EKS-GAG-00154

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-GAG-00154

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/SRPK	811.8	2.5E-244	80	659	580

Status

Unreviewed

Ensembl Protein

ENSGALP00000001306

UniProt Accession

E1C5I9;

Protein Name

Protein Synonyms/Alias

Gene Name

SRPK1

Gene Synonyms/Alias

SRPK1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGALG00000000890	ENSGALP00000001306	ENSGALT00000001308

Organism

Gallus gallus

Functional Description

Protein Length

661

Protein Sequence
(FASTA)

MERKVLALQA RKKRTKAKKD KAQRKADPQH RGPAAHSETD LPEQEEEILG SDDDEQEDPN 60

DYCKGGYHLV KIGDLFNGRY HVIRKLGWGH FSTVWLAWDI QGKRFVAMKV VKSAEHYTET 120

ALDEIKLLKS VRNSDPNDPN KERVVQLLDD FKISGVNGSH ICMVFEVLGH HLLKWIIKSN 180

YQGLPLPCVK KIIKQVLQGL DYLHTKCRII HTDIKPENIL LCVNDQYIRR LAAEATEWQR 240

SGAPPPSGSA VSTAPQPKPA DKMSKNKKKK LKKKQKRQAE LLEKRMQEIE EMEKEASPGQ 300

THPEEEEEAQ SPLKMLIKVS PPSEDADKKK AEVIVREQSV LMESSIEKCV KEINCNGVIR 360

MSDFPDSGSQ GSVQLEDDLH NANDCGDHPH TQKENFHSCN YSQRNGDVEN RPRAAVSDSF 420

VPLVSEDSMV CQPTSSEEQS FNEQEISHLQ ESIRTEMPSE DENENNSPAD NKGKSTAGNF 480

LLNPLEPKNA DKLKVKIADL GNACWVHKHF TEDIQTRQYR SLEVLIGSGY SSPADIWSTA 540

CMAFELATGD YLFEPHSGED YSRDEEKNAD HIALIIELLG KIPRKLILAG KYSKEFFTKK 600

GDLKHITKLK PWGLFEVLVE KYEWSQDEAA AFTDFLLPML ELIPEKRATA AECLRHPWLL 660

S 661

Nucleotide Sequence
(FASTA)

ATGGAGCGGA AAGTACTGGC GCTGCAGGCC CGGAAGAAGC GGACCAAAGC CAAGAAGGAT 60

AAGGCCCAGA GAAAAGCCGA CCCTCAGCAC CGTGGCCCTG CTGCTCACTC TGAGACTGAT 120

CTTCCAGAGC AAGAGGAAGA AATTCTGGGG TCAGATGACG ATGAACAAGA GGACCCGAAT 180

GATTACTGTA AAGGTGGTTA TCACCTTGTG AAAATTGGAG ATCTCTTTAA TGGACGCTAC 240

CATGTGATTC GGAAGCTCGG ATGGGGCCAC TTCTCCACTG TCTGGCTGGC GTGGGACATC 300

CAAGGGAAGA GATTTGTGGC GATGAAAGTG GTCAAGAGTG CAGAGCACTA CACAGAAACA 360

GCACTGGATG AAATCAAGTT GCTAAAATCG GTTCGCAACA GTGATCCAAA TGATCCAAAT 420

AAAGAGAGAG TTGTTCAGTT ATTAGATGAC TTCAAGATCT CAGGAGTTAA TGGTTCTCAT 480

ATCTGTATGG TGTTTGAAGT TTTAGGACAT CATCTCCTGA AGTGGATCAT CAAGTCAAAT 540

TATCAGGGGC TCCCGCTCCC TTGTGTCAAA AAGATCATCA AACAGGTTCT TCAGGGTCTG 600

GACTACTTGC ACACGAAGTG TAGGATCATC CACACAGATA TTAAACCTGA AAACATTCTT 660

CTGTGTGTTA ATGACCAGTA TATCCGCAGA CTGGCTGCAG AAGCAACAGA ATGGCAGAGA 720

TCTGGGGCCC CCCCACCGTC TGGCTCTGCA GTGAGTACTG CACCACAGCC AAAACCAGCT 780

GACAAAATGT CAAAGAATAA GAAAAAGAAG TTGAAAAAGA AGCAGAAACG TCAGGCGGAG 840

TTATTAGAGA AGCGAATGCA AGAGATAGAG GAAATGGAGA AGGAAGCAAG CCCTGGGCAG 900

ACGCATCCTG AGGAGGAGGA AGAAGCTCAG AGCCCTCTGA AAATGCTCAT AAAAGTTAGT 960

CCACCCAGTG AAGATGCAGA TAAAAAGAAA GCTGAAGTCA TCGTACGTGA ACAGTCTGTT 1020

CTAATGGAAA GCAGCATAGA GAAATGTGTA AAAGAAATAA ATTGTAATGG TGTGATACGA 1080

ATGTCGGACT TCCCAGACTC TGGCAGTCAA GGGTCTGTGC AACTTGAGGA TGACCTACAC 1140

AATGCCAATG ACTGCGGTGA TCACCCTCAC ACACAGAAGG AGAACTTCCA TAGCTGTAAT 1200

TACAGCCAAC GTAATGGTGA CGTAGAGAAC AGGCCCCGGG CAGCAGTGTC GGACTCTTTC 1260

GTGCCCTTAG TTTCAGAAGA TTCCATGGTG TGTCAGCCTA CTTCCAGCGA AGAGCAATCA 1320

TTCAATGAGC AGGAGATCAG CCACTTGCAA GAAAGCATCC GGACAGAGAT GCCATCAGAG 1380

GATGAGAATG AGAATAATAG CCCAGCAGAC AACAAAGGAA AATCAACTGC TGGGAATTTC 1440

CTTCTTAATC CTCTTGAGCC CAAGAATGCA GATAAGCTTA AGGTGAAGAT AGCTGACCTA 1500

GGAAATGCCT GCTGGGTGCA CAAGCACTTC ACTGAAGACA TCCAGACAAG ACAGTACCGA 1560

TCCTTGGAGG TGTTGATAGG GTCGGGGTAC AGCAGCCCTG CTGACATCTG GAGCACGGCT 1620

TGTATGGCCT TTGAACTAGC AACAGGAGAC TATCTGTTTG AACCTCATTC TGGAGAAGAC 1680

TACTCACGAG ATGAAGAAAA AAATGCAGAT CACATTGCTT TGATCATAGA ACTCCTGGGG 1740

AAAATACCTC GCAAGCTCAT TTTGGCAGGA AAGTATTCCA AGGAGTTTTT CACTAAAAAA 1800

GGTGATCTGA AGCACATCAC TAAACTGAAG CCCTGGGGCC TTTTTGAAGT CTTGGTGGAA 1860

AAATATGAAT GGTCCCAGGA TGAGGCAGCT GCGTTTACAG ACTTCTTACT ACCAATGTTG 1920

GAGCTGATCC CGGAGAAGCG AGCCACAGCA GCAGAGTGTC TCAGGCACCC CTGGCTTCTC 1980

TCTTAA 1986

Domain Profile

S: 1     yhvirkLGWGhfstvWLawdlqekrfvalkvvksaehytetaldeikllksvresdpsdp  60

         yhvirkLGWGhfstvWLawd+q+krfva+kvvksaehytetaldeikllksvr+sdp+dp

Q: 80    YHVIRKLGWGHFSTVWLAWDIQGKRFVAMKVVKSAEHYTETALDEIKLLKSVRNSDPNDP  139

         9***********************************************************

S: 61    krekvvqllddfkisGvnGvhvclvfevLGenLlkliiksnyrGlpleqvkkiirqvLeg  120

         ++e+vvqllddfkisGvnG h+c+vfevLG++Llk+iiksny+Glpl++vkkii+qvL+g

Q: 140   NKERVVQLLDDFKISGVNGSHICMVFEVLGHHLLKWIIKSNYQGLPLPCVKKIIKQVLQG  199

         ************************************************************

S: 121   LdylhekCkiihtdikPenvLlavddeyirrlaaeatewqkagakppsgsavstapqkka  180

         Ldylh+kC+iihtdikPen+Ll+v+d+yirrlaaeatewq++ga+ppsgsavstapq+k+

Q: 200   LDYLHTKCRIIHTDIKPENILLCVNDQYIRRLAAEATEWQRSGAPPPSGSAVSTAPQPKP  259

         ************************************************************

S: 181   ieklsknkkkklkkkqkrqaellekrlqeleele..........................  214

         ++k+sknkkkklkkkqkrqaellekr+qe+ee+e

Q: 260   ADKMSKNKKKKLKKKQKRQAELLEKRMQEIEEMEkeaspgqthpeeeeeaqsplkmlikv  319

         ************************************************************

S: 215   ........aaeanseaedqelked.aekgeleeieadveeevanedeaseeee.......  258

                  ++a+ ++++q++ ++ + ++ ++ei+++ ++ +    ++ ++++

Q: 320   sppsedadKKKAEVIVREQSVLMEsSIEKCVKEINCNGVIRMSDFPDSGSQGSvqleddl  379

         ***999986666666666665544044556788888888888877777433334455556

S: 259   ............essltsssdaesksgelseastellsesleqlacgsvls.........  297

                     +++  +s ++++ +g+  + +   +s+s  +l+++ ++

Q: 380   hnandcgdhphtQKENFHSCNYSQRNGDVENRPRAAVSDSFVPLVSEDSMVcqptsseeq  439

         666667777777666667778888888874444444444444443333333344444779

S: 298   ..........................................vnplepknadkikvkiad  315

                                                   +nplepknadk+kvkiad

Q: 440   sfneqeishlqesirtempsedenennspadnkgkstagnflLNPLEPKNADKLKVKIAD  499

         999999999999999999999***************************************

S: 316   LGnaCwvhkhftediqtrqyrslevliGagygtpadiWstaClafeLatGdyLfephsge  375

         LGnaCwvhkhftediqtrqyrslevliG+gy+ padiWstaC+afeLatGdyLfephsge

Q: 500   LGNACWVHKHFTEDIQTRQYRSLEVLIGSGYSSPADIWSTACMAFELATGDYLFEPHSGE  559

         ************************************************************

S: 376   dysrde....dhiakiiellGkiPrklilkGkysreffnkkgeLrhitkLkpwsLlevLv  431

         dysrde    dhia iiellGkiPrklil+Gkys+eff+kkg+L+hitkLkpw+L+evLv

Q: 560   DYSRDEeknaDHIALIIELLGKIPRKLILAGKYSKEFFTKKGDLKHITKLKPWGLFEVLV  619

         *****977778*************************************************

S: 432   ekyewskeeaaefsdfLlPmleldpekrasaaeclkhpwL  471

         ekyews++eaa f+dfLlPmlel+pekra+aaecl+hpwL

Q: 620   EKYEWSQDEAAAFTDFLLPMLELIPEKRATAAECLRHPWL  659

         ***************************************8

Domain Sequence
(FASTA)

YHVIRKLGWG HFSTVWLAWD IQGKRFVAMK VVKSAEHYTE TALDEIKLLK SVRNSDPNDP 60

NKERVVQLLD DFKISGVNGS HICMVFEVLG HHLLKWIIKS NYQGLPLPCV KKIIKQVLQG 120

LDYLHTKCRI IHTDIKPENI LLCVNDQYIR RLAAEATEWQ RSGAPPPSGS AVSTAPQPKP 180

ADKMSKNKKK KLKKKQKRQA ELLEKRMQEI EEMEKEASPG QTHPEEEEEA QSPLKMLIKV 240

SPPSEDADKK KAEVIVREQS VLMESSIEKC VKEINCNGVI RMSDFPDSGS QGSVQLEDDL 300

HNANDCGDHP HTQKENFHSC NYSQRNGDVE NRPRAAVSDS FVPLVSEDSM VCQPTSSEEQ 360

SFNEQEISHL QESIRTEMPS EDENENNSPA DNKGKSTAGN FLLNPLEPKN ADKLKVKIAD 420

LGNACWVHKH FTEDIQTRQY RSLEVLIGSG YSSPADIWST ACMAFELATG DYLFEPHSGE 480

DYSRDEEKNA DHIALIIELL GKIPRKLILA GKYSKEFFTK KGDLKHITKL KPWGLFEVLV 540

EKYEWSQDEA AAFTDFLLPM LELIPEKRAT AAECLRHPWL 580

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Choloepus hoffmanni"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0007059	; P:chromosome segregation
GO:0045071	; P:negative regulation of viral genome replication
GO:0045070	; P:positive regulation of viral genome replication

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 2.

SMARTs

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013