EKS-GAA-00536

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-GAA-00536

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/DMPK	464.6	1.2E-139	76	338	263

Status

Unreviewed

Ensembl Protein

ENSGACP00000022893

UniProt Accession

G3PZ53;

Protein Name

Protein Synonyms/Alias

Gene Name

ROCK1

Gene Synonyms/Alias

ROCK1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGACG00000017327	ENSGACP00000022893	ENSGACT00000022936

Organism

Gasterosteus aculeatus

Functional Description

Protein Length

1365

Protein Sequence
(FASTA)

MSAGESMAAR FEKIDAMLKN PKSEVNTDCL LDGLDALVYD LDFPALRKNK SIDNFLSRYK 60

DTISKIRDLR MKAVDYEVVK VIGRGAFGEV QLVRHKATCK VYAMKLLSKF EMIKRSDSAF 120

FWEERDIMAF ANSSWVVQLF FAFQDDRYLY MVMEYMPGGD LVNLMSNYDV PEKWARFYTA 180

EVVLALDGIH SMGFIHRDVK PDNMLLDKAG HLKLADFGTC MKMNKDGMVR CDTAVGTPDY 240

ISPEVLKSQG GDGYYGRECD WWSVGVFLYE MLVGDTPFYA DSLVGTYSKI MNHKNALNFP 300

DDSDISNDAK NLICAFLTDR EVRLGRNGFD EIKRHPFFKN DQWTWENIRD TAAPVVPELS 360

SDVDTSNFDD IEEDRGEEET FPIPKAFVGN QLPFVGFTYY SSQHQLRSSS APTKTSEKRS 420

SATKEDKSHL ENLQKRIYQL EEQLHSEMQL KDELEQKCRT SNTKMDKIIK ELDEEANLRK 480

SAESSISLLE KDKIMLQHRF TEYQRKADQD AEKRRNLENE VSSLKEQLED MKKISQNSQA 540

SNDKMVQLQN QMEEANDLLR AESDTAARLR KSHTEMAKSM SQLESLNREL QERSRAADSE 600

KAQLEKELLL LQSSLDSERR NYSLGSEEIR ELQARMAGLQ EDNKSLKLSL SKVESERKQA 660

QERSNNQEKE KNNLEIDLNY KLKTLQQRLE QEQTEHRVTR AQLTDKYESI EEAKSAATNA 720

VQQKMSEENV ARMRAESRVV EVEKQCSMLE FDLKQSVQKM EQLMKQKERL EDEVMNLQLQ 780

GEQESSKRVQ TQNDLKGRMQ EVDRLRCSEK QLKQEINASL ESKRSLEFQL AQLTKQYRGN 840

EGQMRELQDQ LEAEQYFSTL YKTQVKELKE EIEEKNRQVQ ETHKRVQELC SERDSLSAQL 900

DLTVTKAESE QLARALQEEQ YFELSQENKK AISRHKQDIG EKEATIARLE ESNNTLTKAV 960

ENLSKEKTDL SEKFSSLEED YAAEKEEISN TIKSNYEKIL NTERTLKTQA VNKLAEIMNR 1020

KDMKLDQKKK GSTADLRKKE KENRKLQLEL NQEKEKFNHM AIKYQKELSE MQAQLSEEST 1080

YRNELQMQLD SKESDIEQLR EKLNDLQLRM DTSSVTSLQT DETDGNIAES RLEGWLSIPN 1140

RANIKRYGWR KQYVVVSSKK ILFYNNEEDK ELSNPSMVLD IDKLFHVRPV TQGDVYRAET 1200

EEIPRIFQIL YANEGECRKE AEMEAVPQGD KTNCLPHKGH EFIPTLYHFP SNCEACSKPL 1260

WHVFKPPPAL ECRRCHVKCH KDHLDKKEDL IAPCKVNYDV TSARDMLLLA LTQDEQKKWI 1320

GHLGKKIPKT PPSTFSRASP RSMSTRSGPN QSFRKNPKGN TTKLR 1365

Nucleotide Sequence
(FASTA)

ATGTCCGCCG GGGAAAGCAT GGCGGCTCGG TTTGAAAAGA TCGATGCCAT GTTGAAGAAC 60

CCGAAGTCCG AAGTGAACAC GGATTGTCTT CTGGATGGTC TGGACGCGCT GGTGTACGAC 120

CTCGACTTCC CCGCCCTGAG GAAAAACAAG AGCATTGACA ACTTTTTGAG TAGATACAAG 180

GACACCATTA GTAAGATTCG TGATCTACGC ATGAAAGCGG TTGACTATGA GGTGGTTAAA 240

GTTATCGGGA GGGGAGCATT TGGAGAGGTG CAACTGGTAA GACACAAAGC CACGTGCAAG 300

GTGTACGCCA TGAAGCTGCT CAGCAAGTTT GAGATGATCA AGAGGTCGGA CTCTGCTTTC 360

TTTTGGGAGG AGAGGGACAT CATGGCTTTT GCCAACAGCT CATGGGTGGT GCAGCTCTTT 420

TTTGCATTCC AAGATGACCG CTACCTCTAC ATGGTGATGG AATACATGCC GGGTGGCGAC 480

TTGGTGAACC TGATGAGCAA CTACGACGTC CCTGAGAAGT GGGCCCGTTT TTACACCGCT 540

GAGGTGGTTC TGGCTTTGGA CGGAATCCAC TCCATGGGCT TCATTCACAG GGACGTGAAG 600

CCCGATAACA TGCTGCTGGA CAAAGCAGGC CATTTAAAAC TGGCAGACTT TGGGACCTGC 660

ATGAAAATGA ACAAGGATGG AATGGTACGA TGTGACACAG CAGTGGGAAC TCCAGACTAC 720

ATTTCGCCCG AGGTACTGAA ATCCCAAGGA GGAGATGGCT ATTACGGCAG AGAGTGTGAC 780

TGGTGGTCAG TGGGAGTGTT CCTGTACGAA ATGCTAGTTG GCGACACTCC CTTCTACGCA 840

GACTCCCTGG TGGGGACCTA CAGCAAAATC ATGAACCACA AGAATGCCCT GAACTTCCCC 900

GACGACAGCG ACATCTCCAA CGATGCCAAG AATCTCATCT GTGCTTTCCT CACTGACAGG 960

GAAGTTCGAC TGGGCCGCAA TGGTTTCGAT GAGATCAAGA GGCATCCTTT CTTCAAGAAC 1020

GACCAGTGGA CATGGGAGAA CATCCGAGAC ACGGCCGCCC CTGTGGTGCC TGAACTGAGC 1080

AGCGACGTCG ACACCAGTAA CTTTGATGAC ATCGAGGAGG ATCGGGGAGA GGAGGAGACC 1140

TTCCCCATAC CAAAGGCCTT TGTGGGCAAC CAGCTCCCCT TCGTCGGCTT CACTTACTAC 1200

AGCAGTCAGC ACCAGTTGCG CAGCTCCAGC GCCCCCACAA AGACCAGCGA GAAGCGTAGC 1260

AGTGCCACAA AGGAAGACAA GAGTCATCTG GAGAACCTGC AGAAAAGGAT TTACCAGCTG 1320

GAGGAGCAGC TCCACAGTGA GATGCAGCTG AAGGATGAGT TGGAGCAGAA ATGCAGGACA 1380

TCAAACACCA AGATGGACAA GATCATAAAG GAACTGGATG AAGAGGCGAA CCTGAGGAAA 1440

AGTGCGGAGA GCAGCATCTC TCTGCTGGAG AAGGACAAGA TCATGCTTCA GCACAGATTC 1500

ACAGAGTACC AAAGAAAAGC TGACCAGGAT GCAGAGAAGA GGCGCAACCT GGAGAATGAG 1560

GTGTCGAGTT TAAAGGAGCA ACTTGAAGAC ATGAAGAAGA TCAGCCAGAA CTCTCAGGCC 1620

TCAAATGACA AGATGGTCCA ACTGCAGAAT CAGATGGAAG AGGCCAACGA CCTTCTGCGA 1680

GCCGAGTCGG ACACGGCAGC GAGGCTGAGG AAGAGCCACA CCGAGATGGC CAAGTCCATG 1740

AGCCAGCTGG AGAGCTTGAA CCGCGAGCTG CAGGAGAGAA GCCGGGCGGC GGACAGCGAG 1800

AAGGCCCAGC TGGAGAAGGA GCTCCTGCTT CTGCAGAGTT CCCTGGACTC TGAGAGGAGG 1860

AACTACAGCC TCGGCTCCGA GGAGATCAGG GAGCTACAAG CCAGGATGGC GGGCTTGCAA 1920

GAGGACAACA AAAGCTTGAA GCTCAGCCTC TCCAAGGTGG AGTCGGAGCG CAAACAGGCT 1980

CAGGAGAGGA GCAACAACCA AGAGAAGGAG AAGAACAACC TGGAGATAGA CCTGAACTAC 2040

AAACTGAAGA CGCTGCAGCA GCGTCTGGAG CAGGAGCAGA CCGAGCACCG GGTGACGCGG 2100

GCGCAGCTCA CCGACAAATA CGAGTCGATC GAAGAAGCCA AATCGGCCGC CACGAATGCT 2160

GTTCAGCAGA AGATGTCCGA GGAGAACGTT GCGAGGATGC GAGCGGAGAG CCGGGTCGTG 2220

GAGGTCGAGA AGCAGTGCTC GATGTTAGAG TTTGATCTCA AGCAGTCTGT GCAGAAGATG 2280

GAGCAGCTGA TGAAGCAAAA AGAGCGGCTG GAAGATGAGG TGATGAATCT GCAGCTTCAG 2340

GGAGAGCAGG AGTCGAGCAA GCGCGTCCAG ACTCAGAACG ACCTGAAGGG CCGCATGCAG 2400

GAGGTGGACC GACTCAGGTG TTCAGAGAAG CAGCTCAAGC AGGAGATCAA CGCGTCGCTG 2460

GAGAGCAAGC GCTCTCTGGA GTTCCAGCTG GCGCAGTTGA CCAAGCAATA CAGAGGCAAC 2520

GAGGGACAAA TGAGGGAACT TCAGGACCAG CTTGAGGCCG AACAGTATTT TTCTACGCTT 2580

TACAAAACTC AGGTCAAGGA ACTTAAAGAG GAGATTGAGG AAAAGAACCG GCAGGTACAA 2640

GAGACTCATA AAAGGGTGCA GGAGTTGTGC AGTGAAAGGG ACTCCCTGTC CGCCCAGCTG 2700

GATCTGACGG TGACCAAGGC CGAGTCAGAG CAGCTGGCCC GAGCCCTGCA GGAGGAGCAG 2760

TACTTTGAGC TCAGCCAGGA GAACAAAAAG GCAATCAGTA GACATAAGCA GGACATCGGG 2820

GAAAAGGAGG CCACTATTGC TCGGCTTGAG GAATCCAATA ACACTCTGAC CAAAGCTGTG 2880

GAGAACCTCA GCAAAGAGAA GACTGACTTA AGCGAGAAGT TCAGTAGTCT GGAGGAAGAC 2940

TATGCTGCTG AGAAGGAAGA GATTTCCAAC ACAATCAAGT CCAACTATGA GAAGATCCTC 3000

AACACGGAGC GCACACTGAA GACTCAGGCG GTGAACAAGC TGGCAGAGAT TATGAACCGA 3060

AAGGACATGA AGCTGGACCA GAAGAAGAAG GGCAGTACCG CCGACCTGCG GAAGAAGGAG 3120

AAGGAGAACC GCAAGCTCCA GCTGGAACTC AATCAGGAGA AAGAGAAGTT CAACCACATG 3180

GCCATCAAGT ACCAGAAAGA GCTGAGCGAG ATGCAGGCGC AACTGTCGGA GGAATCCACG 3240

TATCGCAACG AGCTGCAAAT GCAGCTGGAC AGCAAGGAGA GCGACATCGA GCAGCTACGG 3300

GAGAAACTGA ACGACCTGCA GCTGCGCATG GACACCTCGA GCGTCACCAG CCTGCAGACC 3360

GACGAGACCG ACGGCAACAT CGCAGAATCC AGACTGGAGG GCTGGCTGTC GATTCCCAAC 3420

CGAGCAAATA TCAAGCGATA CGGATGGAGG AAGCAGTATG TGGTGGTGAG CAGCAAGAAG 3480

ATTCTGTTCT ACAACAATGA GGAGGATAAG GAACTGTCCA ACCCCTCGAT GGTACTAGAT 3540

ATCGACAAAC TGTTTCACGT GAGACCAGTC ACACAAGGAG ACGTGTACCG GGCTGAGACA 3600

GAAGAGATTC CAAGGATATT CCAGATCCTT TACGCCAACG AGGGCGAGTG CAGGAAGGAG 3660

GCGGAGATGG AGGCTGTCCC TCAGGGCGAC AAGACCAACT GTCTCCCACA CAAAGGCCAC 3720

GAGTTCATCC CCACGCTGTA CCACTTCCCT TCAAACTGTG AGGCCTGCTC CAAGCCGCTG 3780

TGGCACGTCT TCAAGCCGCC GCCGGCCCTG GAGTGCCGCC GCTGCCACGT CAAGTGCCAC 3840

AAAGACCACC TGGACAAAAA GGAGGACCTT ATTGCTCCTT GCAAAGTAAA CTACGATGTG 3900

ACCTCTGCCC GGGACATGCT CCTGCTGGCT CTGACCCAGG ATGAGCAGAA GAAATGGATC 3960

GGCCACCTGG GAAAGAAGAT TCCCAAGACC CCACCATCCA CATTCTCGCG GGCCTCGCCT 4020

CGCTCCATGT CCACGCGCTC CGGACCAAAC CAGTCCTTCC GCAAGAACCC TAAAGGCAAT 4080

ACCACGAAGC TGAGGTAA 4098

Domain Profile

S: 1     feilkviGrGafgevavvrekatekvyamkilkklellkraesaffreerdvlvkadsew  60

         +e++kviGrGafgev++vr+kat kvyamk+l+k+e++kr++saff+eerd++++a+s+w

Q: 76    YEVVKVIGRGAFGEVQLVRHKATCKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSSW  135

         89**********************************************************

S: 61    ivqlqyafqdekylylvmeylvGGdlltllskyedklpeelarfylaelvlaldsvhelg  120

         +vql++afqd++yly+vmey++GGdl++l+s+y+  +pe++arfy+ae+vlald +h++g

Q: 136   VVQLFFAFQDDRYLYMVMEYMPGGDLVNLMSNYD--VPEKWARFYTAEVVLALDGIHSMG  193

         **********************************..9***********************

S: 121   yvhrdikpdnilldksGhikladfGsclklnedgtvkssvavGtpdyispevlkaleegk  180

         ++hrd+kpdn+lldk Gh+kladfG+c+k+n+dg+v++++avGtpdyispevlk+++ g+

Q: 194   FIHRDVKPDNMLLDKAGHLKLADFGTCMKMNKDGMVRCDTAVGTPDYISPEVLKSQG-GD  252

         ********************************************************9.**

S: 181   geygkecdwwslGvilyellvgetpfyaeslvetyskilnhkeslkfpedekvseeakdl  240

         g+yg+ecdwws+Gv+lye+lvg+tpfya+slv tyski+nhk+ l+fp+d+++s++ak+l

Q: 253   GYYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMNHKNALNFPDDSDISNDAKNL  312

         ************************************************************

S: 241   ikklltsreerlgregiedlkkhpff  266

         i+++lt+re rlgr+g +++k+hpff

Q: 313   ICAFLTDREVRLGRNGFDEIKRHPFF  338

         *************************9

Domain Sequence
(FASTA)

YEVVKVIGRG AFGEVQLVRH KATCKVYAMK LLSKFEMIKR SDSAFFWEER DIMAFANSSW 60

VVQLFFAFQD DRYLYMVMEY MPGGDLVNLM SNYDVPEKWA RFYTAEVVLA LDGIHSMGFI 120

HRDVKPDNML LDKAGHLKLA DFGTCMKMNK DGMVRCDTAV GTPDYISPEV LKSQGGDGYY 180

GRECDWWSVG VFLYEMLVGD TPFYADSLVG TYSKIMNHKN ALNFPDDSDI SNDAKNLICA 240

FLTDREVRLG RNGFDEIKRH PFF 263

Keyword

ATP-binding; Complete proteome; Kinase; Metal-binding; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase; Zinc; Zinc-finger.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005622	; C:intracellular
GO:0005524	; F:ATP binding
GO:0046872	; F:metal ion binding
GO:0005543	; F:phospholipid binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0000910	; P:cytokinesis
GO:0035556	; P:intracellular signal transduction

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR011072	; HR1_rho-bd.
IPR011009	; Kinase-like_dom.
IPR011993	; PH_like_dom.
IPR017892	; Pkinase_C.
IPR001849	; Pleckstrin_homology.
IPR002219	; Prot_Kinase_C-like_PE/DAG-bd.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR020684	; Rho-assoc_coiled-coil_kin.
IPR015008	; Rho-bd.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF02185	; HR1; 1.
PF00069	; Pkinase; 1.
PF00433	; Pkinase_C; 1.
PF08912	; Rho_Binding; 1.

SMARTs

SM00109	; C1; 1.
SM00233	; PH; 1.
SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS50081	; ZF_DAG_PE_2; 1.

Prints

Created Date

20-Feb-2013