG CGACCTGAAG 480
CCCTCCAACC TGCTGCTCAA CACCACCTGC GATCTCAAGA TCTGCGATTT TGGTTTGGCC 540
CGCGTGGCTG ACCCGGACCA CGATCACACC GGCTTCCTGA CGGAGTACGT CGCCACCCGT 600
TGGTACAGAG CGCCTGAGAT CATGTTGAAC TCCAAGGGCT ACACCAAGTC CATAGACATC 660
TGGTCAGTGG GCTGCATCCT GGCCGAGATG TTGTCAAACA GGCCAATCTT TCCCGGGAAG 720
CACTACTTGG ATCAGCTCAA CCACATTTTG GGGATCCTGG GTTCTCCCTC TCAGGAGGAT 780
CTCAACTGCA TCATCAACAT CAAAGCCAGG AACTACCTCC TGTCGCTGCC GCTGCGCTGC 840
AAAGTTCCGT GGAACCGCCT CTTCCCCAAC GCCGACCCCA AAGCTCTGGA CCTGCTGGAC 900
AAGATGTTGA CCTTCAACCC TCACAAGCGG ATCGAGGTGG AGGAGGCCCT GGCGCACCCT 960
TACCTGGAGC AGTACTACGA CCCCACGGAT GAGCCTGTCG CTGAGGCGCC GTTCAAGTTC 1020
GACATGGAGC TGGATGACCT CCCCAAAGAG ACGCTGAAGG AGCTCATCTT TGCAGAAACG 1080
TCACGTTTCC AGACCGCCTT TAGGTCCTAA 1110
Domain Profile
S: 1     yeslkplgeGaygvvvsavdkrteervaikklsrpfqketsakrtlRElkllkelkheNi  60
         y++l+++geGayg+v+sa+d++++ rvaikk+s pf+++t ++rtlRE+k+l ++kheNi
Q: 34    YSNLSYIGEGAYGMVCSAYDRDNKVRVAIKKIS-PFEHQTYCQRTLREIKILLRFKHENI  92
         78999***************************9.**************************
S: 61    iklldvftpeeeleelkdvYlvtelmetdLkkviksqklsdehiklllyqilrglkylHs  120
         i + d++++ + ++ +kdvY+v++lmetdL+k++k+q+ls++hi ++lyqilrglky+Hs
Q: 93    IGINDIIRTPT-IDLMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHS  151
         ********999.************************************************
S: 121   anviHrDlKPsNllvnedcelkildFGlarsadkekekk..lteyvatrwYraPeillsl  178
         anv+HrDlKPsNll+n++c+lki+dFGlar+ad++++++  lteyvatrwYraPei+l++
Q: 152   ANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTgfLTEYVATRWYRAPEIMLNS  211
         ***********************************999999*******************
S: 179   keytkavDiWsvGCIlaElltgkplfpgkdeidqlekilevlgtpseeflkkieseearn  238
         k ytk++DiWsvGCIlaE+l+++p+fpgk+++dql++il +lg+ps+e+l++i + +arn
Q: 212   KGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINIKARN  271
         ************************************************************
S: 239   yikslpkkkkkdfeelfpkaseealdLleklLvldpdkRisveeaLehpYl  289
         y+ slp + k ++++lfp+a+++aldLl+k+L+++p+kRi+veeaL+hpYl
Q: 272   YLLSLPLRCKVPWNRLFPNADPKALDLLDKMLTFNPHKRIEVEEALAHPYL  322
         **************************************************7
Domain Sequence
(FASTA)
YSNLSYIGEG AYGMVCSAYD RDNKVRVAIK KISPFEHQTY CQRTLREIKI LLRFKHENII 60
GINDIIRTPT IDLMKDVYIV QDLMETDLYK LLKTQHLSND HICYFLYQIL RGLKYIHSAN 120
VLHRDLKPSN LLLNTTCDLK ICDFGLARVA DPDHDHTGFL TEYVATRWYR APEIMLNSKG 180
YTKSIDIWSV GCILAEMLSN RPIFPGKHYL DQLNHILGIL GSPSQEDLNC IINIKARNYL 240
LSLPLRCKVP WNRLFPNADP KALDLLDKML TFNPHKRIEV EEALAHPYL 289
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dasypus novemcinctus"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>
EKS-AIM-00435
EKS-ANC-00450
EKS-BOT-00462
EKS-CAE-00385
EKS-CAJ-00466
EKS-CAF-00460
EKS-CAP-00493
EKS-CII-00260
EKS-CIS-00220
EKS-DAR-00868
EKS-DAN-00034
EKS-DIO-00097
EKS-DRM-00222
EKS-ECT-00060
EKS-EQC-00449
EKS-ERE-00049
EKS-FEC-00439
EKS-GAM-00267
EKS-GAG-00389
EKS-GOG-00450
EKS-HOS-00469
EKS-ICT-00444
EKS-LAC-00473
EKS-LOA-00473
EKS-MAM-00459
EKS-MEG-00382
EKS-MIM-00088
EKS-MOD-00452
EKS-MUM-00494
EKS-MUP-00452
EKS-MYL-00461
EKS-NOL-00423
EKS-OCP-00120
EKS-ORN-00584
EKS-ORA-00408
EKS-ORC-00441
EKS-OTG-00474
EKS-PAT-00435
EKS-PES-00410
EKS-PEM-00252
EKS-POA-00449
EKS-PTV-00167
EKS-RAN-00476
EKS-SAH-00435
EKS-SUS-00410
EKS-TAG-00529
EKS-TAR-00574
EKS-TEN-00574
EKS-TUT-00168
EKS-XET-00610
EKS-XIM-00573
EKS-SAC-00101
EKS-SCP-00101
Gene Ontology
GO:0005524; F:ATP binding
GO:0004707; F:MAP kinase activity
GO:0000165; P:MAPK cascade
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR003527; MAP_kinase_CS.
IPR008349; MAPK_ERK1/2.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00069; Pkinase; 1.
SMARTs
SM00220; S_TKc; 1.
Prosites
PS01351; MAPK; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
PR01770; ERK1ERK2MAPK.
Created Date20-Feb-2013