EKS-GAA-00189

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-GAA-00189

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/RSKb	477.6	1.2E-143	425	683	259

Status

Unreviewed

Ensembl Protein

ENSGACP00000024513

UniProt Accession

G3Q3R1;

Protein Name

Ribosomal protein S6 kinase

Protein Synonyms/Alias

Gene Name

RPS6KA6

Gene Synonyms/Alias

RPS6KA6;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGACG00000018545	ENSGACP00000024513	ENSGACT00000024562

Organism

Gasterosteus aculeatus

Functional Description

Protein Length

745

Protein Sequence
(FASTA)

LRCRRLGEQS WHKMEVNSVC SEVNGHEIMD EPMEEGESFS HCDEDTYEEI PITHHVKEGC 60

EKADPSQFEL LKVLGQGSFG KVFLVRKILG PDAGQLYAMK VLKKASLKVR DRVRTKMERD 120

ILVEVNHPFI VKLHYAFQTE GKLYLILDFL RGGDVFTRLS KEVMFTEEDV KFYLAELALA 180

LDHLHSLGIV YRDLKPENIL LDEAGHIKLT DFGLSKESVD ADKKAYSFCG TVEYMAPEVV 240

NRRGHTQSAD WWSLGVLMFE MLTGTLPFQG KDRNETMNMI LKAKLGMPQF LSLEAQSLLR 300

MLFKRNPANR LGAGPDGVEE IKRHAFFSTI DWNVSAHKHT HTHNSPASGE ASHLSNGWLV 360

KFWPSVSCVC LGRGPVLNVC AIFCFIMFVQ PVAVNEHSSL HPFYIHPFEC SFQMHGGSTK 420

FSDLYELQED IGVGSYSICK RCVHRVSAMD YAVKVIIDKS KRDPSEEIEI LMRYGQHPNI 480

ITLKDVYDEG RYVYLVTELM KGGELLDKIL RQKFFSEREA SAVLYTITKT VDYLHCQGVV 540

HRDLKPSNIL YMDDSGNPDS IRICDFGFAK QLRGGNGLLL TPCYTANFVA PEVLMRQGYD 600

AACDIWSLGV LLYTMLAGYT PFANGPNDTP EEILLRIGSG KFSLTGGNWD TVSDTSKDLL 660

SHMLHVDPHQ RYTAEQVLKH SWITCRDALP HFQLTRHDAP HLVKGAMAAT YSALSQKTSQ 720

PVLEPVAASS LAQRRSMKKL TSTDM 745

Nucleotide Sequence
(FASTA)

CTGCGATGCC GTAGACTTGG AGAGCAATCC TGGCACAAGA TGGAGGTAAA CAGCGTCTGT 60

AGTGAGGTCA ACGGACATGA GATCATGGAC GAGCCCATGG AGGAGGGAGA GTCTTTCTCA 120

CACTGCGATG AAGATACGTA CGAGGAGATT CCGATCACCC ACCACGTGAA GGAAGGCTGC 180

GAGAAAGCGG ATCCATCGCA GTTCGAGCTG CTCAAAGTCC TCGGCCAAGG CTCCTTCGGC 240

AAGGTGTTTC TGGTCAGGAA GATCTTGGGC CCAGATGCTG GTCAGTTATA TGCAATGAAA 300

GTCCTAAAAA AGGCATCCTT GAAAGTCAGG GACAGAGTTC GCACTAAGAT GGAAAGAGAC 360

ATTTTAGTGG AAGTCAATCA TCCCTTCATA GTGAAGCTGC ACTACGCCTT TCAGACAGAA 420

GGGAAACTGT ATTTAATACT GGACTTTCTC AGGGGAGGGG ATGTATTCAC TCGCCTATCC 480

AAAGAGGTTA TGTTTACAGA GGAAGATGTG AAATTCTACC TTGCAGAGCT GGCCCTGGCC 540

CTCGACCACT TGCACAGCCT GGGCATAGTT TACAGAGATC TAAAGCCGGA GAACATCTTA 600

CTTGATGAAG CTGGACACAT AAAGTTAACA GACTTTGGTT TGAGTAAAGA GTCAGTAGAT 660

GCTGATAAGA AGGCTTATTC CTTCTGTGGT ACGGTGGAGT ATATGGCCCC TGAGGTGGTC 720

AACCGGAGAG GACACACACA GAGCGCGGAC TGGTGGTCTC TGGGAGTGCT TATGTTTGAG 780

ATGCTAACGG GGACGCTACC ATTCCAAGGG AAAGACCGTA ATGAAACCAT GAACATGATT 840

CTCAAGGCAA AGTTGGGAAT GCCCCAGTTC CTGAGTTTGG AAGCCCAGAG TTTGCTGAGA 900

ATGCTGTTCA AACGTAACCC TGCGAACCGG CTAGGGGCCG GGCCCGACGG AGTGGAGGAG 960

ATCAAACGGC ACGCTTTCTT TTCCACCATC GACTGGAATG TGAGCGCACA CAAACACACA 1020

CACACACATA ACTCTCCAGC TTCTGGTGAG GCTTCACACC TATCAAACGG TTGGCTTGTG 1080

AAGTTCTGGC CATCAGTGTC GTGTGTGTGT CTGGGCAGAG GGCCAGTTCT CAATGTGTGT 1140

GCGATATTTT GTTTCATAAT GTTCGTTCAA CCTGTAGCTG TTAATGAACA TTCATCACTT 1200

CACCCCTTTT ATATCCACCC GTTTGAATGT TCCTTCCAGA TGCACGGGGG CTCGACCAAG 1260

TTCTCCGATC TTTACGAGCT GCAGGAGGAC ATTGGTGTGG GCTCCTACTC CATTTGTAAA 1320

CGCTGTGTAC ACCGAGTCTC TGCCATGGAC TACGCTGTGA AGGTAATTAT AGACAAAAGT 1380

AAGCGGGACC CTTCTGAAGA GATCGAAATC CTGATGCGAT ACGGACAGCA TCCCAACATC 1440

ATCACGCTGA AAGACGTGTA TGACGAGGGC AGGTATGTCT ACCTCGTGAC TGAGCTAATG 1500

AAGGGAGGGG AGCTGCTGGA CAAGATCCTC AGGCAGAAGT TCTTCTCTGA GAGAGAGGCC 1560

AGTGCTGTGC TCTACACCAT CACCAAGACT GTTGACTACC TCCACTGCCA AGGGGTGGTG 1620

CACCGAGACC TGAAGCCCAG TAACATCCTA TACATGGATG ACTCGGGGAA CCCAGACTCC 1680

ATCAGGATCT GTGACTTTGG ATTTGCCAAA CAGCTTCGGG GAGGCAACGG CCTGCTCCTC 1740

ACGCCCTGTT ACACCGCCAA CTTTGTGGCG CCAGAGGTAC TTATGCGACA AGGTTATGAT 1800

GCGGCCTGTG ATATATGGAG TCTTGGAGTT CTACTGTATA CTATGCTGGC AGGGTACACG 1860

CCGTTTGCTA ACGGCCCAAA CGACACGCCG GAGGAGATCC TCCTGCGGAT AGGATCGGGA 1920

AAGTTCTCTC TGACCGGTGG CAACTGGGAC ACGGTATCGG ACACCTCAAA GGACCTGCTG 1980

TCCCATATGC TCCATGTGGA CCCCCACCAG CGATACACAG CCGAGCAGGT GCTGAAGCAC 2040

TCCTGGATCA CCTGCAGAGA TGCGCTACCA CATTTCCAGC TCACACGCCA CGACGCGCCG 2100

CATCTCGTGA AGGGAGCTAT GGCTGCAACC TATTCCGCAC TGAGCCAGAA GACGAGTCAG 2160

CCGGTGTTGG AGCCTGTGGC GGCGTCCAGT TTAGCCCAGA GACGCAGCAT GAAGAAACTC 2220

ACCTCAACTG ACATGTAG 2238

Domain Profile

S: 1     yevkedlGvGsysvckrcvhkatnqefavk.iidkskrdtseeieillryeqhpnivtlk  59

         ye++ed+GvGsys+ckrcvh+ + +++avk iidkskrd+seeieil+ry+qhpni+tlk

Q: 425   YELQEDIGVGSYSICKRCVHRVSAMDYAVKvIIDKSKRDPSEEIEILMRYGQHPNIITLK  484

         6899**************************4479**************************

S: 60    dvyddgkyvylvlellkGGelldrikkkkffsereasailrtlvkaveylheqGvvhrdl  119

         dvyd+g+yvylv+el+kGGelld+i+++kffsereasa+l+t++k+v+ylh+qGvvhrdl

Q: 485   DVYDEGRYVYLVTELMKGGELLDKILRQKFFSEREASAVLYTITKTVDYLHCQGVVHRDL  544

         ************************************************************

S: 120   kpenilyvdesdnaesikiidfGfaklkraengllktpcytlnfvapevlkrqGydeacd  179

         kp+nily+d+s+n++si+i+dfGfak++r  ngll tpcyt+nfvapevl+rqGyd+acd

Q: 545   KPSNILYMDDSGNPDSIRICDFGFAKQLRGGNGLLLTPCYTANFVAPEVLMRQGYDAACD  604

         ************************************************************

S: 180   lwslGvllytmlaGyvpfangpedtaeeilakikeGkfslsGeawdsvseeakdlvskll  239

         +wslGvllytmlaGy+pfangp+dt+eeil +i++Gkfsl G++wd+vs+++kdl+s++l

Q: 605   IWSLGVLLYTMLAGYTPFANGPNDTPEEILLRIGSGKFSLTGGNWDTVSDTSKDLLSHML  664

         ************************************************************

S: 240   tvdpakrlkleqllkhswl  258

         +vdp++r+++eq+lkhsw+

Q: 665   HVDPHQRYTAEQVLKHSWI  683

         ******************8

Domain Sequence
(FASTA)

YELQEDIGVG SYSICKRCVH RVSAMDYAVK VIIDKSKRDP SEEIEILMRY GQHPNIITLK 60

DVYDEGRYVY LVTELMKGGE LLDKILRQKF FSEREASAVL YTITKTVDYL HCQGVVHRDL 120

KPSNILYMDD SGNPDSIRIC DFGFAKQLRG GNGLLLTPCY TANFVAPEVL MRQGYDAACD 180

IWSLGVLLYT MLAGYTPFAN GPNDTPEEIL LRIGSGKFSL TGGNWDTVSD TSKDLLSHML 240

HVDPHQRYTA EQVLKHSWI 259

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Callithrix jacchus"; ?>Danio rerio"; ?>Equus caballus"; ?>Gallus gallus"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryzias latipes"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0000287	; F:magnesium ion binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0007243	; P:intracellular protein kinase cascade

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR016239	; Ribosomal_S6_kinase_II.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 2.

SMARTs

SM00220

; S_TKc; 2.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 2.
PS50011	; PROTEIN_KINASE_DOM; 2.
PS00108	; PROTEIN_KINASE_ST; 2.

Prints

Created Date

20-Feb-2013