EKS-GAA-00368

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-GAA-00368

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/EGFR	487.6	1.0E-146	722	978	257

Status

Unreviewed

Ensembl Protein

ENSGACP00000022837

UniProt Accession

G3PYZ7;

Protein Name

Protein Synonyms/Alias

Gene Name

EGFR (1 of 2)

Gene Synonyms/Alias

EGFR (1 of 2);

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGACG00000017289	ENSGACP00000022837	ENSGACT00000022880

Organism

Gasterosteus aculeatus

Functional Description

Protein Length

1207

Protein Sequence
(FASTA)

LLPGIPEEKK NPTMATGLEK WLRLTSVLCW GCCVLAEKKV CQGITNRLNL LGTEDDHYLN 60

MVKTYSNCTV VLENLEVTYM ADHRDLSFLS SIEEVGGYVL IALNTASRIP LQNLRIIRGH 120

SLYEGMFGLA VLTNYDKPTG QMTSELLLTS LTEILKGGVK FGTKQPCNVE TIQWYDIVNA 180

ESKPKMVLPL AISHPRCGKC DPSCYNGSCW APGPQNCQTL TKLNCAQQCS KRCKGPSPSD 240

CCNEHCAAGC TGPRPTDCLA CRDFQDDGVC KDSCPGLMRY DPNLHQLVPN PLGKYNFGAT 300

CVRSCPHNYV VTDHGACVRT CSVNTFEVDE GGIRKCAKCD GLCPKVCNGL GTGNMTSILS 360

INATNIDSFK NCTKIDGNVA IIHTSIYGDP FTNTPAMDPA QLDVFKTVKE ITGYLLIQTW 420

PANMTSLSPF ENLEIIRGRT KRGSRSVILP NLNIEYLGLR SMKEISDGDV VIIRNKNLCY 480

TDKSHWEELF KSKSQTVNIE GNADAATCAT RNHTCDRKCS TDSCWGPGSN MCFACRDFSR 540

GGSCVDSCNV LEGEPRETVV NKTCMECHPE CQRMNGTATC NAPGSGNCAK CANFRDGLFC 600

VAQCPQGVPG EDDALVWKYN DQMKVCKLCH RNCTRGCTGP GLKGCQNKSH SGLSVISAGV 660

VGGLLAVLVA GLSVFVLLRR RHIKRKRTTR RLLQERELVE PLTPSGEAPN QALLRILKEP 720

EFKKIKVLGS GAFGTVYKGL WVPEGEDVKI PVAIKVLREA TSPKANKEIL DEAYVMASVD 780

HPHVCRLLGI CLTSTVQLIT QLMPYGCLLD YVRENKDNVG SQYLLNWCVQ IAKKGMNYLE 840

ERHLVHRDLA ARNVLVKTPQ HVKITDFGLA KLLNADEKEY HADGGKVPIK WMALESILNR 900

TYTHQSDVWS YGVTVWELMT FGTKPYDGIP ASEIAAVLEK GERLPQPPIC TIDVYMIMVK 960

CWMIDADSRP RFRELIAECT KMARDPSRYL VIQGDDRMHL PSPTDTKLFR SLISGDGTED 1020

AVDADEYLLP QHGFFSSRST SQTPLLHSTS LNSSIGTCHS RTGLVNAFPS RDGSIVLRYI 1080

PDPTDKLIDE AFLPSPEYMN QNGVSDVMNP VYQHPGPPRT VLLPTISSDD AEAEYLNCFR 1140

SGSSGPEYLN EVAAPAFLPF ASNGVQKYAP QNSIDNPDYQ QDFTPPVKTH ANGHIPAAEN 1200

AGYLGPD 1207

Nucleotide Sequence
(FASTA)

CTTCTGCCCG GGATTCCTGA GGAGAAAAAA AACCCCACGA TGGCAACCGG GCTGGAGAAG 60

TGGCTGCGGC TCACCTCCGT GCTCTGCTGG GGCTGCTGCG TTCTGGCGGA AAAGAAAGTT 120

TGCCAAGGCA TCACCAACCG TTTAAACCTT CTTGGTACTG AAGATGACCA CTACCTGAAC 180

ATGGTCAAGA CCTACAGCAA CTGCACCGTG GTCCTGGAGA ACCTGGAGGT GACCTACATG 240

GCGGACCACC GAGACCTCTC CTTCCTCTCG TCCATCGAAG AAGTGGGCGG CTATGTGCTG 300

ATCGCCCTCA ACACGGCGTC CAGGATTCCG CTGCAAAACC TACGCATCAT TCGAGGTCAT 360

TCGCTCTACG AGGGAATGTT TGGCCTCGCT GTGCTGACCA ATTATGACAA ACCTACGGGT 420

CAGATGACCA GCGAGCTCCT TCTGACCAGC CTGACGGAAA TTCTTAAAGG AGGTGTTAAG 480

TTCGGGACCA AACAGCCATG TAATGTGGAA ACGATACAGT GGTATGACAT TGTCAACGCC 540

GAAAGCAAAC CCAAAATGGT GCTCCCTTTG GCCATCAGCC ATCCGCGTTG TGGGAAATGT 600

GACCCGAGCT GCTACAATGG TTCATGTTGG GCACCCGGTC CTCAAAACTG TCAGACCTTA 660

ACAAAGCTGA ACTGTGCACA GCAGTGCTCT AAGCGATGCA AAGGGCCTTC TCCCAGTGAC 720

TGCTGTAATG AACATTGTGC TGCGGGCTGC ACGGGGCCGC GGCCCACCGA CTGCCTGGCC 780

TGTCGGGACT TCCAGGACGA CGGAGTGTGC AAGGACTCCT GCCCGGGCCT CATGCGCTAC 840

GACCCCAACC TGCACCAGCT GGTACCCAAC CCACTGGGAA AGTACAACTT CGGGGCCACC 900

TGCGTCAGGA GCTGCCCACA TAACTATGTG GTAACTGATC ATGGAGCGTG TGTGCGGACA 960

TGTAGTGTGA ACACGTTCGA GGTGGACGAG GGAGGAATCA GAAAGTGCGC CAAGTGTGAC 1020

GGACTGTGCC CAAAAGTGTG TAATGGACTT GGGACAGGGA ACATGACTTC CATCCTGTCT 1080

ATCAATGCCA CCAACATCGA CTCCTTTAAA AACTGCACGA AAATCGATGG TAACGTTGCT 1140

ATCATCCACA CATCGATTTA CGGAGATCCG TTTACCAATA CGCCAGCGAT GGACCCTGCC 1200

CAGCTTGACG TGTTTAAGAC AGTCAAGGAA ATTACTGGAT ACTTGTTGAT TCAAACGTGG 1260

CCAGCGAACA TGACGTCCCT CAGTCCTTTT GAGAACCTGG AGATCATTCG AGGACGAACA 1320

AAGCGGGGGA GCCGCAGTGT TATTTTGCCC AACCTCAATA TTGAGTACTT GGGCCTTCGC 1380

TCCATGAAGG AAATCAGCGA TGGAGACGTC GTCATCATCA GGAACAAGAA CCTGTGCTAC 1440

ACAGACAAAA GCCACTGGGA GGAGCTGTTC AAATCAAAAA GCCAAACTGT TAACATAGAA 1500

GGGAATGCAG ATGCTGCCAC ATGTGCCACC AGGAACCACA CGTGTGACAG GAAGTGCTCC 1560

ACAGACAGCT GCTGGGGCCC CGGCTCAAAC ATGTGCTTTG CCTGCCGCGA CTTCAGCCGC 1620

GGTGGGAGCT GTGTGGACTC CTGCAACGTC CTGGAGGGAG AGCCCCGGGA GACTGTCGTG 1680

AATAAAACCT GCATGGAGTG TCACCCAGAG TGTCAACGCA TGAATGGGAC CGCGACCTGC 1740

AACGCACCTG GCTCTGGCAA CTGCGCAAAG TGTGCCAACT TTCGAGACGG CCTGTTCTGC 1800

GTGGCTCAAT GTCCCCAGGG CGTGCCGGGG GAGGACGACG CGCTGGTGTG GAAGTACAAC 1860

GATCAGATGA AAGTGTGCAA GCTGTGCCAC AGAAACTGCA CCCGAGGGTG CACGGGACCT 1920

GGTCTGAAGG GCTGCCAGAA TAAAAGCCAT TCCGGCCTTT CTGTGATTTC GGCCGGCGTG 1980

GTCGGCGGGC TGCTGGCCGT TCTCGTAGCG GGCCTGTCTG TGTTTGTGTT GCTACGCCGA 2040

CGCCACATCA AGAGGAAGAG AACCACGCGC AGACTCCTCC AGGAGAGAGA GCTGGTGGAA 2100

CCTCTGACTC CGAGCGGCGA GGCACCAAAC CAGGCTCTGC TGCGGATTCT CAAGGAACCC 2160

GAGTTTAAGA AAATCAAAGT GCTGGGATCA GGAGCTTTCG GGACAGTTTA CAAGGGCCTG 2220

TGGGTTCCAG AGGGAGAGGA CGTGAAGATA CCCGTGGCCA TCAAGGTTTT GAGAGAGGCC 2280

ACTTCGCCAA AAGCAAACAA GGAGATCTTG GACGAGGCTT ACGTGATGGC CAGCGTCGAT 2340

CACCCCCACG TGTGCCGCCT GCTCGGCATC TGCCTCACCT CCACCGTGCA GCTCATCACC 2400

CAGCTGATGC CCTACGGCTG CCTGCTGGAC TACGTCAGGG AGAACAAGGA CAACGTCGGC 2460

TCCCAGTACC TGCTCAACTG GTGCGTGCAG ATAGCCAAGA AGGGAATGAA CTACCTGGAG 2520

GAGCGCCATC TGGTACATCG GGACCTGGCA GCGAGAAACG TCCTGGTGAA GACTCCTCAA 2580

CACGTCAAGA TCACCGACTT CGGTCTGGCC AAACTCCTCA ACGCGGATGA GAAGGAGTAC 2640

CATGCAGATG GTGGAAAGGT ACCAATTAAA TGGATGGCTC TTGAATCCAT CCTCAACAGA 2700

ACCTACACGC ACCAGAGTGA CGTATGGAGC TACGGCGTGA CCGTTTGGGA GCTGATGACA 2760

TTCGGCACCA AGCCGTACGA CGGGATTCCA GCCAGCGAAA TAGCCGCGGT CCTGGAGAAA 2820

GGGGAGCGGT TGCCTCAACC CCCAATCTGT ACCATCGATG TCTACATGAT CATGGTGAAA 2880

TGTTGGATGA TTGACGCAGA TAGCCGACCT CGTTTCCGGG AACTCATAGC GGAGTGTACA 2940

AAAATGGCCC GGGATCCCTC TCGATATCTG GTCATTCAGG GCGACGACCG CATGCACCTG 3000

CCGAGTCCCA CGGACACCAA GTTGTTCCGC AGCCTGATCA GCGGGGACGG CACGGAGGAC 3060

GCCGTGGACG CGGACGAGTA CCTGCTGCCG CAACACGGCT TCTTCAGCAG CCGGAGCACC 3120

TCCCAAACGC CGCTGCTTCA CTCCACGAGC CTGAACAGCA GCATTGGGAC GTGCCACAGC 3180

AGGACCGGCT TAGTGAACGC ATTCCCGAGC AGAGATGGGA GCATAGTGCT CCGATACATT 3240

CCCGACCCCA CCGACAAACT CATCGACGAG GCCTTCCTGC CGTCTCCGGA GTACATGAAC 3300

CAGAACGGCG TCTCCGATGT GATGAATCCC GTCTACCAGC ACCCGGGTCC GCCTCGCACC 3360

GTCCTCCTTC CCACCATCTC CTCGGACGAC GCCGAGGCCG AGTACCTGAA CTGCTTCAGA 3420

AGCGGGTCCA GCGGCCCCGA GTACCTCAAC GAGGTCGCGG CGCCCGCCTT CCTCCCGTTC 3480

GCCTCCAACG GCGTCCAGAA GTACGCGCCG CAGAACAGCA TCGACAACCC GGACTACCAG 3540

CAGGATTTCA CTCCCCCCGT TAAGACCCAC GCCAACGGAC ACATCCCGGC GGCCGAGAAC 3600

GCGGGCTACC TGGGCCCGGA CTGA 3624

Domain Profile

S: 1     lkklkvlGsGafGtvykGiwipegenvkipvaikvleektgkkankelldealvlasldh  60

         +kk+kvlGsGafGtvykG+w+pege+vkipvaikvl+e+t++kanke+ldea+v+as+dh

Q: 722   FKKIKVLGSGAFGTVYKGLWVPEGEDVKIPVAIKVLREATSPKANKEILDEAYVMASVDH  781

         59**********************************************************

S: 61    anlvrllglclsstlqlvtqllplGclldyvrehkdklGsqellnwcvqia.kGmsylee  119

         ++++rllg+cl+st+ql+tql+p+Gclldyvre+kd++Gsq+llnwcvqia kGm+ylee

Q: 782   PHVCRLLGICLTSTVQLITQLMPYGCLLDYVRENKDNVGSQYLLNWCVQIAkKGMNYLEE  841

         **************************************************955*******

S: 120   krlvhrdlaarnvlvkspnhvkitdfGlaklleadekelkaeggkvpikwlalesilkrk  179

         ++lvhrdlaarnvlvk+p+hvkitdfGlakll+adeke++a+ggkvpikw+alesil+r+

Q: 842   RHLVHRDLAARNVLVKTPQHVKITDFGLAKLLNADEKEYHADGGKVPIKWMALESILNRT  901

         ************************************************************

S: 180   ythqsdvwsyGvtvwelltfGakpydgipakeipdllekGerlaqppictidvymvlvkc  239

         ythqsdvwsyGvtvwel+tfG+kpydgipa+ei  +lekGerl+qppictidvym++vkc

Q: 902   YTHQSDVWSYGVTVWELMTFGTKPYDGIPASEIAAVLEKGERLPQPPICTIDVYMIMVKC  961

         ************************************************************

S: 240   wmidaesrpkfkelaee  256

         wmida+srp+f+el++e

Q: 962   WMIDADSRPRFRELIAE  978

         **************987

Domain Sequence
(FASTA)

FKKIKVLGSG AFGTVYKGLW VPEGEDVKIP VAIKVLREAT SPKANKEILD EAYVMASVDH 60

PHVCRLLGIC LTSTVQLITQ LMPYGCLLDY VRENKDNVGS QYLLNWCVQI AKKGMNYLEE 120

RHLVHRDLAA RNVLVKTPQH VKITDFGLAK LLNADEKEYH ADGGKVPIKW MALESILNRT 180

YTHQSDVWSY GVTVWELMTF GTKPYDGIPA SEIAAVLEKG ERLPQPPICT IDVYMIMVKC 240

WMIDADSRPR FRELIAE 257

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0005524	; F:ATP binding
GO:0004716	; F:receptor signaling protein tyrosine kinase activity
GO:0004714	; F:transmembrane receptor protein tyrosine kinase activity
GO:0023014	; P:signal transduction by phosphorylation
GO:0007169	; P:transmembrane receptor protein tyrosine kinase signaling pathway

KEGG

InterPros

IPR000494	; EGF_rcpt_L.
IPR006211	; Furin-like_Cys-rich_dom.
IPR006212	; Furin_repeat.
IPR009030	; Growth_fac_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016245	; Tyr_kinase_EGF/ERB/XmrK_rcpt.

Pfam

PF00757	; Furin-like; 1.
PF07714	; Pkinase_Tyr; 1.
PF01030	; Recep_L_domain; 2.

SMARTs

SM00261	; FU; 5.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013