EKS-GAG-00138

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-GAG-00138

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/RSKb	491.1	7.3E-148	435	692	258

Status

Reviewed

Ensembl Protein

ENSGALP00000034577

UniProt Accession

P18652;

Protein Name

Ribosomal protein S6 kinase 2 alpha

Protein Synonyms/Alias

MAP kinase-activated protein kinase 1; MAPK-activated protein kinase 1; MAPKAP kinase 1; MAPKAPK-1; Ribosomal protein S6 kinase II alpha; S6KII-alpha; p90-RSK;

Gene Name

RPS6KA

Gene Synonyms/Alias

RPS6KA; RSK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGALG00000000366	ENSGALP00000000497	ENSGALT00000000498
ENSGALG00000000366	ENSGALP00000034577	ENSGALT00000035223

Organism

Gallus gallus

Functional Description

Serine/threonine kinase that may play a role inmediating the growth-factor and stress induced activation of transcription (By similarity).

Protein Length

752

Protein Sequence
(FASTA)

MPLAQLAEPW PNMELVQLDT ENGQAAPEEG GNPPCKAKSD ITWVEKDLVD STDKGEGVVK 60

EINITHHVKE GSEKADPSQF ELLKVLGQGS FGKVFLVRKI TPPDSNHLYA MKVLKKATLK 120

VRDRVRTKIE RDILADVNHP FVVKLHYAFQ TEGKLYLILD FLRGGDLFTR LSKEVMFTEE 180

DVKFYLAELA LGLDHLHSLG IIYRDLKPEN ILLDEEGHIK LTDFGLSKEA IDHEKKAYSF 240

CGTVEYMAPE VVNRQGHSHS ADWWSYGVLM FEMLTGSLPF QGKDRKETMT LILKAKLGMP 300

QFLSAEAQSL LRALFKRNPA NRLGSGPDGA EEIKRHPFYS TIDWNKLYRR EIKPPFKPAV 360

GQPDDTFYFD TEFTSRTPKD SPGIPPSAGA HQLFRGFSFV ATGLMEDSKV KPAQPPLHSV 420

VQQLHGKNIQ FSDGYVVKEA IGVGSYSVCK RCIHKTTNME YAVKVIDKSK RDPSEEIEIL 480

LRYGQHPNII TLKDVYDDGK YVYLVTELMR GGELLDKILR QKFFSEREAS SVLHTICKTV 540

EYLHSQGVVH RDLKPSNILY VDESGNPESI RICDFGFAKQ LRAENGLLMT PCYTANFVAP 600

EVLKRQGYDE GCDIWSLGVL LYTMLAGCTP FANGPSDTPE EILTRIGGGK FSVNGGNWDT 660

ISDVAKDLVS KMLHVDPHQR LTAKQVLQHP WITQKDSLPQ SQLNYQDVQL VKGAMAATYS 720

ALNSSKPSPQ LKPIESSILA QRRVKKLPST TL 752

Nucleotide Sequence
(FASTA)

ATGCCGCTCG CACAGCTGGC CGAGCCCTGG CCCAACATGG AGCTGGTGCA GCTGGACACG 60

GAGAATGGGC AGGCTGCTCC AGAGGAAGGC GGGAACCCTC CGTGCAAGGC AAAGTCAGAC 120

ATCACTTGGG TAGAGAAAGA TCTGGTGGAC TCAACAGACA AGGGCGAGGG CGTTGTGAAG 180

GAAATCAACA TCACGCACCA TGTGAAGGAG GGCTCTGAGA AGGCCGACCC TTCGCAGTTT 240

GAGCTTCTGA AGGTTCTGGG ACAGGGCTCT TTTGGCAAGG TTTTCTTGGT AAGAAAAATA 300

ACACCACCAG ACAGCAACCA CCTCTATGCC ATGAAAGTGC TTAAAAAGGC AACACTGAAA 360

GTGCGTGATC GTGTAAGGAC AAAGATAGAG AGAGACATCC TAGCTGATGT AAACCATCCC 420

TTTGTGGTAA AGCTGCACTA CGCATTCCAG ACAGAGGGGA AGCTGTATCT CATCTTGGAT 480

TTCCTCCGAG GAGGTGACCT TTTCACTCGG CTTTCCAAAG AGGTCATGTT CACAGAAGAG 540

GATGTGAAGT TCTACCTAGC AGAGCTTGCT CTTGGACTTG ACCATTTGCA CAGCCTGGGA 600

ATCATATACA GAGACCTCAA ACCGGAGAAC ATCCTCCTGG ATGAAGAAGG ACACATCAAA 660

CTCACAGATT TTGGCTTGAG TAAGGAGGCT ATAGACCACG AGAAGAAAGC CTACTCCTTC 720

TGCGGGACGG TGGAATATAT GGCCCCAGAG GTTGTAAACC GTCAGGGCCA CTCCCACAGC 780

GCGGACTGGT GGTCCTATGG GGTGCTGATG TTTGAGATGC TCACCGGCTC GCTGCCATTC 840

CAGGGAAAGG ACCGCAAGGA GACGATGACC CTCATCCTTA AAGCAAAACT GGGCATGCCT 900

CAGTTTCTGA GTGCTGAGGC ACAGAGCCTC CTGCGAGCCC TTTTCAAAAG GAACCCAGCC 960

AACAGATTAG GTTCTGGTCC AGATGGGGCA GAAGAGATAA AGCGTCATCC GTTCTACTCT 1020

ACTATTGACT GGAATAAGCT GTACCGAAGG GAAATCAAGC CACCCTTCAA GCCTGCTGTA 1080

GGCCAGCCTG ATGACACCTT TTATTTTGAT ACAGAATTTA CATCGCGTAC ACCAAAAGAT 1140

TCCCCAGGCA TCCCTCCCAG TGCAGGTGCA CATCAGCTCT TCCGCGGCTT CAGCTTTGTG 1200

GCCACTGGAC TGATGGAAGA CAGTAAGGTG AAACCTGCAC AGCCCCCTCT GCATTCTGTG 1260

GTGCAGCAGC TGCATGGCAA GAACATCCAG TTCAGCGACG GCTACGTGGT GAAGGAGGCG 1320

ATTGGTGTGG GCTCCTACTC GGTGTGCAAA CGGTGCATTC ACAAAACAAC CAACATGGAG 1380

TATGCGGTGA AGGTTATTGA CAAGAGCAAA CGGGACCCTT CTGAGGAAAT TGAAATTCTC 1440

CTGCGATACG GACAGCATCC AAACATCATT ACCTTGAAAG ATGTTTATGA TGACGGGAAG 1500

TACGTGTATC TGGTGACAGA ACTGATGAGA GGAGGGGAGC TGCTAGATAA AATCCTGAGA 1560

CAGAAGTTTT TCTCGGAGAG GGAGGCCAGT TCAGTCCTGC ACACAATCTG CAAAACAGTG 1620

GAATATCTGC ATTCTCAAGG GGTAGTTCAC AGGGACTTGA AACCCAGCAA TATTCTCTAT 1680

GTGGATGAGT CAGGAAATCC AGAAAGCATT CGCATATGTG ACTTTGGCTT TGCCAAGCAG 1740

CTGAGAGCTG AGAATGGTCT TCTCATGACT CCTTGCTATA CCGCAAACTT TGTGGCACCT 1800

GAGGTACTGA AGCGACAGGG CTACGATGAG GGCTGTGACA TCTGGAGCCT GGGAGTCCTC 1860

CTTTACACTA TGCTTGCAGG CTGCACTCCA TTTGCAAATG GACCCAGTGA CACTCCAGAA 1920

GAGATCCTGA CGCGAATAGG CGGGGGAAAG TTCTCTGTCA ATGGAGGCAA CTGGGACACC 1980

ATTTCTGACG TGGCCAAGGA CCTGGTATCA AAGATGCTTC ATGTAGATCC TCACCAGCGC 2040

CTGACAGCCA AGCAGGTCCT GCAGCACCCA TGGATAACAC AGAAGGACAG CTTACCCCAG 2100

AGCCAGCTGA ATTACCAGGA TGTCCAGCTG GTAAAGGGGG CAATGGCTGC CACGTACTCT 2160

GCACTGAACA GCTCCAAGCC GAGCCCCCAG CTGAAGCCTA TCGAGTCTTC CATCCTGGCA 2220

CAGCGGCGGG TGAAGAAGCT CCCCTCCACC ACCCTGTGA 2259

Domain Profile

S: 1     yevkedlGvGsysvckrcvhkatnqefavkiidkskrdtseeieillryeqhpnivtlkd  60

         y+vke +GvGsysvckrc+hk+tn+e+avk+idkskrd+seeieillry+qhpni+tlkd

Q: 435   YVVKEAIGVGSYSVCKRCIHKTTNMEYAVKVIDKSKRDPSEEIEILLRYGQHPNIITLKD  494

         689*********************************************************

S: 61    vyddgkyvylvlellkGGelldrikkkkffsereasailrtlvkaveylheqGvvhrdlk  120

         vyddgkyvylv+el++GGelld+i+++kffsereas++l+t++k+veylh+qGvvhrdlk

Q: 495   VYDDGKYVYLVTELMRGGELLDKILRQKFFSEREASSVLHTICKTVEYLHSQGVVHRDLK  554

         ************************************************************

S: 121   penilyvdesdnaesikiidfGfaklkraengllktpcytlnfvapevlkrqGydeacdl  180

         p+nilyvdes+n+esi+i+dfGfak++raengll+tpcyt+nfvapevlkrqGyde+cd+

Q: 555   PSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDEGCDI  614

         ************************************************************

S: 181   wslGvllytmlaGyvpfangpedtaeeilakikeGkfslsGeawdsvseeakdlvskllt  240

         wslGvllytmlaG +pfangp+dt+eeil++i+ Gkfs++G++wd++s+ akdlvsk+l+

Q: 615   WSLGVLLYTMLAGCTPFANGPSDTPEEILTRIGGGKFSVNGGNWDTISDVAKDLVSKMLH  674

         ************************************************************

S: 241   vdpakrlkleqllkhswl  258

         vdp++rl+++q+l+h+w+

Q: 675   VDPHQRLTAKQVLQHPWI  692

         *****************8

Domain Sequence
(FASTA)

YVVKEAIGVG SYSVCKRCIH KTTNMEYAVK VIDKSKRDPS EEIEILLRYG QHPNIITLKD 60

VYDDGKYVYL VTELMRGGEL LDKILRQKFF SEREASSVLH TICKTVEYLH SQGVVHRDLK 120

PSNILYVDES GNPESIRICD FGFAKQLRAE NGLLMTPCYT ANFVAPEVLK RQGYDEGCDI 180

WSLGVLLYTM LAGCTPFANG PSDTPEEILT RIGGGKFSVN GGNWDTISDV AKDLVSKMLH 240

VDPHQRLTAK QVLQHPWI 258

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; Repeat; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0000287	; F:magnesium ion binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0007243	; P:intracellular protein kinase cascade

KEGG

gga:386579

;

InterPros

IPR000961	; AGC-kinase_C.
IPR011009	; Kinase-like_dom.
IPR017892	; Pkinase_C.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR016239	; Ribosomal_S6_kinase_II.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069	; Pkinase; 2.
PF00433	; Pkinase_C; 1.

SMARTs

SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 2.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS00107	; PROTEIN_KINASE_ATP; 2.
PS50011	; PROTEIN_KINASE_DOM; 2.
PS00108	; PROTEIN_KINASE_ST; 2.

Prints

Created Date

20-Feb-2013