EKS-GAA-00174
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-GAA-00174
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/FGFR532.03.2E-160551827277
StatusUnreviewed
Ensembl ProteinENSGACP00000027500
UniProt AccessionG3QC84;
Protein NameFibroblast growth factor receptor
Protein Synonyms/Alias
Gene NameFGFR4
Gene Synonyms/Alias FGFR4;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSGACG00000020799ENSGACP00000027500ENSGACT00000027552
OrganismGasterosteus aculeatus
Functional Description
Protein Length883
Protein Sequence
(FASTA)
DLRVSRPLIV PGYPENITGV VGGQAKLACK IHRPASTKVQ WLKAEVSLEG PPRLSALTVL 60
QSNGSKVNTL HLSNISLEDA GEYICMAEST HEGQMVQAMQ SAWLEVLHEG AIDDRSEDTS 120
EHLLLEPGNV LKLRCDPSAR PGMAVHWYKE ASRVLPTPRI QIRGAVMEIA DVTYEDSGLY 180
VCVLRGTKEP VRNFTITVAD SLGSGDDDED NGLDDSSAEI ENDQVYFSGG PYWTHTQRME 240
KKLYAVPAGN TVKLRCPAMG SPMPSIRWLK NGREFRGEHR IGGIKLRHQH WSLVMESVVP 300
SDRGNYTCLV ENKYGSITHS YVLDVLERSP HRPILQAGLP ANITAVVGSD VQFLCKVYSD 360
AQPHIQWLKH IAVNGSLYGS DGAPFVRVLK TGSLNMSEVE VLYLSKVAME DAGEYTCLAG 420
NSIGFAYQSA WLTVLSEEET VDSIETMETK YTDIIIYACG FLALIMAIVI VVLCRMQVQP 480
RREPFDALPV QKLSKFPLRR QYSVESNSSG KSSASLMRVA RLSSSCSPML AGVMEFELPY 540
DPDWEFPREN LTLGKPLGEG CFGQVVRADA YGINKDSPDP ASTVAVKMLK DDATDKDLAD 600
LISEMELMKV MDKHKNIINL LGVCTQDGPL YVLVEYASKG SLREYLRARR PPGTDYTFDM 660
TKVPEEQLTF KDLLSCAYQV ARGMEYLASK RCIHRDLAAR NVLVTEDNVM KIADFGLARG 720
VHQIDYYKKT TNGRLPVKWM APEALFDRVY THQSDVWSFG VLMWEIFTLG GSPYPGIPVE 780
ELFKLLKEGH RMDKPSNCTH ELYMMMRECW HAVPTQRPTF KQLVEELDKV LLSISDEYLD 840
LSTPFEQYSP SCEDTSSSCS SDNDSVFTHD ALSTDPCLLG YKD 883
Nucleotide Sequence
(FASTA)
GATCTTCGGG TATCCAGGCC TCTGATTGTG CCAGGTTACC CAGAAAACAT CACGGGGGTA 60
GTAGGTGGTC AGGCAAAGCT GGCGTGTAAA ATCCACCGGC CGGCGTCCAC CAAGGTGCAG 120
TGGCTGAAGG CTGAGGTTAG CCTGGAAGGA CCGCCTCGCC TCAGCGCCCT GACGGTCCTA 180
CAGAGCAACG GGTCTAAGGT GAACACTTTG CATCTGTCCA ACATCAGTCT GGAGGATGCA 240
GGGGAGTACA TCTGCATGGC CGAGAGCACC CACGAAGGAC AGATGGTTCA GGCCATGCAG 300
TCGGCGTGGC TGGAGGTCCT GCACGAAGGC GCTATTGATG ACCGCAGCGA GGACACCTCA 360
GAGCATCTCC TGCTGGAGCC GGGCAACGTC CTGAAATTGC GCTGCGACCC GAGCGCCCGG 420
CCCGGCATGG CGGTGCACTG GTACAAGGAG GCGAGCCGGG TTCTGCCCAC ACCCCGCATC 480
CAGATCCGCG GAGCCGTCAT GGAGATTGCA GACGTGACAT ACGAGGACTC TGGCCTTTAT 540
GTGTGTGTTC TCCGGGGAAC CAAAGAGCCT GTGAGGAACT TCACCATCAC TGTGGCAGAC 600
TCGTTGGGGT CGGGGGACGA CGATGAGGAC AACGGGTTGG ACGACTCATC GGCTGAGATC 660
GAAAACGACC AGGTCTACTT CTCCGGAGGT CCTTACTGGA CCCACACCCA GCGTATGGAG 720
AAGAAGCTGT ACGCTGTACC CGCGGGCAAC ACGGTGAAGC TTCGTTGCCC CGCCATGGGC 780
AGCCCCATGC CGAGCATCCG CTGGCTAAAA AATGGGCGTG AATTTAGAGG AGAGCACCGC 840
ATCGGTGGCA TCAAGCTGAG GCACCAGCAC TGGAGTTTGG TGATGGAGAG CGTCGTGCCT 900
TCAGACAGAG GGAACTACAC TTGCCTGGTG GAGAACAAAT ATGGCTCCAT AACTCACAGC 960
TACGTGCTCG ATGTCCTGGA GCGTTCCCCA CACAGGCCCA TCCTGCAGGC CGGTCTACCA 1020
GCCAACATCA CAGCAGTGGT GGGAAGCGAT GTCCAGTTCC TCTGTAAGGT CTACAGCGAC 1080
GCCCAGCCTC ACATTCAGTG GCTCAAACAC ATTGCAGTCA ACGGCAGCCT TTACGGTTCT 1140
GATGGGGCGC CTTTCGTTCG GGTACTCAAG ACCGGCAGTC TGAACATGTC AGAGGTGGAG 1200
GTGCTCTACC TGTCCAAAGT TGCCATGGAG GATGCAGGAG AGTACACCTG TCTGGCTGGC 1260
AATTCAATCG GATTTGCTTA CCAGTCCGCC TGGCTCACCG TCCTCTCAGA AGAGGAAACC 1320
GTGGACTCCA TTGAGACCAT GGAGACAAAG TACACTGACA TCATCATCTA CGCCTGTGGT 1380
TTCCTGGCAC TGATCATGGC CATCGTCATC GTGGTGTTGT GTAGAATGCA GGTCCAACCC 1440
AGAAGGGAGC CGTTCGATGC GCTGCCAGTA CAAAAGCTCT CCAAGTTTCC TCTTCGCAGA 1500
CAGTACTCGG TGGAGTCCAA CTCATCGGGG AAGTCCAGCG CGTCGCTTAT GAGGGTGGCT 1560
CGACTCTCGT CCAGCTGCTC TCCCATGCTG GCTGGAGTCA TGGAGTTTGA ATTGCCCTAT 1620
GACCCGGACT GGGAGTTCCC CAGAGAAAAT TTAACCTTGG GCAAACCTCT AGGAGAAGGC 1680
TGCTTCGGTC AGGTGGTCAG AGCAGATGCC TACGGCATCA ATAAGGACTC TCCGGATCCG 1740
GCCTCCACTG TGGCGGTCAA GATGCTCAAA GATGACGCCA CAGACAAAGA TCTGGCAGAC 1800
CTCATCTCGG AGATGGAGCT CATGAAGGTC ATGGACAAAC ACAAGAACAT CATAAACCTG 1860
CTTGGGGTTT GCACACAGGA TGGGCCTCTG TATGTGCTGG TGGAGTACGC CTCCAAAGGC 1920
AGTCTGAGGG AGTACCTGCG GGCCCGGAGA CCCCCCGGCA CCGACTACAC CTTTGATATG 1980
ACTAAAGTGC CCGAAGAGCA GCTCACCTTC AAAGACCTGC TGTCCTGCGC CTACCAGGTG 2040
GCCAGAGGCA TGGAGTACCT GGCCTCCAAA AGGTGCATCC ACAGAGATCT GGCAGCCAGA 2100
AACGTTCTGG TGACCGAGGA CAACGTGATG AAGATCGCCG ACTTCGGCCT GGCCAGAGGA 2160
GTCCACCAGA TCGACTACTA CAAGAAAACC ACAAATGGAC GGCTGCCGGT GAAGTGGATG 2220
GCACCAGAGG CTTTGTTCGA CAGGGTCTAC ACACACCAGA GCGACGTGTG GTCCTTCGGT 2280
GTCCTGATGT GGGAGATCTT CACGCTGGGC GGCTCGCCGT ACCCCGGTAT CCCCGTCGAG 2340
GAGCTCTTCA AGCTGCTGAA GGAAGGACAC CGCATGGACA AACCCTCCAA CTGCACACAT 2400
GAACTCTACA TGATGATGCG TGAGTGCTGG CATGCTGTTC CCACCCAGAG GCCGACCTTC 2460
AAGCAGCTGG TGGAGGAGCT GGACAAAGTG CTGCTGTCCA TCTCCGACGA GTACCTGGAC 2520
TTGTCGACGC CCTTCGAGCA GTACTCGCCT TCCTGCGAGG ACACGTCCAG CTCCTGCTCC 2580
TCCGACAACG ACTCTGTCTT TACCCACGAT GCATTGTCCA CTGACCCCTG TCTCCTGGGC 2640
TACAAGGACT AG 2652
Domain Profile
S: 1     lvlgkllGeGafGqvvkaeaigldkdkekkevtvavkmlkedatdkdladlvsemevlkl  60
         l+lgk+lGeG+fGqvv+a+a g++kd ++ ++tvavkmlk+datdkdladl+seme++k+
Q: 551   LTLGKPLGEGCFGQVVRADAYGINKDSPDPASTVAVKMLKDDATDKDLADLISEMELMKV  610
         79**********************************************************
S: 61    iGkhkniinllGactqeGplyviveyaakGnlreflrarrpkgeeaskdkskaseeqlte  120
         + khkniinllG+ctq+Gplyv+veya+kG lre+lrarrp+g++++ d++k++eeqlt+
Q: 611   MDKHKNIINLLGVCTQDGPLYVLVEYASKGSLREYLRARRPPGTDYTFDMTKVPEEQLTF  670
         ************************************************************
S: 121   kdlvsfayqvarGmeylaskkcihrdlaarnvlvtednvlkiadfGlardvheidyykkt  180
         kdl+s+ayqvarGmeylask+cihrdlaarnvlvtednv+kiadfGlar+vh+idyykkt
Q: 671   KDLLSCAYQVARGMEYLASKRCIHRDLAARNVLVTEDNVMKIADFGLARGVHQIDYYKKT  730
         ************************************************************
S: 181   tnGrlpvkwmapealfdrvytsqsdvwsfGvllweiltlGgspypgiaveelfkllkeGh  240
         tnGrlpvkwmapealfdrvyt+qsdvwsfGvl+wei+tlGgspypgi+veelfkllkeGh
Q: 731   TNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGH  790
         ************************************************************
S: 241   rmekpakctkelyvlmrecwhakaserptfkqlvedl  277
         rm+kp++ct+ely++mrecwha++++rptfkqlve+l
Q: 791   RMDKPSNCTHELYMMMRECWHAVPTQRPTFKQLVEEL  827
         ***********************************86
Domain Sequence
(FASTA)
LTLGKPLGEG CFGQVVRADA YGINKDSPDP ASTVAVKMLK DDATDKDLAD LISEMELMKV 60
MDKHKNIINL LGVCTQDGPL YVLVEYASKG SLREYLRARR PPGTDYTFDM TKVPEEQLTF 120
KDLLSCAYQV ARGMEYLASK RCIHRDLAAR NVLVTEDNVM KIADFGLARG VHQIDYYKKT 180
TNGRLPVKWM APEALFDRVY THQSDVWSFG VLMWEIFTLG GSPYPGIPVE ELFKLLKEGH 240
RMDKPSNCTH ELYMMMRECW HAVPTQRPTF KQLVEEL 277
KeywordATP-binding; Complete proteome; Disulfide bond; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00141
EKS-ANC-00141
EKS-BOT-00149
EKS-CAF-00155
EKS-CAP-00149
EKS-DAR-00435
EKS-EQC-00146
EKS-FEC-00139
EKS-GAM-00077
EKS-ICT-00141
EKS-LAC-00159
EKS-LOA-00148
EKS-MOD-00149
EKS-MUM-00152
EKS-MUP-00153
EKS-MYL-00158
EKS-ORN-00184
EKS-ORL-00172
EKS-OTG-00154
EKS-PAT-00138
EKS-PES-00131
EKS-RAN-00146
EKS-SAH-00144
EKS-SUS-00130
EKS-TAG-00178
EKS-TAR-00193
EKS-TEN-00185
EKS-XET-00138
EKS-XIM-00178
Gene Ontology
GO:0016021; C:integral to membrane
GO:0005524; F:ATP binding
GO:0005007; F:fibroblast growth factor-activated receptor activity
GO:0008284; P:positive regulation of cell proliferation
KEGG
InterPros
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR013098; Ig_I-set.
IPR003598; Ig_sub2.
IPR013151; Immunoglobulin.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016248; Tyr_kinase_fibroblast_GF_rcpt.
Pfam
PF07679; I-set; 3.
PF00047; ig; 1.
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00408; IGc2; 4.
SM00219; TyrKc; 1.
Prosites
PS50835; IG_LIKE; 4.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013