EKS-GAA-00320
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-GAA-00320
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Abl549.91.1E-165269520252
StatusUnreviewed
Ensembl ProteinENSGACP00000022183
UniProt AccessionG3PX44;
Protein Name
Protein Synonyms/Alias
Gene NameABL1
Gene Synonyms/Alias ABL1;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSGACG00000016802ENSGACP00000022183ENSGACT00000022225
OrganismGasterosteus aculeatus
Functional Description
Protein Length1141
Protein Sequence
(FASTA)
PVWRVPAAAW HRALMGQQPG KFVGDQRRPS LPAFIRGGRR ESSRHGTQPC NVFVVHEALQ 60
RPDFESPGLT EAARWNSKEN LLAGPSENDP NLFVALYDFV ASGDNTLSIT KGEKLRVLGY 120
NHNGEWCEAQ TKNGQGWVPS NYITPVNSLE KHSWYHGPVS RNAAEYLLSS GINGSFLVRE 180
SESSPGQRSI SLRYEGRVYH YRINTASDGK LYVSSESRFN TLAELVHHHS TVSDGLITTL 240
HYPAPKRNKP TIYGVSPNYD KWEMERTDIT MKHKLGGGQY GEVYEGVWKK YNLTVAVKTL 300
KEDTMEVEEF LKEAAVMKEI KHPNLVQLLG VCTREPPFYI ITEFMTHGNL LDYLRECNRE 360
EVNAVVLLYM ATQISSAMEY LEKKNFIHRD LAARNCLVGE NHLVKVADFG LSRLMTGDTY 420
TAHAGAKFPI KWTAPESLAY NKFSIKSDVW AFGVLLWEIA TYGMSPYPGI DLSQVYELLE 480
KDYRMDRPEG CPEKVYDLMR DCWRWNPSER PSFAETHQAF ETMFQESSIS DEVEKELGKK 540
GKKATLGPTQ KAPELPTKTR TLRKNMENRD GDSPVMISSF HLGTSPDPLE PDVAVPSPML 600
PRKERPSLDS NLNEDDRLIP KDKDKTRGSG FLSLIKKKKK NAPTPPKRSS SFREMDIHPD 660
RRGTTPDLRD GDGFNNGASL AINDITQGLD SAKFLSNNNG AGGITNGAPT YPGPLFPRKK 720
GAPAVPGPGG KVATTPPSEE ESMSNSKRFL WSSSMPSGRD GTEWKSVTLP RDLGQRHFDS 780
GTLGGKPALP RKRTSEQKGE AAPRKGTLTP PPRLNTLSDG SSAFPGRDAE PGSGSSPQAL 840
TPKVVRRSGL LGLENSRTSA LHAASQAQCV PCLGRWGRVQ GPPTRHPGDP SSVRERGKLQ 900
KPKPAPPPPP TNAKTGKMSR SPTQDLPSPA SSTSESKAKG LPSLSELHHS TTTGSDHARS 960
PLSEGPKKLP PGSTAKPQPS KTPTSVTTSL SSPGGFSASL SSPSDLSSTT AFIPLVNTRR 1020
SLRKTAPRQA SERTPNSAVT CNMVLEGAEL LRAAICRNSE QTGSHSAVLE AGKNLSKYCW 1080
SYVDSIQQMR NKFAFREAIT KLENSLRELQ ICPATTGGAS GQQDFSKLLS SVKEIGDIVQ 1140
R 1141
Nucleotide Sequence
(FASTA)
CCAGTTTGGA GAGTCCCGGC TGCGGCCTGG CACCGTGCCC TTATGGGGCA GCAGCCGGGG 60
AAGTTTGTCG GGGACCAGAG GAGACCTAGT CTGCCGGCCT TCATCAGAGG TGGAAGGAGA 120
GAGTCGTCGC GCCATGGCAC CCAGCCCTGT AACGTTTTCG TTGTGCACGA AGCTCTCCAG 180
AGACCCGACT TTGAGAGTCC GGGTCTGACC GAAGCGGCCC GCTGGAACTC CAAGGAGAAC 240
CTGTTGGCTG GACCCAGCGA GAATGACCCC AACCTGTTCG TCGCACTCTA TGACTTCGTG 300
GCCAGTGGCG ACAACACACT CAGCATTACT AAAGGAGAGA AGCTACGTGT GCTGGGCTAC 360
AACCACAACG GCGAGTGGTG CGAGGCACAG ACCAAGAACG GCCAGGGTTG GGTGCCGTCC 420
AACTACATCA CCCCCGTCAA CAGCTTGGAG AAGCACAGCT GGTACCATGG GCCCGTGTCC 480
CGCAACGCTG CCGAGTACCT GCTCAGCTCG GGCATCAACG GGAGCTTTCT GGTGCGGGAG 540
AGCGAGAGCA GCCCCGGCCA GAGGTCCATT TCTCTGCGCT ACGAAGGGCG AGTCTACCAT 600
TACAGGATTA ACACCGCGTC CGACGGCAAG CTGTACGTGT CGTCGGAGAG CCGCTTCAAC 660
ACGCTGGCGG AGCTGGTGCA CCACCATTCC ACGGTGTCCG ACGGCCTCAT CACCACGCTG 720
CACTACCCGG CGCCGAAGCG CAACAAGCCC ACCATCTACG GAGTCTCTCC CAACTACGAT 780
AAGTGGGAGA TGGAACGCAC CGACATCACC ATGAAGCACA AGCTGGGAGG GGGCCAGTAC 840
GGGGAGGTGT ACGAGGGGGT TTGGAAGAAG TACAACCTCA CCGTGGCTGT CAAGACGCTA 900
AAGGAGGATA CAATGGAGGT GGAGGAGTTT CTTAAGGAGG CAGCTGTCAT GAAAGAGATC 960
AAACATCCCA ACCTGGTACA ACTTTTGGGT GTGTGCACAC GGGAACCACC GTTCTACATT 1020
ATAACAGAGT TCATGACCCA CGGTAACCTG CTAGACTACC TGAGGGAGTG CAACAGAGAG 1080
GAGGTCAATG CAGTGGTGCT GCTCTACATG GCCACACAGA TCTCCTCTGC TATGGAGTAC 1140
CTGGAGAAAA AAAACTTTAT ACACAGGGAC TTGGCTGCCC GTAACTGTCT GGTCGGGGAG 1200
AACCACCTGG TGAAGGTTGC GGACTTTGGC CTGAGCCGGC TGATGACTGG AGATACCTAC 1260
ACGGCCCACG CCGGGGCTAA GTTCCCCATC AAGTGGACCG CTCCGGAGAG TCTGGCCTAC 1320
AACAAGTTCT CCATTAAATC CGATGTCTGG GCATTTGGTG TGCTGCTGTG GGAGATCGCC 1380
ACCTACGGCA TGTCTCCCTA CCCCGGCATC GACCTGTCCC AGGTGTACGA GCTGCTGGAG 1440
AAAGACTACC GCATGGACCG ACCAGAGGGC TGCCCCGAGA AGGTCTACGA CCTCATGAGG 1500
GACTGCTGGA GGTGGAACCC CTCAGAACGT CCGTCTTTTG CTGAGACACA CCAAGCCTTC 1560
GAGACCATGT TCCAGGAGTC GAGCATCTCG GATGAGGTGG AAAAGGAACT CGGCAAAAAG 1620
GGGAAGAAGG CAACGTTAGG TCCCACCCAG AAGGCTCCAG AGCTGCCCAC CAAAACAAGA 1680
ACTCTCCGCA AAAACATGGA GAACCGGGAT GGAGACAGTC CAGTGATGAT TTCCTCCTTC 1740
CATCTGGGCA CTTCCCCAGA CCCACTGGAG CCGGACGTGG CTGTGCCGTC ACCCATGCTC 1800
CCCAGGAAGG AGCGTCCCAG CCTGGACAGT AACCTGAATG AGGACGACCG CTTGATACCC 1860
AAAGACAAGG ACAAGACTCG AGGCAGTGGC TTTCTCAGTC TTATAAAGAA AAAGAAAAAG 1920
AATGCTCCAA CTCCGCCCAA ACGCAGCTCT TCCTTCAGAG AGATGGACAT CCACCCCGAC 1980
AGGCGGGGCA CGACTCCAGA TCTCCGGGAC GGCGACGGCT TCAACAACGG CGCGTCTCTG 2040
GCCATCAATG ACATCACACA GGGCCTCGAC TCGGCAAAGT TCCTGAGCAA CAACAACGGG 2100
GCGGGGGGCA TCACCAACGG GGCTCCCACC TACCCGGGAC CTCTGTTCCC CCGGAAGAAG 2160
GGGGCTCCCG CCGTGCCCGG CCCCGGCGGG AAAGTGGCGA CCACGCCGCC GAGTGAGGAG 2220
GAGTCCATGT CCAACTCGAA GCGCTTCCTC TGGTCCTCCA GCATGCCGAG TGGCCGAGAC 2280
GGCACCGAGT GGAAGTCTGT CACGCTGCCG CGAGACCTCG GCCAGCGCCA CTTTGACTCG 2340
GGCACCCTCG GGGGCAAGCC CGCTCTGCCC CGCAAGAGAA CCAGTGAGCA AAAAGGGGAG 2400
GCCGCCCCTC GAAAGGGCAC CCTGACTCCC CCGCCGCGCC TGAACACCTT ATCGGACGGT 2460
TCCTCGGCCT TCCCGGGCAG GGACGCCGAG CCAGGTTCGG GTTCGAGTCC CCAGGCGTTG 2520
ACGCCCAAAG TGGTCAGGAG GTCGGGGCTG CTGGGCCTGG AGAACTCCAG GACCAGCGCT 2580
CTCCACGCCG CTTCTCAAGC CCAATGTGTT CCCTGCTTAG GGCGCTGGGG AAGAGTGCAA 2640
GGCCCGCCGA CACGGCACCC GGGGGACCCT TCGTCGGTTA GGGAGAGGGG AAAGTTACAG 2700
AAACCCAAGC CGGCCCCGCC TCCACCACCC ACCAATGCCA AAACGGGCAA GATGTCCCGC 2760
AGCCCCACTC AAGATCTCCC CTCTCCCGCA TCCTCCACCT CCGAGAGCAA AGCTAAGGGC 2820
CTCCCCTCTC TGTCGGAGCT CCACCACAGC ACAACCACTG GCAGCGACCA CGCCCGCTCA 2880
CCCCTCAGCG AGGGCCCCAA GAAGCTGCCC CCGGGCTCCA CCGCCAAACC TCAGCCGTCA 2940
AAGACCCCCA CCTCTGTGAC CACCTCCCTC TCCAGCCCGG GCGGGTTCTC CGCTTCCCTC 3000
TCCTCCCCCA GCGACCTGAG CTCGACCACC GCTTTCATCC CCTTGGTGAA CACCCGGCGC 3060
TCCCTCCGCA AGACGGCCCC GCGCCAGGCC TCCGAGCGCA CCCCCAACTC GGCCGTGACG 3120
TGCAACATGG TGCTGGAGGG CGCCGAGCTG CTGCGCGCCG CCATTTGCCG CAACTCTGAG 3180
CAGACGGGGA GCCACAGCGC CGTGCTGGAG GCCGGCAAGA ACCTGTCCAA GTACTGCTGG 3240
AGCTACGTGG ACTCCATACA GCAGATGAGG AACAAGTTTG CCTTTCGCGA GGCCATCACC 3300
AAGCTGGAGA ACAGCCTGCG CGAGCTGCAG ATCTGCCCCG CCACCACGGG GGGCGCCAGC 3360
GGCCAGCAGG ACTTCAGCAA GCTGCTGTCC TCCGTCAAAG AGATCGGTGA CATTGTTCAG 3420
AGGTAG 3426
Domain Profile
S: 1     iimkhklgggqygevyegvwkkysltvavktlkedtmeveeflkeaavmkelkhpnlvql  60
         i+mkhklgggqygevyegvwkky+ltvavktlkedtmeveeflkeaavmke+khpnlvql
Q: 269   ITMKHKLGGGQYGEVYEGVWKKYNLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQL  328
         89**********************************************************
S: 61    lgvctreppfyiitefmsygnlldylreadreeveavvllymatqissameylekknfih  120
         lgvctreppfyiitefm++gnlldylre++reev+avvllymatqissameylekknfih
Q: 329   LGVCTREPPFYIITEFMTHGNLLDYLRECNREEVNAVVLLYMATQISSAMEYLEKKNFIH  388
         ************************************************************
S: 121   rdlaarnclvgenklvkvadfglsrlmkedtytahagakfpikwtapeslaynkfsiksd  180
         rdlaarnclvgen+lvkvadfglsrlm++dtytahagakfpikwtapeslaynkfsiksd
Q: 389   RDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNKFSIKSD  448
         ************************************************************
S: 181   vwafgvllweiatygmspypgidlsqvyellekgyrmerpegcppkvyelmracwkwsps  240
         vwafgvllweiatygmspypgidlsqvyellek+yrm+rpegcp+kvy+lmr+cw+w+ps
Q: 449   VWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMDRPEGCPEKVYDLMRDCWRWNPS  508
         ************************************************************
S: 241   drpsfaeihqal  252
         +rpsfae+hqa+
Q: 509   ERPSFAETHQAF  520
         *********986
Domain Sequence
(FASTA)
ITMKHKLGGG QYGEVYEGVW KKYNLTVAVK TLKEDTMEVE EFLKEAAVMK EIKHPNLVQL 60
LGVCTREPPF YIITEFMTHG NLLDYLRECN REEVNAVVLL YMATQISSAM EYLEKKNFIH 120
RDLAARNCLV GENHLVKVAD FGLSRLMTGD TYTAHAGAKF PIKWTAPESL AYNKFSIKSD 180
VWAFGVLLWE IATYGMSPYP GIDLSQVYEL LEKDYRMDRP EGCPEKVYDL MRDCWRWNPS 240
ERPSFAETHQ AF 252
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dasypus novemcinctus"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00218
EKS-ANC-00228
EKS-BOT-00257
EKS-CAE-00214
EKS-CAJ-00243
EKS-CAF-00245
EKS-CAP-00293
EKS-CII-00141
EKS-CIS-00017
EKS-DAR-00593
EKS-DAN-00005
EKS-DRM-00121
EKS-EQC-00230
EKS-FEC-00244
EKS-GAG-00198
EKS-GOG-00256
EKS-HOS-00245
EKS-ICT-00225
EKS-LAC-00270
EKS-LOA-00268
EKS-MAM-00260
EKS-MEG-00204
EKS-MIM-00012
EKS-MOD-00237
EKS-MUM-00242
EKS-MUP-00256
EKS-MYL-00237
EKS-NOL-00240
EKS-ORN-00335
EKS-ORA-00227
EKS-ORC-00244
EKS-ORL-00286
EKS-OTG-00264
EKS-PAT-00226
EKS-PES-00229
EKS-PEM-00134
EKS-POA-00230
EKS-PTV-00011
EKS-RAN-00272
EKS-SAH-00243
EKS-SUS-00223
EKS-TAG-00253
EKS-TAR-00332
EKS-TAS-00010
EKS-TEN-00297
EKS-TUT-00026
EKS-XET-00314
EKS-XIM-00328
Gene Ontology
GO:0005524; F:ATP binding
GO:0004715; F:non-membrane spanning protein tyrosine kinase activity
KEGG
InterPros
IPR015015; F-actin_binding.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980; SH2.
IPR001452; SH3_domain.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
Pfam
PF08919; F_actin_bind; 1.
PF07714; Pkinase_Tyr; 1.
PF00017; SH2; 1.
PF00018; SH3_1; 1.
SMARTs
SM00808; FABD; 1.
SM00252; SH2; 1.
SM00326; SH3; 1.
SM00219; TyrKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS50001; SH2; 1.
PS50002; SH3; 1.
Prints
PR00401; SH2DOMAIN.
PR00109; TYRKINASE.
Created Date20-Feb-2013