EKS-GAA-00176
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-GAA-00176
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/FGFR505.83.2E-152397673277
StatusUnreviewed
Ensembl ProteinENSGACP00000020469
UniProt AccessionG3PS83;
Protein NameFibroblast growth factor receptor
Protein Synonyms/Alias
Gene NameFGFR1 (2 of 2)
Gene Synonyms/Alias FGFR1 (2 of 2);
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSGACG00000015518ENSGACP00000020469ENSGACT00000020508
OrganismGasterosteus aculeatus
Functional Description
Protein Length710
Protein Sequence
(FASTA)
MPPPRCLRLL LCCILLVLLV QFPQTRSSPA TEDTDTANTG KSSEDEEEDE SSSEENKLSN 60
ELSTSNEKLQ ASAPLWVNAE KMEKKLHAVP ASQTVKFRCQ ATGNPVPLLR WYKNGKVFRK 120
DQRIGGFKIR DHMWTLIMES VVPSDKGNYT CVVENEYGSL KHTYLLDVVE RSPHRPILQA 180
GLPANQTAQV GRNVEFVCRV FSDPQPHIRW LKHITVNGSR EAPDGHPYIL VLKTAGLNTT 240
DKEMEVLTLR NVTPGDSGEY TCMAENSIGV SHHSAWLSVV DVTEVPPALL PSQTYLEIFI 300
YCLGFFIIVI VVATAVVCRL CCAPKKSDFS GPLAVQKLAK SIPLRRQVSL DSSSSLQSGM 360
CLVRQCRLSS GATTILTGMS EYELPYDSAW ELPRDRLTLG TPLGEGCFGQ VVLAEAVGLD 420
RNKPTRLSKV AVKMLKADAT EKDLSDLISE MEMMKMIGKH KNIINLLGAC TQRGPLYVVV 480
EYASQGNLRE FLRARRPVGL EYWSGPRQAT LGRLEVRELV SAAYQVARGM AYLASKKCIH 540
RDLAARNVLV TEDDVMKIAD FGLARDVHHI DYYMKTPNGR LPGKWMAPEA LFDRVYTHQS 600
DVWSFGVLLW EIFTLGGSPY PGVPVEELFK LLKEGHRMEK PSACTEELYM MMRDCWAAVP 660
SRRPTFLQLV EDLDRTLSLM ANQEYLELAV PLVQYSTVTS TSSAGSCSST 710
Nucleotide Sequence
(FASTA)
ATGCCGCCCC CCCGCTGCCT CCGGCTGCTG CTCTGCTGCA TCCTGCTGGT TCTGTTGGTC 60
CAGTTTCCTC AGACCCGGTC CTCACCGGCC ACCGAGGACA CGGATACAGC CAACACGGGG 120
AAATCTTCTG AAGACGAGGA GGAAGACGAG TCATCTTCGG AAGAGAACAA ACTGTCCAAC 180
GAGTTGTCGA CGAGCAACGA GAAGCTCCAA GCGTCGGCGC CTCTGTGGGT GAACGCGGAG 240
AAGATGGAGA AGAAGCTGCA CGCCGTCCCC GCCAGCCAGA CGGTAAAGTT CCGTTGCCAG 300
GCGACGGGAA ACCCAGTTCC CTTGTTGCGC TGGTACAAGA ACGGGAAGGT TTTCAGGAAG 360
GACCAAAGGA TCGGTGGCTT CAAGATCAGA GACCACATGT GGACTCTGAT AATGGAGTCT 420
GTGGTCCCGT CGGATAAAGG GAACTACACT TGTGTGGTGG AGAATGAATA TGGGAGCCTC 480
AAGCACACCT ACCTGCTGGA CGTAGTTGAG CGCTCCCCCC ACAGGCCGAT CCTGCAGGCC 540
GGTCTGCCGG CCAACCAGAC GGCGCAGGTC GGCCGTAACG TGGAGTTTGT GTGCCGCGTG 600
TTCAGTGACC CGCAGCCTCA CATCCGGTGG CTCAAACACA TCACCGTCAA TGGCAGCCGA 660
GAGGCCCCGG ATGGACACCC GTACATCCTG GTCCTCAAGA CGGCGGGCTT GAACACAACG 720
GACAAAGAGA TGGAGGTTCT GACCCTGAGG AATGTGACAC CGGGCGACTC AGGCGAGTAC 780
ACCTGTATGG CGGAAAACTC CATCGGCGTC TCTCATCACT CCGCCTGGCT CTCAGTGGTC 840
GACGTCACAG AAGTGCCTCC CGCCCTGCTG CCCTCTCAGA CATACCTGGA GATCTTCATC 900
TACTGCTTGG GCTTCTTCAT CATCGTCATC GTGGTGGCCA CGGCGGTGGT CTGCCGGCTC 960
TGCTGCGCCC CGAAGAAGAG CGACTTCAGC GGGCCACTGG CGGTCCAGAA GTTGGCCAAG 1020
AGCATCCCGC TGAGGAGACA GGTGTCGTTG GATTCCTCGT CCTCCCTCCA GTCCGGGATG 1080
TGTTTGGTGC GCCAGTGTCG TCTCTCCAGC GGCGCGACCA CCATCCTGAC AGGGATGTCG 1140
GAGTACGAAC TCCCCTACGA CTCCGCCTGG GAGCTTCCTC GTGACAGGCT GACCCTGGGG 1200
ACGCCTCTGG GCGAAGGCTG TTTCGGTCAG GTGGTTCTGG CCGAGGCCGT CGGGCTCGAC 1260
AGGAATAAAC CGACGCGTCT CTCTAAGGTG GCCGTGAAGA TGCTGAAAGC GGACGCCACG 1320
GAGAAGGACC TGTCCGACCT GATCTCTGAG ATGGAGATGA TGAAGATGAT CGGCAAGCAC 1380
AAGAACATCA TCAACCTGCT GGGCGCGTGC ACTCAGCGCG GCCCCCTGTA CGTGGTGGTG 1440
GAGTACGCCT CCCAGGGGAA CCTGAGGGAG TTCCTCCGGG CTCGCCGACC GGTCGGGTTG 1500
GAGTACTGGA GCGGGCCGAG GCAGGCGACC TTGGGGAGGC TGGAGGTCAG GGAGCTGGTG 1560
TCGGCTGCGT ACCAGGTGGC CCGAGGGATG GCCTACCTGG CCTCCAAGAA GTGTATCCAC 1620
AGAGACCTGG CAGCCAGGAA CGTGTTGGTC ACAGAGGACG ACGTCATGAA GATCGCTGAC 1680
TTTGGTCTCG CTCGAGACGT CCACCACATC GACTACTATA TGAAGACCCC CAATGGTCGT 1740
CTCCCGGGGA AATGGATGGC ACCTGAAGCT TTATTTGACC GCGTCTACAC ACATCAAAGC 1800
GACGTGTGGT CCTTCGGAGT CCTGCTGTGG GAGATCTTCA CCCTGGGCGG GTCCCCGTAC 1860
CCCGGGGTCC CCGTGGAGGA GCTCTTCAAG CTGCTGAAGG AGGGCCACCG CATGGAGAAA 1920
CCCTCGGCCT GCACGGAGGA GCTGTACATG ATGATGAGGG ACTGCTGGGC CGCCGTCCCG 1980
TCTCGCAGGC CCACGTTCCT CCAGCTGGTC GAAGACCTGG ACCGCACGCT GTCTCTCATG 2040
GCCAACCAGG AGTACCTGGA GCTCGCCGTT CCTCTGGTCC AGTATTCTAC GGTCACCTCC 2100
ACCTCCTCGG CTGGTTCCTG TAGCTCCACG TAG 2133
Domain Profile
S: 1     lvlgkllGeGafGqvvkaeaigldkdkekkevtvavkmlkedatdkdladlvsemevlkl  60
         l+lg++lGeG+fGqvv aea+gld++k+++ ++vavkmlk dat+kdl+dl+seme++k+
Q: 397   LTLGTPLGEGCFGQVVLAEAVGLDRNKPTRLSKVAVKMLKADATEKDLSDLISEMEMMKM  456
         79**********************************************************
S: 61    iGkhkniinllGactqeGplyviveyaakGnlreflrarrpkgeeaskdkskaseeqlte  120
         iGkhkniinllGactq Gplyv+veya++Gnlreflrarrp g e+ + +++a+  +l  
Q: 457   IGKHKNIINLLGACTQRGPLYVVVEYASQGNLREFLRARRPVGLEYWSGPRQATLGRLEV  516
         ************************************************************
S: 121   kdlvsfayqvarGmeylaskkcihrdlaarnvlvtednvlkiadfGlardvheidyykkt  180
         ++lvs ayqvarGm ylaskkcihrdlaarnvlvted+v+kiadfGlardvh+idyy kt
Q: 517   RELVSAAYQVARGMAYLASKKCIHRDLAARNVLVTEDDVMKIADFGLARDVHHIDYYMKT  576
         ************************************************************
S: 181   tnGrlpvkwmapealfdrvytsqsdvwsfGvllweiltlGgspypgiaveelfkllkeGh  240
          nGrlp kwmapealfdrvyt+qsdvwsfGvllwei+tlGgspypg++veelfkllkeGh
Q: 577   PNGRLPGKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGH  636
         ************************************************************
S: 241   rmekpakctkelyvlmrecwhakaserptfkqlvedl  277
         rmekp+ ct+ely++mr+cw a++s rptf qlvedl
Q: 637   RMEKPSACTEELYMMMRDCWAAVPSRRPTFLQLVEDL  673
         ***********************************97
Domain Sequence
(FASTA)
LTLGTPLGEG CFGQVVLAEA VGLDRNKPTR LSKVAVKMLK ADATEKDLSD LISEMEMMKM 60
IGKHKNIINL LGACTQRGPL YVVVEYASQG NLREFLRARR PVGLEYWSGP RQATLGRLEV 120
RELVSAAYQV ARGMAYLASK KCIHRDLAAR NVLVTEDDVM KIADFGLARD VHHIDYYMKT 180
PNGRLPGKWM APEALFDRVY THQSDVWSFG VLLWEIFTLG GSPYPGVPVE ELFKLLKEGH 240
RMEKPSACTE ELYMMMRDCW AAVPSRRPTF LQLVEDL 277
KeywordATP-binding; Complete proteome; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Oreochromis niloticus"; ?>Oryzias latipes"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>
EKS-ORN-00185
EKS-ORL-00173
EKS-TAR-00194
EKS-TEN-00187
EKS-XIM-00179
Gene Ontology
GO:0016021; C:integral to membrane
GO:0005524; F:ATP binding
GO:0005007; F:fibroblast growth factor-activated receptor activity
GO:0008284; P:positive regulation of cell proliferation
KEGG
InterPros
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR013098; Ig_I-set.
IPR003598; Ig_sub2.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016248; Tyr_kinase_fibroblast_GF_rcpt.
Pfam
PF07679; I-set; 2.
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00408; IGc2; 2.
SM00219; TyrKc; 1.
Prosites
PS50835; IG_LIKE; 2.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013