EKS-GAA-00564

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-GAA-00564

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/MAPK	410.1	5.9E-123	64	361	298

Status

Unreviewed

Ensembl Protein

ENSGACP00000021655

UniProt Accession

G3PVL6;

Protein Name

Protein Synonyms/Alias

Gene Name

MAPK10

Gene Synonyms/Alias

MAPK10;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGACG00000016396	ENSGACP00000021652	ENSGACT00000021693
ENSGACG00000016396	ENSGACP00000021655	ENSGACT00000021696

Organism

Gasterosteus aculeatus

Functional Description

Protein Length

466

Protein Sequence
(FASTA)

MSRHFLYNCS QPILDVKIAF CQGFGKQVDV SYIAKHYNMS KSKVDNQFYS VEVGDSTFTV 60

LKRYQNLKPI GSGAQGIVCA GYDAVLDRNV AIKKLSRPFQ NQTHAKRAYR ELVLMKCVNH 120

KNIISLLNVF TPQKSLEDFQ DVYLVMELMD ANLCQVIQME LDHERMSYLL YQMLCGIKHL 180

HSAGIIHRDL KPSNIVVKSD CTLKILDFGL ARTAGTSFMM TPYVVTRYYR APEVILGMGY 240

KENVDLWSVG CIMGEMVRHK ILFPGRDYID QWNKVIEQLG TPSPDFMKKL QPTVRNYVEN 300

RPKYAGLTFP KLFPDCLFPA DSEHNKLKAT ASQARDLLSK MLIIDPAKRI SVDDALQHPY 360

INVWYDPAEV EAPPPQIYDK QLDEREHSID EWKELIYKEV MNFEERTKNG VVKGQPSPSG 420

AAVNSSDSLA HSTYINDISS MSTDQTLASD TDSSLETSAG PLGCCR 466

Nucleotide Sequence
(FASTA)

ATGAGCAGAC ATTTCTTATA TAACTGCAGC CAACCGATCC TGGATGTGAA GATAGCCTTT 60

TGTCAGGGTT TTGGAAAACA AGTGGATGTG TCATATATCG CCAAACATTA CAACATGAGT 120

AAAAGCAAAG TGGACAACCA GTTCTACAGC GTGGAAGTGG GAGACTCCAC TTTCACAGTT 180

TTAAAACGGT ACCAGAATTT AAAGCCCATC GGTTCCGGAG CTCAGGGAAT CGTCTGTGCT 240

GGTTATGACG CTGTCTTGGA CAGAAACGTG GCCATCAAGA AGTTGAGCAG ACCCTTCCAG 300

AACCAGACCC ATGCCAAGAG GGCGTACCGG GAGTTGGTGC TCATGAAATG TGTCAATCAC 360

AAAAATATTA TCAGTTTATT AAACGTCTTC ACACCACAGA AATCATTAGA GGACTTCCAG 420

GATGTGTACC TAGTGATGGA GCTGATGGAT GCCAACTTGT GCCAGGTGAT TCAGATGGAG 480

CTGGACCACG AGAGAATGTC CTACCTGCTC TACCAGATGC TGTGTGGTAT CAAACATCTG 540

CACTCGGCTG GCATTATTCA CAGGGACCTG AAACCAAGCA ATATAGTGGT GAAGTCAGAC 600

TGCACCCTGA AGATCCTGGA CTTTGGTCTG GCCAGGACCG CAGGCACCAG CTTCATGATG 660

ACCCCTTATG TGGTGACTAG ATACTACAGA GCCCCGGAGG TCATCCTCGG CATGGGGTAC 720

AAAGAGAATG TGGATTTATG GTCGGTGGGG TGCATTATGG GAGAAATGGT GCGCCACAAA 780

ATCCTCTTCC CTGGGCGGGA CTACATCGAC CAGTGGAACA AGGTGATTGA GCAGCTGGGA 840

ACGCCCTCTC CCGATTTCAT GAAGAAGCTT CAGCCCACAG TGAGGAACTA CGTGGAGAAC 900

CGGCCAAAGT ACGCAGGCCT CACCTTCCCC AAGCTCTTCC CCGACTGCCT TTTCCCTGCT 960

GACTCTGAGC ACAACAAACT CAAAGCCACA GCCAGCCAGG CCAGAGACCT GCTGTCCAAG 1020

ATGCTGATCA TCGACCCGGC CAAGCGGATA TCGGTGGACG ACGCCTTGCA GCACCCCTAC 1080

ATCAACGTGT GGTACGATCC AGCTGAGGTG GAGGCGCCTC CACCTCAGAT CTACGACAAG 1140

CAACTGGATG AGAGAGAACA CTCCATTGAT GAATGGAAAG AACTAATTTA CAAAGAGGTG 1200

ATGAACTTTG AGGAGAGAAC GAAGAATGGC GTAGTGAAGG GACAGCCTTC ACCTTCAGGT 1260

GCAGCCGTGA ACAGCAGCGA CAGCCTCGCC CACTCCACCT ACATCAACGA CATCTCCTCC 1320

ATGTCAACCG ACCAGACCCT GGCCTCAGAC ACCGACAGCA GCCTGGAGAC CTCCGCGGGG 1380

CCCCTCGGGT GTTGCAGGTG A 1401

Domain Profile

S: 1     yeslkplgeGaygvvvsavdkrteervaikklsrpfqketsakrtlRElkllkelkheNi  60

         y++lkp+g+Ga+g+v++ +d+  +++vaikklsrpfq++t+akr++REl l+k+++h+Ni

Q: 64    YQNLKPIGSGAQGIVCAGYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNI  123

         899*********************************************************

S: 61    iklldvftpeeeleelkdvYlvtelmetdLkkviksqklsdehiklllyqilrglkylHs  120

         i+ll+vftp+++le+++dvYlv+elm+++L++vi+++ l++e++++llyq+l+g+k+lHs

Q: 124   ISLLNVFTPQKSLEDFQDVYLVMELMDANLCQVIQME-LDHERMSYLLYQMLCGIKHLHS  182

         ************************************9.**********************

S: 121   anviHrDlKPsNllvnedcelkildFGlarsadkekekklteyvatrwYraPeillslke  180

         a++iHrDlKPsN++v++dc+lkildFGlar+a ++ +  +t+yv+tr+YraPe++l  +

Q: 183   AGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFM--MTPYVVTRYYRAPEVILG-MG  239

         **********************************976..*****************9.99

S: 181   ytkavDiWsvGCIlaElltgkplfpgkdeidqlekilevlgtpseeflkkieseearnyi  240

         y+++vD+WsvGCI++E++++k+lfpg+d+idq++k++e+lgtps +f+kk++  ++rny+

Q: 240   YKENVDLWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPSPDFMKKLQP-TVRNYV  298

         *****************************************************.5*****

S: 241   kslpkkkkkdfeelfpk..............aseealdLleklLvldpdkRisveeaLeh  286

         +++pk++  +f +lfp+              + ++a+dLl+k+L++dp kRisv++aL+h

Q: 299   ENRPKYAGLTFPKLFPDclfpadsehnklkaTASQARDLLSKMLIIDPAKRISVDDALQH  358

         ******************************999***************************

S: 287   pYl  289

pY+

Q: 359   PYI  361

**7

Domain Sequence
(FASTA)

YQNLKPIGSG AQGIVCAGYD AVLDRNVAIK KLSRPFQNQT HAKRAYRELV LMKCVNHKNI 60

ISLLNVFTPQ KSLEDFQDVY LVMELMDANL CQVIQMELDH ERMSYLLYQM LCGIKHLHSA 120

GIIHRDLKPS NIVVKSDCTL KILDFGLART AGTSFMMTPY VVTRYYRAPE VILGMGYKEN 180

VDLWSVGCIM GEMVRHKILF PGRDYIDQWN KVIEQLGTPS PDFMKKLQPT VRNYVENRPK 240

YAGLTFPKLF PDCLFPADSE HNKLKATASQ ARDLLSKMLI IDPAKRISVD DALQHPYI 298

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004707	; F:MAP kinase activity
GO:0000165	; P:MAPK cascade

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR003527	; MAP_kinase_CS.
IPR008351	; MAPK_JNK.
IPR000719	; Prot_kinase_cat_dom.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS01351	; MAPK; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR01772

; JNKMAPKINASE.

Created Date

20-Feb-2013