EKS-GAG-00223

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-GAG-00223

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/DYRK	465.0	1.4E-139	142	455	314

Status

Unreviewed

Ensembl Protein

ENSGALP00000001263

UniProt Accession

F1ND56;

Protein Name

Protein Synonyms/Alias

Gene Name

DYRK3

Gene Synonyms/Alias

DYRK3;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGALG00000000863	ENSGALP00000001263	ENSGALT00000001265

Organism

Gallus gallus

Functional Description

Protein Length

520

Protein Sequence
(FASTA)

NKLAMKDHPL SGSQVKVEQL FEDSGNRRSS TLQSTGITCS ERSLPSLTKD KSIESLSTCK 60

GGSSSSKAHK AISQAPEQAV KQYKHQLSAY EQQEIFNFSE IYFVGPAAKK RQGVIGGPNN 120

GGYDDDQGSY IHVPHDHLAY RYEVLKIIGK GSFGQVAKVY DHKLHQHLAL KMVRNEKRFH 180

RQAAEEIRIL EHLKKQDKTG SMNVIHMLES FTFRNHICMT FELLSMNLYE LIKRNKFQGF 240

SVQLVRKFAH SILQCLDALY RNKIIHCDLK PENILLKQQG RSGIKVIDFG SSCFEHQRVY 300

TYIQSRFYRA PEVILGSRYG MPIDMWSFGC ILVELLTGYP LFPGEDEGDQ LACMMELLGM 360

PPQKLLDQSK RAKNFINSKG HPRYCTVTTH ADGRVTLNGS RSRRGKVRGA PGNKDWVTAL 420

KGCDDPLFIE FLKECLSWDP AVRMTPSQAL RHPWICKRTP KPPSTDKTSS KRISSYTSSF 480

TGIGSKLPPV VGVANKLRAN LTSDTNGSIP LCTVLPKLVS 520

Nucleotide Sequence
(FASTA)

AACAAACTTG CGATGAAGGA TCACCCTCTG AGTGGGAGCC AGGTCAAAGT GGAACAGTTG 60

TTTGAGGACT CTGGGAACAG AAGGAGTAGT ACCCTTCAGT CTACAGGAAT TACTTGTTCA 120

GAAAGATCTC TTCCTTCCCT GACGAAAGAT AAAAGCATAG AGAGCTTAAG CACTTGTAAA 180

GGTGGCAGCA GTTCCTCAAA AGCACACAAA GCCATTTCCC AGGCTCCAGA ACAAGCTGTC 240

AAACAGTACA AGCATCAGTT ATCTGCGTAT GAGCAGCAAG AGATATTTAA CTTCTCTGAG 300

ATTTACTTTG TGGGTCCAGC TGCAAAGAAG AGGCAAGGAG TGATTGGTGG TCCCAACAAC 360

GGAGGTTATG ATGATGACCA AGGCAGCTAC ATTCACGTGC CCCACGACCA TCTCGCTTAC 420

CGCTATGAAG TGCTCAAAAT CATTGGCAAG GGCAGTTTTG GACAAGTTGC TAAAGTCTAT 480

GATCACAAAC TCCACCAGCA CTTAGCCTTA AAGATGGTTC GCAATGAAAA GAGATTCCAT 540

CGCCAAGCAG CGGAAGAAAT CCGGATCCTG GAGCACCTGA AGAAGCAGGA TAAAACTGGC 600

AGTATGAACG TTATTCACAT GCTGGAAAGC TTCACCTTTC GGAACCACAT CTGTATGACC 660

TTTGAACTCT TGAGTATGAA CTTGTATGAG CTGATTAAGA GAAATAAGTT CCAGGGCTTC 720

AGCGTCCAGC TGGTGCGCAA GTTTGCTCAC TCTATACTGC AGTGCTTGGA TGCTCTCTAT 780

AGAAACAAAA TCATACACTG TGACTTGAAG CCGGAAAATA TCCTCCTAAA ACAGCAAGGG 840

AGGAGTGGAA TCAAGGTTAT AGATTTTGGG TCCAGCTGTT TTGAGCACCA AAGAGTCTAC 900

ACGTACATTC AGTCTCGATT TTATCGAGCA CCAGAGGTAA TTTTAGGAAG TCGTTATGGG 960

ATGCCCATAG ATATGTGGAG TTTTGGCTGT ATTCTGGTGG AGCTATTGAC TGGATACCCT 1020

CTTTTTCCTG GAGAGGATGA GGGAGACCAA TTGGCTTGTA TGATGGAACT TCTTGGAATG 1080

CCCCCTCAGA AGCTTTTGGA TCAATCCAAG CGAGCCAAGA ACTTTATCAA CTCCAAGGGT 1140

CATCCTCGCT ACTGCACTGT GACTACTCAT GCAGATGGAA GAGTGACCCT CAACGGGAGC 1200

CGATCACGCA GGGGGAAAGT GCGAGGTGCT CCAGGGAACA AGGACTGGGT GACAGCACTG 1260

AAAGGCTGCG ACGACCCCTT GTTCATAGAG TTCTTAAAGG AATGTCTCAG CTGGGATCCT 1320

GCTGTGCGCA TGACGCCAAG TCAAGCTTTA AGGCACCCGT GGATTTGTAA ACGAACACCC 1380

AAACCACCCA GCACTGATAA AACCTCCAGT AAAAGGATTT CCAGCTACAC GAGTTCTTTC 1440

ACGGGAATTG GTTCCAAGTT GCCTCCTGTG GTTGGGGTAG CAAACAAGCT GAGGGCCAAC 1500

TTAACGTCCG ACACCAATGG CAGTATACCT TTATGTACTG TGCTGCCAAA GCTGGTCAGC 1560

TAG 1563

Domain Profile

S: 1     yevlevigkGsfgqVvkaldkktkeivaikiiknkkrfarqaqeEveiLeklnkkdkeek  60

         yevl++igkGsfgqV+k++d+k ++++a+k+++n+krf+rqa+eE++iLe+l+k+dk+ +

Q: 142   YEVLKIIGKGSFGQVAKVYDHKLHQHLALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGS  201

         9***********************************************************

S: 61    ynvvrllelfvfrnhlclvfellsqnLyellkknkfsglslklvrklaqqilkaLklLke  120

         +nv+++le+f+frnh+c++fells+nLyel+k+nkf+g+s++lvrk+a++il++L++L++

Q: 202   MNVIHMLESFTFRNHICMTFELLSMNLYELIKRNKFQGFSVQLVRKFAHSILQCLDALYR  261

         ************************************************************

S: 121   lkiiHaDlKPeNillvekkrsevkviDFGsssavsqkeiytyiqsrfYraPEiilglkyd  180

         +kiiH+DlKPeNill++++rs +kviDFGss++++q+ +ytyiqsrfYraPE+ilg +y

Q: 262   NKIIHCDLKPENILLKQQGRSGIKVIDFGSSCFEHQR-VYTYIQSRFYRAPEVILGSRYG  320

         *************************************.**********************

S: 181   eaiDmWSlGcvlaElftGkpLfpGenevdqlalivevlglppekllekakkakkfftkke  240

         + iDmWS+Gc+l+El+tG+pLfpGe+e dqla+++e+lg+pp+kll+++k+ak+f+++k+

Q: 321   MPIDMWSFGCILVELLTGYPLFPGEDEGDQLACMMELLGMPPQKLLDQSKRAKNFINSKG  380

         ************************************************************

S: 241   apkyilktkksdrkkklvlnvkkaakkrkaplskelgealkekedklfkdllkrmleldp  300

         +p+y+++t+++d +++l+ ++++++k r ap++k++++alk ++d lf+++lk++l++dp

Q: 381   HPRYCTVTTHADGRVTLNGSRSRRGKVRGAPGNKDWVTALKGCDDPLFIEFLKECLSWDP  440

         ************************************************************

S: 301   akRitpkealkhpfv  315

         a R+tp++al+hp++

Q: 441   AVRMTPSQALRHPWI  455

         **************7

Domain Sequence
(FASTA)

YEVLKIIGKG SFGQVAKVYD HKLHQHLALK MVRNEKRFHR QAAEEIRILE HLKKQDKTGS 60

MNVIHMLESF TFRNHICMTF ELLSMNLYEL IKRNKFQGFS VQLVRKFAHS ILQCLDALYR 120

NKIIHCDLKP ENILLKQQGR SGIKVIDFGS SCFEHQRVYT YIQSRFYRAP EVILGSRYGM 180

PIDMWSFGCI LVELLTGYPL FPGEDEGDQL ACMMELLGMP PQKLLDQSKR AKNFINSKGH 240

PRYCTVTTHA DGRVTLNGSR SRRGKVRGAP GNKDWVTALK GCDDPLFIEF LKECLSWDPA 300

VRMTPSQALR HPWI 314

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Dasypus novemcinctus"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0000287	; F:magnesium ion binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013