EKS-GAA-00322

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-GAA-00322

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/PLK	409.9	5.9E-123	35	287	253

Status

Unreviewed

Ensembl Protein

ENSGACP00000021825

UniProt Accession

G3PW36;

Protein Name

Protein Synonyms/Alias

Gene Name

PLK1

Gene Synonyms/Alias

PLK1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGACG00000016526	ENSGACP00000021825	ENSGACT00000021866

Organism

Gasterosteus aculeatus

Functional Description

Protein Length

579

Protein Sequence
(FASTA)

MSAATAKPAA HVDPKSAPLK EIPEVLVDPR TMKRYARGRF LGKGGFAKCY EITDLETQQV 60

FAGKIVPKSL ILKQHQREKM TSEIAIHKSL NHANVVGFHG FFEDDDFVFV VLEICRRRSL 120

LELHKRRKAV TEPEVRYYMT KLLNGIQYLH NNRVIHRDLK LGNIFLNDDM EVKIGDFGLA 180

TKIEFDGERK KTLCGTPNYI APEVLCKKGH SYEVDIWSLG CILYTLLVGK PPFETSCLKE 240

TYNRIKKNNY TIPWHINPLA TALIKRMLHA EPAQRPTIAE LQADEYFSTG YIPLHLPTTC 300

LTVPPRFSIA PSTAAELNQR RPLTAINNKA GTEKADGKDE PAQREPEPTE CHLKDLLQQL 360

NSIIAAKPSE KAVICQEEAE DPACVPIFWI SKWVDYSDKY GLGYQLCDNS VGVLFNDYTR 420

LIMYTDGDSL QYIDKAAVES YLSVRSFNSS LHKKVTLLKY FRNYMSEHLL KAGANMARRD 480

GDELARLPYL SLWFRTKSAI VLHLSNGTVQ INFFQDHTKL ILCPLMGAVT YIDEKREFRT 540

YKLSLLEEFG CCKELASRMR YAKLMVEKLQ DSKQAPAAR 579

Nucleotide Sequence
(FASTA)

ATGAGCGCAG CCACCGCGAA GCCGGCGGCA CATGTCGACC CCAAATCGGC TCCACTCAAA 60

GAGATCCCCG AGGTCCTGGT CGACCCGCGC ACCATGAAGC GGTACGCGAG GGGCAGGTTC 120

CTCGGGAAAG GCGGCTTCGC CAAGTGCTAC GAGATCACGG ACCTGGAGAC GCAGCAGGTT 180

TTCGCCGGGA AAATCGTGCC CAAGTCCCTG ATCCTGAAGC AGCACCAGAG GGAGAAGATG 240

ACCTCCGAGA TCGCCATTCA CAAGAGCCTC AACCACGCCA ACGTCGTCGG TTTCCATGGC 300

TTCTTCGAGG ACGACGACTT TGTCTTCGTT GTCTTGGAAA TCTGCAGGAG ACGGTCCCTG 360

TTGGAGCTGC ACAAGCGCCG TAAGGCCGTG ACCGAGCCCG AGGTCCGATA CTACATGACC 420

AAACTGCTCA ACGGCATCCA GTACCTGCAC AACAACCGCG TCATCCACAG GGACCTGAAG 480

CTGGGCAACA TCTTCCTCAA CGACGACATG GAGGTCAAGA TAGGGGACTT TGGTTTGGCC 540

ACAAAGATCG AGTTCGACGG GGAGCGGAAG AAGACTCTGT GCGGAACGCC CAACTACATC 600

GCGCCCGAGG TGCTCTGCAA GAAAGGCCAC AGCTACGAGG TGGACATCTG GTCGCTGGGG 660

TGCATACTGT ACACTTTGCT GGTGGGAAAG CCCCCGTTCG AGACCTCCTG CCTGAAGGAG 720

ACCTACAACC GCATCAAGAA GAACAACTAC ACCATCCCCT GGCACATCAA CCCGCTGGCG 780

ACGGCTCTCA TCAAGCGGAT GCTGCACGCC GAGCCCGCCC AGAGGCCCAC CATCGCCGAG 840

CTGCAGGCCG ACGAGTACTT CTCCACCGGC TACATCCCGC TGCACCTGCC CACCACCTGC 900

CTCACCGTGC CCCCGCGCTT CTCCATCGCC CCCTCCACGG CCGCCGAGCT CAACCAGAGG 960

CGGCCCCTGA CGGCCATCAA CAACAAAGCC GGGACGGAGA AGGCGGACGG CAAGGACGAG 1020

CCGGCGCAAA GAGAGCCCGA GCCGACCGAG TGCCACCTGA AGGACCTGCT GCAGCAGCTC 1080

AACAGCATCA TCGCTGCCAA GCCCTCCGAG AAGGCGGTCA TCTGCCAAGA AGAGGCCGAG 1140

GACCCCGCCT GTGTGCCCAT CTTCTGGATC AGCAAATGGG TCGACTACTC TGACAAATAT 1200

GGATTGGGCT ACCAGCTGTG CGACAACAGC GTGGGCGTTC TCTTCAACGA CTACACGCGG 1260

CTCATCATGT ACACGGACGG GGACAGCCTG CAGTACATCG ACAAGGCGGC GGTGGAGAGC 1320

TACCTCAGCG TGCGCAGCTT CAACTCGTCC CTCCACAAGA AGGTCACGCT GCTGAAATAC 1380

TTCCGCAACT ACATGAGCGA GCACCTGCTG AAGGCCGGCG CCAACATGGC GCGGCGGGAC 1440

GGCGACGAGC TTGCGCGCCT CCCCTACCTC TCCCTGTGGT TCCGCACCAA GAGCGCCATC 1500

GTCCTGCACC TCTCCAACGG CACCGTGCAG ATCAACTTCT TCCAGGACCA CACCAAGCTG 1560

ATCCTGTGCC CGCTGATGGG CGCCGTCACC TACATCGACG AGAAGCGAGA GTTCCGCACC 1620

TACAAGCTGT CGCTGCTGGA GGAGTTTGGC TGCTGCAAGG AGCTGGCCAG CCGCATGCGC 1680

TACGCCAAGC TGATGGTGGA GAAGCTGCAG GACAGCAAGC AGGCCCCCGC CGCCCGCTAG 1740

Domain Profile

S: 1     yergkllGkGgfakcyelkdletkevfavkvvpksllakekqrekvekeieihrslkhkn  60

         y rg++lGkGgfakcye++dlet++vfa k+vpksl+ k++qrek+++ei+ih+sl+h n

Q: 35    YARGRFLGKGGFAKCYEITDLETQQVFAGKIVPKSLILKQHQREKMTSEIAIHKSLNHAN  94

         89**********************************************************

S: 61    ivklyeffedkenvylvlelcsrrslaellkrrkaltepevryylrqivsglkylhekri  120

         +v ++ ffed+++v++vle+c+rrsl el+krrka+tepevryy++++++g++ylh++r+

Q: 95    VVGFHGFFEDDDFVFVVLEICRRRSLLELHKRRKAVTEPEVRYYMTKLLNGIQYLHNNRV  154

         ************************************************************

S: 121   lhrdlklgnlflneelevkigdfGlatrlekeeerkktlcGtPnyiaPevlskkghslev  180

         +hrdlklgn+fln+++evkigdfGlat++e ++erkktlcGtPnyiaPevl kkghs+ev

Q: 155   IHRDLKLGNIFLNDDMEVKIGDFGLATKIEFDGERKKTLCGTPNYIAPEVLCKKGHSYEV  214

         ************************************************************

S: 181   diWslGcilytllvGkPPfetkelketyekikkaeyslPsslskeaksliakllkkePee  240

         diWslGcilytllvGkPPfet++lkety++ikk++y++P ++++ a+ li+++l++eP++

Q: 215   DIWSLGCILYTLLVGKPPFETSCLKETYNRIKKNNYTIPWHINPLATALIKRMLHAEPAQ  274

         ************************************************************

S: 241   rpsleevlkdefl  253

         rp++ e+  de++

Q: 275   RPTIAELQADEYF  287

         *******999987

Domain Sequence
(FASTA)

YARGRFLGKG GFAKCYEITD LETQQVFAGK IVPKSLILKQ HQREKMTSEI AIHKSLNHAN 60

VVGFHGFFED DDFVFVVLEI CRRRSLLELH KRRKAVTEPE VRYYMTKLLN GIQYLHNNRV 120

IHRDLKLGNI FLNDDMEVKI GDFGLATKIE FDGERKKTLC GTPNYIAPEV LCKKGHSYEV 180

DIWSLGCILY TLLVGKPPFE TSCLKETYNR IKKNNYTIPW HINPLATALI KRMLHAEPAQ 240

RPTIAELQAD EYF 253

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000959	; POLO_box_duplicated_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069	; Pkinase; 1.
PF00659	; POLO_box; 2.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS50078	; POLO_BOX; 2.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013