EKS-GAA-00491

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-GAA-00491

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/PDGFR	542.6	6.1E-163	593	949	357

Status

Unreviewed

Ensembl Protein

ENSGACP00000023788

UniProt Accession

G3Q1P0;

Protein Name

Tyrosine-protein kinase receptor

Protein Synonyms/Alias

Gene Name

PDGFRB

Gene Synonyms/Alias

PDGFRB;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGACG00000018005	ENSGACP00000023788	ENSGACT00000023835

Organism

Gasterosteus aculeatus

Functional Description

Protein Length

1044

Protein Sequence
(FASTA)

HTAARLPSNL TFFLVVPTAA LFYFCTELRC LEITPDDEEL VLAEGSSLTL TCSGSEDTKW 60

EFKRDDAPHF QAEELQNDGQ SHTTSVLTLH NLSWKHTGVY QCNDRHTGET KEVAVFVPGK 120

GSYADVWFIK SSHGMVTKTS EETTIPCVVT NPTINVTLYE RDTDLPIRGL YVPSEGYKAR 180

LEDRTYVCRG ELDGEVKESQ DFYVFSIVGA VPEAIDAYIN ASKTILKQGP LTVNCTVHGV 240

ELIYFSWDIP NRELVVVEPL TEFLPGTTMR SCLVFPRATL AHGGSYACHV HDSIQDQTAS 300

ASVNVTVLER GFVDVKTARK NNISAKLQEN VELRVEIEAY PPPQVRWSKE GVSIKRDRTI 360

TTRRDHEISY VTVLTLVRVR KEQKGRYTVL VTNGDDTKEV TFDLEVQVPS RIKDLTDHHL 420

PGKKHLVTCV AEGVPTPTIQ WYSCDSVHQF SNQTAVWHPL VPEAGVLSIL TNVTYSETGK 480

TSQVRSQVTF HQPQQVTVRC ETNNQVGLMD RRDVKLVSST LYSQVAVLAA VLALVVIIII 540

SIIILIALWR KKPRYEIRWK VIESVSQDGH EYIYVDPIHL PYDLAWEMPR DNLVLGRTLG 600

SGAFGRVVEA TAYGLTHSQS STKVAVKMLK STARRSETQA LMSELKIMSH LGPHLNIVNL 660

LGACTKHGPL YLVTEYCRYG DLVDYLHRNK HTLLQCQAEK NQDDGCLISG GSTPLSQRKG 720

YVSFGSESDG GYMDMSKDEP TIYVPMQMEQ MDNIKYADIQ PSSYESPYQQ DIYQEQGGSR 780

LELAISDSSI LTYDDLLGFS YQVAQGMEFL ASKNCVHRDL AARNVLICEG KLVKICDFGL 840

ARDIMHDSNY ISKGSTFLPL KWMAPESIFN NLYTTLSDVW SYGILLWEIF TLGGTPYPDL 900

PMNELFYSAL KRGYRMAKPA HASDEVYDIM KKCWDEKYET RPDFSRLVHS VGNMLADSYK 960

KKYSQVNDNF LKSDHPAVAR TKPRLSSPFP IANPAFGTPP PQYAPPDPYN QSAGEFRQEA 1020

DSQEVITLYN EYIIPIPDPK PEDV 1044

Nucleotide Sequence
(FASTA)

CATACCGCTG CCAGATTGCC CTCCAATCTG ACCTTCTTTC TTGTTGTGCC AACGGCAGCT 60

CTCTTCTATT TCTGCACCGA GCTGCGTTGT CTGGAGATCA CCCCCGATGA TGAGGAGCTC 120

GTCCTGGCCG AGGGTTCCTC CCTCACCCTC ACCTGCTCCG GCTCAGAAGA CACAAAGTGG 180

GAGTTCAAGA GGGACGACGC GCCGCACTTC CAAGCGGAAG AACTTCAAAA CGATGGTCAG 240

AGTCACACAA CCAGTGTTTT GACCTTGCAC AACCTGAGCT GGAAGCACAC GGGGGTGTAT 300

CAGTGCAACG ATCGACACAC TGGGGAAACC AAGGAGGTGG CAGTTTTTGT CCCAGGTAAG 360

GGTTCATACG CAGATGTGTG GTTCATAAAG AGCTCACATG GCATGGTGAC AAAGACCAGT 420

GAGGAGACCA CCATCCCCTG TGTGGTCACC AATCCCACCA TCAACGTCAC CCTGTACGAG 480

AGGGACACCG ATCTGCCCAT CAGGGGGCTT TATGTGCCGA GTGAGGGGTA CAAGGCACGG 540

CTGGAGGACA GGACCTACGT GTGTCGGGGA GAGCTGGACG GCGAGGTGAA AGAGTCTCAG 600

GACTTCTACG TCTTCAGCAT TGTCGGCGCA GTCCCAGAGG CCATCGACGC ATACATCAAT 660

GCGTCAAAGA CCATCCTGAA GCAAGGGCCG CTGACAGTGA ACTGCACAGT GCACGGAGTG 720

GAGCTGATCT ATTTTTCCTG GGATATCCCC AACAGGGAGC TTGTTGTGGT CGAGCCACTC 780

ACAGAATTCC TACCTGGTAC GACCATGCGC TCCTGCCTCG TCTTCCCTCG CGCCACGCTT 840

GCCCACGGCG GATCCTACGC CTGCCATGTC CACGACAGCA TCCAAGACCA GACGGCCTCT 900

GCCAGCGTTA ACGTCACTGT GCTCGAGCGA GGCTTTGTCG ATGTGAAGAC TGCTCGGAAA 960

AACAACATTT CAGCGAAGCT GCAGGAGAAC GTGGAGTTGA GAGTGGAGAT TGAAGCCTAC 1020

CCGCCACCTC AGGTCCGTTG GAGCAAAGAA GGCGTCTCAA TCAAGAGAGA TAGAACCATC 1080

ACAACCAGAC GAGATCATGA GATCAGCTAC GTCACTGTGC TCACCTTGGT GAGGGTGAGG 1140

AAAGAGCAGA AGGGACGCTA CACTGTTCTC GTCACAAACG GAGATGACAC AAAGGAAGTG 1200

ACCTTTGACC TGGAAGTGCA AGTTCCCTCT CGGATTAAAG ACCTTACTGA CCACCACCTC 1260

CCTGGGAAAA AACATTTGGT GACCTGTGTG GCCGAGGGGG TCCCAACCCC GACCATCCAG 1320

TGGTACAGCT GTGACAGCGT GCACCAGTTC AGCAACCAAA CAGCAGTTTG GCATCCACTG 1380

GTACCGGAGG CCGGGGTGCT GAGCATCCTG ACCAACGTCA CCTACAGCGA GACTGGTAAA 1440

ACCAGCCAGG TGCGGAGCCA GGTGACCTTC CACCAGCCGC AGCAGGTCAC AGTGCGCTGC 1500

GAGACCAACA ACCAAGTAGG ACTCATGGAC AGACGGGACG TCAAACTGGT GTCCAGCACG 1560

CTGTACTCCC AGGTGGCAGT ATTGGCTGCT GTTTTAGCCT TAGTGGTCAT CATTATCATC 1620

TCCATCATCA TCCTCATTGC TCTATGGAGA AAGAAACCTC GCTATGAGAT CAGATGGAAG 1680

GTGATAGAGT CCGTGAGCCA GGACGGTCAT GAGTACATCT ACGTGGACCC CATCCACCTG 1740

CCCTACGACC TGGCTTGGGA AATGCCACGA GACAACCTGG TGCTTGGTCG CACTCTTGGA 1800

TCGGGAGCTT TCGGCAGGGT GGTTGAGGCG ACTGCGTACG GTCTCACTCA TTCCCAGTCC 1860

AGCACAAAGG TGGCTGTGAA AATGCTGAAA TCCACAGCCA GGAGGAGTGA GACGCAGGCT 1920

TTGATGTCCG AGTTGAAGAT CATGAGTCAC CTGGGACCTC ACCTCAACAT TGTCAACTTG 1980

CTGGGAGCTT GCACCAAACA CGGCCCCCTG TATTTGGTGA CCGAGTACTG TCGCTATGGC 2040

GACCTGGTGG ACTACCTGCA CAGGAACAAG CACACCCTCC TGCAGTGTCA AGCAGAGAAG 2100

AACCAAGACG ACGGCTGCCT CATCTCTGGA GGAAGCACTC CGCTCAGCCA GAGGAAAGGC 2160

TACGTGTCCT TTGGGAGTGA GAGCGACGGA GGATACATGG ACATGAGTAA AGATGAGCCC 2220

ACCATCTACG TGCCCATGCA GATGGAGCAG ATGGACAACA TCAAGTACGC GGACATCCAG 2280

CCTTCTTCAT ACGAGTCGCC GTACCAGCAG GACATCTATC AGGAACAAGG TGGCAGCAGG 2340

TTGGAACTGG CCATCAGTGA CTCCTCCATT CTCACCTACG ACGATCTGTT GGGCTTCAGC 2400

TATCAAGTGG CCCAGGGGAT GGAGTTTCTC GCCTCCAAGA ATTGCGTTCA CCGTGACCTC 2460

GCTGCCAGGA ATGTTCTGAT CTGCGAGGGA AAACTGGTGA AGATCTGTGA CTTTGGCCTG 2520

GCCAGAGACA TAATGCATGA TTCCAACTAC ATCTCTAAAG GCAGCACCTT CCTGCCCCTG 2580

AAGTGGATGG CACCAGAAAG TATTTTCAAT AATTTGTACA CCACCCTGAG TGACGTGTGG 2640

TCATACGGCA TTCTTCTTTG GGAGATTTTC ACTCTAGGAG GAACCCCTTA CCCCGACTTG 2700

CCCATGAATG AGTTGTTCTA CAGCGCTCTG AAGAGAGGCT ACCGGATGGC CAAACCTGCA 2760

CACGCCTCCG ATGAAGTTTA TGACATCATG AAGAAGTGCT GGGACGAGAA GTACGAGACG 2820

AGGCCCGACT TCTCCCGTCT GGTGCACAGT GTTGGGAACA TGCTGGCAGA CAGCTATAAA 2880

AAGAAATACA GCCAAGTCAA CGACAACTTC CTGAAGAGTG ACCACCCGGC AGTCGCCCGC 2940

ACGAAACCCA GACTCTCCTC CCCCTTTCCG ATCGCCAACC CGGCATTCGG CACTCCACCC 3000

CCACAATACG CCCCCCCGGA CCCCTACAAC CAGAGCGCCG GGGAGTTCAG ACAGGAGGCA 3060

GACTCACAGG AAGTCATAAC CTTATACAAC GAATACATCA TTCCCATCCC CGACCCCAAG 3120

CCGGAGGACG TT 3132

Domain Profile

S: 1     lelGkvlGsGafGkvveatayGlsksdavlkvavkmlkstarssekealmselkilshlG  60

         l+lG++lGsGafG+vveatayGl++s+++ kvavkmlkstar se +almselki+shlG

Q: 593   LVLGRTLGSGAFGRVVEATAYGLTHSQSSTKVAVKMLKSTARRSETQALMSELKIMSHLG  652

         78**********************************************************

S: 61    ehenivnllGactkgGpiyviteyccyGdllnylrrkresflkkslekkkekeeeldska  120

         +h+nivnllGactk Gp+y++teyc+yGdl++yl+r+++++l+ ++ek++++   ++  +

Q: 653   PHLNIVNLLGACTKHGPLYLVTEYCRYGDLVDYLHRNKHTLLQCQAEKNQDDGCLISGGS  712

         ******************************************999999888776666555

S: 121   lladkslrsksslssesseeyvdlkkd.................vsdvssskadklasek  163

          +  ++ + ++s+ ses++ y+d++kd                 ++d+++s+++++++++

Q: 713   TPL-SQRKGYVSFGSESDGGYMDMSKDeptiyvpmqmeqmdnikYADIQPSSYESPYQQD  771

         544.45678999************************************************

S: 164   kksalerevkaaleeedsevleledllsfsyqvakGmeflaskncvhrdlaarnvllteG  223

         + + +  ++  +l   ds+ l+++dll fsyqva+Gmeflaskncvhrdlaarnvl++eG

Q: 772   IYQEQGGSRL-ELAISDSSILTYDDLLGFSYQVAQGMEFLASKNCVHRDLAARNVLICEG  830

         7776666665.55556699*****************************************

S: 224   kvvkicdfGlardimkdsnyvvkGnarlpvkwmapesifdslytvksdvwsyGillweif  283

         k+vkicdfGlardim+dsny++kG+++lp+kwmapesif++lyt+ sdvwsyGillweif

Q: 831   KLVKICDFGLARDIMHDSNYISKGSTFLPLKWMAPESIFNNLYTTLSDVWSYGILLWEIF  890

         ************************************************************

S: 284   slGstpypgllvdskfyklikeGyrmaqpayateeiyeimqkcweaepekrpsfkqlve  342

         +lG+tpyp+l++++ fy ++k+Gyrma+pa+a++e+y+im+kcw+++ e+rp f++lv+

Q: 891   TLGGTPYPDLPMNELFYSALKRGYRMAKPAHASDEVYDIMKKCWDEKYETRPDFSRLVH  949

         *******************************************************9986

Domain Sequence
(FASTA)

LVLGRTLGSG AFGRVVEATA YGLTHSQSST KVAVKMLKST ARRSETQALM SELKIMSHLG 60

PHLNIVNLLG ACTKHGPLYL VTEYCRYGDL VDYLHRNKHT LLQCQAEKNQ DDGCLISGGS 120

TPLSQRKGYV SFGSESDGGY MDMSKDEPTI YVPMQMEQMD NIKYADIQPS SYESPYQQDI 180

YQEQGGSRLE LAISDSSILT YDDLLGFSYQ VAQGMEFLAS KNCVHRDLAA RNVLICEGKL 240

VKICDFGLAR DIMHDSNYIS KGSTFLPLKW MAPESIFNNL YTTLSDVWSY GILLWEIFTL 300

GGTPYPDLPM NELFYSALKR GYRMAKPAHA SDEVYDIMKK CWDEKYETRP DFSRLVH 357

Keyword

ATP-binding; Complete proteome; Disulfide bond; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0005524	; F:ATP binding
GO:0004714	; F:transmembrane receptor protein tyrosine kinase activity
GO:0007169	; P:transmembrane receptor protein tyrosine kinase signaling pathway

KEGG

InterPros

IPR007110	; Ig-like.
IPR013783	; Ig-like_fold.
IPR013098	; Ig_I-set.
IPR003599	; Ig_sub.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016243	; Tyr_kinase_CSF1/PDGF_rcpt.
IPR001824	; Tyr_kinase_rcpt_3_CS.

Pfam

PF07679	; I-set; 1.
PF07714	; Pkinase_Tyr; 1.

SMARTs

SM00409	; IG; 3.
SM00219	; TyrKc; 1.

Prosites

PS50835	; IG_LIKE; 3.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS00240	; RECEPTOR_TYR_KIN_III; 1.

Prints

Created Date

20-Feb-2013