EKS-GAA-00127
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-GAA-00127
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Tec436.14.8E-131431681251
StatusUnreviewed
Ensembl ProteinENSGACP00000023098
UniProt AccessionG3PZQ8;
Protein Name
Protein Synonyms/Alias
Gene NameBTK
Gene Synonyms/Alias BTK;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSGACG00000017483ENSGACP00000023098ENSGACT00000023142
OrganismGasterosteus aculeatus
Functional Description
Protein Length691
Protein Sequence
(FASTA)
IMSDIILEEI FIKRSQQKKK TSPLNYKERW FVLTREKIAY YDFDADKGKR KGLKGSVDLD 60
KIKCVEWVQP EPNSPQERMY AFQVIYDEGP LYVFAKTEET RIQWIKKLKD MVRLNKDLMQ 120
KYHPCFWADG TWLCCQQEVK QAMGCKVLDR LSSKSCYRRG SRKPLPPTPT EVYTQSLFND 180
IRGLLKKPTQ LIPPLILCLF QEKAVRPLPP QPPEEPSPSV GMTVMAEYDY TPMTPQDLEL 240
RKDEEYTILE MSDQNWWKAR DKFGASHFSQ DAHLFTLLMN KICFFFFCRK EGYIPCNYVV 300
EATNGLEKFD WYSKNMNRSQ AEHLLKTENK DGGFLIRDSS KAGKYTVSLF SKGGGDSGGS 360
CRHYNICTTA QGQFYLAEKH NFSTIPELIN YHQHNAAGMV SRLKYIVSNR AQPPSTAGLG 420
YGVWEIDPRY LTFIKELGTG QFGVVKYGKW QGQHDVAIKM IKEGSMSEDD FIEEAKIMMK 480
LRHENLVQLY GVCTKQKPIY IVTEFLPNGC LLTYLREGLT QHPTAVQLLE MCKDVSEGMA 540
YLESQQYIHR DLAARNCLVD GNGTIKVTDF GLSRYVLDDE YTSSAGSKFP VRWSPPEVLL 600
YCKFSSKSDI WAYGVLLWEV YTLGRLPYER LNNTEIVDQV SRGLRLFRPQ LANEKVYSLM 660
TTCWLEKADE RPTFQELALT VQDLLKVKGN H 691
Nucleotide Sequence
(FASTA)
ATCATGTCAG ACATTATACT GGAAGAAATC TTCATTAAAC GATCTCAGCA GAAGAAGAAG 60
ACCTCCCCTC TGAACTACAA GGAGAGATGG TTTGTTCTCA CCCGGGAAAA AATAGCCTAC 120
TATGATTTTG ATGCTGACAA AGGGAAGCGA AAAGGTTTGA AGGGATCGGT TGACCTCGAC 180
AAGATCAAAT GTGTGGAGTG GGTCCAGCCG GAGCCCAATT CCCCGCAGGA GCGCATGTAC 240
GCTTTCCAGG TCATTTACGA CGAGGGGCCG TTGTACGTCT TTGCAAAGAC AGAGGAGACC 300
CGCATTCAGT GGATAAAGAA GCTGAAAGAC ATGGTGCGCT TGAACAAGGA CCTCATGCAG 360
AAGTACCACC CTTGTTTCTG GGCGGATGGG ACGTGGCTTT GCTGCCAGCA GGAGGTTAAA 420
CAAGCAATGG GTTGCAAGGT GCTGGACCGC CTTTCATCCA AGTCATGTTA TCGAAGGGGA 480
TCCAGAAAAC CCCTTCCTCC TACCCCAACC GAGGTTTACA CTCAGTCCCT TTTCAATGAT 540
ATTCGCGGAC TACTCAAAAA GCCAACTCAA TTAATACCTC CACTAATCCT GTGTTTGTTC 600
CAGGAAAAGG CTGTTCGGCC TTTACCTCCA CAGCCACCTG AAGAACCTTC ACCCTCCGTA 660
GGCATGACTG TCATGGCAGA GTATGATTAC ACGCCTATGA CACCCCAAGA CCTGGAGTTG 720
AGGAAGGACG AGGAGTACAC CATCCTGGAG ATGTCTGATC AGAACTGGTG GAAAGCCCGG 780
GACAAATTTG GTGCTTCACA TTTCAGCCAA GATGCACATT TGTTTACATT ACTAATGAAC 840
AAAATATGTT TTTTTTTCTT TTGCAGAAAG GAAGGATACA TACCTTGTAA TTACGTTGTG 900
GAAGCCACAA ATGGGCTAGA AAAATTTGAC TGGTATTCCA AGAACATGAA CCGTAGCCAG 960
GCAGAGCACC TGTTGAAGAC TGAGAATAAA GATGGTGGCT TCCTGATACG GGACTCCAGC 1020
AAGGCCGGGA AATACACTGT GTCTTTGTTC AGTAAGGGCG GCGGGGACTC TGGGGGAAGC 1080
TGCAGACATT ATAACATCTG TACCACAGCA CAGGGACAGT TCTACCTGGC AGAGAAACAT 1140
AATTTCAGCA CCATCCCAGA ACTCATCAAC TACCATCAGC ACAATGCAGC AGGTATGGTT 1200
AGCAGGCTGA AATACATCGT ATCGAACCGG GCACAGCCTC CTTCAACAGC AGGACTCGGC 1260
TACGGTGTTT GGGAGATTGA CCCCCGTTAC CTCACCTTCA TCAAGGAGCT GGGCACTGGT 1320
CAGTTTGGAG TGGTGAAGTA TGGAAAGTGG CAGGGCCAGC ATGACGTTGC CATTAAAATG 1380
ATTAAAGAGG GATCCATGTC CGAAGATGAT TTCATAGAAG AAGCCAAAAT CATGATGAAG 1440
CTTCGCCATG AAAACCTGGT CCAGCTGTAC GGCGTGTGCA CCAAGCAGAA ACCCATTTAC 1500
ATAGTGACTG AGTTCCTTCC CAACGGCTGC CTGCTGACGT ACCTGAGAGA AGGCCTGACG 1560
CAGCACCCGA CAGCGGTCCA GCTCCTGGAG ATGTGTAAAG ACGTCTCTGA GGGCATGGCC 1620
TATCTCGAGT CCCAGCAGTA CATCCACAGA GACCTGGCGG CCAGGAACTG TTTAGTTGAT 1680
GGGAATGGCA CCATTAAAGT GACTGATTTT GGACTTTCAA GGTATGTCTT AGATGATGAG 1740
TACACAAGCT CAGCAGGGTC CAAGTTTCCT GTTCGCTGGT CACCTCCCGA GGTCCTCCTC 1800
TACTGCAAGT TCAGCAGCAA GTCAGACATA TGGGCGTATG GGGTTCTTCT GTGGGAGGTC 1860
TACACCCTGG GACGGCTTCC GTATGAGCGC CTCAACAACA CAGAAATAGT TGATCAGGTG 1920
TCTCGGGGCC TGCGCCTCTT CCGCCCCCAG CTGGCCAACG AAAAGGTCTA CAGCCTTATG 1980
ACAACCTGTT GGCTCGAGAA AGCAGATGAG AGACCCACCT TTCAGGAGCT GGCACTGACG 2040
GTTCAGGATT TGTTGAAAGT CAAGGGCAAC CAC 2073
Domain Profile
S: 1     ltllkelgsgqfgvvklgkwrakidvaikaikegamseedfieeakvmmklshpklvqly  60
         lt++kelg+gqfgvvk+gkw++++dvaik+ikeg+mse+dfieeak+mmkl h++lvqly
Q: 431   LTFIKELGTGQFGVVKYGKWQGQHDVAIKMIKEGSMSEDDFIEEAKIMMKLRHENLVQLY  490
         79**********************************************************
S: 61    gvclkqkpiyivteylengcllnylrekkkkl.ekelllemckdvcegmeylerksfihr  119
         gvc+kqkpiyivte+l ngcll ylre   +  ++ +llemckdv+egm+yle++++ihr
Q: 491   GVCTKQKPIYIVTEFLPNGCLLTYLREGLTQHpTAVQLLEMCKDVSEGMAYLESQQYIHR  550
         **************************98665516678***********************
S: 120   dlaarnclvdeelvvkvsdfglaryvlddqyvssvgakfpvkwsppevlsyskyssksdv  179
         dlaarnclvd + ++kv+dfgl+ryvldd+y+ss+g+kfpv+wsppevl y k+ssksd+
Q: 551   DLAARNCLVDGNGTIKVTDFGLSRYVLDDEYTSSAGSKFPVRWSPPEVLLYCKFSSKSDI  610
         ************************************************************
S: 180   wafgvlmwevfsegklpyekksnsevvekvsrglrlyrpklaskkvyevmkscwkekpee  239
         wa+gvl+wev+++g+lpye+ +n+e+v++vsrglrl+rp+la++kvy++m++cw ek++e
Q: 611   WAYGVLLWEVYTLGRLPYERLNNTEIVDQVSRGLRLFRPQLANEKVYSLMTTCWLEKADE  670
         ************************************************************
S: 240   rptfkellsal  250
         rptf+el  ++
Q: 671   RPTFQELALTV  681
         ******97666
Domain Sequence
(FASTA)
LTFIKELGTG QFGVVKYGKW QGQHDVAIKM IKEGSMSEDD FIEEAKIMMK LRHENLVQLY 60
GVCTKQKPIY IVTEFLPNGC LLTYLREGLT QHPTAVQLLE MCKDVSEGMA YLESQQYIHR 120
DLAARNCLVD GNGTIKVTDF GLSRYVLDDE YTSSAGSKFP VRWSPPEVLL YCKFSSKSDI 180
WAYGVLLWEV YTLGRLPYER LNNTEIVDQV SRGLRLFRPQ LANEKVYSLM TTCWLEKADE 240
RPTFQELALT V 251
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00098
EKS-ANC-00100
EKS-BOT-00108
EKS-CAJ-00109
EKS-CAF-00109
EKS-CAP-00103
EKS-CII-00053
EKS-DAR-00355
EKS-DRM-00050
EKS-EQC-00104
EKS-FEC-00102
EKS-GAM-00052
EKS-GAG-00088
EKS-HOS-00110
EKS-ICT-00102
EKS-LAC-00112
EKS-LOA-00102
EKS-MAM-00103
EKS-MEG-00083
EKS-MOD-00109
EKS-MUM-00109
EKS-MUP-00110
EKS-MYL-00121
EKS-NOL-00100
EKS-ORN-00132
EKS-ORA-00087
EKS-ORC-00099
EKS-ORL-00124
EKS-OTG-00109
EKS-PAT-00098
EKS-PES-00092
EKS-POA-00100
EKS-PTV-00097
EKS-RAN-00109
EKS-SAH-00100
EKS-SOA-00057
EKS-SUS-00094
EKS-TAR-00136
EKS-TEN-00126
EKS-XET-00090
EKS-XIM-00130
Gene Ontology
GO:0005622; C:intracellular
GO:0005524; F:ATP binding
GO:0005543; F:phospholipid binding
GO:0004713; F:protein tyrosine kinase activity
GO:0035556; P:intracellular signal transduction
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR011993; PH_like_dom.
IPR001849; Pleckstrin_homology.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980; SH2.
IPR001452; SH3_domain.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR001562; Znf_Btk_motif.
Pfam
PF00779; BTK; 1.
PF00169; PH; 1.
PF07714; Pkinase_Tyr; 1.
PF00017; SH2; 1.
PF00018; SH3_1; 1.
SMARTs
SM00107; BTK; 1.
SM00233; PH; 1.
SM00252; SH2; 1.
SM00326; SH3; 1.
SM00219; TyrKc; 1.
Prosites
PS50003; PH_DOMAIN; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS50001; SH2; 1.
PS50002; SH3; 1.
PS51113; ZF_BTK; 1.
Prints
PR00401; SH2DOMAIN.
PR00452; SH3DOMAIN.
PR00109; TYRKINASE.
Created Date20-Feb-2013