EKS-GAG-00261

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-GAG-00261

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE20	356.3	1.0E-106	269	520	252

Status

Unreviewed

Ensembl Protein

ENSGALP00000000961

UniProt Accession

E1C3P6;

Protein Name

Protein Synonyms/Alias

Gene Name

PAK1

Gene Synonyms/Alias

PAK1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGALG00000000681	ENSGALP00000000961	ENSGALT00000000963

Organism

Gallus gallus

Functional Description

Protein Length

544

Protein Sequence
(FASTA)

MSNNGVETED KPPAPPMRNT STMIGSGSKD TGTLNHGSKP LPPNPEEKKK RDRFYRSILP 60

GDKTNKKKEK ERPEISLPSD FEHTIHVGFD AVTGEFTGMP EQWARLLQTS NITKLEQKKN 120

PQAVLDVLEF YNSKKTSSSQ KYMSFTDKLA EEYNSSNTLN VKAVSETPAV PSVSEDEDDE 180

DDAAPPPVIA PRPEHTKSIY TRSVIDPLPP PTRDVATSPI SSPSENSTAA PDMLIRNAEK 240

QKKKPKMSDE EILEKLRSIV SVGDPKKKYT RFEKIGQGAS GTVYTAMDVA TGQEVAIKQM 300

NLQQQPKKEL IINEILVMRE NKNPNIVNYL DSYLVGEELW VVMEYLAGGS LTDVVTETCM 360

DEGQIAAVCR ECLQALEFLH SNQVIHRDIK SDNILLGMDG SVKLTDFGFC AQITPEQSKR 420

STMVGTPYWM APEVVTRKAY GPKVDIWSLG IMAIEMIEGE PPYLNENPLR ALYLIATNGT 480

PELQNPEKLS PIFRDFLNRC LEMDVEKRGS AKELLQHQFL KIAKPLSSLT PLIIAAKEAT 540

KNNH 544

Nucleotide Sequence
(FASTA)

ATGTCCAACA ATGGAGTTGA AACAGAAGAC AAACCACCTG CTCCTCCGAT GAGAAACACC 60

AGCACTATGA TTGGATCAGG AAGCAAAGAC ACCGGGACTT TAAACCATGG CTCAAAACCT 120

TTGCCTCCCA ACCCAGAAGA AAAGAAGAAG AGGGACCGAT TTTACCGATC TATTTTACCA 180

GGAGATAAAA CCAACAAGAA GAAAGAGAAG GAGCGGCCGG AGATCTCCCT CCCTTCTGAC 240

TTTGAACACA CAATTCATGT GGGGTTTGAT GCAGTCACTG GAGAATTCAC AGGAATGCCG 300

GAGCAATGGG CACGCTTACT ACAGACTTCC AACATCACCA AATTAGAGCA GAAGAAGAAC 360

CCCCAGGCAG TGCTGGACGT ACTGGAGTTT TACAACTCCA AGAAGACCTC CAGCAGCCAG 420

AAGTACATGA GTTTCACAGA TAAGTTGGCA GAGGAATACA ATTCGTCAAA TACTCTGAAT 480

GTGAAAGCTG TGTCTGAGAC CCCTGCAGTG CCCTCAGTGT CTGAAGATGA AGATGATGAA 540

GATGATGCAG CTCCACCCCC TGTGATAGCT CCACGACCTG AACACACCAA ATCTATATAC 600

ACTCGCTCTG TGATAGACCC CCTTCCTCCT CCTACCAGAG ATGTGGCCAC CTCTCCTATT 660

TCTTCTCCCT CGGAAAACAG CACAGCAGCA CCCGACATGC TGATCAGGAA TGCGGAGAAA 720

CAAAAGAAAA AGCCAAAAAT GTCAGATGAA GAGATTCTGG AAAAATTAAG AAGCATCGTG 780

AGTGTGGGTG ATCCAAAAAA GAAGTACACG CGTTTTGAGA AGATTGGACA AGGAGCCTCA 840

GGTACAGTTT ACACAGCAAT GGATGTAGCT ACAGGACAGG AGGTTGCAAT CAAGCAGATG 900

AATTTGCAGC AGCAGCCCAA AAAGGAATTG ATTATCAATG AAATCCTCGT AATGAGGGAA 960

AACAAAAACC CCAACATTGT CAACTACTTG GACAGTTACC TTGTAGGAGA AGAGCTCTGG 1020

GTAGTCATGG AGTACTTGGC AGGAGGCTCC CTAACAGATG TCGTTACGGA GACCTGCATG 1080

GACGAAGGAC AGATTGCAGC TGTGTGCCGA GAGTGTCTTC AGGCTTTGGA ATTCCTCCAC 1140

TCAAACCAAG TTATTCACAG AGACATCAAG AGTGACAACA TCCTACTGGG AATGGATGGC 1200

TCTGTCAAAT TAACTGACTT TGGCTTCTGT GCCCAGATCA CTCCTGAGCA GAGCAAACGC 1260

AGCACCATGG TGGGGACCCC ATACTGGATG GCACCTGAAG TGGTGACACG GAAAGCATAC 1320

GGGCCCAAAG TGGACATCTG GTCGCTGGGG ATAATGGCCA TCGAGATGAT TGAAGGAGAA 1380

CCCCCCTACC TCAACGAGAA CCCCCTGAGA GCACTGTATC TCATTGCTAC CAATGGGACT 1440

CCAGAACTGC AGAATCCAGA AAAGCTTTCA CCCATATTCA GAGACTTCCT AAACCGCTGT 1500

CTTGAAATGG ATGTGGAAAA AAGAGGTTCT GCAAAAGAGC TGCTACAGCA CCAGTTCCTG 1560

AAAATCGCAA AGCCTCTTTC TAGCCTCACT CCTCTAATTA TTGCTGCCAA AGAGGCAACA 1620

AAGAACAACC ATTAA 1635

Domain Profile

S: 1     yelleeigkGalgkvylarekktgelvaikkinlekqekleelqkeisvlkklkhpnive  60

         y+ +e+ig+Ga+g+vy+a ++ tg+ vaik++nl++q+k+e++++ei v+++ k+pniv+

Q: 269   YTRFEKIGQGASGTVYTAMDVATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVN  328

         7889********************************************************

S: 61    ylesflkeeelwlvmeylagGslsdlvkeelkselkEeqiayilrevlkaLeylHskkvi  120

         yl+s+l+ eelw+vmeylagGsl+d+v+   ++ ++E qia+++re+l+aLe+lHs++vi

Q: 329   YLDSYLVGEELWVVMEYLAGGSLTDVVT---ETCMDEGQIAAVCRECLQALEFLHSNQVI  385

         ****************************...9****************************

S: 121   HrdikakniLlteegeVkLsdfgvaaqlektrkkrktvvgtpywmAPEviaqeekgYdek  180

         Hrdik++niLl ++g+VkL+dfg++aq++ +++kr+t+vgtpywmAPEv++  +k Y  k

Q: 386   HRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVT--RKAYGPK  443

         ***************************************************..9******

S: 181   aDiwslGItaielaegepPfkdleplkallkilkneppklkskkkfskefkefvekclqk  240

         +DiwslGI+aie++egepP+ +++pl+al++i++n +p+l++++k+s+ f++f+++cl+

Q: 444   VDIWSLGIMAIEMIEGEPPYLNENPLRALYLIATNGTPELQNPEKLSPIFRDFLNRCLEM  503

         ************************************************************

S: 241   npekRpsasellkhkFl  257

         ++ekR sa+ell+h+Fl

Q: 504   DVEKRGSAKELLQHQFL  520

         ****************7

Domain Sequence
(FASTA)

YTRFEKIGQG ASGTVYTAMD VATGQEVAIK QMNLQQQPKK ELIINEILVM RENKNPNIVN 60

YLDSYLVGEE LWVVMEYLAG GSLTDVVTET CMDEGQIAAV CRECLQALEF LHSNQVIHRD 120

IKSDNILLGM DGSVKLTDFG FCAQITPEQS KRSTMVGTPY WMAPEVVTRK AYGPKVDIWS 180

LGIMAIEMIE GEPPYLNENP LRALYLIATN GTPELQNPEK LSPIFRDFLN RCLEMDVEKR 240

GSAKELLQHQ FL 252

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0030424	; C:axon
GO:0005911	; C:cell-cell junction
GO:0005794	; C:Golgi apparatus
GO:0030426	; C:growth cone
GO:0005634	; C:nucleus
GO:0043234	; C:protein complex
GO:0001726	; C:ruffle
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0031532	; P:actin cytoskeleton reorganization
GO:0060244	; P:negative regulation of cell proliferation involved in contact inhibition
GO:0033148	; P:positive regulation of intracellular estrogen receptor signaling pathway
GO:0043507	; P:positive regulation of JUN kinase activity
GO:0033138	; P:positive regulation of peptidyl-serine phosphorylation
GO:0051496	; P:positive regulation of stress fiber assembly
GO:0043113	; P:receptor clustering
GO:0042060	; P:wound healing

KEGG

gga:419083

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000095	; PAK_box_Rho-bd.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00786	; PBD; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00285	; PBD; 1.
SM00220	; S_TKc; 1.

Prosites

PS50108	; CRIB; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013