EKS-GAG-00385

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-GAG-00385

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/MAPK	425.9	7.7E-128	25	308	284

Status

Unreviewed

Ensembl Protein

ENSGALP00000001204

UniProt Accession

E1C7W3;

Protein Name

Protein Synonyms/Alias

Gene Name

MAPK13

Gene Synonyms/Alias

MAPK13;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGALG00000000826	ENSGALP00000001204	ENSGALT00000001206

Organism

Gallus gallus

Functional Description

Protein Length

365

Protein Sequence
(FASTA)

MNFTRRRGFY RQELNRTIWE LPRRYTSLHP VGSGAYGSVC SAIDKKTGEK VAIKKLCRPF 60

QSEIFAKRAY RELTLLKQMQ HENVIGLLDV FTSAPSYHGF QDFYLVMPYM RTDLQKIMGH 120

EFSDEKIQYL VYQMLKGLKY IHSAGIIHRD LKPGNLAVNE DCQLKILDFG LARHADAEMT 180

GYVVTRWYRA PEVILNWMHY NQTVDIWSIG CIMAEMLTGK TLFKGKDYVD QLTQILKVTG 240

HPGDDFVEKL EDKAAKSYIK SLPKMPKKDL SVLFPTANPQ AVDLLDKMLQ LDVEKRLTAT 300

EALAHPYFDQ FRDIEEETEA QQSYDDSLER EKLSIEEWKK HIYKEILSFS PIAQKDSKKR 360

SGMSL 365

Nucleotide Sequence
(FASTA)

ATGAACTTCA CAAGGAGAAG AGGCTTTTAC AGACAGGAGC TGAACAGAAC CATCTGGGAG 60

CTGCCCAGGA GGTACACCTC CCTGCACCCC GTGGGCTCTG GGGCCTACGG TTCCGTCTGC 120

TCCGCCATAG ACAAGAAGAC AGGAGAGAAA GTGGCCATCA AGAAGCTGTG CCGCCCATTC 180

CAGTCGGAGA TCTTTGCCAA GAGAGCGTAC AGAGAGCTCA CGCTCTTGAA GCAAATGCAG 240

CATGAGAATG TCATTGGGCT GCTTGATGTC TTCACCTCCG CCCCTTCCTA CCACGGATTC 300

CAGGACTTCT ACCTGGTGAT GCCATACATG CGGACAGATT TACAAAAGAT CATGGGACAT 360

GAATTCAGTG ATGAAAAGAT CCAGTACCTG GTCTACCAGA TGCTGAAAGG GCTGAAGTAT 420

ATTCATTCTG CCGGAATCAT CCACAGGGAC CTGAAGCCAG GCAACCTGGC TGTGAATGAA 480

GACTGCCAGC TAAAGATCTT GGACTTTGGC TTGGCAAGAC ATGCTGATGC TGAAATGACA 540

GGCTATGTGG TCACGCGCTG GTATAGAGCT CCAGAAGTCA TTCTGAACTG GATGCATTAC 600

AACCAGACAG TGGATATCTG GTCTATTGGT TGCATCATGG CAGAAATGCT GACTGGAAAA 660

ACGCTGTTTA AAGGAAAAGA CTACGTTGAT CAGCTGACTC AGATCCTGAA AGTAACAGGG 720

CATCCCGGAG ATGACTTTGT GGAGAAGCTT GAGGACAAGG CGGCTAAAAG TTATATCAAG 780

TCTCTTCCAA AAATGCCCAA GAAGGATTTG TCTGTGCTCT TCCCCACAGC CAATCCTCAG 840

GCAGTGGACC TGCTGGACAA GATGCTGCAG CTGGATGTGG AGAAGCGCCT TACGGCCACA 900

GAAGCATTAG CCCACCCATA CTTTGATCAA TTCCGAGACA TTGAGGAGGA GACAGAGGCA 960

CAACAGTCCT ACGATGATTC TCTGGAGCGT GAAAAGCTTT CAATAGAAGA ATGGAAAAAA 1020

CATATCTACA AGGAGATCTT ATCCTTCAGT CCAATTGCAC AGAAGGACTC AAAGAAGCGA 1080

AGTGGAATGT CGCTGTAG 1098

Domain Profile

S: 1     yeslkplgeGaygvvvsavdkrteervaikklsrpfqketsakrtlRElkllkelkheNi  60

         y+sl+p+g+Gayg v+sa+dk+t+e+vaikkl rpfq+e+ akr++REl+llk+++heN+

Q: 25    YTSLHPVGSGAYGSVCSAIDKKTGEKVAIKKLCRPFQSEIFAKRAYRELTLLKQMQHENV  84

         78899*******************************************************

S: 61    iklldvftpeeeleelkdvYlvtelmetdLkkviksqklsdehiklllyqilrglkylHs  120

         i lldvft++ +++ ++d+Ylv+ +m tdL+k++ ++ +sde+i++l+yq+l+glky+Hs

Q: 85    IGLLDVFTSAPSYHGFQDFYLVMPYMRTDLQKIMGHE-FSDEKIQYLVYQMLKGLKYIHS  143

         **********************************998.**********************

S: 121   anviHrDlKPsNllvnedcelkildFGlarsadkekekklteyvatrwYraPeillslke  180

         a++iHrDlKP+Nl+vnedc+lkildFGlar+ad+e    +t+yv+trwYraPe++l++++

Q: 144   AGIIHRDLKPGNLAVNEDCQLKILDFGLARHADAE----MTGYVVTRWYRAPEVILNWMH  199

         ***********************************....*********************

S: 181   ytkavDiWsvGCIlaElltgkplfpgkdeidqlekilevlgtpseeflkkieseearnyi  240

         y+++vDiWs+GCI+aE+ltgk+lf+gkd++dql++il+v+g+p ++f++k+e++ a++yi

Q: 200   YNQTVDIWSIGCIMAEMLTGKTLFKGKDYVDQLTQILKVTGHPGDDFVEKLEDKAAKSYI  259

         ************************************************************

S: 241   kslpkkkkkdfeelfpkaseealdLleklLvldpdkRisveeaLehpYl  289

         kslpk++kkd++ lfp+a+++a+dLl+k+L+ld +kR++++eaL+hpY+

Q: 260   KSLPKMPKKDLSVLFPTANPQAVDLLDKMLQLDVEKRLTATEALAHPYF  308

         ************************************************6

Domain Sequence
(FASTA)

YTSLHPVGSG AYGSVCSAID KKTGEKVAIK KLCRPFQSEI FAKRAYRELT LLKQMQHENV 60

IGLLDVFTSA PSYHGFQDFY LVMPYMRTDL QKIMGHEFSD EKIQYLVYQM LKGLKYIHSA 120

GIIHRDLKPG NLAVNEDCQL KILDFGLARH ADAEMTGYVV TRWYRAPEVI LNWMHYNQTV 180

DIWSIGCIMA EMLTGKTLFK GKDYVDQLTQ ILKVTGHPGD DFVEKLEDKA AKSYIKSLPK 240

MPKKDLSVLF PTANPQAVDL LDKMLQLDVE KRLTATEALA HPYF 284

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004707	; F:MAP kinase activity
GO:0018105	; P:peptidyl-serine phosphorylation
GO:0032755	; P:positive regulation of interleukin-6 production
GO:0006970	; P:response to osmotic stress

KEGG

gga:771145

;

InterPros

IPR011009	; Kinase-like_dom.
IPR003527	; MAP_kinase_CS.
IPR008352	; MAPK_p38.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS01351	; MAPK; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.

Prints

PR01773

; P38MAPKINASE.

Created Date

20-Feb-2013