EKS-GAG-00097

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-GAG-00097

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/NAK	391.3	2.4E-117	46	309	264

Status

Unreviewed

Ensembl Protein

ENSGALP00000000025

UniProt Accession

E1C584;

Protein Name

Protein Synonyms/Alias

Gene Name

AAK1

Gene Synonyms/Alias

AAK1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGALG00000000019	ENSGALP00000000025	ENSGALT00000000026

Organism

Gallus gallus

Functional Description

Protein Length

742

Protein Sequence
(FASTA)

MKKFFDSRRE QGGSGPGSGT SGGGGGSGGP GSGYIGRVFG IGRRQVTVDE VLAEGGFAIV 60

FLVRTNNGMK CALKRMYVNN EYDLQVCKRE IQIMRDLSGH KNIVGYIDSS INSVSSGDVW 120

EVLILMDFCR GGQVVNLMNQ RLQTGFTENE VLQIFCDTCE AVARLHQCKT PIIHRDLKVE 180

NILLHDRGHY VLCDFGSATN KFQNPQTEGV NAVEEEIKKY TTLSYRAPEM VNLYSGKLIT 240

TKADIWALGC LLYKLCYFTL PFGESQVAIC DGNFTIPDNS RHSQDMHCLI RYMLEPDPDK 300

RPDIYQVSYF AFKLAKKECP VQNVQNSPIP AKLPDPVKAS EAAAKKSQPK ARLTDPIPTT 360

ETSIAPRQRP KAGQTQPNPG ILPIQPALTP RKRPTAQAAI QPQGETPGCA VLYSIAGPAA 420

LGSGQPSLPA SVPQQKAAPQ PTSAQPQAKQ VSAPQQASQA QPQVPSAQPQ ATPQHQQQLF 480

LKQQLLQQQQ QQQAAYYQQQ QVMQAQQAQF PAVQQVSQLL LVSQFPVMQQ GAPAQQQLMQ 540

NYYQQQQQQQ QMMAQQAAMQ QKTAAAAVQQ KQQATAPPQP QAQQSAAQMQ AQIRQQQKPQ 600

TTPPTAVQGQ KLGSLTPPSS PKTQRAGHRR ILSDVTHSAV FGVPASKSTQ LLQAAAAEAS 660

LNKSKSASTT PSGSPRTSQQ NVYNPPDVST WNPFDDDNFS KLTAEELLNK DFAKLGDGKA 720

PEKMGSSTEN LIPGFQPASS AA 742

Nucleotide Sequence
(FASTA)

ATGAAGAAGT TCTTCGACTC GCGCCGGGAG CAGGGCGGCT CTGGGCCCGG GTCGGGCACC 60

AGCGGCGGCG GCGGAGGCAG CGGAGGGCCC GGCAGCGGTT ACATCGGCAG AGTGTTCGGC 120

ATCGGCCGCC GCCAGGTGAC GGTGGACGAG GTGCTGGCGG AAGGTGGATT TGCCATAGTG 180

TTTCTTGTGA GGACAAACAA TGGGATGAAA TGTGCCCTGA AGCGGATGTA CGTCAATAAC 240

GAGTACGACT TGCAAGTATG CAAAAGAGAA ATCCAAATCA TGCGGGATCT ATCTGGCCAC 300

AAGAACATTG TAGGATACAT TGATTCCAGT ATAAACTCAG TAAGCAGCGG TGATGTGTGG 360

GAAGTGCTGA TATTAATGGA CTTCTGCCGA GGAGGACAGG TGGTGAACCT CATGAACCAA 420

CGCCTTCAGA CAGGGTTCAC AGAGAATGAG GTCCTGCAGA TCTTCTGTGA CACCTGTGAA 480

GCTGTAGCAA GGCTGCATCA GTGTAAAACA CCAATAATCC ACAGGGATCT GAAGGTTGAA 540

AATATCTTGC TACACGATCG TGGCCACTAT GTTCTCTGTG ACTTTGGAAG TGCTACTAAC 600

AAATTCCAGA ACCCTCAAAC AGAAGGGGTG AACGCGGTGG AGGAGGAGAT CAAGAAGTAC 660

ACTACGTTAT CTTACAGAGC ACCAGAAATG GTCAACCTGT ATAGTGGCAA ACTTATCACT 720

ACAAAAGCAG ACATATGGGC CCTTGGCTGT TTGCTGTACA AGCTGTGTTA CTTCACTTTG 780

CCATTTGGGG AGAGTCAGGT GGCAATCTGT GATGGCAACT TCACCATTCC AGATAACTCT 840

CGGCATTCAC AGGACATGCA CTGCCTCATC CGGTATATGC TTGAGCCAGA CCCTGATAAG 900

AGACCTGATA TTTATCAAGT CTCCTACTTT GCATTCAAAC TGGCGAAGAA GGAATGCCCA 960

GTCCAGAATG TCCAGAACTC TCCAATCCCT GCTAAACTCC CAGACCCAGT CAAAGCAAGT 1020

GAAGCTGCAG CAAAGAAGAG TCAACCAAAG GCCAGGTTGA CAGATCCCAT TCCTACAACA 1080

GAAACTTCCA TAGCACCCCG GCAGAGACCT AAAGCAGGAC AGACACAACC CAACCCTGGA 1140

ATTTTACCTA TTCAGCCAGC CCTGACGCCT AGGAAGAGAC CCACAGCCCA AGCAGCAATT 1200

CAGCCTCAAG GTGAGACTCC TGGCTGTGCT GTGCTGTATT CAATTGCAGG GCCTGCTGCC 1260

CTGGGCAGTG GTCAGCCTTC ACTCCCTGCA AGTGTCCCTC AGCAAAAAGC AGCACCGCAA 1320

CCAACTTCAG CGCAGCCACA AGCCAAGCAG GTGTCAGCAC CCCAGCAGGC ATCACAGGCA 1380

CAGCCCCAGG TCCCCTCTGC TCAGCCACAA GCCACACCTC AGCACCAACA GCAGCTTTTC 1440

TTGAAGCAGC AGCTACTGCA ACAGCAGCAG CAGCAGCAGG CTGCGTATTA CCAGCAGCAG 1500

CAGGTGATGC AAGCTCAGCA GGCCCAGTTC CCAGCTGTGC AGCAGGTGTC TCAACTACTG 1560

CTTGTTTCCC AGTTCCCAGT GATGCAGCAG GGAGCACCAG CACAGCAGCA GCTGATGCAA 1620

AACTACTACC AGCAACAGCA GCAGCAGCAG CAGATGATGG CCCAGCAGGC AGCAATGCAG 1680

CAGAAGACGG CAGCAGCAGC AGTTCAGCAA AAACAACAGG CTACAGCACC ACCACAGCCC 1740

CAGGCCCAGC AAAGTGCAGC CCAGATGCAG GCACAAATAA GGCAACAGCA AAAACCTCAA 1800

ACCACACCAC CTACAGCAGT TCAGGGGCAG AAGCTGGGTT CTCTCACCCC TCCGTCCTCC 1860

CCCAAGACAC AGCGTGCAGG ACACAGGAGG ATTCTGAGTG ATGTGACCCA CAGTGCTGTT 1920

TTTGGGGTTC CAGCCAGCAA ATCTACCCAG CTCCTGCAGG CAGCTGCTGC TGAAGCCAGT 1980

CTCAACAAGT CCAAATCGGC TTCCACTACG CCCTCGGGTT CCCCAAGGAC CTCACAGCAG 2040

AACGTCTATA ATCCGCCCGA TGTCTCCACG TGGAATCCAT TTGATGATGA TAACTTCTCC 2100

AAACTCACAG CTGAGGAGCT GCTGAACAAG GACTTTGCAA AGCTGGGTGA TGGGAAAGCT 2160

CCAGAAAAGA TGGGCAGTTC CACAGAGAAC TTGATTCCAG GTTTCCAACC AGCTTCATCT 2220

GCAGCC 2226

Domain Profile

S: 1     vriekvlaeGGfalvylaedastgekyalKrilvneeedleeikrEieimkklsghkniv  60

         v++++vlaeGGfa+v+l++ +++g k+alKr++vn+e dl+ +krEi+im++lsghkniv

Q: 46    VTVDEVLAEGGFAIVFLVR-TNNGMKCALKRMYVNNEYDLQVCKREIQIMRDLSGHKNIV  104

         6899***************.9999************************************

S: 61    klvdssvkeekdngskevlllleyckkgslvdllnkrlekgelseaeilkilldvtrava  120

          ++dss+++ ++++++evl+l+++c+ g++v+l+n+rl++g ++e+e+l+i++d+++ava

Q: 105   GYIDSSINSVSSGDVWEVLILMDFCRGGQVVNLMNQRLQTG-FTENEVLQIFCDTCEAVA  163

         ************9***************************9.******************

S: 121   alHalsvpliHRDlkveNillsdegelvlcDlGSattaileveskqelsalqeeiekntt  180

         +lH++++p+iHRDlkveNill+d+g++vlcD+GSat+++++++ +++++a++eei+k+tt

Q: 164   RLHQCKTPIIHRDLKVENILLHDRGHYVLCDFGSATNKFQNPQ-TEGVNAVEEEIKKYTT  222

         *******************************************.9***************

S: 181   lsyrsPElidlysnlvideksDiWaLGcllYklcffesPfeesvklailngkysiPensr  240

         lsyr+PE+++lys++ i++k+DiWaLGcllYklc+f+ Pf+es ++ai++g+++iP+nsr

Q: 223   LSYRAPEMVNLYSGKLITTKADIWALGCLLYKLCYFTLPFGES-QVAICDGNFTIPDNSR  281

         *******************************************.****************

S: 241   yseklkslikkmlevdpeeRptiaqvle  268

         +s+++++li++mle+dp++Rp+i+qv++

Q: 282   HSQDMHCLIRYMLEPDPDKRPDIYQVSY  309

         **************************87

Domain Sequence
(FASTA)

VTVDEVLAEG GFAIVFLVRT NNGMKCALKR MYVNNEYDLQ VCKREIQIMR DLSGHKNIVG 60

YIDSSINSVS SGDVWEVLIL MDFCRGGQVV NLMNQRLQTG FTENEVLQIF CDTCEAVARL 120

HQCKTPIIHR DLKVENILLH DRGHYVLCDF GSATNKFQNP QTEGVNAVEE EIKKYTTLSY 180

RAPEMVNLYS GKLITTKADI WALGCLLYKL CYFTLPFGES QVAICDGNFT IPDNSRHSQD 240

MHCLIRYMLE PDPDKRPDIY QVSY 264

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0045747	; P:positive regulation of Notch signaling pathway
GO:0050821	; P:protein stabilization
GO:2000369	; P:regulation of clathrin-mediated endocytosis
GO:0032880	; P:regulation of protein localization

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

Prosites

PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013