EKS-GAA-00317

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-GAA-00317

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/CAMKL	233.8	2.6E-69	881	1133	253

Status

Unreviewed

Ensembl Protein

ENSGACP00000019837

UniProt Accession

G3PQF2;

Protein Name

Protein Synonyms/Alias

Gene Name

PASK

Gene Synonyms/Alias

PASK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGACG00000015034	ENSGACP00000019837	ENSGACT00000019875

Organism

Gasterosteus aculeatus

Functional Description

Protein Length

1147

Protein Sequence
(FASTA)

NPNKAFLTID HKSREIVSAN EQACKLLECT RNEVIGKKLL SILKKTSQVL EEALEEDIPL 60

TDGTVVAVSG KVMDVVTSAG ELTVSVCTQR CSQNEEHWLV MMEVVERVSA FLSFTQDGNI 120

LTCDLAFSHL HGYQHPDELK GVSVKELIPS LQIPLHSNAL PKMLRIQRVC GKSRGGASVP 180

LCVKLKGAVV KEGLIKPELE YSGAVWVFAP LSGLLLLRPD GSICHIHNRL ALSLFGYDQD 240

ELLSKSVTFL MPGFYGWMSD TEKKAGPFSD SQAEVDKSRA SFKMERPNLH WNQQPAGETG 300

QRFIDTRSSY CHLHKSSHAC KLLDCEVGYI QKKLSERYMY LHSHRRENKS LGTFSGGADD 360

TTELLEEAAQ VALCTGQLDA ADTTEALLKT FALVEPPEDE TYCLVATGPP RRNQQLGDEV 420

HKSNLPAVRV ISGMRRLVVS VHVEVVLKLS PQTKCTQVNK GILLKLFLDT ATQNGYAVGR 480

QGETTPDRGK APCSCASVLQ DSSFEVISLG SRWVESHVAI QCLKRPFVYI LAPKYVTGFD 540

FICMKTPNHT NMQVVASEFL GTRMWCCTKR RKCKLDLFLS LKDLPFDLLP SVVLLGPRFI 600

ETQFPRSSSG FCERFAGNGG SDPGLAEHSC SAHVVHSASC FLDINSDGDV VTRALADLDL 660

SRSIEVLSGR GGNDDNQRSM TSCDTAELLR TPSTCVVGSD QEAGSGNAGV EARSSREEPV 720

EKNQCDQDQW AALSSIQKEK SREFCMAENG GIQSMTDIPA TSTPKKQKAN GQNPSADSTQ 780

IQEGRYEGSA YHRDGTRLDV QCDVCRINRP DGTAVICVWM SRPLHNQSDG SLGEYVKLVV 840

LPSSCHPVLF WIGDASHGEV LRSTMDLEQS RACDGQFEED YQPIKAVGRG AFGFVWKAIR 900

RSDGTDVIVK FIKKARIIKD CWVDDPMLGQ VSQEIAILTR VQHHNIVKVL EVFENGSYFQ 960

MVMEKNGDDL DLFEFIDMQP RLDEPLASYI YRQLVAAVFY LRTKNILHRD IKDENIIIDK 1020

SFHIRLIDFG SAAMMAPKKL FYNFCGTLEY CSPEVLRGNP YEGPELEMWS LGVLLYTLLF 1080

SENPFCGVDE ILDAKLKLPF RVSPELHAVL SGLLHPDPAQ RMTLDQLLLQ SWISQPISLA 1140

EYSWSEV 1147

Nucleotide Sequence
(FASTA)

AACCCAAACA AAGCTTTTCT TACAATCGAC CATAAAAGCA GAGAGATCGT GTCTGCAAAC 60

GAACAGGCCT GCAAGCTGTT AGAGTGCACC CGCAATGAGG TTATTGGAAA AAAGCTGCTT 120

TCCATCTTGA AGAAAACCAG TCAGGTCCTG GAAGAAGCAT TGGAAGAAGA TATTCCCCTG 180

ACGGATGGAA CCGTTGTGGC TGTGTCTGGA AAAGTGATGG ATGTTGTGAC ATCAGCTGGA 240

GAGTTGACAG TGTCAGTGTG TACGCAAAGA TGCTCACAAA ACGAAGAGCA CTGGCTCGTC 300

ATGATGGAAG TTGTGGAAAG GGTTTCAGCC TTTCTGTCTT TTACACAAGA CGGTAATATC 360

CTAACCTGTG ACTTGGCGTT TAGTCATCTC CATGGATACC AACATCCCGA CGAGTTAAAA 420

GGGGTGTCTG TGAAGGAGCT AATACCCTCC TTACAAATCC CCCTCCACAG TAATGCATTG 480

CCCAAAATGC TGCGGATTCA GAGAGTTTGT GGTAAAAGCA GAGGGGGTGC ATCAGTCCCA 540

CTGTGTGTCA AACTTAAGGG GGCAGTAGTC AAGGAGGGAT TAATAAAGCC TGAACTGGAG 600

TACTCTGGAG CAGTGTGGGT GTTTGCTCCT CTGAGCGGTC TCCTCCTGCT CCGCCCTGAC 660

GGCTCCATCT GCCACATCCA CAACCGCCTG GCCCTCAGTC TGTTTGGCTA CGACCAGGAC 720

GAGCTCCTGT CAAAGAGTGT CACTTTCCTG ATGCCTGGTT TCTACGGATG GATGTCTGAC 780

ACGGAGAAAA AGGCCGGCCC CTTCTCTGAC TCTCAAGCAG AGGTGGATAA AAGTAGAGCC 840

TCATTCAAAA TGGAGAGGCC GAATCTTCAC TGGAACCAGC AGCCGGCTGG AGAAACCGGG 900

CAGCGCTTTA TCGACACTCG CTCCTCCTAC TGTCACCTCC ACAAGAGTAG TCATGCTTGC 960

AAACTCCTTG ATTGTGAAGT TGGTTATATA CAAAAGAAGT TGAGTGAGCG GTACATGTAT 1020

CTTCACTCTC ATAGGAGGGA AAATAAGTCA TTAGGGACTT TTAGTGGAGG GGCTGATGAC 1080

ACTACGGAGC TGTTGGAGGA GGCCGCCCAG GTGGCTCTCT GCACCGGCCA GCTGGACGCT 1140

GCTGACACCA CTGAGGCTCT CCTCAAGACA TTTGCCTTGG TGGAACCTCC AGAAGATGAG 1200

ACGTACTGCC TGGTGGCCAC TGGTCCACCA CGCCGTAACC AGCAGTTAGG CGATGAAGTT 1260

CATAAAAGCA ATCTACCTGC CGTCAGGGTT ATCTCAGGTA TGAGGCGACT TGTAGTTTCA 1320

GTTCATGTAG AAGTGGTACT GAAACTGTCA CCTCAAACAA AATGCACACA AGTAAACAAA 1380

GGCATTCTTT TAAAACTTTT TTTAGACACT GCCACTCAGA ACGGATATGC TGTTGGCAGG 1440

CAGGGTGAGA CCACTCCTGA CAGAGGCAAA GCCCCTTGCT CATGTGCCTC CGTCCTCCAA 1500

GACTCCAGCT TTGAGGTCAT CTCACTGGGG AGCAGGTGGG TAGAATCACA TGTTGCAATT 1560

CAGTGTCTCA AGAGACCATT CGTTTACATT CTGGCACCAA AATATGTTAC TGGCTTTGAC 1620

TTTATTTGCA TGAAAACACC AAATCACACA AATATGCAGG TAGTAGCCTC AGAGTTCTTA 1680

GGGACTCGAA TGTGGTGCTG CACTAAACGT CGTAAATGCA AGCTTGATTT GTTTTTGTCT 1740

TTGAAAGATT TACCATTCGA CCTCTTGCCA TCAGTTGTTC TTCTTGGTCC TCGGTTTATT 1800

GAAACTCAAT TCCCCAGGTC GTCGTCTGGC TTCTGTGAAA GGTTTGCCGG CAATGGTGGT 1860

TCTGATCCAG GCCTGGCAGA GCATTCTTGC TCAGCACACG TGGTGCACTC AGCCAGCTGT 1920

TTCCTGGACA TTAACAGCGA TGGTGATGTG GTGACCCGGG CCCTAGCCGA CCTAGATCTG 1980

AGCCGCAGCA TAGAGGTTCT CAGTGGCAGA GGAGGCAACG ACGACAACCA ACGCTCCATG 2040

ACGTCCTGCG ACACCGCTGA GCTGCTGCGT ACGCCCTCCA CGTGCGTGGT TGGGTCTGAC 2100

CAGGAAGCTG GGAGTGGGAA CGCCGGTGTG GAGGCCAGAA GCTCAAGGGA AGAGCCAGTG 2160

GAAAAGAACC AGTGCGACCA GGATCAGTGG GCCGCGCTTT CTTCCATCCA AAAAGAAAAG 2220

AGCCGAGAGT TCTGCATGGC AGAGAACGGC GGGATTCAGT CAATGACGGA CATTCCTGCC 2280

ACGTCTACTC CTAAGAAACA GAAGGCGAAT GGACAAAACC CATCCGCAGA CTCTACACAG 2340

ATACAGGAGG GCCGCTACGA AGGAAGCGCC TACCACAGAG ACGGCACCAG ACTAGATGTG 2400

CAGTGCGATG TGTGCAGGAT TAACCGGCCT GATGGCACCG CCGTGATCTG TGTGTGGATG 2460

AGTCGGCCAT TGCACAACCA GTCCGACGGC AGTTTAGGAG AGTATGTGAA ATTAGTTGTT 2520

TTGCCTTCAA GTTGTCATCC TGTACTCTTC TGGATTGGTG ACGCCAGTCA CGGGGAGGTA 2580

TTACGCTCCA CCATGGATCT CGAGCAGTCT CGAGCCTGTG ACGGACAGTT TGAAGAAGAC 2640

TACCAGCCTA TCAAAGCTGT GGGCAGAGGA GCCTTTGGTT TTGTCTGGAA AGCGATAAGG 2700

CGCTCTGATG GAACAGATGT GATAGTGAAG TTCATTAAGA AGGCCAGGAT AATAAAGGAC 2760

TGCTGGGTAG ATGATCCCAT GCTGGGACAA GTCAGCCAGG AGATTGCCAT ACTGACAAGA 2820

GTACAGCACC ACAACATAGT CAAGGTGCTG GAGGTGTTTG AGAATGGGAG TTACTTCCAG 2880

ATGGTGATGG AGAAAAATGG AGATGACTTG GACCTGTTTG AGTTCATAGA CATGCAGCCA 2940

AGGCTGGATG AGCCCTTAGC CAGCTACATC TATAGACAGC TGGTGGCCGC TGTCTTCTAT 3000

TTGAGGACTA AAAACATCCT TCACAGGGAC ATAAAAGACG AGAACATCAT CATTGACAAA 3060

AGTTTCCACA TTCGACTGAT CGACTTTGGC TCTGCTGCCA TGATGGCTCC CAAGAAGCTC 3120

TTTTACAATT TCTGCGGCAC ATTGGAGTAC TGTTCCCCGG AAGTGCTTCG GGGAAATCCC 3180

TATGAGGGTC CAGAGCTGGA GATGTGGTCT CTTGGTGTGT TGCTGTACAC TCTGCTATTT 3240

AGTGAGAACC CTTTCTGTGG CGTTGATGAG ATCCTGGACG CCAAACTCAA GCTCCCGTTC 3300

CGCGTCTCTC CAGAGCTGCA TGCTGTGTTG AGCGGGCTGC TGCACCCTGA TCCCGCTCAG 3360

AGAATGACTC TGGACCAGCT GCTGCTGCAG TCCTGGATCA GCCAGCCCAT TTCACTGGCA 3420

GAGTACAGCT GGTCAGAGGT G 3441

Domain Profile

S: 1     ykllktlGegsfgkVklakhketkekvavKiikkkkl......seeslekikrEieilkk  54

         y+ +k +G+g+fg V +a++++ ++ v+vK+ikk+++      ++  l ++++Ei+il +

Q: 881   YQPIKAVGRGAFGFVWKAIRRSDGTDVIVKFIKKARIikdcwvDDPMLGQVSQEIAILTR  940

         788999*****************************999999998899*************

S: 55    lkhpniikllevietkkklylvle.yasggeLfdyieekgrlkekearklfkqlvsavkY  113

         ++h+ni+k+lev+e+ +++++v+e   +  +Lf+ i  + rl+e  a+ +++qlv+av Y

Q: 941   VQHHNIVKVLEVFENGSYFQMVMEkNGDDLDLFEFIDMQPRLDEPLASYIYRQLVAAVFY  1000

         ************************445666******************************

S: 114   lhskgivHrDlKpeNllldkkenikiaDFGlanlfkegklletfcGsppYaaPellkgkk  173

         l++k+i HrD+K eN+++dk+ +i+++DFG a+++ ++kl+ +fcG+++Y++Pe+l+g++

Q: 1001  LRTKNILHRDIKDENIIIDKSFHIRLIDFGSAAMMAPKKLFYNFCGTLEYCSPEVLRGNP  1060

         ************************************************************

S: 174   YegpkvDvWslGvvLyalvtgklPfdeenlkellekilkgkleipkklskelesLlrklL  233

         Yegp++++WslGv+Ly+l++ + Pf +       ++il+ kl++p+ +s+el+ +l+ lL

Q: 1061  YEGPELEMWSLGVLLYTLLFSENPFCGV------DEILDAKLKLPFRVSPELHAVLSGLL  1114

         **************************99......79************************

S: 234   vvdpekRatieeilkhewl  252

         + dp++R+t++++l ++w+

Q: 1115  HPDPAQRMTLDQLLLQSWI  1133

         **************99996

Domain Sequence
(FASTA)

YQPIKAVGRG AFGFVWKAIR RSDGTDVIVK FIKKARIIKD CWVDDPMLGQ VSQEIAILTR 60

VQHHNIVKVL EVFENGSYFQ MVMEKNGDDL DLFEFIDMQP RLDEPLASYI YRQLVAAVFY 120

LRTKNILHRD IKDENIIIDK SFHIRLIDFG SAAMMAPKKL FYNFCGTLEY CSPEVLRGNP 180

YEGPELEMWS LGVLLYTLLF SENPFCGVDE ILDAKLKLPF RVSPELHAVL SGLLHPDPAQ 240

RMTLDQLLLQ SWI 253

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013