EKS-GAA-00080

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-GAA-00080

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/CDK	372.7	1.4E-111	19	316	298

Status

Unreviewed

Ensembl Protein

ENSGACP00000024480

UniProt Accession

G3Q3M8;

Protein Name

Protein Synonyms/Alias

Gene Name

CDK9

Gene Synonyms/Alias

CDK9;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGACG00000018517	ENSGACP00000024480	ENSGACT00000024529

Organism

Gasterosteus aculeatus

Functional Description

Protein Length

372

Protein Sequence
(FASTA)

MSKYYDGVEF PFCDEFSKYE KMAKIGQGTF GEVFKAKHRQ TGKKVALKKV LMENEKEGFP 60

ITALREIKIL QLLKHENVVN LIEICRTKAT QYNRYKGSIY LVFDFCEHDL AGLLSNANVK 120

FTLAEIKKVM QMLLNGLYYI HRNKILHRDM KAANVLITRD GVLKLADFGL ARAFSLAKNS 180

QGNRYTNRVV TLWYRPPELL LGERDYGPPI DLWGAGCIMA EMWTRSPIMQ GNTEQHQLTL 240

ISQLCGSITA EVWPSVDKKY ELYQKMELPK GQKRKVKDRL KAYVKDPYAL DLIDKLLVLD 300

PAQRIDSDDA LNHDFFWSDP MPSDLKNMLS THNTSMFEYL APPRRRGHMP QQQPNQNRNP 360

ATTSQAEFDR VF 372

Nucleotide Sequence
(FASTA)

ATGTCGAAAT ACTACGATGG AGTTGAATTT CCTTTCTGTG ACGAGTTCTC CAAATATGAA 60

AAAATGGCAA AAATAGGACA GGGAACCTTT GGGGAGGTGT TCAAAGCGAA GCACAGACAG 120

ACTGGGAAGA AGGTCGCTTT GAAGAAAGTG TTAATGGAGA ATGAGAAGGA AGGGTTCCCG 180

ATCACGGCTC TCAGAGAGAT CAAGATCTTG CAGCTGCTCA AACACGAGAA TGTGGTCAAC 240

CTGATAGAGA TCTGCAGAAC CAAAGCTACT CAGTACAACA GATACAAAGG CAGCATCTAC 300

CTGGTGTTTG ACTTCTGTGA GCACGACCTG GCCGGGCTGC TGAGCAACGC CAATGTAAAG 360

TTTACACTCG CAGAGATCAA GAAGGTCATG CAGATGCTGC TCAACGGATT GTACTACATC 420

CACAGAAACA AGATCCTTCA CAGAGATATG AAAGCAGCCA ACGTGCTGAT CACCAGAGAT 480

GGCGTCCTGA AGCTGGCCGA CTTTGGGTTG GCTCGAGCCT TCAGCCTGGC TAAAAACAGC 540

CAGGGGAACC GCTACACCAA CCGCGTGGTC ACACTCTGGT ACAGGCCTCC AGAGCTGCTG 600

CTGGGTGAGC GAGACTATGG CCCCCCCATC GACCTGTGGG GAGCAGGCTG CATCATGGCG 660

GAAATGTGGA CCAGGAGTCC CATAATGCAA GGGAACACTG AGCAGCATCA ACTCACTCTC 720

ATCAGCCAGC TGTGTGGTTC CATCACTGCT GAGGTGTGGC CGAGTGTGGA TAAGAAGTAT 780

GAGCTTTACC AGAAGATGGA GCTGCCTAAA GGCCAGAAGA GGAAAGTAAA GGATCGCCTG 840

AAAGCGTATG TCAAAGACCC GTACGCCCTG GATCTGATAG ACAAACTCCT GGTCCTGGAC 900

CCGGCACAGC GCATAGACAG CGACGACGCG CTCAACCACG ACTTCTTCTG GTCCGACCCC 960

ATGCCGTCAG ACCTGAAGAA CATGCTCTCC ACCCACAACA CCTCCATGTT TGAATATCTG 1020

GCCCCACCCA GACGGAGAGG CCACATGCCC CAGCAGCAGC CCAACCAGAA CAGAAACCCA 1080

GCCACCACCA GTCAGGCTGA GTTTGATCGG GTGTTTTAG 1119

Domain Profile

S: 1     yeklekigeGtygkvykakdketgevvAlKkirlekekegvpitalrEisllkelkhkni  60

         yek++kig+Gt+g+v+kak+++tg++vAlKk+ +e+ekeg+pitalrEi++l+ lkh+n+

Q: 19    YEKMAKIGQGTFGEVFKAKHRQTGKKVALKKVLMENEKEGFPITALREIKILQLLKHENV  78

         99**********************************************************

S: 61    vkLlevva.......kdkkklyLvfefleqdLkkllkkkkkkklsleevkslllqllegl  113

         v+L+e++        + k ++yLvf+f+e+dL+ ll++ +  k++l+e+k+++++ll+gl

Q: 79    VNLIEICRtkatqynRYKGSIYLVFDFCEHDLAGLLSNANV-KFTLAEIKKVMQMLLNGL  137

         ********99999877789**********************.******************

S: 114   aylHsnkilHRDlKpqNlLiskegklklaDfGlaraf....ssplktytkevvTlwYraP  169

          y+H+nkilHRD+K++N+Li+++g+lklaDfGlaraf    +s+ ++yt++vvTlwYr+P

Q: 138   YYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFslakNSQGNRYTNRVVTLWYRPP  197

         *************************************7665555558*************

S: 170   elLlgakeYstavDiWsvgcilaelltrkplfqgkseidqlerifkllgtpsekvwpevs  229

         elLlg+++Y+  +D+W++gci+ae++tr+p++qg++e++ql+ i++l+g+++ +vwp+v

Q: 198   ELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLTLISQLCGSITAEVWPSVD  257

         **********************************************************97

S: 230   k.lpeyk.ksfpkkkkkklkekvkklkek..aldllekllaldpkkRisakealqhkyf  284

         k ++ y+ +++pk +k+k+k+++k++ ++  aldl++kll ldp++Ri++++al+h++f

Q: 258   KkYELYQkMELPKGQKRKVKDRLKAYVKDpyALDLIDKLLVLDPAQRIDSDDALNHDFF  316

         526777789999*9999******988766579*************************98

Domain Sequence
(FASTA)

YEKMAKIGQG TFGEVFKAKH RQTGKKVALK KVLMENEKEG FPITALREIK ILQLLKHENV 60

VNLIEICRTK ATQYNRYKGS IYLVFDFCEH DLAGLLSNAN VKFTLAEIKK VMQMLLNGLY 120

YIHRNKILHR DMKAANVLIT RDGVLKLADF GLARAFSLAK NSQGNRYTNR VVTLWYRPPE 180

LLLGERDYGP PIDLWGAGCI MAEMWTRSPI MQGNTEQHQL TLISQLCGSI TAEVWPSVDK 240

KYELYQKMEL PKGQKRKVKD RLKAYVKDPY ALDLIDKLLV LDPAQRIDSD DALNHDFF 298

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013