EKS-GAA-00428

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-GAA-00428

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Ack	382.5	1.2E-114	117	371	255

Status

Unreviewed

Ensembl Protein

ENSGACP00000025654

UniProt Accession

G3Q6Z4;

Protein Name

Protein Synonyms/Alias

Gene Name

TNK1

Gene Synonyms/Alias

TNK1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGACG00000019408	ENSGACP00000025654	ENSGACT00000025704

Organism

Gasterosteus aculeatus

Functional Description

Protein Length

699

Protein Sequence
(FASTA)

MLMDQETQWL YHLLVEVQLE KFYTRVRDGL NITRIEHFNY VKESDLEQVG ISKPAQRRLW 60

EALKRYKTSS RTRQWLPKAG GGRGPDGGEQ RGPAQAQAQE GVSRTLPCLI QDSELIMGEK 120

LGSGSFGVVK RAEWHTPTGR VLPVAVKSLR SSMSRQTDTL TDFLQEVTTM QSLDHPNIIR 180

LYGVVLTQPL KMVTELALSG SLYDILRSRQ YDYPLMRLWF FASQIAAGMD YLETRRFIHR 240

DLAARNVLLA SREMVKIGDF GLMRGLNKET DHYVMSAHRR IPFAWCAPES LRVGTFSHSS 300

DVWMFGVTMW EMFTYCEEPW FGLSGRQILW RVEREGERLE KPPDCPKELY AVMRKCWACN 360

PTDRPSFLQL IKMVAERLEA KPKEGRATRD FSESRKLALA ANDPVTVIEH GLELSEWRGQ 420

NQKTLAVGWF PASLAAPAAT PSGPVPYIST PLNGSLHHAG HGDIKPERCW GAPDNLDDSW 480

KTGREGSNLK KMEGLSQSLE SVLGAQRPRA QTVGAFRVDQ QGRLLPPELM AVRNAAMQND 540

PRRFSEASIN PPPRPPLPNL KRLNLKPPRR PAAQPGRYPP HQGNGGSNLA RMAHMARSTP 600

QLDEHADNRE RIMEAVHGVT IEEVHAALQH SDWNPVRAEQ QLKLEQLYLL SLCSREDCVR 660

ILSRYQWNLQ LASSHLLRWA QEERAGPGDR LSVSLERRV 699

Nucleotide Sequence
(FASTA)

ATGCTGATGG ACCAGGAAAC TCAGTGGCTG TACCATCTCC TGGTTGAGGT CCAGCTGGAG 60

AAGTTCTACA CGCGCGTCCG AGATGGCCTC AACATCACCC GCATCGAGCA CTTCAACTAC 120

GTCAAGGAGT CCGACCTGGA GCAAGTCGGG ATCAGCAAAC CCGCACAAAG AAGATTATGG 180

GAAGCCCTGA AACGCTACAA GACGAGTTCC CGAACCCGGC AATGGCTTCC CAAGGCGGGC 240

GGCGGTCGAG GTCCAGACGG AGGGGAGCAG CGCGGCCCGG CTCAGGCTCA GGCTCAGGAG 300

GGAGTCAGCC GGACCCTCCC GTGTCTGATC CAGGACAGCG AGCTGATCAT GGGAGAGAAG 360

CTGGGCTCCG GCTCCTTCGG GGTGGTGAAG AGGGCCGAGT GGCACACGCC CACCGGCAGA 420

GTGTTGCCTG TAGCAGTGAA GTCCCTGAGG AGCAGCATGT CCCGGCAGAC GGACACACTG 480

ACCGACTTCC TGCAAGAGGT CACCACCATG CAGTCGCTGG ACCACCCCAA CATCATCCGA 540

CTCTACGGCG TGGTGCTCAC GCAGCCCCTC AAGATGGTGA CCGAGCTGGC GCTCTCGGGC 600

TCGCTGTACG ACATCCTGCG CTCGCGCCAG TACGACTACC CGCTGATGCG CCTGTGGTTC 660

TTCGCGTCCC AGATCGCGGC GGGCATGGAC TACCTGGAGA CGCGGAGGTT CATCCACAGG 720

GACTTGGCCG CGAGGAACGT GCTGCTGGCA TCCAGGGAGA TGGTGAAGAT CGGGGACTTC 780

GGCCTGATGC GAGGCCTGAA CAAAGAGACG GATCACTACG TGATGTCGGC ACACAGGAGG 840

ATCCCGTTCG CGTGGTGCGC TCCGGAGAGC CTTCGCGTCG GGACCTTCTC GCACTCTTCG 900

GACGTGTGGA TGTTTGGTGT CACCATGTGG GAAATGTTCA CCTACTGTGA AGAACCCTGG 960

TTCGGCCTTT CGGGCAGACA GATTCTGTGG CGCGTGGAGA GGGAGGGCGA GCGCCTGGAG 1020

AAACCGCCCG ATTGCCCCAA AGAGCTGTAC GCCGTCATGC GGAAGTGCTG GGCCTGCAAT 1080

CCCACGGACC GACCCAGCTT CCTCCAGCTC ATCAAGATGG TGGCCGAGCG CTTGGAGGCT 1140

AAACCAAAGG AGGGGCGCGC GACGAGAGAT TTCTCTGAAT CCAGAAAACT CGCACTGGCG 1200

GCCAACGACC CCGTGACCGT CATAGAACAC GGACTGGAGC TGAGCGAGTG GCGAGGCCAG 1260

AACCAGAAGA CGCTGGCGGT CGGCTGGTTT CCCGCCAGCC TCGCCGCCCC GGCGGCCACT 1320

CCCTCGGGCC CCGTCCCTTA CATCTCGACC CCGCTGAACG GCAGCCTGCA CCACGCGGGC 1380

CACGGGGACA TCAAGCCCGA GCGCTGCTGG GGGGCGCCGG ATAACCTGGA CGACAGCTGG 1440

AAGACGGGCA GGGAGGGCTC CAATCTGAAG AAGATGGAGG GTCTGTCTCA GAGCCTGGAG 1500

TCCGTTCTGG GGGCTCAGCG GCCCAGGGCG CAGACGGTCG GGGCTTTCCG AGTGGACCAG 1560

CAGGGCAGAC TCCTGCCCCC CGAGCTGATG GCGGTTCGCA ACGCGGCGAT GCAGAATGAC 1620

CCCCGGCGGT TCAGCGAGGC CAGTATCAAC CCGCCTCCCC GGCCGCCGCT GCCCAACCTG 1680

AAACGCTTGA ACCTGAAACC CCCGAGGAGG CCGGCGGCCC AGCCGGGCAG GTACCCACCT 1740

CACCAGGGCA ACGGGGGCTC CAACCTGGCT AGAATGGCAC ACATGGCGCG CTCGACCCCT 1800

CAGCTGGACG AGCACGCGGA CAACAGGGAG CGGATCATGG AGGCGGTTCA CGGGGTGACC 1860

ATTGAAGAGG TTCACGCCGC GCTCCAACAC AGCGACTGGA ACCCCGTGCG AGCCGAACAA 1920

CAACTCAAGT TGGAGCAGCT GTACTTGCTG AGCCTCTGCT CCAGAGAAGA CTGCGTGAGG 1980

ATCCTCTCCA GATACCAGTG GAACCTGCAG CTGGCCAGCA GCCACCTGCT CCGATGGGCG 2040

CAGGAGGAGA GGGCCGGCCC GGGCGACAGG CTCTCTGTTA GTTTGGAAAG ACGAGTCTGA 2100

Domain Profile

S: 3     lleklGeGsfgvvkrgeWsapsgksvqvavkvlksdkllstel.ddflrevsvllklehe  61

         ++eklG+Gsfgvvkr+eW++p+g++++vavk+l+s    +t++  dfl+ev+++++l+h+

Q: 117   MGEKLGSGSFGVVKRAEWHTPTGRVLPVAVKSLRSSMSRQTDTlTDFLQEVTTMQSLDHP  176

         789*******************************9999999988****************

S: 62    nlvrlyGvvltqplklvtelaelgslldrlrkeakrdsllvallleyavqiaeglayles  121

         n++rlyGvvltqplk+vtela  gsl+d lr+++    +++ +l+ +a qia g+ yle+

Q: 177   NIIRLYGVVLTQPLKMVTELALSGSLYDILRSRQY--DYPLMRLWFFASQIAAGMDYLET  234

         *******************************9999..799********************

S: 122   krlvhrdlaarnlllaskklvkisdfGlvralgeeedlyvlaenkkvPfaWcaPeslrtr  181

         +r++hrdlaarn+llas+++vki+dfGl+r l++e d+yv++ ++++PfaWcaPeslr

Q: 235   RRFIHRDLAARNVLLASREMVKIGDFGLMRGLNKETDHYVMSAHRRIPFAWCAPESLRVG  294

         ************************************************************

S: 182   kfssasdvWafGvtlWemfsyGeePWvglsglqilkkidkekerlekPeacpediyslll  241

         +fs++sdvW+fGvt+Wemf+y eePW glsg qil ++++e+erlekP++cp+++y+++

Q: 295   TFSHSSDVWMFGVTMWEMFTYCEEPWFGLSGRQILWRVEREGERLEKPPDCPKELYAVMR  354

         ************************************************************

S: 242   kcWakkpadrpkfsalk  258

         kcWa +p drp+f +l

Q: 355   KCWACNPTDRPSFLQLI  371

         *************9885

Domain Sequence
(FASTA)

MGEKLGSGSF GVVKRAEWHT PTGRVLPVAV KSLRSSMSRQ TDTLTDFLQE VTTMQSLDHP 60

NIIRLYGVVL TQPLKMVTEL ALSGSLYDIL RSRQYDYPLM RLWFFASQIA AGMDYLETRR 120

FIHRDLAARN VLLASREMVK IGDFGLMRGL NKETDHYVMS AHRRIPFAWC APESLRVGTF 180

SHSSDVWMFG VTMWEMFTYC EEPWFGLSGR QILWRVEREG ERLEKPPDCP KELYAVMRKC 240

WACNPTDRPS FLQLI 255

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Danio rerio"; ?>Echinops telfairi"; ?>Erinaceus europaeus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryzias latipes"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Procavia capensis"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

InterPros

IPR015116	; GTPase_binding.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR001452	; SH3_domain.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF09027	; GTPase_binding; 1.
PF07714	; Pkinase_Tyr; 1.

SMARTs

SM00326	; SH3; 1.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013