EKS-GAA-00371
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-GAA-00371
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/EGFR464.51.2E-139680937258
StatusUnreviewed
Ensembl ProteinENSGACP00000023887
UniProt AccessionG3Q1Y8;
Protein Name
Protein Synonyms/Alias
Gene NameEGFR (2 of 2)
Gene Synonyms/Alias EGFR (2 of 2);
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSGACG00000018079ENSGACP00000023887ENSGACT00000023934
OrganismGasterosteus aculeatus
Functional Description
Protein Length1139
Protein Sequence
(FASTA)
VCQGMHNYLT LLGTREYHYE NMVRMYANCS VVLENLEITY TLEHQDLSFL QTIEEVGGYV 60
LIAMNEAAVI PLVNLKLIRG QNLYEHQFAL LVISNYQRNQ SSATLNYTSG LRQLLLSNLT 120
EILKGGVKMA YNPLLCNADT IKWWDILDGD NRSRVVIETD AFTRRCEKCD PRCVNGSCWA 180
AGSHHCQRFT RLQCAEQCSR RCRGPRPSDC CNEHCASGCS GPQASDCLAC RDLNDDGTCK 240
DACPPMTLYN PKTHQVVNNP NAKFTFGATC VKACPHNYVV AGGSCVRTCS PGTYEVEENG 300
VQRCKDCDGR CSKACDGIGV GVLSNAIAVN ASNIESFRNC NKIIGDVSLL ETSFTGDPHY 360
KIPPMDPAKL DYLRTVKEIT GFLLIQFWPE NMTSLSVFEN LEIIRGRTTR YGYSLLVLRA 420
KNLLWLGLRS LKEVSAGQVI IKDNPQLCYT QPQQWTHLFR SSDQTPTTLL NARPDVCEQQ 480
NRTCDQECSE EGCWGPGPTM CVSCRLFNRR GRCVAFCNLL QGEPREVEVD RRCEECHPEC 540
LLQDGTPTCR GPGADQCSQC ANLKDGAHCV RRCPHGVKYA DRTGRCQPCH QNCTQGCSGE 600
GLPGCNGAPV ASSMAVAVVG GLLIAVIVAL VIFVLLRRRR IRRKRTTRRL LQERELVEPL 660
TPSGEAPNQA LLRILKETEF KKIRVLGSGA FGTVFKGRWN PEGENVRIPV AIKVLREATS 720
PKANKEILDE AYVMASVDHP HVCRLLGICL TSSVQLVTQL MPYGCLLDYV RHHRDHVGAQ 780
WLLNCCVQMA KGMNYLEERH LVHRDLAARN VLVKTPNHVK ITDFGLAKLL ASDEQEYHAD 840
GGKVPIKWMA LESILQWTYT HQSDVWSFGV TVWELMTFGT KPYDGIPASE MSSVLERGDR 900
LPQPPICTIE VYMILVKCWM IDPSSRPRFR ELIVEFSKMA RDPSRYLVVE GDLPSPSDSR 960
FYSRLLSSDD MEDVVDADEY LLPFKGTGCH DNGSCHAANG HPVRQNSIAL RYITDPTHNA 1020
TDKEDFSGHD YRNQSLSETS GTSRLSEVFN PNYEDLSVGW GAASPPLPLE ELKSLGPEYL 1080
NTAQSSLPAA AGDSLDNPDY QADFLPGSPA TPPGNALFLP AAENLEYLGL GAALYAPVR 1139
Nucleotide Sequence
(FASTA)
GTGTGTCAGG GGATGCATAA CTATCTGACG TTGCTGGGGA CTCGTGAGTA TCACTATGAG 60
AACATGGTGA GGATGTATGC AAACTGCTCC GTGGTCCTGG AGAACCTGGA GATCACCTAC 120
ACCCTGGAGC ATCAGGACCT GTCCTTCCTC CAGACCATCG AGGAAGTAGG AGGCTACGTT 180
CTAATCGCCA TGAACGAGGC CGCCGTCATC CCGCTGGTCA ACCTGAAGCT GATCCGCGGC 240
CAGAACCTCT ACGAACACCA GTTCGCCCTG CTGGTCATCT CCAACTACCA GCGGAACCAG 300
TCGTCTGCAA CGCTCAACTA CACCAGCGGG CTGAGGCAGC TGCTGCTAAG CAACCTGACG 360
GAAATCCTGA AAGGAGGCGT GAAGATGGCC TACAATCCTC TGCTGTGCAA CGCTGACACC 420
ATCAAGTGGT GGGACATCCT GGACGGAGAC AACCGCTCCA GAGTGGTCAT CGAGACGGAC 480
GCCTTCACCC GAAGATGTGA GAAGTGTGAC CCCAGGTGTG TTAACGGCTC GTGTTGGGCA 540
GCCGGGTCAC ATCACTGCCA GAGATTCACC AGGCTCCAGT GTGCCGAGCA GTGCAGCAGA 600
CGGTGTCGCG GCCCGAGACC CAGCGACTGC TGCAACGAGC ACTGTGCGTC CGGCTGCTCC 660
GGACCTCAAG CCAGCGACTG CCTGGCCTGC AGGGATTTGA ACGACGACGG CACCTGCAAA 720
GACGCTTGTC CACCGATGAC ACTCTACAAC CCCAAGACCC ACCAGGTGGT CAACAACCCC 780
AACGCCAAGT TCACCTTCGG GGCGACCTGC GTCAAGGCCT GCCCCCATAA CTACGTGGTG 840
GCCGGTGGAT CATGCGTCCG TACCTGCAGC CCTGGAACAT ACGAGGTGGA GGAGAACGGA 900
GTCCAGCGCT GTAAAGACTG CGACGGCCGC TGTTCCAAAG CGTGTGACGG CATTGGGGTC 960
GGGGTTCTGA GCAATGCCAT TGCTGTCAAC GCCTCCAACA TCGAATCCTT CAGGAACTGC 1020
AACAAGATCA TCGGTGACGT CTCGCTCCTC GAAACCTCCT TCACCGGAGA CCCGCACTAT 1080
AAAATACCAC CCATGGACCC GGCTAAACTG GATTATTTGA GGACGGTGAA GGAAATCACA 1140
GGTTTCCTGC TCATCCAGTT CTGGCCAGAG AATATGACTT CTCTGTCAGT GTTTGAGAAC 1200
CTGGAGATCA TCAGAGGGAG AACCACCCGC TACGGTTACA GTCTGTTGGT GCTGCGGGCC 1260
AAGAACCTCC TCTGGCTGGG CCTGCGCTCC TTGAAGGAGG TGAGTGCCGG CCAAGTGATA 1320
ATAAAGGACA ACCCTCAGCT GTGCTACACC CAACCGCAAC AGTGGACCCA CCTCTTCAGG 1380
TCCAGCGACC AGACCCCCAC CACACTGCTG AACGCCCGCC CCGATGTCTG CGAACAACAG 1440
AATCGGACCT GCGACCAGGA GTGTTCGGAA GAGGGCTGCT GGGGTCCAGG ACCCACCATG 1500
TGTGTCTCCT GTCGCCTTTT CAACCGTAGG GGGCGCTGTG TGGCGTTCTG CAACCTGCTG 1560
CAGGGCGAGC CCAGAGAGGT GGAGGTGGAC CGCCGCTGTG AGGAGTGTCA CCCCGAGTGT 1620
CTCCTGCAGG ACGGGACGCC GACCTGCAGA GGACCGGGCG CCGACCAGTG TTCCCAGTGC 1680
GCCAACCTGA AGGACGGCGC CCACTGCGTT CGCCGCTGCC CCCATGGCGT GAAGTACGCG 1740
GACCGGACCG GACGGTGCCA GCCGTGCCAC CAGAACTGCA CCCAGGGGTG TTCCGGAGAA 1800
GGACTCCCAG GATGCAACGG CGCGCCCGTA GCCTCCAGCA TGGCGGTGGC CGTGGTCGGC 1860
GGGCTCCTCA TCGCGGTCAT TGTGGCGTTG GTCATCTTCG TGTTGCTGCG GCGACGGCGA 1920
ATCCGGAGGA AGAGGACGAC GCGCCGCCTG CTGCAGGAGA GAGAGCTGGT GGAGCCGTTG 1980
ACGCCGAGTG GAGAAGCGCC CAATCAGGCG CTGCTGAGGA TCCTCAAGGA GACGGAATTC 2040
AAGAAGATCC GGGTGCTCGG CTCCGGGGCC TTCGGAACCG TCTTCAAGGG CCGGTGGAAC 2100
CCTGAGGGAG AGAACGTGAG GATCCCCGTA GCCATTAAAG TTCTCCGCGA AGCCACGTCG 2160
CCTAAAGCCA ACAAAGAAAT CCTGGACGAG GCGTACGTGA TGGCGAGCGT GGACCACCCT 2220
CACGTGTGCC GCCTGCTGGG GATCTGCCTC ACGTCCTCGG TGCAGCTGGT GACTCAGCTG 2280
ATGCCGTACG GCTGTTTGCT GGACTACGTG CGCCACCACA GGGACCACGT CGGCGCCCAG 2340
TGGCTCCTCA ATTGCTGCGT CCAGATGGCC AAGGGCATGA ACTATCTGGA GGAGCGTCAC 2400
CTGGTGCACC GTGACCTGGC GGCTAGGAAC GTCCTGGTGA AGACCCCCAA CCATGTGAAG 2460
ATCACCGACT TCGGTCTGGC CAAGCTGCTG GCGTCCGACG AGCAGGAGTA CCACGCCGAC 2520
GGAGGGAAGG TTCCCATTAA GTGGATGGCA CTGGAGTCAA TCCTCCAGTG GACCTACACC 2580
CACCAGAGTG ACGTCTGGAG CTTCGGCGTG ACGGTGTGGG AGCTCATGAC GTTTGGCACC 2640
AAGCCGTACG ACGGCATCCC GGCCAGCGAG ATGTCGTCGG TTCTGGAGAG AGGAGACCGG 2700
CTGCCTCAGC CCCCCATCTG CACCATCGAG GTCTACATGA TCCTGGTGAA GTGTTGGATG 2760
ATTGACCCGT CCAGTCGTCC CAGGTTCAGA GAGCTGATAG TGGAGTTCTC AAAGATGGCC 2820
AGAGATCCAT CCAGATACCT GGTTGTGGAG GGTGACCTCC CCAGTCCGTC AGACAGCAGG 2880
TTTTACTCCC GCCTGCTAAG CTCAGATGAC ATGGAGGACG TGGTAGACGC CGACGAGTAC 2940
CTGCTACCCT TCAAAGGAAC GGGTTGCCAT GACAACGGGT CCTGCCATGC CGCGAACGGT 3000
CATCCAGTCC GACAGAACAG CATCGCTCTG CGTTACATCA CCGATCCGAC CCACAACGCC 3060
ACGGACAAAG AAGACTTCAG CGGCCACGAC TACAGGAACC AGAGTCTGAG TGAAACCAGC 3120
GGGACCAGCA GGCTGTCCGA AGTGTTCAAT CCCAACTACG AGGACTTGAG CGTGGGCTGG 3180
GGCGCCGCCT CGCCCCCCTT GCCGCTGGAG GAGCTGAAGT CTTTGGGACC CGAATACCTG 3240
AACACCGCCC AGAGCTCGCT GCCTGCGGCC GCCGGCGACA GCCTCGACAA CCCGGACTAC 3300
CAGGCAGATT TCCTGCCTGG TAGTCCGGCC ACGCCGCCCG GGAACGCTCT TTTCCTCCCG 3360
GCGGCGGAGA ACCTGGAGTA CCTGGGTTTG GGGGCTGCAC TGTACGCCCC CGTCCGCTAG 3420
Domain Profile
S: 1     lkklkvlGsGafGtvykGiwipegenvkipvaikvleektgkkankelldealvlasldh  60
         +kk++vlGsGafGtv+kG w pegenv+ipvaikvl+e+t++kanke+ldea+v+as+dh
Q: 680   FKKIRVLGSGAFGTVFKGRWNPEGENVRIPVAIKVLREATSPKANKEILDEAYVMASVDH  739
         599*********************************************************
S: 61    anlvrllglclsstlqlvtqllplGclldyvrehkdklGsqellnwcvqiakGmsyleek  120
         ++++rllg+cl+s++qlvtql+p+Gclldyvr+h+d++G+q lln cvq+akGm+ylee+
Q: 740   PHVCRLLGICLTSSVQLVTQLMPYGCLLDYVRHHRDHVGAQWLLNCCVQMAKGMNYLEER  799
         ************************************************************
S: 121   rlvhrdlaarnvlvkspnhvkitdfGlaklleadekelkaeggkvpikwlalesilkrky  180
         +lvhrdlaarnvlvk+pnhvkitdfGlakll +de+e++a+ggkvpikw+alesil+ +y
Q: 800   HLVHRDLAARNVLVKTPNHVKITDFGLAKLLASDEQEYHADGGKVPIKWMALESILQWTY  859
         ************************************************************
S: 181   thqsdvwsyGvtvwelltfGakpydgipakeipdllekGerlaqppictidvymvlvkcw  240
         thqsdvws+Gvtvwel+tfG+kpydgipa+e++++le+G+rl+qppicti+vym+lvkcw
Q: 860   THQSDVWSFGVTVWELMTFGTKPYDGIPASEMSSVLERGDRLPQPPICTIEVYMILVKCW  919
         ************************************************************
S: 241   midaesrpkfkelaeefs  258
         mid++srp+f+el+ efs
Q: 920   MIDPSSRPRFRELIVEFS  937
         ****************96
Domain Sequence
(FASTA)
FKKIRVLGSG AFGTVFKGRW NPEGENVRIP VAIKVLREAT SPKANKEILD EAYVMASVDH 60
PHVCRLLGIC LTSSVQLVTQ LMPYGCLLDY VRHHRDHVGA QWLLNCCVQM AKGMNYLEER 120
HLVHRDLAAR NVLVKTPNHV KITDFGLAKL LASDEQEYHA DGGKVPIKWM ALESILQWTY 180
THQSDVWSFG VTVWELMTFG TKPYDGIPAS EMSSVLERGD RLPQPPICTI EVYMILVKCW 240
MIDPSSRPRF RELIVEFS 258
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Oreochromis niloticus"; ?>Oryzias latipes"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>
EKS-ORN-00388
EKS-ORL-00359
EKS-TAR-00392
EKS-TEN-00388
Gene Ontology
GO:0016020; C:membrane
GO:0005524; F:ATP binding
GO:0004714; F:transmembrane receptor protein tyrosine kinase activity
GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway
KEGG
InterPros
IPR000494; EGF_rcpt_L.
IPR006211; Furin-like_Cys-rich_dom.
IPR006212; Furin_repeat.
IPR009030; Growth_fac_rcpt.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
Pfam
PF00757; Furin-like; 1.
PF07714; Pkinase_Tyr; 1.
PF01030; Recep_L_domain; 2.
SMARTs
SM00261; FU; 4.
SM00219; TyrKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013