EKS-GAA-00572

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-GAA-00572

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/MAPK	338.5	4.0E-101	20	316	297

Status

Unreviewed

Ensembl Protein

ENSGACP00000019797

UniProt Accession

G3PQB2;

Protein Name

Protein Synonyms/Alias

Gene Name

MAPK6

Gene Synonyms/Alias

MAPK6;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGACG00000015004	ENSGACP00000019797	ENSGACT00000019835

Organism

Gasterosteus aculeatus

Functional Description

Protein Length

758

Protein Sequence
(FASTA)

MAEKFESLMN IHGFDLGSRY MDLKPLGYGG NGLVFSAVDT DCDKRVAVKK IVLTDPQSVK 60

HALREIKIIR RLDHDNIVKV FETLGPNGRR LTEDVVSLTE VNSVYIVQEY METDLCQLLE 120

RGLLSEDHAR LFMYQFLRGL KYIHSANVLH RDLKPANLFV NTEDLVLKIG DFGLARIMDP 180

HYSHKGHLSE GLVTKWYRSP RLLLSPNNYT KAIDMWAAGC IFAEMLTGKT LFAGAHELEQ 240

MQLILESIPV LREEDRQELH SVIPVFSRKD MSKPHTPLAK LLPDVSPQAL DFMEKILTFN 300

PMDRLTAEEA LAHPYMADYS FPLDEPVSLH PFHIEDEVDD IVLMDQSHSH TWDRYHESQL 360

SEADWHLHST HDPDEVQVDP RALSDVTDEE EVQVDPRKYA DGDREKFLDE PSFDYSTLFE 420

PEQSWQEDHH ENKYCDLQCS HTCNYKAVSP SYLDNLVWRE SEVNHYYEPK LIIDLSNWKE 480

QQSKEKGKAK SKCEKNGLVK AQIAMQGAEK TQSPVEKDRE QEKHLTEKPQ GQQSQGFDFD 540

SFIASTIKLS LQPEPCQEVV LLHEVGFLNE LNSSVSQLEA ARSCSLSMSK SISQEKEEKC 600

LVNLAQLGGG GLGCSVGDGA WPACPWESFG SGERVGENGC LIDEACWDIR KEDQLQKEST 660

YTSYLDHLFS RKEEGAADTV AGAETEPSEV RELDESFLGR TSEIVLNVQL DSLALPVFDS 720

TDDLPLKSIQ ASTPCAVKCS PQVAHKTWAS SSIFKHLN 758

Nucleotide Sequence
(FASTA)

ATGGCGGAGA AGTTTGAGTC GCTGATGAAC ATCCACGGCT TTGACCTGGG TTCTCGCTAC 60

ATGGACTTGA AGCCTCTGGG CTACGGGGGG AACGGCCTGG TGTTCTCCGC GGTCGACACG 120

GACTGTGACA AGCGTGTCGC TGTGAAGAAA ATTGTCTTGA CGGACCCCCA GAGTGTGAAG 180

CATGCCCTGC GCGAAATCAA GATCATTAGA CGCCTCGACC ACGACAACAT CGTGAAGGTG 240

TTTGAGACGT TGGGCCCCAA CGGACGGAGG CTGACGGAGG ATGTGGTGTC TCTGACAGAG 300

GTCAACTCGG TCTACATTGT GCAGGAGTAC ATGGAGACAG ACCTGTGTCA GCTGCTGGAG 360

AGGGGCCTTC TGTCTGAGGA CCATGCCAGG CTGTTCATGT ACCAGTTCCT CAGGGGCCTC 420

AAGTACATCC ACTCTGCCAA CGTGCTGCAC CGCGATCTCA AGCCTGCCAA CCTGTTTGTC 480

AACACGGAGG ACCTGGTCCT GAAGATCGGG GACTTTGGTC TGGCCCGCAT TATGGATCCA 540

CACTATTCTC ATAAGGGCCA TCTCTCTGAA GGTCTGGTCA CAAAGTGGTA CAGGTCTCCT 600

CGCCTGCTGC TGTCTCCTAA CAACTACACC AAAGCCATCG ACATGTGGGC CGCAGGCTGC 660

ATCTTTGCGG AGATGCTCAC AGGGAAAACC CTCTTTGCAG GAGCCCACGA ATTGGAGCAG 720

ATGCAGCTCA TCCTGGAGTC CATCCCCGTA CTGCGCGAGG AAGACCGACA GGAGCTCCAC 780

AGCGTCATCC CCGTCTTCAG CCGCAAGGAC ATGTCCAAGC CTCACACACC GCTGGCCAAG 840

CTGCTGCCTG ACGTCAGTCC CCAGGCCCTG GATTTCATGG AAAAGATCCT GACCTTTAAC 900

CCCATGGATC GTCTGACTGC GGAGGAAGCC TTGGCCCACC CCTATATGGC TGACTACTCC 960

TTCCCCCTCG ATGAACCTGT CTCTCTGCAC CCCTTCCACA TTGAGGACGA AGTAGATGAT 1020

ATCGTGCTCA TGGACCAGAG CCACAGCCAC ACCTGGGACA GGTATCATGA GAGCCAACTG 1080

TCAGAGGCAG ACTGGCACCT GCACAGCACC CACGACCCAG ATGAAGTTCA GGTTGACCCG 1140

AGGGCTCTCT CTGATGTGAC GGACGAGGAG GAGGTTCAGG TGGATCCTCG TAAATATGCT 1200

GATGGAGATC GGGAGAAGTT CTTGGACGAG CCGTCCTTTG ACTACTCCAC CCTGTTCGAG 1260

CCAGAGCAAT CCTGGCAGGA AGACCACCAT GAAAACAAAT ACTGTGACTT ACAGTGTAGC 1320

CACACCTGTA ACTACAAGGC CGTGTCTCCC TCCTACCTGG ACAACCTCGT CTGGAGGGAG 1380

AGTGAAGTCA ACCACTACTA CGAACCCAAG CTCATCATCG ACCTCTCCAA CTGGAAGGAG 1440

CAGCAGAGCA AGGAGAAGGG CAAGGCCAAG AGCAAGTGCG AGAAGAACGG GCTGGTGAAG 1500

GCCCAGATCG CCATGCAGGG GGCCGAGAAG ACCCAGAGCC CGGTGGAGAA GGACCGCGAG 1560

CAGGAGAAAC ACCTGACGGA GAAGCCCCAA GGCCAGCAGA GCCAAGGCTT TGACTTTGAC 1620

TCCTTCATCG CCAGCACCAT CAAACTCAGC CTGCAGCCCG AGCCCTGTCA GGAGGTGGTC 1680

CTCCTGCACG AGGTGGGCTT CCTCAACGAA CTCAACTCTT CCGTTTCCCA GCTGGAAGCC 1740

GCCCGCTCAT GCTCGTTGTC CATGTCCAAG TCCATAAGTC AGGAGAAGGA GGAGAAGTGC 1800

CTGGTGAACC TCGCCCAGTT GGGCGGAGGC GGGTTGGGCT GCAGCGTCGG GGACGGGGCC 1860

TGGCCCGCTT GCCCCTGGGA GAGCTTCGGC TCCGGGGAGC GAGTCGGCGA GAACGGCTGC 1920

TTGATCGACG AGGCATGTTG GGACATTCGC AAAGAGGACC AGCTCCAGAA GGAGAGCACG 1980

TACACCAGCT ACCTGGACCA CCTGTTCAGC AGGAAGGAAG AAGGCGCCGC AGACACCGTG 2040

GCCGGCGCCG AGACGGAGCC CTCGGAGGTG AGAGAGCTGG ACGAGAGCTT CCTTGGCAGG 2100

ACCTCAGAGA TTGTCCTTAA CGTTCAGCTG GACTCTCTGG CCCTGCCCGT CTTTGACAGC 2160

ACCGACGACT TGCCTCTGAA ATCCATCCAG GCGTCTACCC CCTGCGCCGT CAAATGCTCC 2220

CCGCAGGTTG CCCACAAAAC GTGGGCATCG TCAAGCATCT TCAAGCATCT TAATTAA 2277

Domain Profile

S: 1     yeslkplgeGaygvvvsavdkrteervaikklsrpfqketsakrtlRElkllkelkheNi  60

         y++lkplg G +g+v+savd+++++rva+kk++  +++ +s+k++lRE+k++++l+h+Ni

Q: 20    YMDLKPLGYGGNGLVFSAVDTDCDKRVAVKKIV--LTDPQSVKHALREIKIIRRLDHDNI  77

         7899****************************9..9************************

S: 61    iklldvftpee........eleelkdvYlvtelmetdLkkviksqklsdehiklllyqil  112

         +k+++ + p+         +l+e+++vY+v+e+metdL++++++  ls++h++l++yq l

Q: 78    VKVFETLGPNGrrltedvvSLTEVNSVYIVQEYMETDLCQLLERGLLSEDHARLFMYQFL  137

         *********999999999999***************************************

S: 113   rglkylHsanviHrDlKPsNllvnedce.lkildFGlarsadkekekk..lteyvatrwY  169

         rglky+Hsanv+HrDlKP+Nl+vn++   lki dFGlar++d+++++k  l+e ++t+wY

Q: 138   RGLKYIHSANVLHRDLKPANLFVNTEDLvLKIGDFGLARIMDPHYSHKghLSEGLVTKWY  197

         ************************876449**************999999**********

S: 170   raPeillslkeytkavDiWsvGCIlaElltgkplfpgkdeidqlekilevlgtpseeflk  229

         r+P++lls ++ytka+D+W++GCI+aE+ltgk+lf+g++e++q+++ile ++  +ee+ +

Q: 198   RSPRLLLSPNNYTKAIDMWAAGCIFAEMLTGKTLFAGAHELEQMQLILESIPVLREEDRQ  257

         ************************************************************

S: 230   kieseearnyikslpkkkkkdfeelfpkaseealdLleklLvldpdkRisveeaLehpYl  289

         +++s  +  + ++ ++k+++++++l+p+ s++ald++ek+L+++p++R+++eeaL+hpY+

Q: 258   ELHSV-IPVFSRKDMSKPHTPLAKLLPDVSPQALDFMEKILTFNPMDRLTAEEALAHPYM  316

         ****5.999**************************************************7

Domain Sequence
(FASTA)

YMDLKPLGYG GNGLVFSAVD TDCDKRVAVK KIVLTDPQSV KHALREIKII RRLDHDNIVK 60

VFETLGPNGR RLTEDVVSLT EVNSVYIVQE YMETDLCQLL ERGLLSEDHA RLFMYQFLRG 120

LKYIHSANVL HRDLKPANLF VNTEDLVLKI GDFGLARIMD PHYSHKGHLS EGLVTKWYRS 180

PRLLLSPNNY TKAIDMWAAG CIFAEMLTGK TLFAGAHELE QMQLILESIP VLREEDRQEL 240

HSVIPVFSRK DMSKPHTPLA KLLPDVSPQA LDFMEKILTF NPMDRLTAEE ALAHPYM 297

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004707	; F:MAP kinase activity
GO:0000165	; P:MAPK cascade

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR008350	; MAPK_ERK3/4.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR01771

; ERK3ERK4MAPK.

Created Date

20-Feb-2013