EKS-GAA-00595

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-GAA-00595

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/TBCK	356.3	1.0E-106	18	273	256

Status

Unreviewed

Ensembl Protein

ENSGACP00000023140

UniProt Accession

G3PZV0;

Protein Name

Protein Synonyms/Alias

Gene Name

TBCK

Gene Synonyms/Alias

TBCK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGACG00000017502	ENSGACP00000023140	ENSGACT00000023184
ENSGACG00000017502	ENSGACP00000023143	ENSGACT00000023187

Organism

Gasterosteus aculeatus

Functional Description

Protein Length

888

Protein Sequence
(FASTA)

MNPLKDAQLG AFTFFASALP HDVCGSNGLP LTPNSIKILG RFQVLKTITH PRLCQYVDMS 60

RGKHERLIVV AEHFESSLSD FQKQGKTVSP GKLLQVAYEV LEGLEFMNKH GMVHRALSAH 120

NVLMDCKGNV KLAKFGLYHM TDHGADVDFP IGYPSYLAPE VIAQGSFHPS DSYHDEAPLP 180

SGPKTDVWSL GVLLFELCAG RRLLLNIDIS ERLKFILTLG CIDDIVTVLA EEHGCLDAIK 240

ELPENVLALL RKCLTFRPSK RPTPSDLLGD PVFSGVSDLY TPFKKPVSLF SSSLRCAHLE 300

LPEDIRELCK DDDDDYLSER GINEVYHLWC LAGGDLEKEL TNKEIIQSKP PICTLPNFVL 360

EDGESFGQGR DRSFLLDDTT VTLSLCQLRN RLKDVPGEAY YPLLEDEQST LPQSNSSNEL 420

SATVTLPLII RERDTEYQLI RIVLFDRLLK AYPYKKNLVW KEARVDIPPL VRGLAWAALL 480

GIEGDIQAKY ESIDKDTPIP TDRQIEVDIP RCHQYDELLS SPQGHIKFRR VLKAWVVSHP 540

DLVYWQGLDS LCAPFLYLNF NNEALAYACM SAFIPKYLYN FFLKDNSHVI QEYLTVFSQM 600

IAFHDPELSN HLNEIGFIPD LYAIPWFLTM FTHVFPLHKI FHLWDTLLLG NSSFPFCIGV 660

AILQQLRDRL LANGFNECIL LFSDLPEIDI ERCVRESINL FCWSPKSATY RQHAQPPKAA 720

GDVGFGKAAT YYSSDYQDMP RTDLSREPLA LCDLKAEVSP RISAEDLIDL CELSLVGPAK 780

RTRAGKPKII AVDIRSVEDF SRGHISGSIN IPFSTSFNPD GELVQCPATG ILQNYRGRVI 840

VIISHAMKSA AMFAAHLVKV NFQRVSILDG GINKLKPTGL LTVPSPQI 888

Nucleotide Sequence
(FASTA)

ATGAACCCTC TGAAAGACGC ACAGCTGGGG GCCTTCACCT TCTTTGCCTC AGCGCTTCCT 60

CATGATGTCT GTGGTAGTAA TGGCCTCCCT CTCACCCCCA ACTCCATCAA AATCCTGGGA 120

CGTTTCCAGG TCCTCAAAAC CATCACTCAT CCCAGACTCT GCCAATACGT GGACATGTCC 180

AGAGGGAAAC ACGAACGACT GATTGTTGTT GCTGAACACT TTGAAAGCAG TTTAAGTGAC 240

TTTCAAAAAC AAGGGAAAAC AGTCAGCCCA GGGAAGCTGC TGCAGGTAGC TTACGAGGTC 300

CTCGAAGGTC TGGAATTCAT GAACAAACAT GGTATGGTGC ACAGAGCCCT CAGTGCACAC 360

AATGTGCTCA TGGACTGCAA GGGGAATGTT AAGCTGGCAA AGTTTGGCCT TTATCACATG 420

ACTGATCATG GGGCTGACGT AGATTTTCCC ATTGGGTACC CATCATACCT TGCTCCGGAG 480

GTGATTGCTC AGGGCTCTTT CCACCCCAGT GACTCTTACC ACGACGAGGC TCCTCTGCCT 540

TCAGGACCCA AGACGGACGT GTGGTCGCTT GGGGTTTTGC TGTTTGAATT ATGCGCAGGC 600

AGACGACTGC TGCTGAATAT TGATATTAGT GAGAGGCTGA AATTCATCCT AACTTTGGGT 660

TGCATAGACG ACATTGTCAC CGTCCTCGCT GAGGAACATG GTTGCCTGGA TGCCATCAAG 720

GAGCTGCCTG AAAATGTCCT TGCATTATTA AGAAAATGCT TGACATTTCG TCCATCCAAA 780

AGGCCGACCC CTTCAGACCT GCTGGGAGAC CCTGTGTTTA GTGGCGTTTC GGACCTCTAC 840

ACCCCCTTCA AGAAGCCCGT CAGCCTGTTC TCTTCCTCTC TTCGCTGTGC ACATCTGGAA 900

CTCCCAGAAG ACATCAGGGA ACTTTGCAAA GACGATGATG ACGACTACCT CTCGGAGCGG 960

GGCATAAATG AGGTGTACCA TCTGTGGTGT CTGGCTGGGG GAGACCTGGA GAAGGAGCTG 1020

ACCAACAAGG AGATTATACA GTCCAAGCCT CCAATCTGCA CACTGCCCAA TTTTGTCCTG 1080

GAAGACGGGG AATCATTTGG CCAGGGAAGG GACCGCAGTT TCTTACTTGA CGACACAACA 1140

GTGACGTTGT CTCTGTGCCA ACTCCGAAAC CGGCTGAAGG ATGTTCCGGG AGAAGCCTAT 1200

TACCCTCTAC TGGAAGACGA GCAGTCAACT CTGCCTCAGT CCAACAGCAG CAATGAGCTG 1260

TCGGCCACCG TCACGCTCCC ACTCATCATC CGAGAGAGAG ACACTGAGTA CCAGCTCATC 1320

CGCATCGTCC TCTTTGACAG GCTGCTCAAG GCCTACCCTT ACAAGAAGAA CTTGGTGTGG 1380

AAAGAGGCCC GAGTGGATAT CCCCCCTCTT GTTCGAGGTC TGGCGTGGGC AGCACTGCTT 1440

GGCATTGAGG GAGACATTCA AGCCAAATAC GAAAGCATTG ACAAAGATAC TCCCATCCCG 1500

ACAGATCGAC AGATTGAGGT CGACATCCCG CGCTGTCACC AGTACGACGA GCTGCTGTCG 1560

TCTCCTCAGG GCCACATCAA GTTCAGGCGT GTGTTGAAAG CCTGGGTGGT CTCCCACCCG 1620

GACCTGGTCT ACTGGCAGGG TCTGGATTCA CTCTGTGCCC CATTCCTGTA CTTAAACTTT 1680

AATAATGAAG CTCTGGCATA TGCCTGCATG TCTGCCTTCA TCCCCAAGTA CTTGTACAAC 1740

TTTTTCCTGA AGGACAACTC TCACGTCATC CAAGAGTACT TGACCGTCTT CTCCCAAATG 1800

ATTGCCTTCC ACGACCCAGA GCTTAGCAAC CATCTGAATG AGATCGGCTT CATACCGGAC 1860

CTTTACGCCA TTCCGTGGTT CCTGACTATG TTTACACATG TGTTTCCACT GCACAAGATC 1920

TTCCACTTGT GGGACACGCT GCTGCTGGGT AACTCTTCTT TCCCCTTCTG TATCGGCGTG 1980

GCCATATTGC AGCAGCTCAG GGACCGCCTC CTGGCCAACG GCTTCAATGA GTGCATCCTG 2040

CTCTTCTCTG ACCTGCCAGA AATTGACATA GAGCGCTGTG TTCGTGAATC CATCAACCTC 2100

TTCTGCTGGT CTCCAAAGAG TGCTACGTAT CGACAGCACG CTCAGCCACC AAAGGCCGCT 2160

GGCGACGTCG GCTTTGGGAA AGCGGCGACA TACTACTCGT CCGACTACCA GGACATGCCC 2220

AGGACGGACC TGTCTCGCGA GCCGTTGGCG CTGTGCGACC TGAAAGCAGA AGTATCCCCG 2280

AGGATCTCGG CCGAGGACTT AATCGACCTC TGTGAGCTGT CGTTGGTCGG ACCCGCCAAA 2340

AGGACCAGAG CCGGCAAGCC CAAAATCATC GCTGTTGACA TCCGCAGTGT GGAAGACTTC 2400

AGCAGAGGCC ACATTTCTGG CAGCATCAAC ATTCCCTTCA GCACATCGTT CAACCCGGAT 2460

GGTGAGCTGG TGCAGTGTCC TGCAACCGGA ATCCTGCAGA ACTACAGAGG ACGGGTCATC 2520

GTGATCATCA GTCACGCCAT GAAAAGTGCT GCCATGTTTG CAGCACACCT GGTCAAGGTA 2580

AATTTCCAAC GGGTCTCTAT CCTGGACGGT GGAATCAACA AGCTGAAGCC CACTGGACTC 2640

CTGACCGTCC CGTCCCCTCA GATCTGA 2667

Domain Profile

S: 1     llaqdkdGsnGlplasnakkilGrfqiLkelqhdrLcqYldisrgkhervivvaehlels  60

         +l++d++GsnGlpl++n++kilGrfq+Lk+++h+rLcqY+d+srgkher+ivvaeh+e s

Q: 18    ALPHDVCGSNGLPLTPNSIKILGRFQVLKTITHPRLCQYVDMSRGKHERLIVVAEHFESS  77

         589*********************************************************

S: 61    LeDllkerkpvseslvlriayevlsgldylnkhnivhralepksilldrkgqkvkLakyG  120

         L D+ k++k vs  + l++ayevl+gl+++nkh++vhral+ +++l+d kg+ vkLak+G

Q: 78    LSDFQKQGKTVSPGKLLQVAYEVLEGLEFMNKHGMVHRALSAHNVLMDCKGN-VKLAKFG  136

         ****************************************************.*******

S: 121   LyhltayGkdvdfpigygsylaPerilqd.........edkllaatvksDvWsLglille  171

         Lyh+t++G+dvdfpigy+sylaPe+i+q+         ++ +l++++k DvWsLg++l+e

Q: 137   LYHMTDHGADVDFPIGYPSYLAPEVIAQGsfhpsdsyhDEAPLPSGPKTDVWSLGVLLFE  196

         *************************************999********************

S: 172   lilgikLfaeldlserlkillklstvdetliklaeekkcldiikklderleallkkCLtl  231

         l+ g++L  ++d+serlk++l+l+++d+ + +laee++cld ik+l+e++ all+kCLt+

Q: 197   LCAGRRLLLNIDISERLKFILTLGCIDDIVTVLAEEHGCLDAIKELPENVLALLRKCLTF  256

         ************************************************************

S: 232   lpskRpspdellkekvf  248

          pskRp+p++ll ++vf

Q: 257   RPSKRPTPSDLLGDPVF  273

         ************99987

Domain Sequence
(FASTA)

ALPHDVCGSN GLPLTPNSIK ILGRFQVLKT ITHPRLCQYV DMSRGKHERL IVVAEHFESS 60

LSDFQKQGKT VSPGKLLQVA YEVLEGLEFM NKHGMVHRAL SAHNVLMDCK GNVKLAKFGL 120

YHMTDHGADV DFPIGYPSYL APEVIAQGSF HPSDSYHDEA PLPSGPKTDV WSLGVLLFEL 180

CAGRRLLLNI DISERLKFIL TLGCIDDIVT VLAEEHGCLD AIKELPENVL ALLRKCLTFR 240

PSKRPTPSDL LGDPVF 256

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005622	; C:intracellular
GO:0005524	; F:ATP binding
GO:0004672	; F:protein kinase activity
GO:0005097	; F:Rab GTPase activator activity
GO:0032851	; P:positive regulation of Rab GTPase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR000195	; Rab-GTPase-TBC_dom.
IPR001763	; Rhodanese-like_dom.

Pfam

PF00069	; Pkinase; 1.
PF00566	; RabGAP-TBC; 1.
PF00581	; Rhodanese; 1.

SMARTs

SM00450	; RHOD; 1.
SM00164	; TBC; 1.

Prosites

PS50011	; PROTEIN_KINASE_DOM; 1.
PS50206	; RHODANESE_3; 1.
PS50086	; TBC_RABGAP; 1.

Prints

Created Date

20-Feb-2013