EKS-GAA-00182

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-GAA-00182

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/RSK	365.9	1.8E-109	66	327	262

Status

Unreviewed

Ensembl Protein

ENSGACP00000026703

UniProt Accession

G3Q9Y7;

Protein Name

Protein Synonyms/Alias

Gene Name

RPS6KB1 (1 of 2)

Gene Synonyms/Alias

RPS6KB1 (1 of 2);

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGACG00000020215	ENSGACP00000026703	ENSGACT00000026755

Organism

Gasterosteus aculeatus

Functional Description

Protein Length

500

Protein Sequence
(FASTA)

MAGVFDIDLD QPDGNVSDDD LEDGGQPGEY MDQCSGFDFN MDDCEKFEIS ENSVNQGTEP 60

IRPECFELLK VLGKGGYGKV FQVRKVSGST SGKIFAMKVL KKAMIVRNAK DTAHTKAERN 120

ILEEVKHPFI VDLIYAFQTG GKLYLILEYL SGGELFMQLE REGIFMEDTA CFYLAEISMA 180

LGHLHQKGII YRDLKPENIM LNNNGHVKLT DFGLCKESIH DGTVTHTFCG TIEYMAPEIL 240

MRSGHNRAVD WWSLGALMYD MLTGAPPFTG ENRKKTIDKI LKCKLSLPPY LTQEARDLLK 300

KLLKRNASLR LGAGPGDAAE VQAHPFFRHI NWDDLLARKV EPPFKPYLQS ADDVSQFDSK 360

FTSQTPVDSP DDSTLSESAN QAFLGFTYVA PSVLENVKER FSLEPKVRSP RKFPGSPRTP 420

VSPVKFVAGD CWLRGPPATG RTAEQPMEVS AAETMDTSGS GSEASAPLPI RLPKGINAGH 480

SKKQTYPMNS KRPEHLRMNL 500

Nucleotide Sequence
(FASTA)

ATGGCCGGTG TTTTCGACAT CGATTTGGAT CAACCGGATG GGAATGTTTC TGACGACGAC 60

CTCGAGGATG GGGGCCAGCC TGGTGAATAC ATGGACCAGT GCAGTGGCTT TGACTTTAAC 120

ATGGATGACT GTGAGAAGTT TGAAATTTCA GAAAACAGCG TCAACCAGGG AACAGAGCCG 180

ATCAGGCCTG AATGCTTTGA GCTGCTGAAA GTTTTGGGAA AAGGTGGCTA TGGAAAGGTG 240

TTTCAAGTGC GGAAGGTTTC TGGTTCCACC TCTGGGAAGA TATTCGCAAT GAAAGTTTTG 300

AAGAAAGCCA TGATTGTGCG TAATGCGAAG GACACCGCTC ACACTAAAGC CGAGAGGAAC 360

ATCCTGGAGG AGGTGAAGCA TCCTTTCATC GTGGACCTCA TCTATGCCTT CCAGACCGGG 420

GGAAAGCTGT ACCTCATCCT GGAGTATCTG AGCGGAGGGG AGCTGTTTAT GCAACTGGAA 480

AGAGAGGGCA TCTTCATGGA GGACACGGCA TGTTTCTACC TGGCTGAGAT CTCAATGGCA 540

CTTGGCCACC TGCACCAGAA AGGCATCATC TACAGAGACC TGAAGCCCGA GAACATCATG 600

CTCAACAACA ACGGACATGT AAAGCTGACA GACTTTGGTC TTTGCAAAGA GTCCATCCAC 660

GACGGGACGG TGACCCACAC CTTCTGTGGC ACTATCGAAT ACATGGCTCC AGAGATCCTG 720

ATGAGGAGTG GACACAACCG AGCTGTTGAC TGGTGGAGTT TGGGAGCTCT TATGTATGAC 780

ATGCTGACAG GGGCACCCCC ATTCACCGGT GAAAACCGAA AAAAGACAAT TGATAAAATC 840

TTGAAATGCA AACTCAGCCT TCCGCCTTAC CTAACACAAG AAGCCAGGGA CCTCCTGAAA 900

AAGCTGCTGA AACGAAATGC CTCGTTGCGT CTTGGTGCCG GACCAGGAGA TGCTGCCGAG 960

GTCCAGGCCC ACCCATTCTT CCGTCACATC AATTGGGATG ACCTCCTGGC TCGCAAAGTA 1020

GAGCCTCCAT TTAAGCCATA TCTGCAATCG GCTGATGACG TCAGCCAGTT TGACTCCAAG 1080

TTCACCAGCC AGACTCCAGT GGACAGCCCT GATGACTCCA CGCTCAGCGA GAGTGCCAAT 1140

CAAGCCTTCC TGGGTTTCAC ATATGTAGCC CCGTCTGTTC TGGAAAACGT CAAAGAAAGG 1200

TTCTCTCTTG AGCCAAAGGT GCGCTCACCC CGGAAGTTCC CAGGAAGCCC AAGAACACCT 1260

GTGAGTCCGG TGAAGTTTGT AGCTGGGGAC TGCTGGCTGC GGGGACCGCC GGCGACGGGA 1320

CGCACTGCGG AGCAACCCAT GGAGGTGTCT GCAGCGGAGA CAATGGACAC GAGCGGCAGT 1380

GGCTCTGAGG CCTCTGCGCC GCTCCCCATC AGGCTCCCTA AAGGCATCAA CGCGGGACAC 1440

TCCAAAAAGC AGACCTACCC CATGAACTCC AAGCGGCCAG AACACCTACG GATGAACCTA 1500

TGA 1503

Domain Profile

S: 1     fellkvlgkGaygkvflvrkvekkdtgklyavKvlkkaelvk..kkkertkeereiLeev  58

         fellkvlgkG+ygkvf+vrkv+++++gk++a+Kvlkka +v+  k++++tk+er+iLeev

Q: 66    FELLKVLGKGGYGKVFQVRKVSGSTSGKIFAMKVLKKAMIVRnaKDTAHTKAERNILEEV  125

         89***********************************9999999****************

S: 59    ehpfivklheafqdekklylvlellkGgeLlerlkkkklfseeeasfilaelvlaleylH  118

         +hpfiv+l +afq+  klyl+le+l+GgeL+++l+++++f+e++a+f+lae+++al +lH

Q: 126   KHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEISMALGHLH  185

         ************************************************************

S: 119   skgvvyrDLkpeNilldeeghvkltDfglakekiaeneekaysfcgTleyvaPevlkrkg  178

         +kg++yrDLkpeNi+l+++ghvkltDfgl+ke+i ++++ +++fcgT+ey+aPe+l+r+g

Q: 186   QKGIIYRDLKPENIMLNNNGHVKLTDFGLCKESI-HDGTVTHTFCGTIEYMAPEILMRSG  244

         *********************************9.9999999******************

S: 179   ydeavDlwslGvllyemLtGktPftgeerketlarilkgkfslklpaweelseeakdlvk  238

         +++avD+wslG+l+y+mLtG++Pftge+rk+t+++ilk+k  l+lp +  l++ea+dl+k

Q: 245   HNRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILKCK--LSLPPY--LTQEARDLLK  300

         ****************************************..99****..**********

S: 239   klLkkdpakRlga...taeeikehkfl  262

         klLk++ + Rlga   +a+e+++h+f+

Q: 301   KLLKRNASLRLGAgpgDAAEVQAHPFF  327

         *************9***********97

Domain Sequence
(FASTA)

FELLKVLGKG GYGKVFQVRK VSGSTSGKIF AMKVLKKAMI VRNAKDTAHT KAERNILEEV 60

KHPFIVDLIY AFQTGGKLYL ILEYLSGGEL FMQLEREGIF MEDTACFYLA EISMALGHLH 120

QKGIIYRDLK PENIMLNNNG HVKLTDFGLC KESIHDGTVT HTFCGTIEYM APEILMRSGH 180

NRAVDWWSLG ALMYDMLTGA PPFTGENRKK TIDKILKCKL SLPPYLTQEA RDLLKKLLKR 240

NASLRLGAGP GDAAEVQAHP FF 262

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0007165	; P:signal transduction

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR011009	; Kinase-like_dom.
IPR017892	; Pkinase_C.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR016238	; Ribosomal_S6_kinase.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069	; Pkinase; 1.
PF00433	; Pkinase_C; 1.

SMARTs

SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013