EPS-GAA-00066

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-GAA-00066

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PPP/PP7	443.8	3.8E-133	127	479	353

Status

Unreviewed

Ensembl Protein

ENSGACP00000019901

UniProt Accession

G3PQL6;

Protein Name

Serine/threonine-protein phosphatase

Protein Synonyms/Alias

Gene Name

PPEF1

Gene Synonyms/Alias

PPEF1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGACG00000015084	ENSGACP00000019901	ENSGACT00000019939

Organism

Gasterosteus aculeatus

Functional Description

Protein Length

683

Protein Sequence
(FASTA)

MWHLCCYGDT RETSGDRLAM KAAVLIQRWY RRYMARLEMR RRYTWNIFQS IEYAGEQDQL 60

QLSGFFSFML DNFTQLNGNG PDLISQLLEP VVDPWLDREI CYNLIPVPES YTGPRLSFPL 120

SVSDTNALLA AFKDQQILHA RYVLQLLYET KKLLKQMPNI VHLSTSYTNE ITICAGDLHG 180

RLDDLLLIFY KNGLPSAETP YVFNGDFVDR GKKSIEVVCL LFAYLLLYPD YMHLNRGNHE 240

DHIMNLRYGF TKEVMQKYKT HGREILQLFQ DVFSLLPVAT VIDGKILIVH GGISDQTDLD 300

FLSTIERHKV KSALRFPRRS LEQLDIGHSC KRMRSTSGSR PGSRSKNKRT PNQGSECRPQ 360

PLPGSVPPPA PPQHDREWKQ VGDILWSDPK THEGWSPNTF RGRGCYFGPD VTRRLLLQHG 420

LQLLIRSHEC KQEGYELCHG GQVITIFSAS NYYEEGSNRG AYIKVGRELL PRFYQYQVSR 480

ATRKLTLTQR VRVAEGSALK ALKEKLFTHR SELLSGLQQY DLNNTGCVSV SEWAQVFESV 540

LRLDLPWRTL RPHLARLAPD GSVDYPSCFE DMEPRIPLSQ VTPNLAETLF RYRTDIEIIF 600

NIIDKDHSGL ISIEEFRHTW RLFSAHLGVD IDDRAIDDLA RSIDFNKDGS IDFTEFLEAF 660

RVVHKLDNKE QQVNGKTAGG KAL 683

Nucleotide Sequence
(FASTA)

ATGTGGCACC TCTGTTGCTA CGGAGACACA AGGGAAACGA GTGGAGACCG ACTTGCCATG 60

AAGGCGGCTG TTTTGATCCA GCGGTGGTAC CGGCGCTACA TGGCCCGCCT GGAGATGAGG 120

CGCAGGTACA CCTGGAACAT CTTTCAGTCC ATTGAATATG CCGGAGAACA GGACCAGCTG 180

CAGCTCTCAG GTTTCTTCAG TTTCATGCTC GACAACTTCA CTCAGCTGAA TGGAAATGGA 240

CCAGACTTGA TCTCGCAGCT GCTGGAGCCG GTGGTGGACC CCTGGTTAGA CAGAGAGATC 300

TGTTACAACT TGATCCCCGT TCCGGAGTCG TACACGGGGC CCCGGCTCTC GTTTCCTCTC 360

TCTGTCTCTG ATACCAACGC TCTGCTCGCT GCGTTTAAGG ACCAACAGAT TCTACACGCC 420

AGATATGTTC TGCAGCTTCT GTACGAGACC AAAAAGCTCC TCAAACAGAT GCCAAACATT 480

GTCCACTTGT CGACGTCCTA CACCAATGAG ATCACTATAT GTGCAGGTGA TCTGCACGGG 540

CGGCTTGATG ACTTACTTCT CATTTTTTAT AAGAATGGCC TTCCCTCGGC GGAGACCCCA 600

TACGTGTTCA ACGGGGACTT TGTCGACCGT GGGAAAAAGT CCATCGAAGT GGTCTGCCTC 660

CTCTTCGCCT ACCTGCTGCT TTACCCCGAC TACATGCACC TGAACCGAGG AAACCATGAA 720

GACCACATAA TGAACCTCAG ATATGGGTTC ACAAAAGAAG TCATGCAGAA ATACAAGACT 780

CACGGCCGGG AGATCCTCCA GCTGTTTCAG GACGTTTTCA GCCTCCTGCC CGTCGCAACG 840

GTCATCGACG GAAAGATCCT GATCGTTCAC GGGGGAATAT CTGACCAGAC CGACCTGGAC 900

TTCCTCAGCA CCATAGAAAG GCACAAGGTG AAATCGGCCC TGAGGTTTCC CAGACGCAGT 960

TTGGAGCAGC TGGACATCGG TCATTCCTGC AAAAGAATGA GATCGACGTC TGGCTCTCGT 1020

CCGGGCAGCC GCAGCAAGAA CAAGAGGACG CCGAACCAGG GGTCTGAGTG CCGCCCACAG 1080

CCGCTTCCAG GCTCCGTTCC CCCTCCGGCA CCTCCGCAAC ACGATCGGGA ATGGAAACAG 1140

GTGGGGGATA TATTGTGGAG CGACCCGAAA ACCCATGAAG GGTGGAGTCC GAACACATTC 1200

AGGGGGAGAG GGTGCTACTT CGGCCCGGAC GTCACCCGCC GACTGCTGCT GCAGCACGGA 1260

CTCCAGCTGC TCATCAGGTC CCACGAGTGC AAACAGGAGG GATACGAGCT GTGTCACGGG 1320

GGACAGGTGA TCACCATCTT CTCGGCGTCA AACTACTACG AGGAGGGAAG CAACCGCGGC 1380

GCGTACATCA AAGTGGGCCG CGAGCTGCTG CCGCGGTTCT ACCAGTACCA AGTTAGCCGC 1440

GCAACACGCA AACTCACCCT GACACAGAGA GTACGAGTTG CCGAAGGCTC CGCCCTCAAG 1500

GCCCTGAAGG AGAAGCTGTT CACCCACCGC TCCGAGCTGC TGTCGGGCCT CCAGCAGTAC 1560

GACCTGAACA ACACCGGTTG TGTGTCAGTC AGTGAATGGG CTCAGGTGTT TGAGTCCGTC 1620

CTGAGACTGG ATCTTCCCTG GAGGACCCTC CGCCCGCACT TAGCCCGCCT GGCACCAGAT 1680

GGCAGTGTGG ATTATCCGTC CTGCTTTGAG GATATGGAGC CGAGGATCCC TCTGAGTCAG 1740

GTGACTCCAA ACTTGGCTGA AACCCTGTTC AGATACAGGA CGGATATTGA GATAATATTC 1800

AACATTATTG ACAAAGACCA TTCAGGTCTG ATCTCAATCG AGGAGTTTCG CCACACTTGG 1860

CGTCTCTTCA GCGCCCACCT GGGGGTCGAC ATCGACGACC GGGCCATAGA CGACCTGGCC 1920

CGAAGCATCG ATTTCAACAA GGACGGCAGC ATAGACTTCA CTGAGTTCCT GGAGGCCTTC 1980

AGAGTGGTAC ACAAACTGGA CAACAAGGAG CAGCAGGTCA ACGGGAAGAC GGCAGGAGGG 2040

AAGGCTTTGT GA 2052

Domain Profile

S: 3     lllevfkkkrilhakyvlevlfeakkvlkqlpnishvstavskevtvv.GdlhGklddll  61

          ll +fk+++ilha+yvl++l+e+kk lkq+pni h+st+ ++e+t++ GdlhG+lddll

Q: 127   ALLAAFKDQQILHARYVLQLLYETKKLLKQMPNIVHLSTSYTNEITICaGDLHGRLDDLL  186

         5899*******************************************989**********

S: 62    lvlkknGlPsernpyvfnGdfvdrGkrglevllvllslflvfPnavylnrGnhedkvmna  121

         l+++knGlPs + pyvfnGdfvdrGk+++ev+ +l ++ l++P+ ++lnrGnhed++mn+

Q: 187   LIFYKNGLPSAETPYVFNGDFVDRGKKSIEVVCLLFAYLLLYPDYMHLNRGNHEDHIMNL  246

         ************************************************************

S: 122   ryGfekevlskykrkgkrilrileevyewlPlgsivdsrvlvvhGGlsestsldllksve  181

         ryGf+kev++kyk++g+ il++ ++v+  lP+++++d+++l+vhGG+s+ t+ld l ++e

Q: 247   RYGFTKEVMQKYKTHGREILQLFQDVFSLLPVATVIDGKILIVHGGISDQTDLDFLSTIE  306

         ************************************************************

S: 182   rkkrksvllpPeessrd.......................................lgrl  202

         r+k+ks l+ P  s  +                                        g++

Q: 307   RHKVKSALRFPRRSLEQldighsckrmrstsgsrpgsrsknkrtpnqgsecrpqplPGSV  366

         ************8877799******************************99988877777

S: 203   dtdgepreslteteweqiidilwsdPratnGlvPntlrGaGvyfGPdvtedflkkyelkl  262

            + p    +++ew+q+ dilwsdP++++G +Pnt rG G+yfGPdvt  +l ++ l+l

Q: 367   PPPAPP---QHDREWKQVGDILWSDPKTHEGWSPNTFRGRGCYFGPDVTRRLLLQHGLQL  423

         777666...789************************************************

S: 263   virsheckpegyeilhdgkvvtifsasnyyeegsnkgayiklnsqltprfvqyiva  318

         +irsheck egye++h g+v+tifsasnyyeegsn+gayik+  +l+prf+qy+v+

Q: 424   LIRSHECKQEGYELCHGGQVITIFSASNYYEEGSNRGAYIKVGRELLPRFYQYQVS  479

         ******************************************************86

Domain Sequence
(FASTA)

ALLAAFKDQQ ILHARYVLQL LYETKKLLKQ MPNIVHLSTS YTNEITICAG DLHGRLDDLL 60

LIFYKNGLPS AETPYVFNGD FVDRGKKSIE VVCLLFAYLL LYPDYMHLNR GNHEDHIMNL 120

RYGFTKEVMQ KYKTHGREIL QLFQDVFSLL PVATVIDGKI LIVHGGISDQ TDLDFLSTIE 180

RHKVKSALRF PRRSLEQLDI GHSCKRMRST SGSRPGSRSK NKRTPNQGSE CRPQPLPGSV 240

PPPAPPQHDR EWKQVGDILW SDPKTHEGWS PNTFRGRGCY FGPDVTRRLL LQHGLQLLIR 300

SHECKQEGYE LCHGGQVITI FSASNYYEEG SNRGAYIKVG RELLPRFYQY QVS 353

Keyword

Calcium; Complete proteome; Hydrolase; Iron; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005509	; F:calcium ion binding
GO:0005506	; F:iron ion binding
GO:0030145	; F:manganese ion binding
GO:0004721	; F:phosphoprotein phosphatase activity
GO:0050906	; P:detection of stimulus involved in sensory perception

KEGG

InterPros

IPR011992	; EF-hand-like_dom.
IPR018247	; EF_Hand_1_Ca_BS.
IPR018249	; EF_HAND_2.
IPR002048	; EF_hand_Ca-bd.
IPR000048	; IQ_motif_EF-hand-BS.
IPR004843	; Metallo_PEstase_dom.
IPR013235	; PPP_dom.
IPR012008	; Ser/Thr-Pase_EF-hand_contain.
IPR006186	; Ser/Thr-sp_prot-phosphatase.

Pfam

PF00612	; IQ; 1.
PF00149	; Metallophos; 1.
PF08321	; PPP5; 1.

SMARTs

SM00054	; EFh; 3.
SM00015	; IQ; 1.
SM00156	; PP2Ac; 1.

Prosites

PS00018	; EF_HAND_1; 3.
PS50222	; EF_HAND_2; 3.
PS50096	; IQ; 1.
PS00125	; SER_THR_PHOSPHATASE; 1.

Prints

PR00114

; STPHPHTASE.

Created Date

20-Feb-2013