EKS-GAG-00048

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-GAG-00048

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/CDK	385.5	1.5E-115	114	395	282

Status

Unreviewed

Ensembl Protein

ENSGALP00000000973

UniProt Accession

E1C3N0;

Protein Name

Protein Synonyms/Alias

Gene Name

CDK18

Gene Synonyms/Alias

CDK18;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGALG00000000692	ENSGALP00000000973	ENSGALT00000000975

Organism

Gallus gallus

Functional Description

Protein Length

444

Protein Sequence
(FASTA)

MNKMKNFKRR FSLSVPRTET IEESLTEFTE QFNQLNNQRN EVWAHPDPGS VTPGSPTQPQ 60

GVPRAPTLPY ISIVPQPFLG KHSQLALPAL KQPLWKQPPA NTLSDIGFGK METYVKLDKL 120

GEGTYATVFK GRSKLTENLV ALKEIRLEHE EGAPCTAIRE VSLLKNLKHA NIVTLHDIIH 180

TERSLTLVFE YLENDLKQYL DNCGNLMSVH NVKIFMFQLL RGLSYCHERK ILHRDLKPQN 240

LLINERGELK LADFGLARAK SVPTKTYSNE VVTLWYRPPD VLLGSTEYST PIDMWGVGCI 300

HYEMVTGRPM FPGSTVKEEL HLIFRLLGTP TEDTWPGITS NEEFRAYNFT QYRAQPLINH 360

APRLDSDGID LLMNLLLYEA KSRISAEVAL RHPYFKSLGE RVHVLPDNVS IFSLKEIQLQ 420

KDPGYRGSAF QQSARGKNRR QSIF 444

Nucleotide Sequence
(FASTA)

ATGAACAAGA TGAAGAACTT CAAGAGGAGG TTCTCACTCT CAGTTCCTCG GACAGAGACC 60

ATCGAGGAGT CGCTGACAGA GTTCACAGAG CAGTTCAACC AGCTCAACAA CCAGAGGAAT 120

GAGGTGTGGG CCCATCCTGA CCCAGGCAGT GTCACCCCGG GGAGTCCAAC GCAGCCTCAG 180

GGTGTCCCAC GTGCCCCCAC GCTGCCATAC ATCTCCATCG TACCACAGCC TTTCCTTGGC 240

AAACACTCCC AGTTAGCTCT GCCTGCCCTC AAACAGCCCC TCTGGAAGCA GCCCCCTGCG 300

AATACCCTTT CGGATATCGG GTTTGGGAAG ATGGAGACCT ATGTTAAACT GGACAAACTG 360

GGCGAGGGCA CTTATGCCAC TGTCTTCAAG GGGCGCAGCA AGCTGACAGA AAACCTGGTG 420

GCACTGAAGG AGATCCGCCT GGAGCACGAG GAAGGGGCTC CATGCACCGC CATCCGGGAA 480

GTGTCACTGC TGAAGAACCT CAAGCACGCC AACATCGTCA CCCTGCATGA TATCATCCAC 540

ACGGAGCGCT CCCTCACGCT GGTCTTCGAG TACCTGGAAA ACGACCTCAA GCAGTACCTG 600

GATAACTGTG GGAACCTGAT GAGCGTGCAC AACGTGAAGA TCTTCATGTT CCAGCTGCTG 660

CGTGGCCTGT CCTACTGTCA CGAGAGGAAG ATCCTACACC GGGACCTCAA ACCCCAGAAC 720

CTGCTCATCA ACGAGAGAGG AGAGCTCAAG CTGGCCGACT TCGGCCTCGC CAGAGCCAAG 780

TCGGTGCCTA CCAAAACGTA TTCCAACGAG GTGGTCACGC TTTGGTACCG ACCCCCCGAC 840

GTCCTGCTGG GATCCACCGA GTATTCCACC CCCATCGATA TGTGGGGCGT GGGGTGCATC 900

CACTACGAGA TGGTGACCGG GCGGCCCATG TTCCCCGGCT CCACGGTGAA GGAGGAGCTG 960

CATCTCATCT TCCGGCTCTT GGGAACACCG ACAGAAGACA CCTGGCCGGG GATAACGTCC 1020

AACGAGGAGT TCAGGGCGTA CAACTTCACG CAGTACCGCG CGCAGCCGTT AATCAATCAC 1080

GCCCCGAGGT TGGACTCAGA CGGCATTGAC TTGCTGATGA ACCTCCTCCT GTATGAAGCC 1140

AAGAGCCGGA TTTCAGCAGA GGTGGCCCTG CGGCATCCGT ACTTCAAGAG CCTCGGGGAG 1200

AGGGTGCACG TCCTGCCCGA CAATGTCTCC ATCTTCTCTC TGAAGGAGAT CCAGCTTCAG 1260

AAGGACCCTG GCTACCGAGG CTCAGCCTTT CAGCAGTCAG CCCGAGGGAA GAACAGGAGG 1320

CAGAGTATAT TTTAA 1335

Domain Profile

S: 1     yeklekigeGtygkvykakdketgevvAlKkirlekekegvpitalrEisllkelkhkni  60

         y kl+k+geGty++v+k+++k t+++vAlK+irle+e eg p+ta+rE+sllk+lkh+ni

Q: 114   YVKLDKLGEGTYATVFKGRSKLTENLVALKEIRLEHE-EGAPCTAIREVSLLKNLKHANI  172

         7899********************************9.9*********************

S: 61    vkLlevvakdkkklyLvfefleqdLkkllkkkkkkklsleevkslllqlleglaylHsnk  120

         v+L+++++ ++++l+Lvfe+le+dLk++l+++ +  +s ++vk +++qll+gl+y+H++k

Q: 173   VTLHDIIH-TERSLTLVFEYLENDLKQYLDNCGN-LMSVHNVKIFMFQLLRGLSYCHERK  230

         ********.99***********************.*************************

S: 121   ilHRDlKpqNlLiskegklklaDfGlarafssplktytkevvTlwYraPelLlgakeYst  180

         ilHRDlKpqNlLi+++g+lklaDfGlara s+p+kty++evvTlwYr+P++Llg++eYst

Q: 231   ILHRDLKPQNLLINERGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVLLGSTEYST  290

         ************************************************************

S: 181   avDiWsvgcilaelltrkplfqgkseidqlerifkllgtpsekvwpevsklpeyk.ksfp  239

          +D+W+vgci  e++t +p+f+g++ +++l+ if+llgtp+e++wp++++ +e++ ++f+

Q: 291   PIDMWGVGCIHYEMVTGRPMFPGSTVKEELHLIFRLLGTPTEDTWPGITSNEEFRaYNFT  350

         *******************************************************99***

S: 240   kkkkkklkekvkklkekaldllekllaldpkkRisakealqhkyf  284

         +++++ l ++ ++l+++++dll +ll ++ k+Risa+ al+h+yf

Q: 351   QYRAQPLINHAPRLDSDGIDLLMNLLLYEAKSRISAEVALRHPYF  395

         ********************************************9

Domain Sequence
(FASTA)

YVKLDKLGEG TYATVFKGRS KLTENLVALK EIRLEHEEGA PCTAIREVSL LKNLKHANIV 60

TLHDIIHTER SLTLVFEYLE NDLKQYLDNC GNLMSVHNVK IFMFQLLRGL SYCHERKILH 120

RDLKPQNLLI NERGELKLAD FGLARAKSVP TKTYSNEVVT LWYRPPDVLL GSTEYSTPID 180

MWGVGCIHYE MVTGRPMFPG STVKEELHLI FRLLGTPTED TWPGITSNEE FRAYNFTQYR 240

AQPLINHAPR LDSDGIDLLM NLLLYEAKSR ISAEVALRHP YF 282

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013