EKS-GAA-00346

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-GAA-00346

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	405.2	2.0E-121	193	481	289

Status

Unreviewed

Ensembl Protein

ENSGACP00000022047

UniProt Accession

G3PWQ8;

Protein Name

Protein Synonyms/Alias

Gene Name

ACVR2B (1 of 2)

Gene Synonyms/Alias

ACVR2B (1 of 2);

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGACG00000016690	ENSGACP00000022047	ENSGACT00000022089

Organism

Gasterosteus aculeatus

Functional Description

Protein Length

515

Protein Sequence
(FASTA)

SGATIRLTCS LLLGTLCAGY SLGEAETREC VYYNDNWRTE RTNQSGFERC EGEKDKRLHC 60

YASWLNSSGT IKLVKKGCWL DDFNCYDRQE CVSMEENPQV FFCCCEGNYC NERFTHLPDM 120

IGSGNRVKIR PPPRVPSLLN VLVYSLLPLC VLSLALVLAL WMYRHRKPPY GHVDLSEDPG 180

ATPPSPLVGL KPLQLLEIKA RGRFGCVWKA QLMSEYVAVK IFPVQDKQSW INERDIFLTP 240

GMRHENLLRY IAAEKHGTNL ETELWLITEF HERGSLTDYL KGNTVSWSDL CHIAETMSRG 300

LAYLHEDIPS YKGEGPKPTI AHRDFKSKNV MVRDDLSAII GDFGLAVRFE PGKPPGDTHG 360

QVGTRRYMAP EVLEGAINFQ RDSFLRIDMY AMGLVLWELV ARCTETDGTV GEYMLPFEDE 420

IGQHPSLEDL QDVVVHKKMR PAIKDCWLKH PGLSQMCETI EECWDHDAEA RLSAGCVEER 480

IGQIARTIGS TTSDSPVCIV MSLTNEDLPP KESST 515

Nucleotide Sequence
(FASTA)

AGCGGTGCTA CTATCCGACT GACTTGTTCA CTTCTTCTGG GAACTTTATG CGCAGGGTAC 60

AGTCTGGGCG AAGCCGAGAC CCGGGAGTGT GTGTACTACA ATGACAACTG GCGCACGGAG 120

AGGACCAACC AGAGCGGCTT TGAGCGCTGC GAGGGCGAGA AGGACAAGCG GCTGCACTGT 180

TACGCCTCCT GGCTCAACTC CTCAGGGACC ATCAAGCTGG TGAAGAAAGG CTGCTGGCTG 240

GACGACTTCA ACTGCTACGA CAGGCAAGAG TGCGTCTCTA TGGAGGAAAA CCCTCAGGTC 300

TTCTTCTGCT GCTGCGAGGG CAACTACTGC AATGAACGAT TCACCCACCT TCCTGACATG 360

ATTGGCAGTG GCAACCGAGT GAAAATCCGA CCTCCACCCC GAGTGCCGTC CCTGCTCAAC 420

GTGCTTGTGT ACTCCCTGCT GCCTCTCTGT GTGCTGTCCC TGGCCCTCGT CCTGGCCTTG 480

TGGATGTACC GCCACCGCAA ACCTCCCTAC GGCCACGTGG ACCTGAGCGA GGATCCTGGA 540

GCCACTCCTC CCTCCCCCTT AGTGGGTCTG AAACCGCTGC AGCTGCTGGA AATCAAAGCA 600

AGGGGGCGCT TTGGTTGTGT TTGGAAGGCC CAGTTGATGA GCGAGTATGT TGCTGTAAAG 660

ATCTTCCCTG TTCAGGACAA GCAGTCATGG ATAAATGAGC GGGATATATT CCTGACTCCG 720

GGGATGCGTC ATGAAAACCT CTTGCGTTAC ATCGCTGCAG AGAAGCACGG CACCAACCTG 780

GAGACGGAGC TGTGGCTCAT CACAGAGTTT CATGAGAGGG GCTCATTGAC CGACTACCTG 840

AAGGGCAACA CTGTGAGCTG GAGTGATCTG TGTCACATAG CAGAGACCAT GTCCCGCGGC 900

TTGGCTTACC TCCATGAGGA CATTCCCAGC TACAAGGGAG AGGGACCCAA ACCCACCATT 960

GCACACAGGG ACTTCAAGAG TAAGAATGTG ATGGTACGAG ATGATCTGAG TGCAATCATC 1020

GGCGACTTCG GGCTCGCTGT ACGATTTGAA CCGGGAAAAC CTCCAGGAGA CACCCATGGA 1080

CAGGTGGGTA CGAGGCGTTA CATGGCTCCA GAGGTGCTGG AGGGAGCCAT AAACTTCCAG 1140

CGAGACTCCT TCCTGAGGAT CGACATGTAC GCTATGGGCT TGGTGCTGTG GGAGCTGGTG 1200

GCCCGGTGCA CAGAGACGGA CGGTACAGTT GGCGAGTACA TGCTGCCGTT TGAGGATGAA 1260

ATAGGCCAGC ACCCCTCCTT GGAGGATCTG CAGGATGTGG TTGTGCACAA GAAGATGCGT 1320

CCAGCCATCA AAGACTGCTG GCTCAAACAT CCTGGTCTGA GCCAGATGTG CGAGACCATC 1380

GAAGAATGCT GGGACCACGA CGCCGAGGCG CGATTGTCTG CTGGTTGCGT GGAGGAGCGC 1440

ATCGGCCAGA TCGCCCGGAC GATCGGCAGC ACTACCTCGG ACAGCCCCGT CTGCATTGTG 1500

ATGTCTCTCA CCAACGAGGA CCTACCTCCC AAAGAGTCCA GCACCTGA 1548

Domain Profile

S: 1     lklleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfia  60

         l+lle+ ++Gr+g+Vwka+l+ e+vAvKif+ +d++sw +E++i+ t+ +rhen+l++ia

Q: 193   LQLLEIKARGRFGCVWKAQLMSEYVAVKIFPVQDKQSWINERDIFLTPGMRHENLLRYIA  252

         6899********************************************************

S: 61    adkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgtk  120

         a+k+ ++++tel+l+te+he+gsL+dyLk +t+++++l+++a+++++Gla+LHe+i+  k

Q: 253   AEKHGTNLETELWLITEFHERGSLTDYLKGNTVSWSDLCHIAETMSRGLAYLHEDIPSYK  312

         ********************************************************9999

S: 121   g.kkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtkRYmaP  179

         g   Kp+iaHRD+kskN++v++dl+++i+D+GLa+++e  k   d  ++ qvGt+RYmaP

Q: 313   GeGPKPTIAHRDFKSKNVMVRDDLSAIIGDFGLAVRFEPGKPPGD--THGQVGTRRYMAP  370

         989***************************************888..79***********

S: 180   EvleealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsdPslee  239

         Evle+a+n+++ ++f r+D+Y++gLvlWE++ Rc+e+d++v ey+lpfe+++g++Psle+

Q: 371   EVLEGAINFQR-DSFLRIDMYAMGLVLWELVARCTETDGTVGEYMLPFEDEIGQHPSLED  429

         **********9.9***********************************************

S: 240   mkevvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkrl  291

         +++vvv+kk+rP i++ w k++ l+++++++eecWd+d+eaRl+a +v++r+

Q: 430   LQDVVVHKKMRPAIKDCWLKHPGLSQMCETIEECWDHDAEARLSAGCVEERI  481

         *************************************************985

Domain Sequence
(FASTA)

LQLLEIKARG RFGCVWKAQL MSEYVAVKIF PVQDKQSWIN ERDIFLTPGM RHENLLRYIA 60

AEKHGTNLET ELWLITEFHE RGSLTDYLKG NTVSWSDLCH IAETMSRGLA YLHEDIPSYK 120

GEGPKPTIAH RDFKSKNVMV RDDLSAIIGD FGLAVRFEPG KPPGDTHGQV GTRRYMAPEV 180

LEGAINFQRD SFLRIDMYAM GLVLWELVAR CTETDGTVGE YMLPFEDEIG QHPSLEDLQD 240

VVVHKKMRPA IKDCWLKHPG LSQMCETIEE CWDHDAEARL SAGCVEERI 289

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016020	; C:membrane
GO:0017002	; F:activin-activated receptor activity
GO:0005524	; F:ATP binding
GO:0004702	; F:receptor signaling protein serine/threonine kinase activity
GO:0005024	; F:transforming growth factor beta-activated receptor activity
GO:0023014	; P:signal transduction by phosphorylation

KEGG

InterPros

IPR000333	; Activin_II/TGFBeta-II_recpt.
IPR015768	; Activin_II_recpt.
IPR000472	; Activin_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF01064	; Activin_recp; 1.
PF00069	; Pkinase; 1.

SMARTs

Prosites

PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR00653

; ACTIVIN2R.

Created Date

20-Feb-2013