EKS-GAA-00207

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-GAA-00207

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/PKC	442.5	7.5E-133	246	514	269

Status

Unreviewed

Ensembl Protein

ENSGACP00000022412

UniProt Accession

G3PXS3;

Protein Name

Protein Synonyms/Alias

Gene Name

PRKCI

Gene Synonyms/Alias

PRKCI;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGACG00000016956	ENSGACP00000022412	ENSGACT00000022454

Organism

Gasterosteus aculeatus

Functional Description

Protein Length

588

Protein Sequence
(FASTA)

MMPTLRDSTM SHPGENSHQV RVKAYYKGDI MITHFEPSIS YEGLYGEVKD MCSMDNDQLF 60

TMKWIDEEGD PCTVSSQLEF EEALRLYELN KDSELIIHVF PCIPEKPGMP CPGEDKSIYR 120

RGARRWRKLY YACGHAFQAK RFNRRAHCAI CTDRIWGLGR QGYKCINCKL LVHKKCHKLV 180

TVECGRQMIQ EPIMPGGSSS QLDQGEQPGP QNKDSRESLT YDGEEKEARS SRDTGKSPSS 240

LGLADFDLLR VIGRGSYAKV LLVQLKKTER IYAMKVVKKE LVNDDEDIDW VQTEKHVFEQ 300

ASNHPFLVGL HSCFQTESRL FFVIEYVNGG DLMFHMQRQR KLPEEHARFY SAEISLALNY 360

LHERGIIYRD LKLDNVLLDS EGHIKLTDYG MCKEGLRPGD TTSTFCGTPN YIAPEILRGE 420

DYGFSVDWWA LGVLMFEMMA GRSPFDIVGS SDNPDQNTED YLFQVILEKQ IRIPRSLSVK 480

AASVLKGFLN KDPKERLGCH PQTGFADIMG HPFFRNVDWD LLEQKQVVPP FKPNISGEFG 540

LDNFDAQFTN EPIQLTPDDD DVVKKIDQSE FEGFEYINPL LMSAEECV 588

Nucleotide Sequence
(FASTA)

ATGATGCCGA CGTTGCGGGA CAGCACCATG TCCCACCCCG GCGAGAATTC CCACCAAGTC 60

CGGGTGAAAG CGTATTATAA AGGGGACATC ATGATCACTC ATTTTGAGCC GTCCATCTCG 120

TACGAGGGTC TGTACGGGGA GGTGAAGGAC ATGTGCTCCA TGGACAACGA CCAACTCTTC 180

ACCATGAAGT GGATCGACGA GGAAGGTGAC CCGTGCACCG TGTCGTCTCA GCTGGAGTTC 240

GAAGAAGCCC TGCGTCTCTA CGAACTCAAC AAGGACTCTG AGCTCATTAT CCACGTGTTT 300

CCATGTATAC CAGAGAAACC TGGCATGCCG TGTCCTGGAG AGGACAAGTC TATATATCGG 360

CGTGGAGCGA GGCGCTGGAG GAAGCTCTAC TATGCCTGTG GGCATGCCTT CCAGGCCAAG 420

CGCTTCAACA GGCGAGCCCA CTGCGCCATC TGCACAGACC GTATCTGGGG TCTGGGACGA 480

CAAGGCTACA AATGCATCAA CTGCAAACTG CTGGTGCACA AGAAGTGTCA TAAACTGGTC 540

ACAGTGGAGT GTGGCAGGCA GATGATCCAG GAACCAATCA TGCCCGGCGG GTCATCGAGT 600

CAATTAGACC AAGGCGAACA GCCAGGGCCA CAGAATAAAG ACTCCAGAGA AAGCTTGACT 660

TACGACGGTG AAGAGAAAGA GGCACGCAGC AGTAGAGACA CGGGGAAATC GCCCTCCAGC 720

CTGGGCCTGG CAGACTTCGA TCTGCTCAGG GTGATCGGCC GGGGCAGCTA CGCCAAGGTG 780

CTGTTGGTGC AGCTGAAGAA GACCGAGCGC ATCTACGCCA TGAAGGTCGT GAAGAAGGAG 840

CTTGTCAATG ACGACGAGGA CATCGACTGG GTCCAAACGG AGAAGCACGT TTTCGAGCAG 900

GCCTCCAATC ACCCCTTCCT GGTCGGCCTC CATTCCTGTT TCCAGACGGA AAGCCGACTG 960

TTCTTTGTTA TTGAATATGT GAACGGTGGA GATCTAATGT TCCACATGCA GAGACAAAGG 1020

AAACTCCCAG AAGAACACGC AAGATTCTAC TCTGCGGAGA TCAGTCTGGC TCTCAACTAC 1080

CTCCACGAGC GGGGAATCAT CTACAGAGAT CTAAAGCTGG ACAACGTGCT GCTGGACTCT 1140

GAAGGACACA TCAAACTGAC GGACTATGGC ATGTGCAAGG AGGGCTTGAG ACCTGGCGAT 1200

ACGACGAGCA CGTTCTGTGG TACACCTAAT TACATCGCAC CCGAAATACT TAGAGGAGAG 1260

GATTATGGGT TCAGCGTGGA CTGGTGGGCT CTGGGTGTGC TGATGTTTGA GATGATGGCG 1320

GGCCGGTCGC CCTTCGATAT CGTCGGGAGC TCTGACAACC CGGACCAGAA CACAGAAGAC 1380

TACCTCTTCC AAGTGATATT GGAGAAACAG ATCAGAATCC CCCGCTCGTT GTCCGTCAAA 1440

GCCGCCAGCG TCCTCAAGGG CTTCCTCAAC AAGGATCCCA AGGAGCGTCT AGGCTGCCAC 1500

CCTCAGACGG GCTTTGCCGA CATCATGGGC CATCCGTTCT TCCGAAACGT CGATTGGGAC 1560

CTCCTGGAGC AGAAACAGGT GGTCCCTCCT TTCAAGCCCA ATATCTCTGG GGAATTCGGA 1620

TTGGACAACT TTGACGCCCA GTTCACCAAC GAGCCCATCC AGCTAACCCC TGATGATGAC 1680

GATGTGGTCA AGAAGATTGA CCAGTCTGAG TTTGAAGGAT TTGAGTATAT CAACCCACTC 1740

CTGATGTCGG CGGAGGAGTG TGTGTGA 1767

Domain Profile

S: 1     fellkvlGkGsfgkvllaelkktdelyaikvlkkdvvlqdddveltlvekrvlalaskkp  60

         f+ll+v+G+Gs++kvll++lkkt+++ya+kv+kk++v++d+d++++++ek+v+++as++p

Q: 246   FDLLRVIGRGSYAKVLLVQLKKTERIYAMKVVKKELVNDDEDIDWVQTEKHVFEQASNHP  305

         89**********************************************************

S: 61    flvqlfscfqtedrlffvleyvnGGdlmfhiqkarklkeerarfyaaeiilalkflhekg  120

         flv l+scfqte+rlffv+eyvnGGdlmfh+q++rkl+ee+arfy+aei+lal++lhe+g

Q: 306   FLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEISLALNYLHERG  365

         ************************************************************

S: 121   iiyrdlkldnvlldaeGhikladfGlckeeilegkttstfcGtPdyiaPeilkeeeygks  180

         iiyrdlkldnvlld+eGhikl+d+G+cke++  g+ttstfcGtP+yiaPeil++e+yg+s

Q: 366   IIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEILRGEDYGFS  425

         ************************************************************

S: 181   vdwwalGvllyemlagqsPfe.........gededelfesilekevlyPkslskeaveil  231

         vdwwalGvl++em+ag+sPf+         +++ed+lf++ilek++++P+sls++a+++l

Q: 426   VDWWALGVLMFEMMAGRSPFDivgssdnpdQNTEDYLFQVILEKQIRIPRSLSVKAASVL  485

         *****************************99*****************************

S: 232   kglltkdpekrlGvk.eegeedikehaff  259

         kg+l+kdp++rlG++ ++g +di+ h+ff

Q: 486   KGFLNKDPKERLGCHpQTGFADIMGHPFF  514

         **************989***********9

Domain Sequence
(FASTA)

FDLLRVIGRG SYAKVLLVQL KKTERIYAMK VVKKELVNDD EDIDWVQTEK HVFEQASNHP 60

FLVGLHSCFQ TESRLFFVIE YVNGGDLMFH MQRQRKLPEE HARFYSAEIS LALNYLHERG 120

IIYRDLKLDN VLLDSEGHIK LTDYGMCKEG LRPGDTTSTF CGTPNYIAPE ILRGEDYGFS 180

VDWWALGVLM FEMMAGRSPF DIVGSSDNPD QNTEDYLFQV ILEKQIRIPR SLSVKAASVL 240

KGFLNKDPKE RLGCHPQTGF ADIMGHPFF 269

Keyword

ATP-binding; Complete proteome; Kinase; Metal-binding; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase; Zinc; Zinc-finger.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005622	; C:intracellular
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0008270	; F:zinc ion binding
GO:0035556	; P:intracellular signal transduction

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR020454	; DAG/PE-bd.
IPR011009	; Kinase-like_dom.
IPR000270	; OPR_PB1.
IPR012233	; PKC_zeta.
IPR017892	; Pkinase_C.
IPR002219	; Prot_Kinase_C-like_PE/DAG-bd.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00130	; C1_1; 1.
PF00564	; PB1; 1.
PF00069	; Pkinase; 1.
PF00433	; Pkinase_C; 1.

SMARTs

SM00109	; C1; 1.
SM00666	; PB1; 1.
SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS00479	; ZF_DAG_PE_1; 1.
PS50081	; ZF_DAG_PE_2; 1.

Prints

PR00008

; DAGPEDOMAIN.

Created Date

20-Feb-2013