EKS-GAA-00126

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-GAA-00126

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Tec	449.0	5.5E-135	365	614	250

Status

Unreviewed

Ensembl Protein

ENSGACP00000024565

UniProt Accession

G3Q3W4;

Protein Name

Protein Synonyms/Alias

Gene Name

TEC

Gene Synonyms/Alias

TEC;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGACG00000018577	ENSGACP00000024565	ENSGACT00000024614
ENSGACG00000018577	ENSGACP00000024568	ENSGACT00000024617

Organism

Gasterosteus aculeatus

Functional Description

Protein Length

626

Protein Sequence
(FASTA)

MSAGLLLEET LIKRSQQKKR TSPLNYKERL FVLTESQLAY YDGRRERKFQ RGSIELRRIR 60

CAEIVKHGGG IMPCQNKYPF QVVYDNNTLY VFAPNPDSRS LWVQSLKGEI KDNAVVSAKF 120

HPQFWQEGAW LCCRQAEKLA PGCEEYNLFA DIIKVLPPPV SISRKPLPPI PEDERNKKVV 180

VVALYDFPGT EPHDLSLVKG GEYVILDKCD ANWYKARNQQ GEDGYIPSNY VTERKSGSLV 240

QFGWYSKQVN RNKAEELLRK EVSDLVTLLC FFPFTLRHVD ETKLMSSGVA CIKHYHIKET 300

LTSPPQFYLA EKHLFSSVPE LIEYHKHNAA GLVARLRYPV GKQDKSAPST AGFSYEKWEI 360

NPSELTFMKE LGSGQFGVVR LGKWRAQHRV AIKAIRAGAM YEEDFIEEAK VMMRLSHPKL 420

VQLYGVCSQQ KPIYIVTEFM EHGCLLNFLR QRRGSFGLGS LLSICLDICE AMEHLEAHRF 480

IHRDLASRNC LVNDSLVVKV SDFGMTRYVL DDQYTSSSGA KFPVKWSPPE VFNFCKYSSK 540

SDVWSYGVLM WEVFTEGRMP FEQSQNHEVV TMVTKGQRLH RPKMAPLAIY DIMQLTWQER 600

PDDRPSFSQL CPMISDALES DTPPPN 626

Nucleotide Sequence
(FASTA)

ATGAGTGCCG GGCTGCTATT GGAGGAGACG CTCATCAAGC GCTCGCAGCA GAAGAAGAGG 60

ACGTCGCCGC TGAACTACAA GGAGCGACTG TTTGTCCTGA CGGAGAGCCA GCTGGCGTAC 120

TACGATGGAC GGAGAGAGAG GAAGTTTCAG AGAGGCTCGA TCGAGCTGAG ACGCATCCGA 180

TGCGCCGAGA TCGTGAAGCA CGGAGGAGGA ATCATGCCCT GCCAGAACAA ATACCCCTTC 240

CAGGTGGTCT ACGACAACAA CACCCTCTAC GTGTTCGCCC CCAACCCCGA CAGCAGAAGC 300

CTCTGGGTCC AGAGCCTGAA GGGGGAGATC AAAGACAACG CCGTGGTCTC CGCCAAGTTC 360

CACCCTCAGT TCTGGCAGGA AGGGGCGTGG CTCTGCTGCC GGCAGGCGGA GAAACTGGCG 420

CCCGGCTGCG AGGAGTACAA CCTGTTTGCA GACATAATTA AAGTACTTCC ACCTCCAGTC 480

AGCATTTCAA GAAAACCGCT ACCGCCGATT CCTGAAGACG AGCGAAACAA GAAGGTAGTG 540

GTGGTGGCGC TGTACGACTT CCCCGGCACC GAGCCGCACG ACCTGAGTCT GGTCAAAGGG 600

GGCGAGTACG TCATCCTGGA CAAGTGCGAC GCCAACTGGT ACAAAGCGCG CAACCAGCAG 660

GGGGAGGACG GATACATCCC CAGCAACTAC GTCACCGAGC GGAAGTCCGG CAGCCTGGTG 720

CAGTTTGGTT GGTACAGTAA ACAAGTCAAC AGGAACAAGG CAGAGGAGCT GCTGAGGAAG 780

GAGGTGAGCG ATTTGGTCAC GTTGCTTTGT TTCTTTCCTT TCACACTCCG TCATGTGGAT 840

GAAACCAAAC TGATGTCGAG CGGAGTTGCA TGCATCAAAC ATTACCACAT CAAGGAGACG 900

CTCACATCGC CGCCGCAGTT TTACCTGGCT GAGAAACACC TGTTCAGCTC CGTCCCCGAA 960

CTCATCGAGT ACCACAAACA CAACGCGGCA GGTCTAGTTG CCCGGTTGCG GTATCCTGTA 1020

GGGAAGCAGG ACAAGTCGGC TCCGTCCACC GCCGGCTTCA GCTACGAGAA GTGGGAGATC 1080

AACCCCAGCG AGCTGACCTT CATGAAGGAG CTGGGCAGCG GTCAGTTCGG CGTGGTGAGG 1140

CTCGGAAAGT GGCGAGCTCA GCACAGAGTG GCCATCAAGG CCATCAGGGC GGGTGCCATG 1200

TACGAGGAGG ACTTCATCGA GGAGGCTAAA GTCATGATGA GGTTGTCCCA CCCGAAGCTG 1260

GTGCAGCTGT ACGGCGTCTG CAGCCAGCAG AAGCCCATCT ACATCGTCAC GGAGTTCATG 1320

GAGCACGGCT GCCTGCTGAA CTTCCTCAGG CAGCGGCGGG GCAGCTTCGG CCTGGGGTCC 1380

TTGCTGAGCA TCTGCCTGGA CATCTGCGAG GCCATGGAGC ACCTGGAGGC CCACCGCTTC 1440

ATCCACAGAG ACCTGGCTTC CAGAAACTGT CTGGTGAACG ACTCTCTGGT GGTGAAGGTG 1500

TCCGACTTCG GCATGACCAG ATACGTGTTG GACGACCAGT ACACCAGCTC GTCGGGGGCA 1560

AAGTTTCCAG TGAAGTGGTC GCCTCCCGAG GTCTTTAACT TCTGCAAATA CAGCAGCAAG 1620

TCGGACGTGT GGTCGTACGG GGTGCTGATG TGGGAGGTGT TCACAGAGGG CCGCATGCCG 1680

TTTGAGCAGA GTCAGAACCA CGAGGTGGTC ACCATGGTAA CCAAGGGGCA GCGCCTGCAC 1740

AGGCCCAAAA TGGCCCCGCT CGCCATCTAC GACATCATGC AGCTCACCTG GCAGGAGAGA 1800

CCCGACGATC GTCCGTCGTT CTCTCAGCTC TGCCCGATGA TCTCAGACGC CCTGGAGAGC 1860

GACACCCCTC CCCCCAACTG A 1881

Domain Profile

S: 1     ltllkelgsgqfgvvklgkwrakidvaikaikegamseedfieeakvmmklshpklvqly  60

         lt++kelgsgqfgvv+lgkwra+++vaikai+ gam eedfieeakvmm+lshpklvqly

Q: 365   LTFMKELGSGQFGVVRLGKWRAQHRVAIKAIRAGAMYEEDFIEEAKVMMRLSHPKLVQLY  424

         79**********************************************************

S: 61    gvclkqkpiyivteylengcllnylrekkkklekelllemckdvcegmeylerksfihrd  120

         gvc++qkpiyivte++e+gclln+lr++++++    ll++c d+ce+me+le + fihrd

Q: 425   GVCSQQKPIYIVTEFMEHGCLLNFLRQRRGSFGLGSLLSICLDICEAMEHLEAHRFIHRD  484

         ************************************************************

S: 121   laarnclvdeelvvkvsdfglaryvlddqyvssvgakfpvkwsppevlsyskyssksdvw  180

         la+rnclv+++lvvkvsdfg++ryvlddqy+ss+gakfpvkwsppev+++ kyssksdvw

Q: 485   LASRNCLVNDSLVVKVSDFGMTRYVLDDQYTSSSGAKFPVKWSPPEVFNFCKYSSKSDVW  544

         ************************************************************

S: 181   afgvlmwevfsegklpyekksnsevvekvsrglrlyrpklaskkvyevmkscwkekpeer  240

         ++gvlmwevf+eg++p+e+ +n+evv++v++g rl+rpk+a+  +y++m+  w+e+p++r

Q: 545   SYGVLMWEVFTEGRMPFEQSQNHEVVTMVTKGQRLHRPKMAPLAIYDIMQLTWQERPDDR  604

         ************************************************************

S: 241   ptfkellsal  250

         p+f++l   +

Q: 605   PSFSQLCPMI  614

         *****98766

Domain Sequence
(FASTA)

LTFMKELGSG QFGVVRLGKW RAQHRVAIKA IRAGAMYEED FIEEAKVMMR LSHPKLVQLY 60

GVCSQQKPIY IVTEFMEHGC LLNFLRQRRG SFGLGSLLSI CLDICEAMEH LEAHRFIHRD 120

LASRNCLVND SLVVKVSDFG MTRYVLDDQY TSSSGAKFPV KWSPPEVFNF CKYSSKSDVW 180

SYGVLMWEVF TEGRMPFEQS QNHEVVTMVT KGQRLHRPKM APLAIYDIMQ LTWQERPDDR 240

PSFSQLCPMI 250

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dasypus novemcinctus"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tursiops truncatus"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005622	; C:intracellular
GO:0005524	; F:ATP binding
GO:0005543	; F:phospholipid binding
GO:0004713	; F:protein tyrosine kinase activity
GO:0035556	; P:intracellular signal transduction

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR011993	; PH_like_dom.
IPR001849	; Pleckstrin_homology.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR001452	; SH3_domain.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR001562	; Znf_Btk_motif.

Pfam

PF00779	; BTK; 1.
PF00169	; PH; 1.
PF07714	; Pkinase_Tyr; 1.
PF00018	; SH3_1; 1.

SMARTs

SM00107	; BTK; 1.
SM00233	; PH; 1.
SM00252	; SH2; 1.
SM00326	; SH3; 1.
SM00219	; TyrKc; 1.

Prosites

PS50003	; PH_DOMAIN; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50001	; SH2; 1.
PS50002	; SH3; 1.
PS51113	; ZF_BTK; 1.

Prints

PR00452	; SH3DOMAIN.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013