EKS-GAG-00122

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-GAG-00122

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Csk	422.5	4.7E-127	194	437	244

Status

Unreviewed

Ensembl Protein

ENSGALP00000001050

UniProt Accession

E1C2C8;

Protein Name

Protein Synonyms/Alias

Gene Name

MATK

Gene Synonyms/Alias

MATK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGALG00000000736	ENSGALP00000001050	ENSGALT00000001052

Organism

Gallus gallus

Functional Description

Protein Length

447

Protein Sequence
(FASTA)

MSRKHWPAGT QCVTKHDHTK PKAGELAFHK GDVVTVIEAV EGRSWYRARH NESGQEGLVA 60

TGALRERGAI RADPKLSLMP WFHGKISGVE AVQELQPPED GLFLVRESVR HPGDYVLCVS 120

FGKEVIHYRV LHRENTLSID SEQYFCNLID MIEHYTEQQG ALCTKLVKPK AKSGMKSAEK 180

ELAKAGWLLN LQQLTLGERI GQGEFGDVLQ GEYMGQKVAV KNIKCDVTAQ AFLAETAAMT 240

KVRHKNLVRL LGVILHNGLY IVMEFMSKGN LVNFLRTRGR ALVPLPQLLQ FSLDVAQGMD 300

YLESKKLVHR DLAARNILIS EDNVAKVSDF GLASVNPRGA DTTLLPVKWT APEALKHNKF 360

SSKSDVWSYG ILLWEVFSFG RAPYPKLSLK EVTEQLEQGY RMEPPEGCPP TVYVLMRSCW 420

EMEPGKRPSF KKLTEKLQKE LKHLKDV 447

Nucleotide Sequence
(FASTA)

ATGTCCAGGA AACATTGGCC TGCGGGGACA CAGTGCGTCA CCAAGCACGA CCACACCAAG 60

CCCAAGGCCG GCGAGCTGGC ATTCCATAAG GGAGATGTGG TCACCGTCAT CGAGGCCGTG 120

GAGGGCAGGA GTTGGTACCG TGCGCGGCAC AACGAGAGCG GGCAGGAGGG GCTGGTGGCG 180

ACCGGAGCGC TGCGGGAGCG CGGGGCCATC CGTGCTGACC CCAAACTCAG CCTCATGCCC 240

TGGTTCCACG GGAAGATCTC GGGGGTGGAG GCGGTGCAGG AGCTGCAGCC CCCCGAGGAC 300

GGGCTGTTCC TGGTGCGTGA GTCGGTCCGG CACCCCGGTG ACTACGTGCT GTGTGTGAGC 360

TTTGGCAAGG AGGTGATCCA CTACCGTGTG CTGCACCGGG AGAACACGCT GAGCATCGAC 420

AGCGAGCAGT ACTTCTGCAA CCTCATCGAC ATGATCGAGC ACTACACGGA GCAGCAAGGA 480

GCCCTCTGCA CCAAGCTGGT GAAGCCCAAA GCCAAGAGCG GGATGAAGTC GGCCGAGAAG 540

GAGTTGGCCA AAGCCGGCTG GCTGCTCAAC CTGCAGCAAC TCACACTGGG AGAGCGCATC 600

GGGCAAGGCG AGTTCGGAGA CGTCCTGCAG GGCGAGTACA TGGGGCAGAA GGTGGCTGTG 660

AAGAACATCA AGTGCGATGT GACTGCCCAG GCCTTCCTCG CCGAGACCGC CGCCATGACG 720

AAGGTCCGAC ACAAGAACCT GGTGCGTCTG CTCGGCGTCA TCCTGCACAA CGGCCTCTAC 780

ATTGTCATGG AGTTCATGAG CAAGGGCAAC CTGGTCAACT TCCTGCGCAC GCGGGGCCGC 840

GCGCTCGTCC CACTGCCACA GCTCCTGCAG TTCTCTCTGG ACGTGGCCCA GGGCATGGAC 900

TACCTGGAGT CCAAGAAGCT GGTGCACAGG GACCTGGCTG CCCGCAACAT CCTCATCTCT 960

GAGGACAACG TGGCCAAAGT GAGCGATTTT GGCCTGGCCA GCGTCAACCC CCGCGGCGCG 1020

GACACCACGC TGCTGCCCGT GAAGTGGACG GCTCCGGAGG CCCTGAAGCA CAATAAATTC 1080

TCCTCCAAAT CGGACGTGTG GAGCTACGGG ATCCTCCTGT GGGAGGTGTT CTCCTTCGGC 1140

CGAGCGCCCT ACCCCAAGCT GAGTCTGAAG GAGGTGACGG AGCAGCTGGA GCAGGGGTAC 1200

CGCATGGAGC CCCCCGAGGG CTGCCCGCCC ACCGTGTATG TGCTGATGAG GAGCTGCTGG 1260

GAGATGGAGC CGGGCAAGCG GCCGTCCTTC AAGAAGCTCA CGGAGAAGCT GCAGAAAGAG 1320

CTGAAGCACC TGAAGGACGT TTAA 1344

Domain Profile

S: 1     lklgetigkgefgdvllgeyrgekvavkvikndataqafldeasvmtklehenlvkllgv  60

         l+lge+ig+gefgdvl+gey g+kvavk+ik+d+taqafl+e++ mtk++h+nlv+llgv

Q: 194   LTLGERIGQGEFGDVLQGEYMGQKVAVKNIKCDVTAQAFLAETAAMTKVRHKNLVRLLGV  253

         6899********************************************************

S: 61    ileekglylvteyvakgslvdylrsrgrallekkqllkfaldvaegmeyleskklvhrdl  120

         il++ gly+v+e+++kg+lv++lr+rgral+   qll+f+ldva+gm yleskklvhrdl

Q: 254   ILHN-GLYIVMEFMSKGNLVNFLRTRGRALVPLPQLLQFSLDVAQGMDYLESKKLVHRDL  312

         ***9.*******************************************************

S: 121   aarnvlvsedlvakvsdfglakeeskdldsgklpvkwtapealkekkfstksdvwsfgil  180

         aarn+l+sed+vakvsdfgla  + ++ d++ lpvkwtapealk++kfs+ksdvws+gil

Q: 313   AARNILISEDNVAKVSDFGLASVNPRGADTTLLPVKWTAPEALKHNKFSSKSDVWSYGIL  372

         ************************************************************

S: 181   lweifsfgrvpypriplkdvvkavekgykmeapegcppevyelmkeaweleaakrpsfak  240

         lwe+fsfgr+pyp+++lk+v++++e+gy+me+pegcpp+vy lm+++we+e+ krpsf+k

Q: 373   LWEVFSFGRAPYPKLSLKEVTEQLEQGYRMEPPEGCPPTVYVLMRSCWEMEPGKRPSFKK  432

         ************************************************************

S: 241   lkekl  245

         l+ekl

Q: 433   LTEKL  437

         **997

Domain Sequence
(FASTA)

LTLGERIGQG EFGDVLQGEY MGQKVAVKNI KCDVTAQAFL AETAAMTKVR HKNLVRLLGV 60

ILHNGLYIVM EFMSKGNLVN FLRTRGRALV PLPQLLQFSL DVAQGMDYLE SKKLVHRDLA 120

ARNILISEDN VAKVSDFGLA SVNPRGADTT LLPVKWTAPE ALKHNKFSSK SDVWSYGILL 180

WEVFSFGRAP YPKLSLKEVT EQLEQGYRME PPEGCPPTVY VLMRSCWEME PGKRPSFKKL 240

TEKL 244

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

gga:769076

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR001452	; SH3_domain.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF00017	; SH2; 1.
PF00018	; SH3_1; 1.

SMARTs

SM00252	; SH2; 1.
SM00326	; SH3; 1.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50001	; SH2; 1.
PS50002	; SH3; 1.

Prints

PR00401	; SH2DOMAIN.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013