EKS-GAA-00448

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-GAA-00448

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Src	440.7	1.9E-132	282	531	250

Status

Unreviewed

Ensembl Protein

ENSGACP00000022560

UniProt Accession

G3PY71;

Protein Name

Protein Synonyms/Alias

Gene Name

YES1 (1 of 2)

Gene Synonyms/Alias

YES1 (1 of 2);

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGACG00000017071	ENSGACP00000022560	ENSGACT00000022603

Organism

Gasterosteus aculeatus

Functional Description

Protein Length

548

Protein Sequence
(FASTA)

MGCVRSKEDK GSAPGAVKYR PDNSTPNNSH LGHYGPDPTL MGHSPAMKTH NNSYNSHAAA 60

LTPFGGASSI MTPFGGASTS FTSVAVSSPF PGVITGGVTF FVALYDYEAR TSDDLSFKKG 120

DRFQIINNTE GDWWEARSIN TGEKGYIPSN YVAPADSIQA EEWYFGKMGR KDAERLLLLP 180

GNQRGTFLAR ESETTKGAYS LSIRDWDEVK GDNVKHYKIR KLDSGGYYIT TRAQFDALQK 240

LVKHYTEHSD GLCYRLTSVC PTVKPQTQGL AKDAWEIPRE SLRLELKLGQ GCFGEVWMGT 300

WNGTTKVAIK TLKPGTMSPE AFLQEAQIMK KLRHDKLVPL YAVVSEEPIY IVTEFMGKGS 360

LLDFLKEGDG RYLKLPQLVD MAAQIADGMA FIERMNYIHR DLRAANILVA DNLVCKIADF 420

GLARLIEDNE YTARQGAKFP IKWTAPEAAL YGRFTIKSDV WSFGILLTEL VTKGRVPYPG 480

MVNREVLEQV ERGYRMPGPQ GCPDSLHEMM RLCWKKEPDE RPTFEYIQSF LEDYFTATEP 540

LYQPGDNL 548

Nucleotide Sequence
(FASTA)

ATGGGTTGCG TCCGGAGCAA AGAGGACAAG GGCTCGGCGC CCGGCGCTGT GAAGTACCGG 60

CCCGACAACT CCACGCCGAA CAACTCCCAC CTGGGCCACT ACGGGCCCGA CCCCACCCTG 120

ATGGGTCACT CGCCCGCCAT GAAGACGCAC AACAACAGCT ACAACAGTCA CGCCGCCGCC 180

CTCACGCCCT TCGGCGGGGC GTCTTCGATC ATGACGCCGT TCGGCGGGGC CTCCACCTCC 240

TTCACCTCCG TGGCGGTGAG CAGTCCCTTC CCTGGGGTCA TCACAGGCGG CGTCACATTT 300

TTCGTGGCGC TGTACGACTA CGAAGCGAGG ACGTCGGACG ATCTGTCGTT CAAAAAGGGG 360

GACCGCTTCC AGATTATCAA CAACACGGAA GGCGACTGGT GGGAGGCTCG CTCCATCAAC 420

ACCGGGGAGA AGGGCTACAT CCCCAGCAAC TACGTGGCTC CCGCCGACTC CATACAGGCC 480

GAAGAATGGT ACTTTGGTAA AATGGGCCGC AAAGACGCCG AGCGGCTCTT GCTGCTCCCT 540

GGGAACCAGC GGGGGACTTT CTTGGCCAGA GAGAGCGAGA CCACCAAAGG TGCCTACTCG 600

CTGTCCATCC GGGACTGGGA CGAGGTGAAG GGAGACAACG TCAAACACTA CAAGATCCGA 660

AAGCTGGACA GCGGCGGTTA TTACATCACC ACCCGGGCCC AGTTTGATGC CCTGCAGAAG 720

CTGGTGAAAC ACTACACAGA GCACTCAGAC GGTCTGTGCT ACAGGCTGAC CAGCGTGTGC 780

CCCACGGTGA AGCCTCAGAC TCAGGGACTG GCCAAAGACG CCTGGGAAAT CCCGCGGGAG 840

TCACTCCGAC TCGAGCTCAA ACTCGGCCAG GGCTGCTTCG GAGAAGTCTG GATGGGCACG 900

TGGAATGGCA CCACCAAGGT GGCCATCAAG ACCCTGAAGC CGGGCACCAT GTCTCCAGAA 960

GCCTTCCTGC AGGAGGCTCA GATCATGAAG AAACTGCGAC ACGACAAACT GGTGCCTCTC 1020

TATGCCGTGG TGTCGGAGGA GCCCATCTAC ATCGTGACCG AGTTCATGGG CAAAGGTAGT 1080

TTGCTGGACT TCCTGAAGGA GGGAGATGGC AGATATCTGA AGCTGCCCCA GCTGGTGGAC 1140

ATGGCTGCAC AGATCGCAGA TGGCATGGCC TTCATCGAGA GGATGAACTA CATCCACAGG 1200

GACCTGAGAG CTGCCAACAT CCTGGTGGCG GATAACCTGG TGTGCAAGAT CGCCGACTTC 1260

GGCCTGGCTC GGCTCATCGA GGACAACGAG TACACCGCCA GACAAGGTGC TAAATTTCCC 1320

ATCAAGTGGA CGGCGCCTGA GGCGGCTCTG TACGGCCGCT TCACCATCAA ATCGGACGTC 1380

TGGTCGTTTG GTATACTGCT GACCGAACTG GTGACCAAGG GCCGAGTACC GTACCCAGGT 1440

ATGGTGAACC GAGAGGTCCT GGAGCAAGTG GAACGGGGCT ACCGCATGCC CGGCCCCCAG 1500

GGGTGCCCCG ACTCCCTCCA CGAGATGATG AGGCTGTGCT GGAAGAAGGA GCCGGACGAA 1560

AGGCCGACCT TCGAATACAT CCAGTCGTTT TTGGAGGACT ACTTCACAGC CACGGAGCCG 1620

CTGTACCAGC CGGGAGACAA CCTCTAG 1647

Domain Profile

S: 1     lklvkklGeGqfGevwlgkwkgsvkvavktlkegtlspeafleeaqilkklrheklvkly  60

         l+l+ klG+G+fGevw+g+w+g++kva+ktlk+gt+speafl+eaqi+kklrh+klv ly

Q: 282   LRLELKLGQGCFGEVWMGTWNGTTKVAIKTLKPGTMSPEAFLQEAQIMKKLRHDKLVPLY  341

         57899*******************************************************

S: 61    avvseeePiyivtelmakGslldflkeeegkklklpklvdlaaqvaeGmayleeknlihr  120

         avvse ePiyivte+m kGslldflke +g++lklp+lvd+aaq+a+Gma++e++n+ihr

Q: 342   AVVSE-EPIYIVTEFMGKGSLLDFLKEGDGRYLKLPQLVDMAAQIADGMAFIERMNYIHR  400

         ****9.******************************************************

S: 121   dlaarnvlvgeslvvkvadfGlarlieddeytakegaklPikWtaPeaiklgkftiksdv  180

         dl+a+n+lv+++lv+k+adfGlarlied+eyta++gak+PikWtaPea+ +g+ftiksdv

Q: 401   DLRAANILVADNLVCKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDV  460

         ************************************************************

S: 181   WsfGillteivtkGkvPypGmtneevleqvergyrlprpeecpeelyelllecwkkdpee  240

         WsfGillte+vtkG+vPypGm n+evleqvergyr+p p+ cp++l+e++  cwkk+p+e

Q: 461   WSFGILLTELVTKGRVPYPGMVNREVLEQVERGYRMPGPQGCPDSLHEMMRLCWKKEPDE  520

         ************************************************************

S: 241   rPtfetlqevl  251

         rPtfe++q++l

Q: 521   RPTFEYIQSFL  531

         *******9986

Domain Sequence
(FASTA)

LRLELKLGQG CFGEVWMGTW NGTTKVAIKT LKPGTMSPEA FLQEAQIMKK LRHDKLVPLY 60

AVVSEEPIYI VTEFMGKGSL LDFLKEGDGR YLKLPQLVDM AAQIADGMAF IERMNYIHRD 120

LRAANILVAD NLVCKIADFG LARLIEDNEY TARQGAKFPI KWTAPEAALY GRFTIKSDVW 180

SFGILLTELV TKGRVPYPGM VNREVLEQVE RGYRMPGPQG CPDSLHEMMR LCWKKEPDER 240

PTFEYIQSFL 250

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR001452	; SH3_domain.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF00017	; SH2; 1.
PF00018	; SH3_1; 1.

SMARTs

SM00252	; SH2; 1.
SM00326	; SH3; 1.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50001	; SH2; 1.
PS50002	; SH3; 1.

Prints

PR00401	; SH2DOMAIN.
PR00452	; SH3DOMAIN.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013