EKS-GAG-00203

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-GAG-00203

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/CAMKL	341.7	2.4E-102	25	277	253

Status

Unreviewed

Ensembl Protein

ENSGALP00000000416

UniProt Accession

E1C5R4;

Protein Name

Protein Synonyms/Alias

Serine/threonine-protein kinase SIK2;

Gene Name

SIK2

Gene Synonyms/Alias

SIK2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGALG00000000312	ENSGALP00000000416	ENSGALT00000000417

Organism

Gallus gallus

Functional Description

Protein Length

911

Protein Sequence
(FASTA)

MVMAEPRRPP PLLPRGPGPV RVGFYDIEGT LGRGFAVVKL ARHRIQKTEV AIKIIDKSQL 60

DAVNLEKIYR EVQIMKMLDH PHIIKLYQQQ VMETKSMLYL VTEFAKNGEI FDYLASHGRL 120

SESEARRKFW QILSAVEYCH NRKVVHRDLK AENLLLDNNM NIKIADFGFG NFYKSGEPLT 180

TWCGSPPYAA PEVFEGQQYE GPQLDIWSMG VVLYVLVCGA LPFDGPTLPI LRQRVLEGRF 240

RIPYFMSEDC EHLIRRMLVL DPSKRLTIAQ IKEHKWMLIE VPAQRSILYA PGQENQPSIG 300

EYNEQVLRLM HSLGIDQQKT IESLQNKSYN HFAAIYYLLV ERLKSHRSSF PVEQRFDARQ 360

RRPSTIAEQT VVKAQAVVPS VNLCSENTRL MRSPGLPPTS GAEAFSFPPS NCHTETAFME 420

EERVNTPKVN GCLLDPVPPM VIRKGCQSLP TSMMETSIDE GIETEGEAED DPAQAFAALQ 480

AARSGKRRHT LAEVTDQLVV VPGTGKVYSL DEKSSLGSSI ESEYDMGSVQ RNVGLLGDAP 540

PLKDVVPLAA PFLGLRPANP AMQALASQKR ETHNRSPVSF REGRRASDTS LTQGIVAFRQ 600

HLQNLARTKG ILELNKVQLL YEQMRSEELL LPSAVSQLQD LATSPAQEER PQQQEAAATF 660

PSGAHTPVLS RRQSLETQYL QHRLQKPTLL SKAPNTCQLY CKELPRSLEQ QLQEHRLHQK 720

RLFLQKQSQL QAYFNQMQIA ESSYPRSSQM PLSCQEEQQP SAQQQSTQFS LQQALSPVME 780

PSSEQMQYDL FLSHYQKVQL KPPPSSPVTS SSRLSSPIQV QQPPQSLQYS YETCELPVVT 840

SSEPDYPDQC QYSMDPAQQS SVALPDSQGS LAAHESQSNY DTLTLSELPG LFDCEMMETV 900

DPQHSGYVLV N 911

Nucleotide Sequence
(FASTA)

ATGGTAATGG CCGAGCCCCG GCGGCCCCCC CCGCTGCTGC CCCGCGGGCC CGGGCCCGTC 60

CGCGTCGGCT TCTACGATAT TGAGGGCACG CTGGGCAGGG GGTTCGCCGT GGTCAAGCTG 120

GCGCGGCACC GCATCCAAAA GACGGAAGTG GCAATAAAAA TCATTGACAA ATCTCAGCTG 180

GATGCTGTGA ATCTCGAAAA GATATACCGT GAGGTGCAGA TAATGAAGAT GTTGGATCAT 240

CCCCACATCA TAAAGCTCTA CCAGCAACAG GTGATGGAGA CCAAAAGCAT GCTGTACCTC 300

GTGACAGAGT TTGCCAAAAA TGGAGAAATT TTTGATTACC TTGCCAGCCA CGGCCGACTC 360

AGTGAGTCCG AGGCCAGGCG GAAGTTCTGG CAGATCCTCT CAGCAGTGGA GTACTGCCAC 420

AACCGGAAGG TTGTGCACCG AGACCTGAAG GCTGAAAATC TTCTGCTTGA CAACAACATG 480

AACATCAAAA TAGCAGATTT TGGATTTGGA AATTTCTACA AGAGTGGTGA GCCCCTGACG 540

ACATGGTGTG GAAGCCCACC ATATGCAGCC CCAGAGGTCT TTGAAGGACA GCAATATGAA 600

GGACCCCAGT TGGATATCTG GAGCATGGGT GTGGTTCTTT ATGTTTTGGT CTGTGGAGCA 660

TTACCCTTTG ATGGGCCAAC ACTCCCCATA CTGAGGCAAC GAGTTCTGGA AGGAAGGTTC 720

AGGATACCTT ACTTTATGTC AGAAGATTGT GAGCATCTGA TTAGAAGAAT GCTGGTCCTA 780

GACCCATCGA AACGGTTAAC GATTGCTCAG ATTAAGGAAC ACAAGTGGAT GCTGATAGAA 840

GTTCCTGCCC AGAGGTCCAT TCTTTATGCC CCAGGACAGG AGAACCAGCC TTCTATTGGA 900

GAATATAACG AACAGGTTCT CCGGCTAATG CACAGCCTTG GAATAGACCA ACAGAAGACT 960

ATTGAGTCTC TGCAGAACAA GAGTTATAAC CACTTTGCTG CTATCTATTA CTTGTTAGTG 1020

GAAAGACTCA AATCGCATCG AAGCAGCTTC CCTGTAGAGC AGAGATTTGA TGCTCGCCAG 1080

CGCCGCCCAA GCACCATTGC TGAGCAGACA GTAGTCAAGG CACAAGCTGT GGTGCCATCA 1140

GTGAACTTGT GCTCAGAAAA CACAAGGCTG ATGCGGTCCC CAGGTCTTCC CCCCACCTCA 1200

GGAGCAGAGG CTTTTTCATT CCCTCCATCC AACTGCCACA CAGAGACGGC GTTCATGGAA 1260

GAAGAAAGAG TCAACACACC AAAGGTAAAT GGCTGCCTGC TTGATCCTGT GCCTCCCATG 1320

GTGATTCGGA AGGGATGCCA GTCACTGCCA ACTAGCATGA TGGAAACCTC AATCGATGAA 1380

GGAATAGAGA CGGAAGGCGA GGCAGAGGAT GACCCTGCAC AGGCATTTGC AGCCCTGCAG 1440

GCAGCTCGCA GTGGGAAGCG GCGTCACACC CTGGCTGAGG TCACTGACCA ACTAGTGGTG 1500

GTGCCAGGCA CAGGGAAGGT CTACTCTCTG GATGAGAAGT CCTCTCTGGG CAGCAGCATA 1560

GAGTCAGAGT ACGACATGGG GTCAGTGCAG AGGAATGTGG GCCTGCTGGG CGATGCCCCT 1620

CCACTGAAGG ATGTGGTGCC TCTGGCAGCA CCCTTCCTGG GGCTGCGGCC TGCCAACCCT 1680

GCCATGCAGG CTCTTGCTTC CCAGAAGCGC GAGACCCACA ACCGCTCCCC TGTCAGCTTC 1740

CGGGAGGGGC GCAGAGCATC AGACACCTCC CTCACACAAG GTATTGTAGC ATTCAGACAG 1800

CACCTCCAGA ATCTGGCACG AACCAAAGGA ATCCTGGAGC TGAACAAAGT CCAGCTGCTG 1860

TATGAGCAAA TGAGATCAGA AGAACTCCTT CTGCCATCAG CTGTCTCCCA GCTTCAGGAC 1920

CTTGCTACCA GCCCTGCACA GGAAGAAAGA CCTCAGCAGC AGGAGGCTGC GGCCACTTTC 1980

CCCAGTGGTG CACATACCCC AGTGTTATCC CGACGGCAGA GCTTAGAGAC ACAGTACTTG 2040

CAGCACAGGC TCCAGAAACC CACCCTACTA TCAAAAGCTC CAAACACTTG CCAGCTGTAC 2100

TGCAAAGAAT TGCCCCGGAG TCTGGAACAG CAGTTACAGG AGCACAGGCT GCATCAGAAG 2160

CGACTCTTTC TCCAGAAGCA GTCCCAGCTG CAGGCCTATT TTAACCAGAT GCAAATAGCT 2220

GAGAGTTCAT ACCCAAGGTC AAGTCAAATG CCACTTTCAT GCCAGGAGGA GCAGCAGCCA 2280

TCGGCGCAGC AGCAATCAAC CCAGTTCAGC CTCCAGCAGG CTCTGAGCCC TGTCATGGAG 2340

CCTTCCTCAG AGCAAATGCA ATACGACCTC TTCCTCAGTC ACTACCAGAA AGTACAGCTG 2400

AAGCCACCAC CATCCTCCCC AGTCACCAGC TCATCACGAT TGTCATCACC AATTCAGGTG 2460

CAGCAGCCAC CACAATCCTT ACAGTACTCC TATGAGACTT GTGAATTGCC TGTTGTCACC 2520

TCTTCTGAGC CAGACTACCC TGACCAGTGC CAGTATTCCA TGGACCCAGC ACAGCAGAGC 2580

AGTGTAGCAT TGCCTGACAG CCAGGGCAGC TTGGCAGCCC ATGAGTCGCA GTCAAACTAC 2640

GATACATTGA CCCTCTCAGA GCTGCCTGGA CTCTTCGATT GTGAGATGAT GGAAACTGTA 2700

GATCCCCAGC ACAGTGGCTA TGTCCTGGTG AATTAA 2736

Domain Profile

S: 1     ykllktlGegsfgkVklakhketkekvavKiikkkklseeslekikrEieilkklkhpni  60

         y++  tlG+g f+ Vkla+h+ +k++va+Kii+k++l++ +leki+rE++i+k+l+hp+i

Q: 25    YDIEGTLGRG-FAVVKLARHRIQKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHI  83

         88999***99.9************************************************

S: 61    iklle..vietkkklylvleyasggeLfdyieekgrlkekearklfkqlvsavkYlhskg  118

         ikl++  v+etk++lylv+e+a++ge+fdy+ ++grl+e+ear+ f q++sav+Y+h+++

Q: 84    IKLYQqqVMETKSMLYLVTEFAKNGEIFDYLASHGRLSESEARRKFWQILSAVEYCHNRK  143

         ***954489***************************************************

S: 119   ivHrDlKpeNllldkkenikiaDFGlanlfkegklletfcGsppYaaPellkgkkYegpk  178

         +vHrDlK+eNllld+++nikiaDFG++n++k+g+ l+t+cGsppYaaPe+++g++Yegp+

Q: 144   VVHRDLKAENLLLDNNMNIKIADFGFGNFYKSGEPLTTWCGSPPYAAPEVFEGQQYEGPQ  203

         ************************************************************

S: 179   vDvWslGvvLyalvtgklPfdeenlkellekilkgkleipkklskelesLlrklLvvdpe  238

         +D+Ws+GvvLy+lv+g+lPfd+++l  l++++l+g+++ip+ +s+++e+L+r++Lv dp+

Q: 204   LDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPS  263

         ************************************************************

S: 239   kRatieeilkhewl  252

         kR+ti +i++h+w+

Q: 264   KRLTIAQIKEHKWM  277

         *************8

Domain Sequence
(FASTA)

YDIEGTLGRG FAVVKLARHR IQKTEVAIKI IDKSQLDAVN LEKIYREVQI MKMLDHPHII 60

KLYQQQVMET KSMLYLVTEF AKNGEIFDYL ASHGRLSESE ARRKFWQILS AVEYCHNRKV 120

VHRDLKAENL LLDNNMNIKI ADFGFGNFYK SGEPLTTWCG SPPYAAPEVF EGQQYEGPQL 180

DIWSMGVVLY VLVCGALPFD GPTLPILRQR VLEGRFRIPY FMSEDCEHLI RRMLVLDPSK 240

RLTIAQIKEH KWM 253

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005794	; C:Golgi apparatus
GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0000287	; F:magnesium ion binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0008286	; P:insulin receptor signaling pathway
GO:0007243	; P:intracellular protein kinase cascade
GO:0046777	; P:protein autophosphorylation

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR015940	; UBA/transl_elong_EF1B_N_euk.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS50030	; UBA; 1.

Prints

Created Date

20-Feb-2013