EKS-GAG-00129

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-GAG-00129

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/NDR	518.9	3.9E-156	89	382	294

Status

Unreviewed

Ensembl Protein

ENSGALP00000000720

UniProt Accession

E1C8Z7;

Protein Name

Protein Synonyms/Alias

Gene Name

STK38

Gene Synonyms/Alias

STK38;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGALG00000000523	ENSGALP00000000720	ENSGALT00000000721

Organism

Gallus gallus

Functional Description

Protein Length

465

Protein Sequence
(FASTA)

MAMTGPTPCS SMSNHTKERV TMTKVTLENF YSNLIAQHEE REMRQKKLEQ MMEEEGLKDE 60

EKRIRRSAHA QKETEFLRLK RTRLGLEDFE SLKVIGRGAF GEVRLVQKKD TGHVYAMKIL 120

RKADMLEKEQ VGHIRAERDI LVEADSLWVV KMFYSFQDKL NLYLIMEFLP GGDMMTLLMK 180

KDTLTEEETQ FYIAETVLAI DSIHQLGFIH RDIKPDNLLL DSKGHVKLSD FGLCTGLKKA 240

HRTEFYRNLN HSLPSDFTFQ NMNSKRKAET WKRNRRQLAF STVGTPDYIA PEVFMQTGYN 300

KLCDWWSLGV IMYEMLIGYP PFCSETPQET YKKVMNWKET LTFPPEVPIS DKAKDLILRF 360

CCEWEHRIGA SGVEEIKSNP FFEGVDWEHI RERPAAISIE IKSIDDTSNF DEFPESDILK 420

PTVATSNHPE TDYKNKDWVF INYTYKRFEG LTARGAIPSY MKAGK 465

Nucleotide Sequence
(FASTA)

ATGGCCATGA CGGGCCCGAC GCCGTGCTCC TCTATGAGCA ACCACACCAA GGAGCGGGTG 60

ACGATGACGA AGGTGACGCT GGAGAACTTC TACAGCAATC TCATTGCACA GCATGAGGAG 120

CGGGAGATGA GACAAAAGAA GCTAGAACAA ATGATGGAAG AAGAAGGATT GAAAGATGAG 180

GAGAAAAGGA TCAGGAGATC AGCGCACGCA CAGAAAGAAA CGGAGTTCCT TCGCCTGAAG 240

AGAACAAGGC TCGGCCTGGA GGACTTCGAG TCCTTAAAAG TAATAGGCAG AGGAGCTTTT 300

GGAGAGGTGC GGCTTGTCCA GAAGAAGGAC ACGGGGCACG TTTATGCCAT GAAAATACTG 360

CGTAAAGCTG ATATGCTGGA GAAAGAGCAG GTTGGCCACA TCCGTGCTGA GCGGGACATC 420

CTCGTGGAAG CAGACAGCTT GTGGGTTGTG AAGATGTTCT ATAGCTTTCA GGATAAGCTG 480

AACCTCTACC TTATCATGGA GTTCCTGCCT GGAGGTGATA TGATGACACT CTTGATGAAA 540

AAAGACACGC TAACAGAAGA AGAGACGCAG TTCTATATAG CTGAGACTGT GCTCGCCATT 600

GATTCTATTC ATCAACTGGG CTTTATCCAT CGAGATATCA AACCAGACAA CCTTCTTCTG 660

GACAGCAAGG GCCACGTGAA ACTCTCAGAT TTTGGTCTGT GCACCGGACT GAAGAAAGCC 720

CATAGAACAG AGTTCTATAG GAACCTGAAC CATAGCCTTC CCAGTGACTT CACTTTCCAG 780

AACATGAATT CCAAACGGAA AGCAGAGACG TGGAAGAGAA ACAGACGGCA GCTGGCTTTT 840

TCTACTGTGG GGACTCCGGA TTACATTGCT CCTGAAGTTT TCATGCAGAC AGGCTACAAC 900

AAGCTCTGTG ACTGGTGGTC GCTGGGGGTC ATCATGTATG AGATGCTGAT TGGTTATCCA 960

CCTTTCTGTT CTGAGACTCC TCAAGAAACG TACAAGAAAG TAATGAATTG GAAAGAGACC 1020

CTCACATTTC CTCCAGAAGT CCCCATATCT GACAAAGCCA AGGACCTTAT TTTAAGATTT 1080

TGCTGTGAAT GGGAGCACAG AATTGGTGCA TCTGGTGTGG AGGAAATAAA GAGTAATCCA 1140

TTCTTTGAAG GGGTTGATTG GGAGCATATA AGGGAGAGAC CTGCTGCAAT TTCAATAGAA 1200

ATTAAAAGCA TTGATGATAC CTCAAACTTT GATGAATTTC CAGAATCTGA TATCCTTAAG 1260

CCAACAGTGG CAACCAGCAA CCACCCAGAG ACAGACTACA AGAACAAGGA CTGGGTTTTC 1320

ATCAATTACA CCTATAAGCG TTTCGAGGGC CTGACAGCCC GAGGAGCAAT ACCATCCTAT 1380

ATGAAAGCAG GAAAGTAA 1398

Domain Profile

S: 1     feklkvigkGafGevrlvrkkdtkevyalkilrkkdllkknqvahvkaerdilaeadsew  60

         fe+lkvig+GafGevrlv+kkdt++vya+kilrk+d+l+k+qv h++aerdil+eads w

Q: 89    FESLKVIGRGAFGEVRLVQKKDTGHVYAMKILRKADMLEKEQVGHIRAERDILVEADSLW  148

         899*********************************************************

S: 61    vvklyysfqdkenlylvmeylPGGdlmtllikkeilkeelarfyiaelvlavesvhklGf  120

         vvk++ysfqdk nlyl+me+lPGGd+mtll+kk++l+ee+++fyiae+vla++s+h+lGf

Q: 149   VVKMFYSFQDKLNLYLIMEFLPGGDMMTLLMKKDTLTEEETQFYIAETVLAIDSIHQLGF  208

         ************************************************************

S: 121   ihrdlkPdnllidakGhikltdfGlctGlkkthrseyykelekakeddleaseelkvler  180

         ihrd+kPdnll+d+kGh+kl+dfGlctGlkk+hr+e+y++l+++ ++d+ ++    ++++

Q: 209   IHRDIKPDNLLLDSKGHVKLSDFGLCTGLKKAHRTEFYRNLNHSLPSDFTFQ----NMNS  264

         *************************************************555....5555

S: 181   rkk....kknrrllayslvGtpdyiapevlekkgynklcdwWslGvilyemlvGypPfla  236

         ++k    k+nrr+la+s+vGtpdyiapev++++gynklcdwWslGvi+yeml+GypPf++

Q: 265   KRKaetwKRNRRQLAFSTVGTPDYIAPEVFMQTGYNKLCDWWSLGVIMYEMLIGYPPFCS  324

         5544556*****************************************************

S: 237   etpqetykkvinwketlkfpeevelseeakdlierliadaekrlgkkGvdeikkhpff  294

         etpqetykkv+nwketl+fp+ev++s++akdli r+++++e+r+g++Gv+eik++pff

Q: 325   ETPQETYKKVMNWKETLTFPPEVPISDKAKDLILRFCCEWEHRIGASGVEEIKSNPFF  382

         *********************************************************9

Domain Sequence
(FASTA)

FESLKVIGRG AFGEVRLVQK KDTGHVYAMK ILRKADMLEK EQVGHIRAER DILVEADSLW 60

VVKMFYSFQD KLNLYLIMEF LPGGDMMTLL MKKDTLTEEE TQFYIAETVL AIDSIHQLGF 120

IHRDIKPDNL LLDSKGHVKL SDFGLCTGLK KAHRTEFYRN LNHSLPSDFT FQNMNSKRKA 180

ETWKRNRRQL AFSTVGTPDY IAPEVFMQTG YNKLCDWWSL GVIMYEMLIG YPPFCSETPQ 240

ETYKKVMNWK ETLTFPPEVP ISDKAKDLIL RFCCEWEHRI GASGVEEIKS NPFF 294

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0070688	; C:MLL5-L complex
GO:0005886	; C:plasma membrane
GO:0005524	; F:ATP binding
GO:0000287	; F:magnesium ion binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0007243	; P:intracellular protein kinase cascade
GO:0043407	; P:negative regulation of MAP kinase activity

KEGG

gga:428260

;

InterPros

IPR000961	; AGC-kinase_C.
IPR011009	; Kinase-like_dom.
IPR017892	; Pkinase_C.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069	; Pkinase; 1.
PF00433	; Pkinase_C; 1.

SMARTs

SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013