EKS-GAA-00311

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-GAA-00311

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/CAMKL	293.1	2.1E-87	9	265	257

Status

Unreviewed

Ensembl Protein

ENSGACP00000027293

UniProt Accession

G3QBM7;

Protein Name

Protein Synonyms/Alias

Gene Name

CHEK1

Gene Synonyms/Alias

CHEK1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGACG00000020635	ENSGACP00000027293	ENSGACT00000027345

Organism

Gasterosteus aculeatus

Functional Description

Protein Length

474

Protein Sequence
(FASTA)

MAVPFVQDWD LVQTLGEGAY GEVRLLVNRQ TEEAVAVKVI DTSQAKECAE NVKKEVCVHK 60

MLKHANIVRF FGHRKEGTTM YLFLEYCTGG ELFDRIEPDV GMVEKEAHRL FQQLIAAVEY 120

LHNAGITHRD IKPENILLDD KDNLKLTDFG LATMFRFKGR ERLLSRLCGT LPYVAPELLS 180

QTEYKAQPAD IWACGIVLTA MLAGELPWDQ PTESCQEYSD WLQKKTYLPP WKKIQPMPLS 240

LLSKLLLASP DARITISDIQ KDRWFSQSKF LKMNTIQSCV STGVKQPPPG SIGNKLFRSD 300

GGLSSRTKSS DDRMQFSSSQ PDFAAGSWEA MLIIGQSEGQ VSFSQPTKPE HMLLGSQLLG 360

TPGASQSQWQ RLVRRMTRFF TTVNADVSLS ALKDTCEGLS LCFKLTCTKQ VTVSTLDKRN 420

NKLIFKVHLL EMNRRVLLDF RLSKGDGLEF KRLFVKIKQK LGDIISTQKI LPPI 474

Nucleotide Sequence
(FASTA)

ATGGCGGTGC CTTTTGTGCA GGACTGGGAC CTTGTTCAGA CGCTGGGAGA GGGAGCATAT 60

GGAGAAGTGA GGCTGCTGGT GAACAGGCAG ACAGAAGAGG CGGTTGCTGT GAAGGTGATC 120

GATACGTCTC AGGCTAAAGA GTGTGCTGAA AATGTCAAGA AAGAGGTCTG CGTGCATAAA 180

ATGCTCAAAC ACGCCAACAT CGTTCGTTTT TTTGGCCATC GAAAGGAAGG TACTACTATG 240

TATCTGTTCC TGGAGTACTG CACCGGAGGA GAGCTGTTCG ACCGAATAGA GCCGGATGTG 300

GGGATGGTAG AGAAAGAAGC TCATAGACTT TTCCAGCAGC TAATAGCGGC TGTGGAATAC 360

CTCCACAATG CTGGAATCAC CCACAGAGAC ATAAAGCCAG AGAACATTCT CCTGGATGAC 420

AAAGATAACC TGAAGCTGAC AGATTTTGGC CTGGCCACCA TGTTTCGTTT CAAAGGACGA 480

GAACGTCTCC TTAGTCGTCT CTGTGGGACA CTTCCGTACG TGGCTCCGGA GCTTCTCAGC 540

CAAACAGAGT ACAAAGCTCA GCCTGCCGAT ATCTGGGCTT GTGGGATTGT CCTCACTGCC 600

ATGCTGGCTG GAGAGTTGCC GTGGGATCAG CCGACCGAGA GCTGTCAAGA ATATTCAGAC 660

TGGCTTCAAA AGAAAACTTA CCTACCTCCT TGGAAGAAAA TACAACCAAT GCCTCTTAGT 720

TTGTTGTCCA AATTATTGCT GGCCAGTCCG GATGCACGCA TCACAATCTC AGACATACAG 780

AAAGACCGCT GGTTCAGTCA AAGCAAGTTT TTAAAAATGA ACACAATACA ATCGTGTGTC 840

TCTACAGGTG TGAAGCAGCC GCCACCAGGC TCCATAGGAA ACAAACTTTT TCGGTCAGAT 900

GGGGGACTCT CATCACGCAC CAAAAGCAGT GATGATAGGA TGCAGTTTTC CAGCTCTCAA 960

CCTGATTTTG CGGCAGGTAG CTGGGAAGCC ATGTTGATCA TCGGCCAAAG CGAAGGCCAG 1020

GTCAGCTTCT CCCAGCCAAC CAAGCCGGAA CACATGCTGC TGGGTAGTCA GCTACTCGGC 1080

ACACCGGGAG CCAGTCAGTC GCAGTGGCAG AGATTAGTGC GGAGAATGAC TCGTTTCTTC 1140

ACCACTGTGA ATGCCGACGT CTCCTTATCA GCGCTGAAAG ACACCTGTGA GGGCCTGTCG 1200

CTCTGCTTCA AACTCACCTG CACCAAACAG GTGACGGTGA GCACACTTGA CAAACGCAAT 1260

AATAAACTCA TCTTCAAAGT CCACTTGCTA GAGATGAACC GGCGAGTGCT GCTTGACTTC 1320

AGGCTGTCTA AGGGTGACGG TCTCGAGTTC AAGCGTCTCT TTGTGAAAAT AAAACAGAAG 1380

CTTGGAGACA TCATCAGCAC TCAGAAGATT TTGCCTCCCA TC 1422

Domain Profile

S: 1     ykllktlGegsfgkVklakhketkekvavKiikkkklseeslekikrEieilkklkhpni  60

         ++l++tlGeg++g+V+l ++++t+e+vavK+i++++++e  +e++k+E+ ++k+lkh ni

Q: 9     WDLVQTLGEGAYGEVRLLVNRQTEEAVAVKVIDTSQAKE-CAENVKKEVCVHKMLKHANI  67

         7899******************************77765.579*****************

S: 61    ikllevietkkklylvleyasggeLfdyieekgrlkekearklfkqlvsavkYlhskgiv  120

         ++++   ++ +++yl+ley++ggeLfd+ie +  + ekea++lf+ql++av+Ylh+ gi+

Q: 68    VRFFGHRKEGTTMYLFLEYCTGGELFDRIEPDVGMVEKEAHRLFQQLIAAVEYLHNAGIT  127

         ************************************************************

S: 121   HrDlKpeNllldkkenikiaDFGlanlfkeg...klletfcGsppYaaPellkgkkYegp  177

         HrD+KpeN+lld+k+n+k++DFGla++f+ +   +ll++ cG++pY+aPell++++Y+++

Q: 128   HRDIKPENILLDDKDNLKLTDFGLATMFRFKgreRLLSRLCGTLPYVAPELLSQTEYKAQ  187

         **************************998776779*************************

S: 178   kvDvWslGvvLyalvtgklPfdee..nlkellekilkgkleipkk.lskelesLlrklLv  234

         ++D+W++G+vL a+++g+lP+d++  +++e++++++k+++  p k +++   sLl+klL

Q: 188   PADIWACGIVLTAMLAGELPWDQPteSCQEYSDWLQKKTYLPPWKkIQPMPLSLLSKLLL  247

         ***********************96668999988888888777668**************

S: 235   vdpekRatieeilkhewl  252

          +p+ R+ti++i+k++w+

Q: 248   ASPDARITISDIQKDRWF  265

         *****************7

Domain Sequence
(FASTA)

WDLVQTLGEG AYGEVRLLVN RQTEEAVAVK VIDTSQAKEC AENVKKEVCV HKMLKHANIV 60

RFFGHRKEGT TMYLFLEYCT GGELFDRIEP DVGMVEKEAH RLFQQLIAAV EYLHNAGITH 120

RDIKPENILL DDKDNLKLTD FGLATMFRFK GRERLLSRLC GTLPYVAPEL LSQTEYKAQP 180

ADIWACGIVL TAMLAGELPW DQPTESCQEY SDWLQKKTYL PPWKKIQPMP LSLLSKLLLA 240

SPDARITISD IQKDRWF 257

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013