EKS-GAA-00369

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-GAA-00369

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/EGFR	484.9	6.9E-146	688	948	261

Status

Unreviewed

Ensembl Protein

ENSGACP00000019454

UniProt Accession

G3PPC1;

Protein Name

Protein Synonyms/Alias

Gene Name

ERBB4 (2 of 2)

Gene Synonyms/Alias

ERBB4 (2 of 2);

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGACG00000014727	ENSGACP00000019454	ENSGACT00000019492

Organism

Gasterosteus aculeatus

Functional Description

Protein Length

1283

Protein Sequence
(FASTA)

ASEVTQHSRS LSAVCPGTEN KLSTLSDLDQ QYRTLKKLYE NCEVVMGNLE ITSIDRNRNL 60

SFLKSIREVT GYVLVALNQF DYLPLENLRI VRGTKLYEGR YSLAIFLNYR RDGYYGLRQL 120

GLRNLTEILN GGVYVDQNKF LCHADTIHWR DIIKNPQAEL LVVPSNNSNL GCRRCHRSCN 180

GRCWGHQEDQ CQTLTKTVCA EQCDGRCFGP YVSDCCHREC AGGCSGPKDT DCFACTNFND 240

SGACVTQCPQ PFVYNPTSFQ LEHNPRAKYT YGAFCVKKCP HNFVVDHSSC VRACPSNKME 300

VEENRIKMCI PCTDICPKVC DGIGTGSLQS AQTVDASNID KFVNCTKING NLIFLITGIK 360

GDIYHGIGPM DPERLNAFRT VREITGFLNI QSWPENMTDL GVFSSLATIG GRSLYSGAPA 420

PSRRSQSGRS CNGLRRGEYQ CSLAQLCVTH KIAFSVPLQA ITTSFLHTAQ QQMVCDRMCS 480

DDGCWGPGPD QCLSCRYFRR GRACVESCNL FDGDMRKFDN GSVCLECDGQ CEKMDGNAMT 540

CLGQGPDQCV KCLHFKDGPN CVEKCPDGLQ GANSFIFKYA KANNECHPCH VNCTQGQCGS 600

ETRKRCTPWS WSTLPFFTMT PLIAAGIIGG MFIVVILALS VAVSVRRKSI KKKRALRRFL 660

ETELVEPLTP SGTAPNQAQL RILKETELKR VKILGSGAFG TVYKGIWVPE GETVKIPVAI 720

KILNETTGPK ANVEFMDEAL IMASVEHPHL VRLLGVCLSP TIQLVTQLMP HGCLLDYVHE 780

HKDNIGSQLL LNWCVQIAKG MMYLEERRLV HRDLAARNVL VKSPNHIKIT DFGLARLLDA 840

DEKEYNADGG KMPIKWMALE CIHYRKFTHQ SDVWSYGVTI WELMTFGGKP YDGIPTREIP 900

DILEKGERLP QPPICTIDVY MVMVKKDIKG WMIDADSRPK FKELAAEFCR MARDPQRYLV 960

IQGDDRMKLP SPNDSKFFQS LLEEEDLNDL MDADEYLVPR GFNAPPPSYT TRPRVDSNRL 1020

CLAALHSPLR QMTTLSENQF GYRDGGPNPA EASGPGALAS VNPDATGATG PAPEDQRCNG 1080

SLLRKSHGPA GGEDSGGQRY SADPTIFLGE RTPRGDTDED GYMTSMKDKS SSEYLNPIEE 1140

NPFVSRRKNG EVHALDNPGY HSTPNSQPKG EDEYINEPLY LNTFHSPVDL SLEALRRNGK 1200

VSGKKLKVTF DNPEYWQHSL PPKPSNPAAP EGAVGGSTNA KLFYKQNGHI RPAVAENPEY 1260

MSEFSLKAGF LPPPPYRQRN TVV 1283

Nucleotide Sequence
(FASTA)

GCCTCCGAAG TGACTCAGCA CTCTCGCTCT CTTTCCGCAG TTTGCCCCGG CACGGAGAAC 60

AAGCTGAGCA CTTTGTCCGA CCTGGACCAG CAGTACCGCA CCCTGAAGAA GCTCTACGAA 120

AACTGTGAAG TCGTCATGGG CAACTTGGAG ATCACCAGCA TCGATCGCAA TCGCAACCTC 180

TCCTTCCTCA AGTCCATCAG AGAAGTGACC GGCTACGTGC TGGTGGCTCT CAACCAGTTC 240

GACTACCTGC CGCTGGAGAA CCTGAGGATC GTCCGAGGCA CCAAACTGTA CGAGGGTCGC 300

TACTCTCTGG CCATCTTCCT CAACTACCGG CGGGACGGGT ACTACGGCCT GAGGCAGCTG 360

GGCCTGCGCA ACCTCACAGA GATACTGAAC GGGGGGGTTT ATGTGGACCA GAACAAATTC 420

CTGTGCCACG CAGACACCAT CCATTGGCGT GACATCATCA AGAACCCCCA GGCGGAGCTG 480

CTGGTGGTAC CGTCCAACAA CAGCAACCTC GGATGCCGAC GCTGCCACCG CTCGTGTAAC 540

GGACGCTGCT GGGGCCATCA GGAAGACCAG TGTCAGACCT TGACAAAGAC GGTGTGTGCA 600

GAGCAGTGTG ACGGTCGCTG CTTCGGGCCT TACGTCAGCG ACTGCTGCCA TCGCGAGTGT 660

GCTGGCGGCT GCTCGGGCCC CAAGGACACC GACTGCTTCG CCTGCACCAA CTTCAACGAC 720

AGCGGCGCGT GCGTGACCCA GTGCCCGCAG CCGTTTGTGT ACAACCCCAC ATCCTTCCAG 780

CTGGAGCACA ACCCCAGAGC CAAGTACACC TACGGAGCCT TCTGCGTCAA GAAATGCCCA 840

CACAACTTCG TGGTGGACCA CAGCTCCTGC GTCAGAGCGT GTCCCAGCAA CAAGATGGAA 900

GTGGAGGAGA ACCGCATCAA AATGTGCATC CCCTGTACCG ACATCTGCCC TAAAGTGTGC 960

GACGGCATCG GGACGGGCAG CCTGCAGAGC GCTCAAACTG TGGACGCCAG CAACATTGAT 1020

AAGTTTGTCA ACTGCACCAA AATCAACGGC AACCTCATCT TCCTCATCAC GGGCATCAAA 1080

GGGGATATTT ATCACGGCAT TGGACCTATG GACCCCGAGC GGCTGAACGC GTTCCGCACT 1140

GTGAGAGAGA TCACAGGTTT CCTCAATATC CAGTCGTGGC CCGAGAACAT GACGGATCTT 1200

GGCGTTTTTT CCAGCCTGGC GACCATTGGC GGGAGATCTC TTTACAGTGG CGCGCCTGCG 1260

CCGTCGCGAA GGTCCCAGTC GGGGCGTTCT TGTAATGGCC TGAGGCGCGG GGAATACCAA 1320

TGCTCGCTCG CACAGCTGTG CGTTACGCAC AAAATTGCTT TTTCCGTGCC TCTGCAGGCT 1380

ATAACCACGT CCTTTCTCCA CACAGCTCAG CAGCAGATGG TGTGCGATCG GATGTGCTCG 1440

GACGACGGGT GCTGGGGCCC GGGGCCCGAT CAGTGTCTTT CCTGCCGGTA CTTCAGACGA 1500

GGTCGCGCCT GTGTGGAGTC CTGCAACCTT TTTGACGGGG ACATGCGAAA ATTTGACAAT 1560

GGATCCGTGT GCCTGGAGTG TGATGGCCAG TGTGAGAAGA TGGATGGGAA CGCCATGACA 1620

TGCCTCGGCC AGGGCCCGGA CCAATGTGTA AAATGCCTCC ACTTCAAAGA CGGACCCAAC 1680

TGTGTGGAGA AATGCCCCGA TGGGTTGCAG GGGGCCAACA GCTTCATCTT CAAGTACGCC 1740

AAGGCCAACA ACGAGTGTCA TCCCTGCCAT GTCAACTGCA CCCAGGGTCA ATGTGGGAGT 1800

GAGACAAGAA AAAGATGTAC GCCTTGGAGT TGGAGCACTC TACCATTTTT CACAATGACA 1860

CCACTGATAG CGGCCGGCAT TATCGGCGGC ATGTTCATCG TCGTCATCCT GGCGCTCAGC 1920

GTGGCCGTTT CTGTCCGACG CAAAAGCATC AAGAAGAAGA GGGCCCTGCG GCGCTTCCTG 1980

GAGACGGAGC TGGTGGAGCC CTTGACCCCC AGCGGAACGG CCCCCAACCA GGCCCAGCTG 2040

CGCATCCTCA AAGAGACCGA GCTGAAGAGG GTCAAGATCC TGGGCTCCGG AGCTTTCGGG 2100

ACCGTCTACA AGGGCATCTG GGTCCCCGAA GGTGAGACGG TGAAGATCCC CGTGGCTATT 2160

AAAATCCTCA ACGAGACCAC GGGCCCCAAA GCCAACGTGG AGTTCATGGA CGAGGCCCTG 2220

ATCATGGCCA GCGTGGAGCA CCCCCACCTG GTGCGCCTGC TGGGCGTCTG CCTGAGCCCC 2280

ACCATCCAGC TGGTCACCCA GCTCATGCCC CACGGCTGCC TCCTGGACTA CGTGCACGAG 2340

CACAAGGACA ACATCGGCTC GCAGCTGCTG CTCAACTGGT GTGTCCAGAT CGCCAAGGGG 2400

ATGATGTACC TGGAGGAGAG GAGGCTGGTC CACAGGGACC TGGCGGCCCG GAACGTGCTG 2460

GTGAAGTCGC CCAATCACAT CAAGATCACC GACTTCGGCC TGGCGCGGCT GCTGGACGCC 2520

GACGAGAAGG AGTACAACGC AGACGGCGGC AAGATGCCCA TTAAATGGAT GGCTCTGGAA 2580

TGCATCCACT ACAGGAAGTT CACCCACCAG AGTGACGTGT GGAGCTACGG AGTGACCATC 2640

TGGGAGCTGA TGACATTCGG AGGAAAGCCG TATGACGGCA TCCCCACGCG GGAGATCCCA 2700

GACATCCTGG AGAAGGGGGA GCGCCTGCCC CAGCCGCCCA TTTGCACCAT AGATGTCTAC 2760

ATGGTCATGG TCAAAAAAGA TATTAAAGGC TGGATGATCG ACGCGGACAG CAGGCCGAAG 2820

TTCAAGGAGC TGGCGGCCGA GTTCTGCAGG ATGGCCCGGG ACCCCCAGCG CTACCTGGTC 2880

ATCCAGGGAG ACGACCGCAT GAAGCTCCCC AGCCCCAACG ACAGCAAGTT CTTCCAGAGC 2940

CTTCTGGAGG AGGAGGACCT GAATGACCTG ATGGATGCTG ACGAGTATCT GGTGCCTCGA 3000

GGCTTCAACG CGCCGCCTCC GTCGTACACC ACCAGGCCTC GCGTCGACTC CAACCGACTC 3060

TGCCTTGCTG CCCTTCACAG TCCCTTAAGG CAGATGACTA CTCTGTCGGA AAACCAGTTT 3120

GGCTATCGAG ACGGCGGCCC GAACCCGGCG GAGGCCTCGG GGCCGGGGGC CCTAGCCTCC 3180

GTGAACCCGG ACGCCACGGG GGCAACGGGG CCGGCCCCGG AGGACCAGCG CTGCAACGGG 3240

AGCCTGCTCA GGAAGAGCCA TGGCCCGGCT GGGGGAGAGG ACAGCGGGGG TCAGAGGTAC 3300

AGCGCCGACC CCACCATCTT CCTGGGGGAG AGGACGCCCA GAGGGGACAC CGACGAGGAC 3360

GGATACATGA CGTCCATGAA GGACAAGAGC TCCTCAGAAT ACCTGAATCC CATCGAGGAG 3420

AACCCGTTCG TCTCGCGGCG TAAGAACGGC GAGGTGCACG CCTTGGATAA CCCCGGCTAC 3480

CACAGCACGC CCAACAGCCA GCCCAAAGGA GAGGACGAGT ACATCAACGA GCCGCTGTAC 3540

CTCAACACCT TCCACAGCCC CGTCGATCTG AGCCTAGAGG CCCTGAGGAG AAATGGCAAA 3600

GTCAGCGGCA AAAAGCTGAA GGTGACCTTT GACAATCCAG AATACTGGCA GCACAGCCTG 3660

CCTCCCAAAC CGTCCAACCC GGCGGCCCCC GAGGGCGCCG TGGGCGGCTC CACCAACGCC 3720

AAGCTCTTCT ACAAACAGAA CGGGCACATA CGGCCGGCGG TGGCTGAAAA CCCCGAGTAC 3780

ATGTCGGAGT TTTCCCTGAA AGCCGGCTTC TTGCCGCCTC CGCCTTACCG GCAGCGGAAC 3840

ACTGTGGTCT GA 3852

Domain Profile

S: 1     lkklkvlGsGafGtvykGiwipegenvkipvaikvleektgkkankelldealvlasldh  60

         lk++k+lGsGafGtvykGiw+pege+vkipvaik+l+e+tg+kan e++deal++as++h

Q: 688   LKRVKILGSGAFGTVYKGIWVPEGETVKIPVAIKILNETTGPKANVEFMDEALIMASVEH  747

         699*********************************************************

S: 61    anlvrllglclsstlqlvtqllplGclldyvrehkdklGsqellnwcvqiakGmsyleek  120

         ++lvrllg+cls t+qlvtql+p+Gclldyv+ehkd++Gsq llnwcvqiakGm+ylee+

Q: 748   PHLVRLLGVCLSPTIQLVTQLMPHGCLLDYVHEHKDNIGSQLLLNWCVQIAKGMMYLEER  807

         ************************************************************

S: 121   rlvhrdlaarnvlvkspnhvkitdfGlaklleadekelkaeggkvpikwlalesilkrky  180

         rlvhrdlaarnvlvkspnh+kitdfGla+ll+adeke++a+ggk+pikw+ale+i++rk+

Q: 808   RLVHRDLAARNVLVKSPNHIKITDFGLARLLDADEKEYNADGGKMPIKWMALECIHYRKF  867

         ************************************************************

S: 181   thqsdvwsyGvtvwelltfGakpydgipakeipdllekGerlaqppictidvymvlvk..  238

         thqsdvwsyGvt+wel+tfG kpydgip++eipd+lekGerl+qppictidvymv+vk

Q: 868   THQSDVWSYGVTIWELMTFGGKPYDGIPTREIPDILEKGERLPQPPICTIDVYMVMVKkd  927

         ********************************************************8533

S: 239   ..cwmidaesrpkfkelaeef  257

            wmida+srpkfkela+ef

Q: 928   ikGWMIDADSRPKFKELAAEF  948

         338****************99

Domain Sequence
(FASTA)

LKRVKILGSG AFGTVYKGIW VPEGETVKIP VAIKILNETT GPKANVEFMD EALIMASVEH 60

PHLVRLLGVC LSPTIQLVTQ LMPHGCLLDY VHEHKDNIGS QLLLNWCVQI AKGMMYLEER 120

RLVHRDLAAR NVLVKSPNHI KITDFGLARL LDADEKEYNA DGGKMPIKWM ALECIHYRKF 180

THQSDVWSYG VTIWELMTFG GKPYDGIPTR EIPDILEKGE RLPQPPICTI DVYMVMVKKD 240

IKGWMIDADS RPKFKELAAE F 261

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016020	; C:membrane
GO:0005524	; F:ATP binding
GO:0004714	; F:transmembrane receptor protein tyrosine kinase activity
GO:0007169	; P:transmembrane receptor protein tyrosine kinase signaling pathway

KEGG

InterPros

IPR000494	; EGF_rcpt_L.
IPR006211	; Furin-like_Cys-rich_dom.
IPR006212	; Furin_repeat.
IPR009030	; Growth_fac_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF00757	; Furin-like; 1.
PF07714	; Pkinase_Tyr; 1.
PF01030	; Recep_L_domain; 2.

SMARTs

SM00261	; FU; 4.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013