EKS-GAA-00426

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-GAA-00426

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Ack	421.6	1.4E-126	145	405	261

Status

Unreviewed

Ensembl Protein

ENSGACP00000021637

UniProt Accession

G3PVJ8;

Protein Name

Protein Synonyms/Alias

Gene Name

TNK2 (1 of 2)

Gene Synonyms/Alias

TNK2 (1 of 2);

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGACG00000016384	ENSGACP00000021637	ENSGACT00000021678

Organism

Gasterosteus aculeatus

Functional Description

Protein Length

1122

Protein Sequence
(FASTA)

MQCEEGTEWL LELLMEVQLQ QYLLRIRDDL NVTRLSHFDY VKNEDLEKIG MGRPGQRRLW 60

EAVKRRKAMC KRKSWMSKVF SGKRPDGGDF PQQGQPASSF RKLSPTPPLG LEEGVLATHP 120

GGGGGAPLDE QQQALTCLIP EKDLTLFEKL GDGTFGVVKR GEWLTPAGKV LNVAVKCLKT 180

DVLSQPEALE DFICEVNAMH SLDHQNLIRL YGVVLTHPMK MVTELAPLGS LLERLRCVRP 240

LGPVLIHTLC QYAVQVACGM AYLEQRRFIH RDLAARNILL ASAHRVKIGD FGLMRALPNN 300

HEHYVMQEHR KVPFAWCAPE SLKTRTFSHA TDTWMFGVTL WEMFTHGQEP WLGLNGSQIL 360

HKIDKEGERL PKPEDCPQDV YHVALQCWAQ KPDDRPSFVA LREFLLETMP TDMCALQDFD 420

EPDKLHIQIN DVITIIEGRA ENYWWRGQNK RTLKVGPFPR NVVTSVAGLS AHDISRPLKN 480

SFIHTGHGDS NPHRCWGFPD RIDDLYLGNP MDPPDVIGVD PGGTRLTQLP GRARKEPPPR 540

PPQPAVLIKT PCYDAVNDDE DPTSAGLKRL SLWKTASVKG LKLKPSAWVS ASKQGSGRIS 600

GSGHTPGSEV SLIDFGEEFP PPTPSPSPVV EIQIPTLAKL ALEAENLLDR TPPQSPRRSL 660

PRPLHPTPVV DWDARPLPPP PAYDDVAQDE DDMEVRSSNF METGCLSPVL IPEVEGDAVV 720

ARGPDRSGLG DNLFLPSKQS QILSTSFSQS AEIFQELQQE CMKRLNVPTG SAARSSSPSH 780

EDKPQIPPRV PIPPRPMKRG DYTSPRWSQD LSLSPTPADV TEDASGQGQP PRIPPRDPLS 840

QPGSRTPSPM AHHTSCPPAH TYGSYLSSSP GKLMPTTHSF ASDPKYAAPK VIQAQGHGRD 900

SAGKGPCILP IVRDGRKVSS THYYLLPERP PYLDRYDRFF RETDGQPAGS AEERPLRQAN 960

TATVRPMVAG GQILQGHAQG QALVQPGELK ANFSSNNNSS LGGPRSGMKT SVSLPRVGSD 1020

GPTAAVVAAS CGGTEGGGNS ADRVKMVQEA VHGVTIEECQ GALQNHSWNV QKAVHSLKVE 1080

QLFCLGLRSR AECLKLLEMC DWNLEVASTQ MLDNYGSTTR QR 1122

Nucleotide Sequence
(FASTA)

ATGCAGTGTG AGGAAGGTAC AGAGTGGCTG CTGGAGCTGC TGATGGAGGT GCAGCTGCAG 60

CAGTACCTCC TTCGGATCCG AGATGACCTC AACGTCACGC GGCTGTCCCA CTTTGACTAC 120

GTCAAGAACG AAGACCTGGA GAAGATCGGC ATGGGTCGAC CTGGACAGAG ACGACTGTGG 180

GAGGCTGTGA AAAGGAGGAA AGCCATGTGC AAGCGTAAAT CCTGGATGAG CAAGGTGTTC 240

AGTGGAAAGC GGCCAGACGG AGGAGACTTC CCCCAGCAGG GCCAGCCGGC CTCCTCCTTC 300

CGTAAGCTGT CTCCCACACC TCCACTGGGC CTGGAGGAGG GAGTCCTGGC CACGCACCCC 360

GGTGGTGGTG GTGGGGCTCC TCTCGATGAG CAGCAGCAGG CCCTGACCTG CCTCATCCCA 420

GAGAAGGATC TGACGCTGTT TGAGAAGCTG GGGGACGGAA CCTTCGGTGT GGTGAAGAGA 480

GGAGAGTGGC TGACGCCCGC AGGGAAGGTG CTGAATGTAG CCGTGAAGTG TCTGAAGACA 540

GACGTGCTCA GCCAGCCCGA AGCTCTGGAG GACTTCATCT GTGAGGTCAA CGCCATGCAC 600

TCCCTGGACC ACCAGAACCT CATTCGTCTC TACGGTGTGG TGCTGACACA TCCAATGAAA 660

ATGGTGACCG AGCTGGCTCC CCTGGGTTCC CTGCTGGAGC GCCTGCGCTG TGTGCGTCCG 720

CTGGGCCCGG TGTTGATCCA CACTCTGTGC CAGTACGCTG TGCAGGTGGC TTGTGGCATG 780

GCCTATCTGG AGCAAAGGAG GTTCATCCAC AGGGACCTGG CAGCCAGGAA CATCCTGCTG 840

GCCTCAGCTC ACAGAGTGAA GATAGGAGAC TTTGGCCTGA TGAGGGCGCT GCCCAACAAC 900

CACGAGCACT ACGTCATGCA GGAGCATCGC AAGGTCCCCT TTGCATGGTG CGCCCCAGAG 960

AGTCTCAAGA CCAGAACGTT CTCTCACGCC ACTGACACAT GGATGTTTGG AGTCACTCTC 1020

TGGGAGATGT TCACACACGG CCAGGAGCCT TGGCTCGGTC TCAATGGGAG CCAGATTTTG 1080

CACAAGATTG ATAAAGAAGG TGAGCGCCTC CCTAAGCCTG AAGACTGTCC GCAGGACGTC 1140

TATCATGTGG CGCTGCAGTG TTGGGCTCAG AAACCAGATG ACAGACCCTC CTTTGTTGCG 1200

CTGCGTGAGT TCTTGCTTGA GACCATGCCC ACAGACATGT GTGCCCTGCA GGACTTTGAT 1260

GAGCCTGACA AACTCCATAT CCAGATCAAT GATGTCATCA CTATAATAGA GGGGAGGGCG 1320

GAGAACTACT GGTGGAGAGG TCAAAACAAG CGAACCCTAA AGGTCGGACC TTTCCCCAGA 1380

AACGTGGTGA CCTCGGTGGC AGGTTTGTCA GCTCATGACA TCAGCCGGCC GCTCAAGAAC 1440

AGCTTCATCC ACACGGGACA CGGAGACAGC AACCCGCACC GGTGCTGGGG CTTCCCTGAC 1500

AGGATCGACG ATTTGTACCT CGGTAATCCC ATGGATCCGC CCGATGTCAT CGGTGTTGAC 1560

CCCGGTGGCA CTCGGCTCAC ACAGCTACCA GGACGAGCTA GAAAGGAGCC TCCTCCTCGT 1620

CCTCCTCAAC CAGCAGTGTT AATCAAGACG CCCTGCTACG ACGCGGTGAA TGACGACGAG 1680

GATCCGACTT CGGCCGGTCT AAAGAGATTA TCGCTTTGGA AAACGGCGTC TGTCAAAGGC 1740

TTGAAGCTCA AACCGTCCGC GTGGGTCTCT GCTTCCAAAC AGGGGAGTGG TCGGATTTCA 1800

GGCTCGGGCC ACACCCCCGG CAGTGAAGTG TCCCTCATTG ACTTTGGGGA GGAGTTCCCC 1860

CCGCCCACCC CGTCCCCCTC CCCTGTAGTG GAAATTCAGA TTCCCACACT GGCAAAGCTG 1920

GCTTTGGAAG CAGAGAACCT CCTGGACCGG ACCCCGCCTC AGAGCCCGCG TAGATCGCTG 1980

CCCCGCCCCC TTCACCCCAC ACCAGTAGTG GACTGGGACG CTCGGCCGTT ACCCCCACCC 2040

CCGGCCTATG ACGACGTGGC CCAAGACGAA GACGATATGG AGGTACGAAG CTCAAATTTC 2100

ATGGAAACGG GATGTTTGTC TCCTGTTCTG ATACCTGAGG TTGAGGGTGA TGCTGTGGTT 2160

GCCAGGGGTC CAGACCGATC AGGTCTGGGG GACAACCTTT TTCTCCCCAG CAAGCAGAGC 2220

CAAATTCTGT CCACCTCCTT CTCCCAGTCA GCAGAGATCT TCCAAGAACT CCAGCAGGAG 2280

TGCATGAAGA GGCTTAATGT ACCGACTGGA AGTGCTGCAC GGTCGAGCTC CCCATCTCAC 2340

GAGGACAAAC CCCAAATCCC CCCGCGTGTC CCCATACCCC CTCGCCCCAT GAAGAGGGGC 2400

GACTACACGT CTCCTCGCTG GTCACAGGAT CTCTCCCTGT CACCAACACC GGCTGACGTC 2460

ACAGAAGACG CTTCAGGCCA AGGACAACCA CCTCGGATCC CTCCCAGAGA CCCTCTGTCC 2520

CAGCCGGGCT CCAGGACTCC CAGCCCCATG GCTCACCACA CCTCCTGTCC TCCGGCACAC 2580

ACGTACGGCT CCTACCTCTC CAGCTCGCCA GGCAAACTCA TGCCCACCAC GCACAGCTTC 2640

GCCTCGGATC CGAAATACGC GGCGCCCAAA GTGATCCAGG CCCAGGGGCA CGGGAGGGAC 2700

TCGGCCGGCA AAGGCCCGTG TATCCTCCCC ATCGTCCGCG ACGGACGCAA AGTCAGCAGC 2760

ACCCACTATT ACCTCCTGCC AGAGAGGCCG CCGTACCTCG ACCGCTACGA CCGCTTCTTC 2820

AGGGAGACCG ATGGCCAGCC GGCGGGCAGC GCGGAAGAGC GGCCCCTACG GCAGGCGAAC 2880

ACCGCCACGG TCAGACCCAT GGTCGCCGGC GGCCAGATTC TCCAGGGACA CGCCCAGGGA 2940

CAGGCGCTCG TCCAGCCGGG TGAGCTGAAG GCTAATTTCT CCTCCAACAA TAACAGCAGT 3000

CTGGGCGGGC CGCGGTCAGG GATGAAGACC TCAGTCAGTC TGCCTCGCGT CGGTTCTGAC 3060

GGGCCGACGG CGGCGGTGGT CGCCGCGTCC TGCGGCGGGA CGGAGGGCGG CGGGAACTCG 3120

GCCGACAGGG TCAAAATGGT GCAGGAGGCC GTTCATGGTG TCACAATAGA GGAGTGCCAA 3180

GGCGCCCTCC AAAACCACAG CTGGAACGTC CAGAAAGCTG TGCATTCTCT AAAGGTGGAG 3240

CAGCTGTTCT GTCTGGGTCT GCGGAGCAGA GCAGAGTGCC TAAAGCTGTT GGAGATGTGC 3300

GACTGGAACC TGGAGGTGGC CAGCACGCAG ATGTTGGACA ACTATGGATC CACAACAAGA 3360

CAGAGG 3366

Domain Profile

S: 2     klleklGeGsfgvvkrgeWsapsgksvqvavkvlksdkllstel.ddflrevsvllkleh  60

         +l eklG+G+fgvvkrgeW +p+gk+++vavk+lk+d+l+++e+ +df+ ev+++++l+h

Q: 145   TLFEKLGDGTFGVVKRGEWLTPAGKVLNVAVKCLKTDVLSQPEAlEDFICEVNAMHSLDH  204

         7899***************************************99***************

S: 61    enlvrlyGvvltqplklvtelaelgslldrlrkeakrdsllvallleyavqiaeglayle  120

         +nl+rlyGvvlt+p+k+vtela+lgsll+rlr  +   ++l+++l++yavq+a g+ayle

Q: 205   QNLIRLYGVVLTHPMKMVTELAPLGSLLERLRCVRPLGPVLIHTLCQYAVQVACGMAYLE  264

         ************************************************************

S: 121   skrlvhrdlaarnlllaskklvkisdfGlvralgeeedlyvlaenkkvPfaWcaPeslrt  180

         ++r++hrdlaarn+llas + vki+dfGl+ral++++++yv++e++kvPfaWcaPesl+t

Q: 265   QRRFIHRDLAARNILLASAHRVKIGDFGLMRALPNNHEHYVMQEHRKVPFAWCAPESLKT  324

         ************************************************************

S: 181   rkfssasdvWafGvtlWemfsyGeePWvglsglqilkkidkekerlekPeacpediysll  240

         r+fs+a+d+W+fGvtlWemf++G+ePW gl+g+qil+kidke+erl+kPe+cp+d+y+++

Q: 325   RTFSHATDTWMFGVTLWEMFTHGQEPWLGLNGSQILHKIDKEGERLPKPEDCPQDVYHVA  384

         ************************************************************

S: 241   lkcWakkpadrpkfsalkekl  261

         l+cWa+kp+drp+f+al+e+l

Q: 385   LQCWAQKPDDRPSFVALREFL  405

         *****************9976

Domain Sequence
(FASTA)

TLFEKLGDGT FGVVKRGEWL TPAGKVLNVA VKCLKTDVLS QPEALEDFIC EVNAMHSLDH 60

QNLIRLYGVV LTHPMKMVTE LAPLGSLLER LRCVRPLGPV LIHTLCQYAV QVACGMAYLE 120

QRRFIHRDLA ARNILLASAH RVKIGDFGLM RALPNNHEHY VMQEHRKVPF AWCAPESLKT 180

RTFSHATDTW MFGVTLWEMF THGQEPWLGL NGSQILHKID KEGERLPKPE DCPQDVYHVA 240

LQCWAQKPDD RPSFVALREF L 261

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

InterPros

IPR015116	; GTPase_binding.
IPR021619	; Inhibitor_Mig-6.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR001452	; SH3_domain.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR015940	; UBA/transl_elong_EF1B_N_euk.

Pfam

PF09027	; GTPase_binding; 1.
PF11555	; Inhibitor_Mig-6; 1.
PF07714	; Pkinase_Tyr; 1.
PF00018	; SH3_1; 1.

SMARTs

SM00326	; SH3; 1.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50002	; SH3; 1.
PS50030	; UBA; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013