EKS-GAA-00128
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-GAA-00128
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Tec368.71.7E-110362610249
StatusUnreviewed
Ensembl ProteinENSGACP00000024442
UniProt AccessionG3Q3J0;
Protein Name
Protein Synonyms/Alias
Gene NameITK
Gene Synonyms/Alias ITK;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSGACG00000018485ENSGACP00000024442ENSGACT00000024491
OrganismGasterosteus aculeatus
Functional Description
Protein Length613
Protein Sequence
(FASTA)
MFPRVILKGT LIKKSQQKKR TSPCNYKERF FVLDTQDLKY SERRPGRKPM QKGCIELSRI 60
KCVEIVCSDL PIPCDYKYPF QVFHNNYYLY IFAPDNDCRL RWVRALKEET KSNDLATKYH 120
PNFWTDGKWR CCQQTGKLAT GCHLYDPVGY ASKKPLPQLP DKEMELHDTG TVIALQDYTP 180
PGGADLPLLK DQEYTLVNKG HCDWWAVRDD RGNTGFVPST YVAEKSGANF QRFQWYNKNI 240
TRGMAEDLLM KQGKEGAFMV RDSRQAGVYT VSVFTKAPGS NGEKNPRVKH YQIRQTETAE 300
SKFYLAEKYL FSTIPELIHY HQHNAAGLIT RLRHPVSQDG GCCSKDIAGP STDQWELDPE 360
ELTFGRELGS GQFGLVLEGR WRDSKVAVKT IREECMSDED FKEEARIMMR LSHCKLVQLY 420
AVHTQRSPMC LVFEFMDNGC LSDYLRARKG HFSQDTMLSM CMDVSEGMAY LENCNFIHRD 480
LAARNCLVSK NNEVKVSDFG MTRFVLDDQY TSSQCSKFPV RWSAPEVIKF SKFSSKSDIW 540
SFGVFLLPSL CLSLVEYKSK SNVEVVESLS KGLRLLKPRL APEAIHRLME WCWKEKPEDR 600
PSFALLLREL PSL 613
Nucleotide Sequence
(FASTA)
ATGTTCCCCA GGGTGATTTT GAAGGGAACT TTGATAAAAA AATCTCAACA AAAGAAGAGA 60
ACATCACCGT GCAACTACAA AGAGAGGTTT TTTGTATTGG ACACACAAGA TCTGAAATAT 120
TCTGAACGCC GCCCTGGAAG AAAGCCCATG CAGAAAGGTT GCATCGAGCT CTCCAGAATC 180
AAATGTGTGG AGATTGTGTG CAGCGATCTT CCAATACCAT GCGACTACAA GTACCCGTTT 240
CAGGTTTTTC ACAACAACTA CTACCTGTAC ATTTTCGCCC CAGACAATGA TTGCCGTCTG 300
AGATGGGTCA GAGCTCTGAA AGAGGAGACA AAGTCTAACG ATTTGGCCAC CAAATACCAC 360
CCAAACTTCT GGACGGATGG AAAATGGAGA TGCTGTCAAC AAACAGGGAA ACTGGCCACA 420
GGTTGTCATT TGTATGACCC AGTGGGTTAT GCTTCTAAAA AGCCACTTCC TCAACTCCCA 480
GATAAAGAGA TGGAACTGCA CGATACAGGT ACAGTCATCG CCCTGCAGGA CTACACGCCC 540
CCCGGAGGCG CTGACTTGCC CCTTCTGAAA GACCAGGAGT ACACCCTGGT CAACAAAGGC 600
CACTGCGACT GGTGGGCCGT GCGGGATGAC AGAGGAAACA CGGGCTTTGT GCCCAGTACG 660
TATGTAGCCG AAAAATCCGG CGCCAACTTC CAGAGATTTC AATGGTACAA CAAAAACATA 720
ACCAGGGGCA TGGCAGAGGA TTTGCTAATG AAACAGGGAA AAGAAGGCGC CTTTATGGTA 780
CGTGACTCAA GACAAGCGGG AGTCTACACA GTGTCCGTCT TCACCAAAGC ACCGGGCTCT 840
AACGGGGAGA AGAATCCAAG AGTCAAACAT TACCAAATTC GACAGACGGA AACTGCAGAG 900
TCCAAGTTCT ACCTAGCAGA GAAGTACCTG TTCAGCACCA TTCCTGAGCT CATCCATTAC 960
CATCAACACA ACGCTGCGGG CCTGATAACT CGTTTGCGAC ACCCAGTATC TCAAGACGGG 1020
GGCTGCTGCT CTAAGGACAT CGCCGGCCCC TCAACAGATC AGTGGGAGCT GGACCCAGAG 1080
GAGCTGACCT TCGGTCGGGA GTTGGGCAGC GGCCAGTTTG GTCTCGTGCT GGAAGGGAGG 1140
TGGAGGGACA GCAAGGTGGC AGTGAAGACG ATACGAGAAG AGTGCATGTC AGACGAGGAT 1200
TTTAAAGAAG AGGCGAGAAT CATGATGAGG CTGTCTCATT GTAAGCTGGT CCAGCTCTAC 1260
GCCGTCCACA CCCAGCGCTC CCCCATGTGT CTGGTGTTTG AGTTCATGGA CAACGGCTGT 1320
CTGTCGGACT ACCTGCGAGC CAGGAAGGGG CACTTCTCTC AGGACACCAT GTTGAGTATG 1380
TGCATGGATG TCAGTGAGGG GATGGCGTAC CTGGAGAACT GCAACTTCAT CCACAGAGAT 1440
CTGGCTGCCA GGAACTGCCT AGTTTCAAAG AACAATGAGG TGAAGGTGTC CGACTTCGGC 1500
ATGACCAGAT TTGTGCTTGA TGATCAGTAC ACAAGCTCCC AGTGCTCCAA GTTCCCCGTC 1560
AGGTGGTCGG CGCCAGAGGT CATCAAGTTC TCCAAGTTCA GCAGCAAGTC CGACATCTGG 1620
TCATTTGGTG TGTTTTTGCT TCCATCTCTG TGCCTTTCAC TTGTTGAGTA CAAATCAAAA 1680
TCAAATGTCG AAGTGGTGGA GTCCCTGAGC AAAGGCCTGA GGCTCCTGAA GCCACGCTTG 1740
GCCCCGGAAG CTATCCACCG GCTCATGGAG TGGTGCTGGA AGGAGAAACC AGAAGACCGT 1800
CCGTCCTTTG CTCTTCTCCT GCGTGAGCTG CCCTCCCTCT AA 1842
Domain Profile
S: 1     ltllkelgsgqfgvvklgkwrakidvaikaikegamseedfieeakvmmklshpklvqly  60
         lt+ +elgsgqfg+v  g+wr   +va+k+i+e +ms+edf eea++mm+lsh klvqly
Q: 362   LTFGRELGSGQFGLVLEGRWRD-SKVAVKTIREECMSDEDFKEEARIMMRLSHCKLVQLY  420
         6899****************97.58***********************************
S: 61    gvclkqkpiyivteylengcllnylrekkkklekelllemckdvcegmeylerksfihrd  120
          v +++ p+++v+e+++ngcl++ylr +k++++++++l+mc+dv+egm+yle+ +fihrd
Q: 421   AVHTQRSPMCLVFEFMDNGCLSDYLRARKGHFSQDTMLSMCMDVSEGMAYLENCNFIHRD  480
         ************************************************************
S: 121   laarnclvdeelvvkvsdfglaryvlddqyvssvgakfpvkwsppevlsyskyssksdvw  180
         laarnclv++++ vkvsdfg++r+vlddqy+ss+ +kfpv+ws+pev+++sk+ssksd+w
Q: 481   LAARNCLVSKNNEVKVSDFGMTRFVLDDQYTSSQCSKFPVRWSAPEVIKFSKFSSKSDIW  540
         ************************************************************
S: 181   afgvlmwevfsegklpyekksnsevvekvsrglrlyrpklaskkvyevmkscwkekpeer  240
         +fgv++    ++  + y+ ksn+evve++s+glrl +p+la++ ++++m+ cwkekpe+r
Q: 541   SFGVFLLPSLCLSLVEYKSKSNVEVVESLSKGLRLLKPRLAPEAIHRLMEWCWKEKPEDR  600
         ************************************************************
S: 241   ptfkellsal  250
         p+f+ ll++l
Q: 601   PSFALLLREL  610
         *******987
Domain Sequence
(FASTA)
LTFGRELGSG QFGLVLEGRW RDSKVAVKTI REECMSDEDF KEEARIMMRL SHCKLVQLYA 60
VHTQRSPMCL VFEFMDNGCL SDYLRARKGH FSQDTMLSMC MDVSEGMAYL ENCNFIHRDL 120
AARNCLVSKN NEVKVSDFGM TRFVLDDQYT SSQCSKFPVR WSAPEVIKFS KFSSKSDIWS 180
FGVFLLPSLC LSLVEYKSKS NVEVVESLSK GLRLLKPRLA PEAIHRLMEW CWKEKPEDRP 240
SFALLLREL 249
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00101
EKS-ANC-00099
EKS-BOT-00110
EKS-CAJ-00111
EKS-CAF-00112
EKS-CAP-00105
EKS-DAR-00357
EKS-EQC-00108
EKS-FEC-00105
EKS-GAG-00090
EKS-GOG-00111
EKS-HOS-00113
EKS-ICT-00105
EKS-LAC-00114
EKS-LOA-00106
EKS-MAM-00105
EKS-MEG-00085
EKS-MOD-00106
EKS-MUM-00112
EKS-MUP-00113
EKS-MYL-00124
EKS-NOL-00103
EKS-OCP-00072
EKS-ORN-00134
EKS-ORA-00089
EKS-ORC-00102
EKS-ORL-00125
EKS-OTG-00112
EKS-PAT-00100
EKS-PES-00093
EKS-POA-00103
EKS-RAN-00108
EKS-SAH-00102
EKS-TAG-00138
EKS-TAR-00137
EKS-TEN-00127
EKS-XET-00091
EKS-XIM-00131
Gene Ontology
GO:0005622; C:intracellular
GO:0005524; F:ATP binding
GO:0005543; F:phospholipid binding
GO:0004713; F:protein tyrosine kinase activity
GO:0035556; P:intracellular signal transduction
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR011993; PH_like_dom.
IPR001849; Pleckstrin_homology.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980; SH2.
IPR001452; SH3_domain.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR001562; Znf_Btk_motif.
Pfam
PF00779; BTK; 1.
PF00169; PH; 1.
PF07714; Pkinase_Tyr; 1.
PF00017; SH2; 1.
PF00018; SH3_1; 1.
SMARTs
SM00107; BTK; 1.
SM00233; PH; 1.
SM00252; SH2; 1.
SM00326; SH3; 1.
SM00219; TyrKc; 1.
Prosites
PS50003; PH_DOMAIN; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS50001; SH2; 1.
PS50002; SH3; 1.
PS51113; ZF_BTK; 1.
Prints
PR00401; SH2DOMAIN.
PR00402; TECBTKDOMAIN.
PR00109; TYRKINASE.
Created Date20-Feb-2013