EKS-GAA-00383

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-GAA-00383

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE20	355.0	3.3E-106	25	289	265

Status

Unreviewed

Ensembl Protein

ENSGACP00000020019

UniProt Accession

G3PQY4;

Protein Name

Protein Synonyms/Alias

Gene Name

MAP4K4

Gene Synonyms/Alias

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGACG00000015177	ENSGACP00000020019	ENSGACT00000020057

Organism

Gasterosteus aculeatus

Functional Description

Protein Length

1226

Protein Sequence
(FASTA)

MANDSPAKSL VDIDLASLRD PAGIFELVEV VGNGTYGQVY KGRHVKTGQL AAIKVMDVTE 60

DEEEEIKLEI NMLKKYSHHR NIATYYGAFI KKSPPGHDDQ LWLVMEFCGA GSITDLVKNT 120

KGNQLKEDWI AYISREILRG LAHLHAHHVI HRDIKGQNVL LTENAEVKLV DFGVSAQLDR 180

TVGRRNTFIG TPYWMAPEVI ACDENPDATY DYRSDLWSCG ITAIEMAEGA PPLCDMHPMR 240

ALFLIPRNPP PRLKSKKWSK KFFSFIEGCL VKNYTQRPPT DQLLKHPFIR DQPNERQVRI 300

QLKDHIDRTK KKRGEKDETE YEYSGSEEEE EDPPEQEGEP SSIVNVPGES TLRRDFIRLQ 360

QENKERSEAL RRQQLLQEQQ MREQEEYKRQ LLAERQKRIE QQKEQRRRLE EQQRREREMR 420

RQQEREQRRR EQEDKRRIEE MDRRRKEEEE RRRADDEKRR NDREQEYIRR QLEEEQRHLE 480

MLQEQLLREQ AMLLEFKWRE LEEQRKAERL HKRLQQEQAY LLSLQHESKQ PPPSQTESPS 540

DSEPPQGECS EPDSPAEPIG HPPPPIREAD ERYRKNIQGS PQIAPPPKQP PLPPRSSEPF 600

SNGGSSSEAS AMHRPMEPQV PVRTTSRSPV LARRESPLPS QPGNQVGQRI AAGNVEQRPL 660

WDRVEKLQPR PGSGSSSGSS NSSSQASPGD RFRPRSSSKS EGSPLQRPEN VPKKQDEKNL 720

ARPTRPADLT ALAKELRAVD DVRPPHKVTD YSSSSEDSGT TDEEDDEEVD QEAGEESTSG 780

AEDSRAGFRR RLSNGETESA KTMLLEDSES DQAVTPSKDG TLVIRQSQSE SNSMSKHKSS 840

SSFTPFIDPR LLQISPSSGS ALNNMAAFGP DGRLADPLRS DPSRKGSVVN VNPVNTRPPS 900

DTPEIRKYKK RFNSEILCAA LWGVNLLVGT ESGLMLLDRS GQGKVYPLIN RRRIQQMDVL 960

EGLNVLVTIS GKKNKLRVYY LSWLRNKILH NDPEVEKKQG WVNVGDLEGC VHYKVVKYER 1020

IKFLVLALKN AVEVYAWAPK PYHKFMAFKS FGDLVHKPLL VDLTVEEGQR LKVIYGSCSG 1080

FHAVDVDSGA VYDIYLPTHI QTSIQCHAII ILPNTDGIEL LVCYEDEGVY VNTYGRITKD 1140

VVLQWGEMPT SVAYIRSNQI MGWGEKAIEI RSVETGHLDG VFMHKRAQRL KFLCERNDKV 1200

FFASVRAGGA SQVYFMTLGR TSLMSW 1226

Nucleotide Sequence
(FASTA)

ATGGCGAACG ACTCTCCGGC TAAAAGTCTG GTAGACATCG ACTTGGCTTC ACTGCGGGAT 60

CCAGCCGGGA TATTCGAGTT GGTGGAGGTG GTGGGAAATG GCACCTATGG ACAAGTATAC 120

AAGGGACGAC ACGTCAAGAC TGGACAGCTG GCTGCCATCA AAGTCATGGA CGTCACAGAG 180

GATGAAGAGG AGGAAATTAA ACTGGAGATC AATATGCTGA AGAAGTATTC CCATCATAGA 240

AACATAGCCA CCTACTATGG TGCTTTCATT AAGAAGAGCC CCCCGGGACA CGATGACCAG 300

CTATGGTTGG TGATGGAGTT CTGTGGAGCT GGTTCCATCA CGGACCTGGT GAAGAACACC 360

AAGGGGAACC AGCTGAAGGA AGACTGGATC GCCTACATCT CCAGAGAGAT CCTTAGGGGT 420

CTGGCCCACC TGCACGCCCA CCACGTCATC CACCGCGACA TCAAGGGCCA GAACGTTCTG 480

TTGACGGAGA ACGCTGAGGT CAAATTAGTC GACTTTGGCG TGAGTGCTCA GCTCGATCGA 540

ACGGTGGGGA GGAGAAACAC CTTCATCGGG ACCCCTTATT GGATGGCCCC CGAGGTCATT 600

GCCTGTGACG AGAACCCAGA TGCTACATAT GATTACAGAA GCGATCTGTG GTCTTGTGGA 660

ATCACAGCGA TTGAAATGGC TGAAGGAGCG CCACCACTTT GTGACATGCA CCCAATGCGT 720

GCGCTCTTCC TCATCCCAAG AAACCCTCCA CCCAGGCTCA AGTCTAAAAA ATGGTCCAAA 780

AAGTTTTTCA GTTTCATCGA GGGCTGCCTG GTGAAGAACT ACACGCAGCG GCCCCCGACA 840

GACCAGCTGC TGAAGCACCC CTTCATCAGA GACCAGCCCA ACGAGAGGCA AGTCCGCATC 900

CAGCTCAAAG ACCACATTGA CCGTACCAAG AAGAAGAGGG GGGAGAAAGA CGAGACTGAG 960

TACGAGTACA GTGGCAGTGA GGAGGAGGAA GAGGATCCCC CAGAGCAGGA GGGAGAGCCC 1020

AGCTCCATTG TCAATGTGCC AGGTGAGTCA ACCCTGCGGC GCGACTTCAT CCGCCTGCAG 1080

CAGGAGAACA AGGAGCGATC GGAGGCGTTG CGCCGCCAGC AGCTCCTCCA AGAGCAGCAA 1140

ATGCGGGAGC AAGAGGAGTA CAAACGCCAA CTACTGGCTG AGAGGCAGAA ACGCATTGAG 1200

CAACAGAAGG AGCAGAGGAG GCGGCTGGAG GAGCAACAGC GGCGCGAACG AGAAATGAGG 1260

AGGCAGCAGG AGCGCGAGCA GCGTCGCCGC GAGCAAGAGG ACAAGCGGCG GATCGAAGAA 1320

ATGGACCGCC GACGTAAAGA AGAGGAGGAA CGGCGGCGGG CCGACGACGA GAAAAGGAGG 1380

AACGATCGTG AACAGGAGTA CATCAGGCGT CAGCTGGAGG AGGAGCAGAG ACACCTGGAG 1440

ATGCTGCAGG AGCAGCTGCT CCGTGAACAG GCCATGCTGC TGGAGTTCAA GTGGCGGGAG 1500

CTCGAGGAGC AGCGCAAGGC CGAGCGACTC CACAAGCGCC TGCAGCAGGA GCAGGCCTAC 1560

CTGCTGTCGC TCCAGCACGA ATCCAAACAG CCGCCGCCCT CTCAGACCGA ATCCCCCTCT 1620

GACTCTGAGC CTCCCCAGGG AGAATGTTCG GAGCCCGATA GCCCCGCAGA ACCCATCGGT 1680

CATCCTCCTC CGCCTATTAG AGAGGCTGAT GAACGGTACC GTAAGAACAT TCAGGGCTCC 1740

CCTCAGATTG CCCCTCCTCC CAAGCAGCCC CCTCTGCCTC CCCGCTCCTC TGAACCGTTC 1800

TCCAATGGCG GCTCCTCCTC CGAGGCCTCC GCCATGCACC GGCCCATGGA GCCTCAGGTC 1860

CCAGTAAGGA CGACATCCAG GTCTCCGGTA CTGGCGCGCC GAGAATCCCC TCTGCCGTCA 1920

CAGCCCGGCA ACCAGGTGGG ACAGAGGATC GCTGCAGGGA ACGTGGAGCA GCGGCCGTTG 1980

TGGGACCGAG TGGAGAAGCT GCAGCCTCGG CCGGGCAGCG GCAGCTCCTC CGGCTCCTCC 2040

AACTCCAGCT CCCAGGCCAG CCCCGGTGAC CGCTTCCGAC CACGCTCTTC CTCCAAATCT 2100

GAAGGGTCGC CTCTCCAGCG TCCTGAAAAT GTTCCCAAAA AGCAAGATGA AAAGAACCTT 2160

GCCAGGCCTA CTCGACCAGC TGATCTGACA GCTCTGGCTA AGGAGCTTCG TGCGGTAGAC 2220

GACGTGAGGC CCCCCCACAA GGTCACCGAC TATTCCTCCT CAAGCGAGGA CTCGGGCACC 2280

ACCGACGAGG AAGACGATGA GGAGGTGGAC CAGGAGGCGG GAGAGGAGTC CACCTCAGGG 2340

GCCGAGGACT CCAGGGCTGG CTTCCGCAGG AGGCTGAGTA ACGGGGAGAC AGAGTCTGCA 2400

AAGACCATGC TTCTGGAGGA CTCTGAGAGC GACCAAGCCG TCACGCCTTC CAAGGATGGA 2460

ACGCTGGTCA TCAGACAGTC CCAGTCAGAA AGCAACTCCA TGTCCAAACA CAAGTCTTCC 2520

TCCTCCTTCA CTCCCTTCAT TGACCCTCGT CTTCTACAGA TCTCTCCATC CAGCGGCAGC 2580

GCCCTCAACA ACATGGCAGC GTTTGGGCCG GACGGACGCC TCGCAGACCC GCTGAGGTCC 2640

GACCCGTCTC GCAAAGGCTC GGTGGTTAAC GTCAACCCGG TCAACACGCG CCCGCCGAGC 2700

GATACGCCGG AGATTCGCAA GTACAAGAAG AGGTTCAACT CTGAGATCCT GTGCGCCGCG 2760

CTGTGGGGAG TGAACCTGCT GGTGGGAACG GAGAGCGGTC TGATGCTGCT GGACCGGAGC 2820

GGCCAGGGGA AGGTCTACCC TCTGATCAAC AGGCGACGCA TCCAACAGAT GGATGTCCTG 2880

GAGGGGCTCA ACGTGCTGGT CACCATATCG GGTAAAAAAA ACAAGCTGCG AGTGTACTAC 2940

CTGTCGTGGC TGAGGAACAA GATTTTGCAC AATGACCCCG AGGTGGAGAA GAAGCAGGGT 3000

TGGGTTAATG TGGGCGACCT GGAGGGTTGC GTCCACTACA AAGTCGTGAA ATATGAGCGG 3060

ATTAAGTTCT TGGTGCTGGC CTTGAAGAAC GCGGTGGAGG TGTACGCCTG GGCGCCCAAA 3120

CCATACCACA AATTCATGGC CTTCAAGTCT TTCGGGGATC TGGTGCACAA GCCTCTGCTG 3180

GTTGACCTGA CGGTGGAGGA AGGTCAGAGG TTAAAGGTCA TCTATGGCTC CTGTTCAGGC 3240

TTCCACGCCG TGGATGTGGA CTCCGGAGCC GTCTACGACA TCTACCTGCC CACACACATC 3300

CAGACCAGCA TCCAGTGCCA CGCCATCATC ATCTTGCCCA ACACTGATGG CATCGAGCTG 3360

CTGGTGTGTT ACGAGGACGA GGGCGTCTAC GTCAACACCT ACGGGCGCAT CACCAAGGAC 3420

GTGGTGCTGC AGTGGGGGGA AATGCCGACT TCAGTGGCCT ACATTAGGTC GAACCAGATC 3480

ATGGGCTGGG GTGAGAAGGC CATAGAGATC CGCTCGGTGG AAACGGGCCA CCTGGACGGC 3540

GTTTTCATGC ACAAGAGAGC CCAGAGACTC AAGTTCCTGT GTGAGAGGAA TGACAAGGTC 3600

TTCTTTGCCT CTGTGCGCGC CGGAGGTGCC AGCCAGGTGT ACTTCATGAC CCTGGGACGC 3660

ACCTCCCTCA TGAGCTGGTA G 3681

Domain Profile

S: 1     yelleeigkGalgkvylarekktgelvaikkinlekqekleelqkeisvlkklkh.pniv  59

         +el+e++g+G++g+vy++r++ktg+l+aik++++++ +++ee++ ei++lkk++h +ni

Q: 25    FELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE-DEEEEIKLEINMLKKYSHhRNIA  83

         899********************************8.999*************998****

S: 60    eylesflk......eeelwlvmeylagGslsdlvkeelkselkEeqiayilrevlkaLey  113

         +y+++f+k      +++lwlvme++ +Gs++dlvk+++ ++lkE++iayi re+l++L++

Q: 84    TYYGAFIKksppghDDQLWLVMEFCGAGSITDLVKNTKGNQLKEDWIAYISREILRGLAH  143

         *************9**********************************************

S: 114   lHskkviHrdikakniLlteegeVkLsdfgvaaqlektrkkrktvvgtpywmAPEviaqe  173

         lH+++viHrdik++n+Llte++eVkL+dfgv+aql++t+ +r+t++gtpywmAPEvia++

Q: 144   LHAHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACD  203

         ************************************************************

S: 174   ...ekgYdekaDiwslGItaielaegepPfkdleplkallkilkneppklkskkkfskef  230

            + +Yd+++D+ws+GItaie+aeg+pP++d++p++al++i++n+pp+lksk k+sk+f

Q: 204   enpDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMRALFLIPRNPPPRLKSK-KWSKKF  262

         999999********************************************888.******

S: 231   kefvekclqknpekRpsasellkhkFl  257

          +f+e cl kn+ +Rp +++llkh+F+

Q: 263   FSFIEGCLVKNYTQRPPTDQLLKHPFI  289

         **************************7

Domain Sequence
(FASTA)

FELVEVVGNG TYGQVYKGRH VKTGQLAAIK VMDVTEDEEE EIKLEINMLK KYSHHRNIAT 60

YYGAFIKKSP PGHDDQLWLV MEFCGAGSIT DLVKNTKGNQ LKEDWIAYIS REILRGLAHL 120

HAHHVIHRDI KGQNVLLTEN AEVKLVDFGV SAQLDRTVGR RNTFIGTPYW MAPEVIACDE 180

NPDATYDYRS DLWSCGITAI EMAEGAPPLC DMHPMRALFL IPRNPPPRLK SKKWSKKFFS 240

FIEGCLVKNY TQRPPTDQLL KHPFI 265

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Gallus gallus"; ?>Homo sapiens"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0005083	; F:small GTPase regulator activity

KEGG

InterPros

IPR001180	; Citron.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00780	; CNH; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00036	; CNH; 1.
SM00220	; S_TKc; 1.

Prosites

PS50219	; CNH; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013