EKS-GAG-00134

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-GAG-00134

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/TLK	623.8	3.4E-188	385	664	280

Status

Unreviewed

Ensembl Protein

ENSGALP00000000558

UniProt Accession

E1C3U2;

Protein Name

Protein Synonyms/Alias

Gene Name

TLK2

Gene Synonyms/Alias

TLK2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGALG00000000410	ENSGALP00000000558	ENSGALT00000000559

Organism

Gallus gallus

Functional Description

Protein Length

695

Protein Sequence
(FASTA)

MMEELHSLDP RRQELLEARF TGVGVAKGPL NSESSNQSLC SVGSLSDKEL ETPEKKQNDQ 60

RNRKRKAEAY ETSQGKGTPR GHKISDYFEF AGGSGPGTSP GRSVPPVARS SPQHSLSNPL 120

PQAQQGSPSS TGSGNTEHSC TSQKQISIQH KQSQSDLTME KISALENSKN SDLEKKEGRI 180

DDLLRANCDL RRQIDEQQKM LEKYKERLNR CVTMSKKLLI EKSKQEKMAC RDKSMQDRLR 240

LGHFTTVRHG ASFTEQWTDG YAFQNLIKQQ ERINSQREEI ERQRKMLAKR KPPAMGQTPP 300

ASNEQKQRKN KTNGAENETL TLAEYHEQEE IFKLRLGHLK KEEAEIQAEL ERLERVRNLH 360

IRELKRIHNE DNSQFKDHPT LNDRYLLLHL LGRGGFSEVY KAFDLTEQRY VAVKIHQLNK 420

NWRDEKKENY HKHACREYRI HKELDHPRIV KLYDYFSLDT DSFCTVLEYC EGNDLDFYLK 480

QHKLMSEKEA RSIIMQIVNA LKYLNEIKPP IIHYDLKPGN ILLVNGTACG EIKITDFGLS 540

KIMDDDSYNS VDGMELTSQG AGTYWYLPPE CFVVGKEPPK ISNKVDVWSV GVIFYQCLYG 600

RKPFGHNQSQ QDILQENTIL KATEVQFPPK PVVTPEAKAF IRRCLAYRKE DRIDVQQLAC 660

DPYLLPHIRK SVSTSSPAGA AIASTSGSSN NSSSN 695

Nucleotide Sequence
(FASTA)

ATGATGGAAG AATTGCATAG CCTGGACCCA CGAAGGCAGG AACTACTGGA GGCCAGGTTC 60

ACCGGGGTTG GTGTTGCTAA GGGTCCATTA AATAGCGAGT CTTCCAACCA GAGCTTATGC 120

AGCGTGGGTT CTCTCAGTGA TAAAGAACTG GAGACTCCTG AGAAAAAACA GAATGACCAG 180

CGGAATAGAA AAAGGAAAGC AGAAGCATAT GAGACCAGTC AAGGAAAAGG CACTCCTAGA 240

GGACATAAAA TTAGTGACTA TTTTGAGTTT GCTGGGGGAA GCGGCCCAGG AACCAGTCCT 300

GGTAGAAGTG TGCCACCAGT TGCCAGATCA TCACCGCAGC ATTCCTTATC CAACCCCTTA 360

CCACAGGCCC AGCAAGGCAG CCCATCTTCT ACGGGATCAG GGAACACTGA GCATTCCTGC 420

ACTTCCCAAA AACAGATTTC CATCCAGCAC AAACAGTCAC AGTCGGACCT CACAATGGAA 480

AAAATATCTG CACTAGAAAA CAGTAAGAAC TCTGACTTGG AGAAGAAGGA AGGGAGGATA 540

GATGACTTAC TAAGAGCCAA CTGTGATTTG AGACGGCAGA TAGATGAACA ACAAAAGATG 600

CTGGAGAAGT ACAAGGAGCG GTTGAATAGA TGTGTAACGA TGAGCAAGAA GCTCCTTATA 660

GAAAAGTCAA AACAGGAGAA GATGGCGTGC AGAGATAAGA GCATGCAGGA TCGATTGAGG 720

CTAGGTCACT TCACTACGGT GCGGCATGGG GCGTCCTTCA CCGAGCAGTG GACAGATGGC 780

TATGCCTTCC AGAACCTCAT CAAGCAACAG GAAAGGATAA ATTCCCAGCG GGAAGAAATA 840

GAAAGGCAAC GAAAGATGTT AGCAAAACGG AAGCCACCTG CAATGGGACA GACCCCCCCA 900

GCAAGCAATG AGCAGAAGCA GCGCAAGAAC AAGACCAACG GAGCAGAAAA TGAAACGTTA 960

ACGCTAGCAG AATACCATGA ACAGGAAGAA ATCTTCAAAC TCCGACTGGG TCATCTGAAA 1020

AAGGAAGAAG CAGAGATCCA GGCAGAGCTG GAACGGCTAG AGAGGGTTAG AAATCTACAT 1080

ATCAGGGAAT TGAAAAGGAT ACACAATGAA GATAACTCAC AGTTTAAAGA CCATCCAACG 1140

CTAAACGATA GATATTTGTT GCTACATCTT CTGGGTCGGG GAGGCTTCAG TGAGGTATAT 1200

AAGGCATTTG ATTTAACGGA ACAGAGATAC GTAGCTGTGA AAATACACCA GTTAAATAAA 1260

AACTGGAGAG ATGAGAAGAA AGAAAACTAT CACAAACATG CGTGTAGAGA GTACAGAATT 1320

CACAAAGAAC TGGATCATCC TCGAATAGTT AAGCTATATG ACTACTTTTC ACTGGATACT 1380

GACTCGTTTT GTACAGTGTT AGAATACTGT GAGGGAAACG ATCTGGACTT CTACCTGAAA 1440

CAGCACAAGT TAATGTCGGA GAAGGAGGCA CGATCCATTA TCATGCAGAT TGTGAATGCT 1500

TTAAAATACT TAAATGAAAT CAAACCTCCC ATCATACACT ATGACCTTAA ACCAGGTAAC 1560

ATTCTTCTAG TCAATGGTAC TGCATGCGGA GAGATAAAAA TCACAGATTT TGGGCTTTCC 1620

AAAATCATGG ATGATGACAG CTACAACTCT GTTGATGGCA TGGAGCTGAC ATCGCAGGGG 1680

GCTGGTACTT ACTGGTATTT GCCACCAGAA TGTTTCGTGG TTGGGAAAGA ACCTCCAAAG 1740

ATTTCAAATA AAGTTGATGT CTGGTCAGTA GGGGTCATCT TCTATCAGTG TCTCTATGGC 1800

AGAAAGCCCT TTGGCCACAA CCAGTCACAA CAAGATATTC TACAGGAGAA CACGATTCTG 1860

AAAGCTACCG AGGTGCAGTT CCCTCCAAAG CCAGTAGTCA CACCAGAAGC AAAGGCATTT 1920

ATCAGGCGTT GTTTGGCCTA CCGAAAGGAG GATCGGATAG ATGTCCAGCA GCTGGCCTGT 1980

GACCCATACT TGCTGCCTCA CATCCGCAAA TCTGTATCCA CAAGCAGCCC AGCTGGAGCT 2040

GCAATTGCAT CAACCTCTGG ATCATCCAAT AACAGCTCTT CAAACTGA 2088

Domain Profile

S: 1     ylllkllgkggfsevykafdlkeqryvavkihqlnkdwkdekkenyvkhalreyrihkel  60

         ylll+llg+ggfsevykafdl+eqryvavkihqlnk+w+dekkeny+kha+reyrihkel

Q: 385   YLLLHLLGRGGFSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKHACREYRIHKEL  444

         9***********************************************************

S: 61    dhprivklydllsldtdsfctvleyvegndldfylkqhkllsekearsiimqivsalkyl  120

         dhprivklyd++sldtdsfctvley+egndldfylkqhkl+sekearsiimqiv+alkyl

Q: 445   DHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQIVNALKYL  504

         ************************************************************

S: 121   neikppiihydlkpgnillvegtacgeikitdfglskimdddsydsddgleltsqgagty  180

         neikppiihydlkpgnillv+gtacgeikitdfglskimdddsy+s+dg+eltsqgagty

Q: 505   NEIKPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGAGTY  564

         ************************************************************

S: 181   wylppecfvvgkeppkisnkvdvwsvgvifyqclygkkpfghnqsqqdileentilkate  240

         wylppecfvvgkeppkisnkvdvwsvgvifyqclyg+kpfghnqsqqdil+entilkate

Q: 565   WYLPPECFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPFGHNQSQQDILQENTILKATE  624

         ************************************************************

S: 241   vqfpskpvvsseakafirrclayrkedridvqqlakdeyl  280

         vqfp+kpvv++eakafirrclayrkedridvqqla+d+yl

Q: 625   VQFPPKPVVTPEAKAFIRRCLAYRKEDRIDVQQLACDPYL  664

         **************************************97

Domain Sequence
(FASTA)

YLLLHLLGRG GFSEVYKAFD LTEQRYVAVK IHQLNKNWRD EKKENYHKHA CREYRIHKEL 60

DHPRIVKLYD YFSLDTDSFC TVLEYCEGND LDFYLKQHKL MSEKEARSII MQIVNALKYL 120

NEIKPPIIHY DLKPGNILLV NGTACGEIKI TDFGLSKIMD DDSYNSVDGM ELTSQGAGTY 180

WYLPPECFVV GKEPPKISNK VDVWSVGVIF YQCLYGRKPF GHNQSQQDIL QENTILKATE 240

VQFPPKPVVT PEAKAFIRRC LAYRKEDRID VQQLACDPYL 280

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005882	; C:intermediate filament
GO:0005634	; C:nucleus
GO:0048471	; C:perinuclear region of cytoplasm
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0035556	; P:intracellular signal transduction
GO:0001672	; P:regulation of chromatin assembly or disassembly

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013