EKS-GAG-00207

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-GAG-00207

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/CAMKL	331.7	2.7E-99	56	306	251

Status

Unreviewed

Ensembl Protein

ENSGALP00000000960

UniProt Accession

F1NRW2;

Protein Name

Protein Synonyms/Alias

Gene Name

NUAK2

Gene Synonyms/Alias

NUAK2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGALG00000000680	ENSGALP00000000960	ENSGALT00000000962

Organism

Gallus gallus

Functional Description

Protein Length

656

Protein Sequence
(FASTA)

AGGGGGGAGK ERGMERAAVG FGGTSLVEGF IKSPRPLMKK QAVKRHHHKH NLKHRYEFLE 60

TLGKGTYGKV KKARERSGKL VAIKSIRKDR IKDEQDLIHI RREIEIMSSL NHPHIIAVHE 120

VFENSSKIVI VMEYASKGDL YDYISERQRL SEQEARHFFR QVVSAVYYCH KNGIVHRDLK 180

LENILLDANG NIKIADFGLS NVYQQDKFLQ TYCGSPLYAS PEIINGRPYK GPEVDSWSLG 240

VLLYILVHGT MPFDGHDYKT LVKQITSGDY REPTKLSDAC GLIRWMLMVN PERRATIEDI 300

ATHWWVNWGY RVPVGEQELL RESSESPLAT VAEWLRRSSR PLFENGSKVR CFLKQHIPGV 360

ALERQRSLKK SKKENDVSHA LQEGAAAPEN PSKSILKRPK GILKKRNSCE QKVPIPLPTA 420

PGGESKSEDG DVTAVGLSPV LPSAVLGGSE GSGVVSVAVP KKGILKKPPK RESGYYSSLE 480

CCESGDVLDA GSLDLEGNVF ADSPTAERGP PVLPSSRKGI LKHSSKYTSG AEPHSPPRQS 540

FGCFDEVSLP KAPLAPRPRP PSAVSEDSIL STESFEQLDL PPRVPPGRSG AMRGCVSADS 600

LLLLEEEEEV DEGRRLRRWT VTHCPTALGE SRFSLESCDN VTEVHRRAVA ISMKLS 656

Nucleotide Sequence
(FASTA)

GCGGGCGGCG GAGGCGGCGG AGCCGGGAAG GAGCGCGGTA TGGAGCGGGC GGCGGTGGGG 60

TTCGGGGGCA CCTCGCTGGT CGAGGGGTTC ATCAAATCGC CGCGGCCGCT GATGAAGAAG 120

CAGGCGGTGA AACGGCACCA CCACAAACAC AACCTCAAGC ATCGCTACGA GTTCCTGGAA 180

ACGCTGGGGA AGGGGACGTA TGGGAAGGTG AAGAAAGCAC GGGAGCGTTC CGGCAAGCTG 240

GTGGCCATCA AGTCCATCCG CAAGGACAGA ATCAAAGATG AGCAGGACCT TATCCATATC 300

CGGAGGGAGA TAGAGATCAT GTCGTCCCTC AACCACCCCC ACATCATCGC TGTCCATGAA 360

GTGTTTGAGA ACAGCAGCAA GATCGTCATC GTGATGGAGT ACGCCAGCAA AGGAGACCTG 420

TATGACTACA TCAGTGAGAG GCAGCGGCTG TCGGAGCAGG AGGCTCGCCA CTTCTTCCGG 480

CAGGTCGTGT CGGCCGTCTA CTACTGCCAT AAGAATGGGA TCGTTCACAG GGACCTGAAG 540

CTGGAGAACA TCCTTCTCGA TGCCAATGGG AACATCAAGA TTGCAGACTT TGGCCTGTCC 600

AACGTTTACC AGCAGGACAA GTTCCTGCAG ACATACTGCG GTAGCCCCCT CTACGCATCA 660

CCTGAAATCA TCAACGGACG GCCCTACAAA GGCCCAGAGG TGGACAGCTG GTCCCTCGGT 720

GTCCTCCTCT ACATCCTGGT CCATGGCACG ATGCCCTTTG ATGGCCATGA CTACAAGACC 780

CTGGTCAAAC AGATCACCAG TGGGGACTAC CGGGAGCCCA CGAAGCTGTC AGATGCCTGT 840

GGGCTGATCA GGTGGATGCT GATGGTGAAC CCGGAGCGCC GTGCCACCAT TGAGGACATC 900

GCCACACACT GGTGGGTCAA CTGGGGCTAC CGTGTGCCCG TCGGTGAGCA GGAGCTGCTG 960

CGGGAGAGCA GTGAATCCCC GTTGGCCACG GTGGCCGAGT GGCTGCGGCG CTCCTCCCGA 1020

CCACTCTTTG AGAACGGCTC CAAAGTGAGG TGCTTCTTGA AGCAGCACAT CCCTGGTGTG 1080

GCCCTGGAGA GGCAGCGCTC CCTTAAGAAG TCCAAGAAGG AGAACGATGT CTCCCATGCA 1140

CTGCAGGAGG GGGCTGCGGC TCCGGAGAAC CCCTCCAAGT CCATCCTCAA GCGGCCCAAA 1200

GGCATTCTGA AGAAGAGGAA TTCCTGCGAG CAGAAGGTGC CCATCCCTCT GCCAACGGCT 1260

CCTGGGGGAG AGTCCAAGAG TGAGGATGGG GATGTGACTG CTGTGGGGCT GAGCCCAGTG 1320

CTACCCTCTG CGGTGCTGGG GGGCAGCGAG GGCAGCGGTG TGGTCTCTGT GGCTGTGCCC 1380

AAGAAGGGAA TCCTAAAGAA GCCCCCGAAG AGGGAATCGG GGTATTACTC ATCCCTGGAA 1440

TGCTGTGAAT CCGGAGACGT CCTGGATGCA GGGAGCTTGG ACTTGGAGGG CAACGTGTTT 1500

GCTGACAGCC CCACCGCTGA GCGGGGCCCC CCTGTCCTCC CCAGCAGCCG GAAGGGCATC 1560

CTGAAGCACA GCAGCAAATA CACCAGCGGT GCTGAGCCCC ACAGCCCCCC CAGGCAGAGC 1620

TTTGGATGCT TTGATGAGGT GTCCCTGCCC AAAGCCCCCC TCGCCCCCCG CCCTCGCCCA 1680

CCCAGCGCTG TGAGCGAGGA CAGCATCCTC TCCACCGAAT CCTTTGAGCA GCTCGACCTC 1740

CCTCCACGCG TCCCCCCGGG CAGAAGCGGG GCCATGCGGG GCTGCGTCTC TGCTGACAGC 1800

CTCCTTCTCT TGGAGGAGGA GGAGGAGGTG GATGAAGGGC GCAGGCTGCG CCGCTGGACA 1860

GTGACGCACT GCCCCACAGC ATTGGGGGAG AGCCGCTTCT CCCTGGAGAG CTGTGACAAC 1920

GTCACCGAGG TGCACCGGCG CGCTGTGGCC ATCAGCATGA AGCTGAGCTG A 1971

Domain Profile

S: 1     ykllktlGegsfgkVklakhketkekvavKiikkkkl.seeslekikrEieilkklkhpn  59

         y++l+tlG+g++gkVk+a+++  ++ va+K i+k+++ +e+ l +i+rEiei+++l+hp+

Q: 56    YEFLETLGKGTYGKVKKARER-SGKLVAIKSIRKDRIkDEQDLIHIRREIEIMSSLNHPH  114

         99****************987.799**********996677788****************

S: 60    iikllevietkkklylvleyasggeLfdyieekgrlkekearklfkqlvsavkYlhskgi  119

         ii ++ev+e+++k+++v+eyas+g+L+dyi+e++rl+e+ear++f+q+vsav Y+h++gi

Q: 115   IIAVHEVFENSSKIVIVMEYASKGDLYDYISERQRLSEQEARHFFRQVVSAVYYCHKNGI  174

         ************************************************************

S: 120   vHrDlKpeNllldkkenikiaDFGlanlfkegklletfcGsppYaaPellkgkkYegpkv  179

         vHrDlK+eN+lld+++nikiaDFGl+n+++++k l+t cGsp Ya+Pe+++g++Y+gp+v

Q: 175   VHRDLKLENILLDANGNIKIADFGLSNVYQQDKFLQTYCGSPLYASPEIINGRPYKGPEV  234

         ************************************************************

S: 180   DvWslGvvLyalvtgklPfdeenlkellekilkgkleipkklskelesLlrklLvvdpek  239

         D WslGv+Ly+lv g++Pfd++++k+l+++i++g+++ p+kls+ +  L+r +L+v+pe+

Q: 235   DSWSLGVLLYILVHGTMPFDGHDYKTLVKQITSGDYREPTKLSDAC-GLIRWMLMVNPER  293

         *****************************************99876.7************

S: 240   Ratieeilkhewl  252

         Ratie+i +h w+

Q: 294   RATIEDIATHWWV  306

         ************6

Domain Sequence
(FASTA)

YEFLETLGKG TYGKVKKARE RSGKLVAIKS IRKDRIKDEQ DLIHIRREIE IMSSLNHPHI 60

IAVHEVFENS SKIVIVMEYA SKGDLYDYIS ERQRLSEQEA RHFFRQVVSA VYYCHKNGIV 120

HRDLKLENIL LDANGNIKIA DFGLSNVYQQ DKFLQTYCGS PLYASPEIIN GRPYKGPEVD 180

SWSLGVLLYI LVHGTMPFDG HDYKTLVKQI TSGDYREPTK LSDACGLIRW MLMVNPERRA 240

TIEDIATHWW V 251

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Dasypus novemcinctus"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Microcebus murinus"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0000287	; F:magnesium ion binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0030036	; P:actin cytoskeleton organization
GO:0042149	; P:cellular response to glucose starvation
GO:0043066	; P:negative regulation of apoptotic process

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013