EKS-GAA-00194
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-GAA-00194
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
CAMK/RSKb399.39.1E-120410666257
StatusUnreviewed
Ensembl ProteinENSGACP00000026790
UniProt AccessionG3QA73;
Protein NameRibosomal protein S6 kinase
Protein Synonyms/Alias
Gene NameRPS6KA4
Gene Synonyms/Alias RPS6KA4;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSGACG00000020273ENSGACP00000026789ENSGACT00000026841
ENSGACG00000020273ENSGACP00000026790ENSGACT00000026842
OrganismGasterosteus aculeatus
Functional Description
Protein Length759
Protein Sequence
(FASTA)
KQQQQQKCVV SLYVYEANLT GHTERVGMEN FELLKVLGTG AYGKVFLVRK NTGHDVGQLY 60
AMKVLKKAAI VQKAKTTEHT RTERQVLEHI RQSPFLVTLH YAFQTQSKLH LILGCLCGGE 120
MFTHLYQRDH FPEDAVRIYI GEIILALEHL HKLGIVYRDI KLENILLDSE GHVVLTDFGL 180
SKEFLEEEKE RTYSFCGTIE YMAPEIIRGK SGHGKSVDWW SLGILMFELL TGASPFTLEG 240
ERNSQSEVSK RILRCDPPFP SMIEPTAQDL LRKLLVKDPH RRLGSGPRGS EDIKAHAFFK 300
GLNWADLAQR KVQSPFRPEL KSELDVGNFA EEFTGMDPVY SPASTPPSTD RLFQGYSFVA 360
PSILFNKNAV MGDFVKSHND RPASASVQRS AILEESQFFQ HYELCLHGPP LGEGSFSVCR 420
KCRHKQTGNE FAVKIVSRRM EANTQREVAA LRQCETHPNI VKLHEVYTDQ YHTYLVMELL 480
RGGELLERIK RKKLFGEAEA SQLLQSLVSA VSFMHEAGVV HRDLKPENVL FADEAEDSML 540
KVIDFGFARL CPAGSAPLQT PCFTLQYAAP ELFESAGYDK ACDLWSLGVI LYTMLSGQVP 600
FQSEQRGMTS SYAADIMQKI KEGDFSLDGE AWKGVSENAK ELVKGLLTVD PETRLKLSDL 660
KENSWLQGAA SMSTTPLCTP DVLESSGPTV RTYVNATYKA FNLGKREGFF LKSVDNAPLA 720
KRRKLKMTST GVETRSTTSK TQPKQTGTPK KSGTPKETS 759
Nucleotide Sequence
(FASTA)
AAACAGCAGC AGCAACAAAA ATGTGTGGTT TCACTGTATG TGTATGAAGC TAACCTCACA 60
GGTCACACTG AGAGGGTCGG TATGGAGAAC TTTGAGCTGC TTAAAGTCTT GGGCACCGGA 120
GCTTATGGTA AGGTGTTTTT GGTCCGGAAG AATACGGGTC ACGATGTGGG CCAGCTTTAT 180
GCTATGAAGG TGTTAAAGAA AGCAGCTATT GTTCAAAAAG CAAAGACGAC CGAACACACT 240
CGCACCGAGA GGCAGGTGCT GGAGCACATT CGCCAGTCCC CCTTCCTGGT CACGCTTCAC 300
TACGCCTTTC AGACGCAGAG CAAGCTGCAT CTCATCCTGG GATGTCTATG CGGCGGAGAG 360
ATGTTCACCC ACCTGTACCA GCGGGATCAC TTCCCCGAGG ACGCGGTGCG GATCTATATT 420
GGGGAAATAA TCCTGGCCCT GGAGCACCTG CACAAGCTGG GGATTGTGTA CAGAGACATC 480
AAATTGGAAA ACATTCTTCT GGACAGTGAA GGCCATGTGG TATTGACCGA TTTCGGGCTG 540
AGCAAGGAGT TTTTGGAGGA AGAGAAGGAA AGGACCTACT CTTTCTGTGG CACCATCGAG 600
TACATGGCAC CTGAGATCAT CCGGGGGAAA TCGGGGCACG GCAAGTCGGT AGATTGGTGG 660
AGTCTTGGCA TCCTGATGTT TGAGCTTCTG ACAGGCGCTT CTCCTTTTAC CCTGGAGGGC 720
GAGAGAAACT CCCAGAGCGA GGTGTCAAAA CGTATTCTTC GGTGTGATCC CCCGTTTCCC 780
TCTATGATCG AACCCACTGC TCAGGACCTG CTGAGGAAGT TGCTGGTGAA AGATCCTCAC 840
CGGCGGCTGG GCTCCGGACC ACGAGGGTCC GAAGACATCA AAGCACACGC CTTCTTCAAG 900
GGGCTGAACT GGGCCGACCT GGCACAGAGG AAGGTGCAGA GTCCTTTCAG GCCCGAGCTG 960
AAGAGCGAAC TCGATGTCGG GAACTTTGCT GAGGAATTCA CCGGGATGGA TCCCGTGTAC 1020
TCTCCGGCAA GCACACCGCC GAGCACCGAC CGCCTGTTCC AGGGTTACTC CTTTGTTGCC 1080
CCTTCCATCC TGTTCAACAA GAATGCGGTC ATGGGAGACT TTGTTAAATC CCACAATGAT 1140
CGTCCGGCTT CAGCCTCGGT GCAACGCAGT GCAATACTAG AGGAGTCCCA GTTCTTTCAG 1200
CACTATGAGC TGTGCCTTCA TGGGCCACCC CTGGGTGAGG GTAGCTTCTC AGTGTGCAGA 1260
AAATGCCGAC ATAAGCAAAC TGGCAACGAG TTTGCCGTCA AGATCGTCAG CCGAAGAATG 1320
GAGGCCAACA CCCAGAGGGA GGTTGCTGCT TTGCGGCAAT GTGAAACTCA CCCAAACATC 1380
GTCAAGCTGC ATGAAGTGTA CACTGATCAG TACCACACAT ATCTAGTGAT GGAGCTTCTG 1440
CGAGGTGGGG AGTTGCTGGA AAGGATTAAG AGGAAGAAAC TCTTTGGAGA GGCGGAGGCC 1500
AGTCAGCTGT TACAGAGCCT GGTCTCGGCG GTCAGCTTCA TGCATGAGGC CGGAGTCGTG 1560
CACCGAGACC TCAAACCAGA AAATGTGCTG TTTGCAGATG AGGCGGAGGA CTCCATGCTG 1620
AAAGTAATAG ATTTTGGATT TGCCCGCCTG TGCCCAGCAG GCAGCGCCCC CCTGCAGACT 1680
CCCTGCTTCA CGCTGCAGTA CGCTGCACCT GAACTTTTTG AGAGTGCAGG CTACGACAAA 1740
GCCTGCGACC TCTGGAGTCT TGGGGTCATC TTGTACACCA TGCTGTCAGG CCAGGTGCCA 1800
TTTCAGAGTG AGCAGCGGGG GATGACCTCA TCGTACGCCG CTGACATCAT GCAGAAGATT 1860
AAAGAGGGTG ATTTCTCATT GGATGGGGAG GCATGGAAGG GCGTATCGGA GAACGCCAAA 1920
GAGCTTGTTA AAGGCCTACT GACCGTGGAC CCAGAGACCC GTCTCAAACT GTCGGATCTG 1980
AAAGAGAACA GCTGGCTGCA GGGCGCAGCG TCCATGTCCA CCACTCCTCT GTGCACTCCA 2040
GATGTGCTAG AGTCTAGCGG GCCTACTGTT CGGACCTATG TCAATGCCAC CTACAAGGCT 2100
TTCAACCTCG GTAAGAGAGA AGGTTTCTTC CTGAAGAGTG TCGACAATGC TCCGCTTGCA 2160
AAACGCAGAA AGCTGAAGAT GACGAGCACG GGCGTCGAGA CCCGCTCAAC CACATCCAAG 2220
ACTCAGCCAA AACAAACTGG GACCCCGAAG AAAAGCGGGA CCCCGAAGGA AACGAGCTAG 2280
Domain Profile
S: 6     dlGvGsysvckrcvhkatnqefavkiidks.krdtseeieillryeqhpnivtlkdvydd  64
         +lG+Gs+svc++c+hk+t++efavki++++ +++t++e+++l+++e+hpniv+l++vy d
Q: 410   PLGEGSFSVCRKCRHKQTGNEFAVKIVSRRmEANTQREVAALRQCETHPNIVKLHEVYTD  469
         69****************************9*****************************
S: 65    gkyvylvlellkGGelldrikkkkffsereasailrtlvkaveylheqGvvhrdlkpeni  124
         + ++ylv+ell+GGell+rik+kk f e eas++l++lv+av+++he Gvvhrdlkpen+
Q: 470   QYHTYLVMELLRGGELLERIKRKKLFGEAEASQLLQSLVSAVSFMHEAGVVHRDLKPENV  529
         ************************************************************
S: 125   lyvdesdnaesikiidfGfaklkraengllktpcytlnfvapevlkrqGydeacdlwslG  184
         l++de++++  +k+idfGfa+l +a + +l+tpc+tl+++ape+++  Gyd+acdlwslG
Q: 530   LFADEAEDSM-LKVIDFGFARLCPAGSAPLQTPCFTLQYAAPELFESAGYDKACDLWSLG  588
         ******9988.*************************************************
S: 185   vllytmlaGyvpf....angpedtaeeilakikeGkfslsGeawdsvseeakdlvskllt  240
         v+lytml+G+vpf    +  +++ a++i++kikeG+fsl+Geaw++vse+ak+lv++llt
Q: 589   VILYTMLSGQVPFqseqRGMTSSYAADIMQKIKEGDFSLDGEAWKGVSENAKELVKGLLT  648
         *************877555678899***********************************
S: 241   vdpakrlkleqllkhswl  258
         vdp+ rlkl++l+++swl
Q: 649   VDPETRLKLSDLKENSWL  666
         *****************7
Domain Sequence
(FASTA)
PLGEGSFSVC RKCRHKQTGN EFAVKIVSRR MEANTQREVA ALRQCETHPN IVKLHEVYTD 60
QYHTYLVMEL LRGGELLERI KRKKLFGEAE ASQLLQSLVS AVSFMHEAGV VHRDLKPENV 120
LFADEAEDSM LKVIDFGFAR LCPAGSAPLQ TPCFTLQYAA PELFESAGYD KACDLWSLGV 180
ILYTMLSGQV PFQSEQRGMT SSYAADIMQK IKEGDFSLDG EAWKGVSENA KELVKGLLTV 240
DPETRLKLSD LKENSWL 257
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00156
EKS-ANC-00159
EKS-BOT-00164
EKS-CAF-00171
EKS-CAP-00163
EKS-CII-00093
EKS-CIS-00194
EKS-DAR-00453
EKS-DRM-00077
EKS-HOS-00170
EKS-ICT-00159
EKS-LAC-00165
EKS-LOA-00163
EKS-MAM-00162
EKS-MAE-00060
EKS-MUM-00169
EKS-MUP-00168
EKS-NOL-00157
EKS-ORN-00204
EKS-OTG-00168
EKS-PAT-00154
EKS-PES-00145
EKS-RAN-00161
EKS-SUS-00141
EKS-TAR-00211
EKS-TEN-00204
EKS-XET-00153
EKS-XIM-00199
Gene Ontology
GO:0005524; F:ATP binding
GO:0000287; F:magnesium ion binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0007243; P:intracellular protein kinase cascade
KEGG
InterPros
IPR000961; AGC-kinase_C.
IPR011009; Kinase-like_dom.
IPR017892; Pkinase_C.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR016239; Ribosomal_S6_kinase_II.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00069; Pkinase; 2.
PF00433; Pkinase_C; 1.
SMARTs
SM00133; S_TK_X; 1.
SM00220; S_TKc; 2.
Prosites
PS51285; AGC_KINASE_CTER; 1.
PS00107; PROTEIN_KINASE_ATP; 2.
PS50011; PROTEIN_KINASE_DOM; 2.
PS00108; PROTEIN_KINASE_ST; 2.
Prints
Created Date20-Feb-2013