EKS-GAA-00345

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-GAA-00345

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	407.0	5.6E-122	201	488	288

Status

Unreviewed

Ensembl Protein

ENSGACP00000019896

UniProt Accession

G3PQL1;

Protein Name

Protein Synonyms/Alias

Gene Name

ACVR2A

Gene Synonyms/Alias

ACVR2A;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGACG00000015083	ENSGACP00000019896	ENSGACT00000019934

Organism

Gasterosteus aculeatus

Functional Description

Protein Length

522

Protein Sequence
(FASTA)

AGSASQLAYV RNERMPSCPS AGAILGRSET QECTYYNSSW EKERTNRSGI EPCYGDKEKR 60

RHCFATWKNV SGTVEVVRQG CWLDDMNCYD SSECVERKES PDVFFCCCEG NMCNEKFLYA 120

PEVHHPLCLD LSTATSNPFS QKPQLFSTLL YSLVPIIGLA AVVLFSFWMW RHHKLAYPAA 180

LVPTHDPGPS PPSPILGHKP LQLIEMKARG RFGCVWKAQL LNDVVAVKIF PIQDKLSWQN 240

EYEIFSVSGM KHDNILHFMG AEKRNNNLDL ELWLITAYHE RGSMTDYLKA NVVSWNELCH 300

ITQTAARGLA YLHEDIPGHK DGHKPSIAHR DIKSKNVLLK TNLTACIADF GLALQFEAGK 360

SAGDTHGQVG TRRYMAPEVL EGAINFQRDS FLRIDMYAFG LVLWELAARC TAADGPVDEY 420

MLPFEEEVGQ HPSLEDMQDV VVHKKLRPVL RDCWQKHAGL AMLCETIEDC WDHEAEARLS 480

AGCVEERIGQ MKRQAPVIGP EEIVTVVTTV TNVDLQPKES SL 522

Nucleotide Sequence
(FASTA)

GCAGGGAGTG CAAGCCAATT GGCTTACGTC AGAAATGAAA GAATGCCCTC TTGTCCCTCT 60

GCAGGGGCCA TCCTGGGACG CTCGGAGACG CAAGAGTGCA CCTACTACAA CTCCAGCTGG 120

GAGAAGGAGC GCACCAACCG CAGCGGCATC GAGCCCTGCT ATGGCGATAA AGAGAAGCGA 180

AGGCACTGCT TCGCCACGTG GAAGAACGTC TCCGGCACCG TGGAGGTCGT CCGGCAGGGC 240

TGCTGGCTGG ATGACATGAA CTGCTACGAC AGTAGCGAGT GTGTGGAGAG GAAGGAGAGC 300

CCCGACGTTT TCTTCTGCTG CTGTGAGGGC AACATGTGCA ACGAGAAGTT CCTGTACGCC 360

CCTGAAGTCC ACCATCCTCT CTGTCTTGAT CTGTCCACAG CAACCTCCAA CCCCTTTTCC 420

CAGAAGCCCC AGCTCTTCAG CACCTTGCTC TACTCCCTGG TCCCCATCAT AGGCCTGGCC 480

GCCGTGGTCC TCTTCTCCTT CTGGATGTGG AGACATCATA AACTGGCCTA CCCAGCGGCC 540

CTCGTCCCCA CACATGACCC CGGGCCCTCA CCCCCGTCCC CCATTTTGGG ACACAAACCG 600

CTGCAGCTGA TTGAGATGAA GGCCAGGGGC CGCTTCGGGT GCGTGTGGAA GGCCCAGCTG 660

CTGAACGACG TCGTGGCTGT AAAGATCTTC CCCATTCAGG ACAAGCTGTC ATGGCAGAAC 720

GAATACGAGA TCTTCAGCGT GAGCGGCATG AAGCACGACA ACATCCTCCA CTTTATGGGC 780

GCGGAGAAGA GGAACAACAA CCTGGACCTG GAGCTGTGGC TCATCACCGC CTACCACGAA 840

AGGGGCTCGA TGACCGACTA CCTGAAGGCC AACGTGGTGT CGTGGAATGA GCTGTGCCAC 900

ATCACCCAGA CGGCGGCCCG CGGCCTGGCC TACCTCCACG AGGACATCCC GGGACACAAG 960

GACGGACACA AGCCCTCCAT CGCTCACAGG GACATCAAGA GCAAGAACGT GCTGCTGAAG 1020

ACCAACCTGA CGGCCTGCAT CGCCGACTTT GGCCTTGCCC TGCAGTTTGA GGCGGGGAAA 1080

TCTGCAGGAG ACACACATGG ACAGGTGGGG ACGCGGCGCT ACATGGCTCC CGAAGTCCTG 1140

GAGGGCGCCA TCAACTTCCA ACGTGACTCC TTCCTGCGCA TCGACATGTA CGCCTTCGGC 1200

CTGGTCCTCT GGGAGCTCGC CGCGCGGTGC ACCGCCGCCG ACGGCCCGGT GGATGAGTAC 1260

ATGCTCCCCT TTGAGGAGGA GGTGGGTCAG CACCCGTCTC TGGAGGACAT GCAGGATGTG 1320

GTCGTCCATA AGAAGCTGAG GCCCGTTCTG AGGGACTGCT GGCAGAAACA CGCGGGTCTG 1380

GCCATGCTGT GTGAGACCAT CGAGGACTGC TGGGACCACG AGGCCGAGGC TCGCCTGTCC 1440

GCCGGCTGCG TGGAGGAGCG CATCGGCCAA ATGAAGCGCC AGGCCCCCGT CATCGGGCCC 1500

GAGGAGATCG TCACCGTCGT CACCACGGTG ACCAACGTGG ACCTCCAGCC CAAGGAGTCC 1560

AGCTTATGA 1569

Domain Profile

S: 1     lklleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfia  60

         l+l+e+ ++Gr+g+Vwka+l ++ vAvKif+ +d+ sw++E ei+++  ++h+nil+f++

Q: 201   LQLIEMKARGRFGCVWKAQLLNDVVAVKIFPIQDKLSWQNEYEIFSVSGMKHDNILHFMG  260

         689*********************************************************

S: 61    adkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgtk  120

         a+k+++++  el+l+t+yhe+gs++dyLk+++++++el+++++++a+Gla+LHe+i+g+k

Q: 261   AEKRNNNLDLELWLITAYHERGSMTDYLKANVVSWNELCHITQTAARGLAYLHEDIPGHK  320

         ************************************************************

S: 121   gkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtkRYmaPE  180

         + +Kp+iaHRD+kskN+l+k++lt+ciaD+GLal++e+ k++ d  ++ qvGt+RYmaPE

Q: 321   DGHKPSIAHRDIKSKNVLLKTNLTACIADFGLALQFEAGKSAGD--THGQVGTRRYMAPE  378

         *****************************************888..79************

S: 181   vleealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsdPsleem  240

         vle+a+n+++ ++f r+D+Y++gLvlWE+a Rc+++d+ v+ey+lpfee+vg++Psle+m

Q: 379   VLEGAINFQR-DSFLRIDMYAFGLVLWELAARCTAADGPVDEYMLPFEEEVGQHPSLEDM  437

         *********9.9************************************************

S: 241   kevvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkrl  291

         ++vvv+kklrP +++ w+k++ l++l++++e+cWd+++eaRl+a +v++r+

Q: 438   QDVVVHKKLRPVLRDCWQKHAGLAMLCETIEDCWDHEAEARLSAGCVEERI  488

         ************************************************985

Domain Sequence
(FASTA)

LQLIEMKARG RFGCVWKAQL LNDVVAVKIF PIQDKLSWQN EYEIFSVSGM KHDNILHFMG 60

AEKRNNNLDL ELWLITAYHE RGSMTDYLKA NVVSWNELCH ITQTAARGLA YLHEDIPGHK 120

DGHKPSIAHR DIKSKNVLLK TNLTACIADF GLALQFEAGK SAGDTHGQVG TRRYMAPEVL 180

EGAINFQRDS FLRIDMYAFG LVLWELAARC TAADGPVDEY MLPFEEEVGQ HPSLEDMQDV 240

VVHKKLRPVL RDCWQKHAGL AMLCETIEDC WDHEAEARLS AGCVEERI 288

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Danio rerio"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016020	; C:membrane
GO:0017002	; F:activin-activated receptor activity
GO:0005524	; F:ATP binding
GO:0004702	; F:receptor signaling protein serine/threonine kinase activity
GO:0005024	; F:transforming growth factor beta-activated receptor activity
GO:0023014	; P:signal transduction by phosphorylation

KEGG

InterPros

IPR000333	; Activin_II/TGFBeta-II_recpt.
IPR015768	; Activin_II_recpt.
IPR000472	; Activin_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF01064	; Activin_recp; 1.
PF00069	; Pkinase; 1.

SMARTs

Prosites

PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR00653

; ACTIVIN2R.

Created Date

20-Feb-2013