EKS-GAA-00025

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-GAA-00025

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/InsR	516.3	1.9E-155	1011	1278	268

Status

Unreviewed

Ensembl Protein

ENSGACP00000022371

UniProt Accession

G3PXN2;

Protein Name

Tyrosine-protein kinase receptor

Protein Synonyms/Alias

Gene Name

INSR (1 of 2)

Gene Synonyms/Alias

INSR (1 of 2);

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGACG00000016929	ENSGACP00000022371	ENSGACT00000022413

Organism

Gasterosteus aculeatus

Functional Description

Protein Length

1371

Protein Sequence
(FASTA)

MVFRCDSVMW LRTLCFVVTA VCVAVSCHRA SGEVCPSKDI RNNVTNLHTL ENCTVIEGHL 60

KILLMFSTKP EDFRGLSFPK LTVVTDYLLL FRVSGMETLS NLFPNLTVIR GNKLFFNYAL 120

VMFEMLHLRE IGLHSLMNIT RGAVRIEKNS DLCYLSTLDW SKILDTVEDN YIMANKNGRE 180

CGDVCPGVAI GKTTCQSTTI NGHFSERCWT QNHCQRMCPV QCKHRACTKD DQCCHEQCLG 240

GCLKPHSAGH CVACRGLQHG PSCVERCPAD HFTYKGWRCV PFAFCQDLHN KCKREKEHSK 300

SADCHEYVIH DGACVPECPS GYTTVNSSSL NCTPCAGLCP KVCMGLKVVD SVTAAQDLRG 360

CSVLNGSLVI KLRGGNNIAA ELETSLGQLE EITGYLSVRR SYALVSLSFF RKLRVIRGEE 420

QEIGNYSFYA LDNQNLRQLW DWSKHNLTIL QGRMFFHYNS KLCMAEIKKM ETVTGTKERN 480

VKNDIALKTN GDQASCENYV LKFTQIRTSS DKIMIRWEPF WPPDFRDLLG FMVLYKEARP 540

FQNVTEFDGQ DACGSNSWVI ADVDPPQRAT EGDKEQFEPG HLIMPLKPWT QYAIMVKTQL 600

SASDEHQVNG AKSEILYVRT NSTKPSVPLE PMSSSNSSSQ IILKWKPPND PNGNITHYLV 660

FCQRQPEGSE LYKFNYCQKG MKLPSRVPTQ VDSHEEQKWN QTEERGQGKR CCDCPKTEKE 720

LKKEKEDSDY RKTFEDYLHN EVFEIKRSRK RRSAVGIANW TLPFLTTAPS PPHGTGMPED 780

EDAFEITRIT VDVKAHAKES TVISNLRHFT SYQIEVHACN DKENPLSCSM AAYVSARTMP 840

EDKADDIRGP IKYEVTENVV HITWQEPVSP NAVIILYEVN YKRLGDTDEL HYCVSRNMYK 900

VARGCKLKVM HPGNYTVRIR ATSLAGNGSW TEPTYFFVQD PSDSLYVLKI IIGPVICFVL 960

LLFVAVAGFV MFKKNQTQGP SGPIYASSNP EYLSANDVYE ADEWEVPRDK INILRELGQG 1020

SFGMVYEGIG KDIIKGEGDM HVAVKTVNES ASLRERIEFL NEASVMKAFT CHHVVRLLGV 1080

VSKGQPTLVV MELMTNGDLK SFLRSLRPDA ENNPGRPPPS LKEMIQMAAE IADGMAYLNA 1140

KKFVHRDLAA RNCMVAHDLT VKIGDFGMTR DIYETDYYRK GGKGLLPVRW MAPESLKDGV 1200

FTANSDCWSF GVVLWEISTL AEQPYQGLSN EQVLKFVMDG GYLDRPDNCA DRIHNLMQMC 1260

WQYNPKMRPA FQEVIEMLRE DLHPSFREVS FFYSEENKPP ETEDFDLDME NMESIPLDPS 1320

SYSQREQCSD RDEGLSMGLR GSYEEHHIPF THMNGGKTNG RILALPRSSP S 1371

Nucleotide Sequence
(FASTA)

ATGGTGTTTC GTTGCGACTC AGTTATGTGG CTCCGGACTT TGTGTTTTGT TGTGACCGCT 60

GTCTGCGTCG CGGTGAGCTG TCATCGAGCG AGCGGAGAGG TTTGTCCAAG CAAGGACATC 120

CGCAACAATG TGACCAACCT ACACACGCTA GAGAACTGCA CAGTGATCGA AGGCCACCTG 180

AAGATCTTAC TCATGTTCAG CACCAAGCCC GAGGATTTCC GGGGCCTCAG TTTCCCCAAA 240

CTCACGGTGG TCACCGACTA CCTGTTGCTC TTCAGAGTTT CCGGCATGGA GACCCTCAGC 300

AATCTCTTCC CCAACCTCAC CGTCATCCGA GGCAACAAAC TGTTCTTCAA CTACGCCCTG 360

GTGATGTTCG AGATGCTCCA TCTGCGAGAG ATCGGCCTCC ACAGCTTGAT GAACATCACC 420

CGAGGGGCCG TGAGGATCGA GAAGAACTCG GATCTCTGCT ATCTCTCCAC TCTGGACTGG 480

TCCAAGATCC TCGACACCGT GGAGGACAAC TACATCATGG CTAACAAGAA CGGCCGAGAG 540

TGCGGAGACG TGTGCCCCGG GGTGGCCATC GGAAAGACCA CCTGCCAGTC CACCACCATC 600

AACGGGCACT TCAGCGAGCG CTGCTGGACC CAGAACCACT GTCAGAGAAT GTGCCCCGTT 660

CAATGTAAAC ATCGGGCCTG CACCAAGGAC GACCAGTGCT GCCACGAGCA GTGCCTGGGC 720

GGCTGCCTGA AGCCCCACTC GGCCGGTCAC TGCGTGGCCT GCCGCGGCCT CCAGCACGGG 780

CCCAGCTGCG TGGAGCGCTG CCCGGCGGAC CACTTCACCT ACAAGGGCTG GCGCTGCGTC 840

CCCTTCGCCT TCTGCCAGGA CCTGCACAAC AAGTGCAAGC GGGAGAAGGA GCACAGCAAG 900

AGCGCCGACT GCCACGAGTA CGTCATCCAC GACGGCGCCT GCGTGCCCGA GTGTCCCTCC 960

GGCTACACCA CCGTCAACTC CTCCTCGCTA AACTGCACTC CCTGTGCAGG GCTTTGTCCC 1020

AAGGTATGTA TGGGTCTGAA AGTAGTGGAC TCGGTCACGG CTGCCCAGGA TTTGAGAGGC 1080

TGCTCTGTGC TCAATGGGAG CCTGGTCATC AAGCTGCGTG GAGGAAACAA CATAGCAGCT 1140

GAACTGGAGA CCAGCCTGGG CCAGCTGGAG GAGATCACTG GCTACCTGTC AGTGCGGCGT 1200

TCCTACGCCC TCGTATCCCT CTCTTTTTTC CGCAAACTCC GTGTTATTCG TGGAGAGGAA 1260

CAGGAAATCG GGAATTACTC ATTCTATGCC CTGGACAACC AGAACCTGCG GCAGCTCTGG 1320

GATTGGTCCA AACACAACTT GACTATCCTG CAGGGACGCA TGTTTTTCCA CTACAACTCC 1380

AAACTCTGCA TGGCTGAGAT CAAAAAGATG GAGACTGTGA CGGGGACCAA GGAACGGAAT 1440

GTCAAGAACG ACATCGCCCT CAAGACCAAC GGAGACCAGG CCTCGTGTGA AAACTACGTG 1500

TTGAAGTTTA CCCAGATACG AACCTCGAGT GATAAAATAA TGATCAGGTG GGAACCCTTC 1560

TGGCCGCCAG ACTTCAGAGA TCTGCTGGGC TTCATGGTGC TCTACAAAGA AGCAAGACCT 1620

TTTCAGAACG TAACCGAGTT TGACGGGCAG GACGCCTGCG GCTCCAACAG CTGGGTGATT 1680

GCTGACGTGG ACCCTCCGCA ACGAGCCACA GAGGGGGACA AAGAGCAGTT TGAACCGGGT 1740

CATCTCATCA TGCCACTGAA GCCGTGGACG CAGTACGCCA TAATGGTGAA AACCCAGCTG 1800

TCGGCCTCTG ACGAGCACCA GGTCAACGGA GCAAAGAGCG AGATCCTCTA TGTTCGCACC 1860

AACTCCACCA AACCGTCCGT CCCGCTGGAA CCCATGTCCT CGTCCAACTC GTCCTCCCAG 1920

ATCATCCTCA AGTGGAAACC TCCCAATGAC CCCAACGGCA ACATCACCCA CTACCTGGTG 1980

TTCTGCCAGC GCCAGCCGGA AGGCAGCGAG CTCTACAAGT TTAACTACTG TCAGAAGGGA 2040

ATGAAGTTGC CGTCGCGGGT CCCCACTCAG GTAGACAGTC ATGAGGAGCA GAAGTGGAAC 2100

CAGACGGAGG AGCGGGGCCA GGGGAAACGC TGCTGCGACT GCCCCAAAAC CGAGAAGGAG 2160

CTCAAGAAGG AGAAAGAGGA CTCTGACTAC CGCAAAACCT TCGAGGACTA CCTCCACAAT 2220

GAAGTCTTTG AGATCAAACG CTCGAGAAAG CGGCGCTCTG CGGTGGGCAT TGCCAACTGG 2280

ACACTCCCCT TCCTCACCAC CGCCCCAAGC CCGCCGCACG GCACAGGCAT GCCGGAGGAC 2340

GAGGACGCCT TTGAAATCAC AAGGATCACG GTCGACGTCA AGGCCCACGC CAAGGAGTCC 2400

ACCGTCATCT CCAACCTGCG CCACTTCACC AGCTACCAGA TTGAGGTGCA CGCCTGCAAC 2460

GACAAGGAGA ACCCGCTCAG CTGCAGCATG GCGGCGTACG TCAGCGCCCG CACGATGCCT 2520

GAGGACAAAG CTGATGATAT CAGAGGTCCC ATCAAGTACG AGGTGACAGA AAATGTAGTG 2580

CACATCACGT GGCAAGAACC GGTGTCCCCG AATGCTGTGA TCATCCTGTA TGAGGTCAAC 2640

TACAAGAGAC TGGGAGACAC TGACGAGCTC CACTACTGCG TGTCAAGGAA CATGTACAAA 2700

GTGGCCCGTG GCTGCAAGCT GAAAGTGATG CATCCTGGGA ACTACACGGT GAGGATCCGG 2760

GCCACCTCGC TGGCCGGGAA CGGATCCTGG ACCGAGCCCA CTTACTTCTT TGTGCAGGAC 2820

CCAAGCGATT CTCTCTACGT CTTGAAGATC ATTATCGGAC CCGTCATCTG CTTTGTCTTG 2880

CTGCTGTTTG TGGCTGTGGC AGGATTCGTC ATGTTCAAGA AGAATCAAAC TCAAGGGCCC 2940

AGTGGTCCAA TCTACGCCTC TTCAAACCCG GAGTATCTCA GCGCTAATGA TGTGTATGAG 3000

GCGGACGAGT GGGAGGTGCC CAGAGACAAG ATCAACATTT TGAGGGAACT GGGTCAGGGC 3060

TCTTTCGGCA TGGTCTACGA GGGCATTGGC AAGGACATCA TCAAGGGCGA AGGGGACATG 3120

CACGTGGCGG TGAAGACTGT GAACGAGTCG GCCAGCCTGA GAGAGAGAAT CGAGTTCCTG 3180

AACGAGGCCT CGGTCATGAA AGCCTTCACC TGCCACCATG TGGTGCGTCT GCTGGGTGTT 3240

GTGTCTAAAG GCCAGCCCAC CCTGGTTGTG ATGGAGCTGA TGACCAACGG AGACCTGAAG 3300

AGCTTCCTGC GTTCTCTGCG ACCGGACGCC GAGAACAACC CCGGGCGTCC GCCGCCCTCC 3360

CTGAAGGAGA TGATCCAAAT GGCTGCCGAG ATCGCAGACG GCATGGCTTA CCTCAACGCC 3420

AAGAAGTTTG TCCACAGAGA CCTGGCGGCC AGAAACTGCA TGGTGGCCCA CGATCTTACC 3480

GTGAAAATCG GAGACTTCGG TATGACCAGG GACATTTACG AGACAGACTA CTACAGGAAG 3540

GGAGGGAAGG GCCTGCTGCC CGTCAGGTGG ATGGCCCCCG AGTCCCTGAA GGATGGAGTC 3600

TTCACCGCAA ATTCAGACTG CTGGTCATTT GGGGTCGTGC TGTGGGAAAT CAGCACGCTG 3660

GCCGAGCAGC CGTATCAGGG CCTGTCCAAT GAGCAGGTCC TTAAGTTTGT CATGGACGGG 3720

GGCTACCTGG ACCGGCCGGA CAACTGTGCC GACAGAATAC ACAACCTGAT GCAGATGTGT 3780

TGGCAGTACA ACCCCAAGAT GCGTCCCGCC TTCCAGGAGG TCATCGAAAT GCTCCGCGAG 3840

GACCTGCATC CTTCCTTCCG GGAAGTCTCC TTCTTTTACA GCGAGGAGAA CAAGCCCCCG 3900

GAGACCGAAG ACTTTGACCT GGACATGGAA AACATGGAGA GCATCCCGCT GGACCCTTCG 3960

TCCTACTCCC AGAGGGAGCA GTGTTCAGAC AGGGACGAGG GCTTGTCCAT GGGCCTGCGG 4020

GGCAGCTACG AGGAGCACCA CATCCCCTTC ACACACATGA ACGGGGGAAA GACCAACGGG 4080

CGAATACTGG CGCTGCCGCG GTCCAGCCCG TCATAA 4116

Domain Profile

S: 1     ivllrelGqGsfGmvyeGvakdvvkgeeetrvaiktvneaassrerieflkeasvmkefk  60

         i +lrelGqGsfGmvyeG++kd++kge + +va+ktvne+as reriefl+easvmk+f+

Q: 1011  INILRELGQGSFGMVYEGIGKDIIKGEGDMHVAVKTVNESASLRERIEFLNEASVMKAFT  1070

         6789********************************************************

S: 61    thhvvrllGvvskgqpalvvmelmkkGdlksylrslrpeeeneaalappaldkliqmaae  120

         +hhvvrllGvvskgqp+lvvmelm++Gdlks+lrslrp++en+++++pp+l+++iqmaae

Q: 1071  CHHVVRLLGVVSKGQPTLVVMELMTNGDLKSFLRSLRPDAENNPGRPPPSLKEMIQMAAE  1130

         ************************************************************

S: 121   iadGmayleakkfvhrdlaarncmvaedltvkiGdfGmtrdiyetdyyrkggkgllpvrw  180

         iadGmayl+akkfvhrdlaarncmva+dltvkiGdfGmtrdiyetdyyrkggkgllpvrw

Q: 1131  IADGMAYLNAKKFVHRDLAARNCMVAHDLTVKIGDFGMTRDIYETDYYRKGGKGLLPVRW  1190

         ************************************************************

S: 181   mspeslkdGvftsksdvwsfGvvlweivtlaeqpyqGlsneqvlkfvldggvlekpencp  240

         m+peslkdGvft++sd wsfGvvlwei tlaeqpyqGlsneqvlkfv+dgg+l++p+nc

Q: 1191  MAPESLKDGVFTANSDCWSFGVVLWEISTLAEQPYQGLSNEQVLKFVMDGGYLDRPDNCA  1250

         ************************************************************

S: 241   elltelmrlcwqynpklrpsfleivell  268

         +++++lm++cwqynpk+rp+f e++e+l

Q: 1251  DRIHNLMQMCWQYNPKMRPAFQEVIEML  1278

         ************************9975

Domain Sequence
(FASTA)

INILRELGQG SFGMVYEGIG KDIIKGEGDM HVAVKTVNES ASLRERIEFL NEASVMKAFT 60

CHHVVRLLGV VSKGQPTLVV MELMTNGDLK SFLRSLRPDA ENNPGRPPPS LKEMIQMAAE 120

IADGMAYLNA KKFVHRDLAA RNCMVAHDLT VKIGDFGMTR DIYETDYYRK GGKGLLPVRW 180

MAPESLKDGV FTANSDCWSF GVVLWEISTL AEQPYQGLSN EQVLKFVMDG GYLDRPDNCA 240

DRIHNLMQMC WQYNPKMRPA FQEVIEML 268

Keyword

ATP-binding; Complete proteome; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Felis catus"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0005524	; F:ATP binding
GO:0004714	; F:transmembrane receptor protein tyrosine kinase activity
GO:0046777	; P:protein autophosphorylation
GO:0007169	; P:transmembrane receptor protein tyrosine kinase signaling pathway

KEGG

InterPros

IPR000494	; EGF_rcpt_L.
IPR003961	; Fibronectin_type3.
IPR006211	; Furin-like_Cys-rich_dom.
IPR006212	; Furin_repeat.
IPR009030	; Growth_fac_rcpt.
IPR013783	; Ig-like_fold.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016246	; Tyr_kinase_insulin-like_rcpt.
IPR002011	; Tyr_kinase_rcpt_2_CS.

Pfam

PF00041	; fn3; 1.
PF00757	; Furin-like; 1.
PF07714	; Pkinase_Tyr; 1.
PF01030	; Recep_L_domain; 2.

SMARTs

SM00060	; FN3; 3.
SM00261	; FU; 1.
SM00219	; TyrKc; 1.

Prosites

PS50853	; FN3; 2.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS00239	; RECEPTOR_TYR_KIN_II; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013