EKS-GAG-00214

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-GAG-00214

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/CAMKL	266.5	2.2E-79	2	241	240

Status

Unreviewed

Ensembl Protein

ENSGALP00000040314

UniProt Accession

F1NLQ8;

Protein Name

Protein Synonyms/Alias

Serine/threonine-protein kinase Chk1;

Gene Name

CHEK1

Gene Synonyms/Alias

CHEK1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGALG00000000970	ENSGALP00000001432	ENSGALT00000001434
ENSGALG00000000970	ENSGALP00000040314	ENSGALT00000041108

Organism

Gallus gallus

Functional Description

Protein Length

254

Protein Sequence
(FASTA)

RVQLAVNRRT EEAVAVKIVD MKRAADCPEN IKKEICINKM LNHENVVKFY GHRREGATQY 60

LFLEYCSGGE LFDRIEPDIG MPEPEAQRFF QQLIAGVVYL HSMGITHRDL KPENLLLDER 120

DNLKISDFGL ATVFKHNGRE RLLNKMCGTL PYVAPELLRR PEFRAEPVDV WACGVVLTAM 180

LAGELPWDQP SDSCQEYSDW KERKTYLAPW RKIDSAPLAL LHKILTENPT ARITIPDIKK 240

KRRKKRKLKK GAKQ 254

Nucleotide Sequence
(FASTA)

AGGGTGCAGT TGGCCGTGAA CCGCCGCACC GAGGAGGCCG TGGCCGTGAA GATCGTGGAC 60

ATGAAGCGCG CGGCCGACTG CCCGGAGAAC ATCAAGAAGG AGATCTGCAT CAACAAGATG 120

CTGAACCACG AGAACGTCGT CAAGTTCTAC GGGCACCGGC GGGAGGGGGC CACGCAGTAC 180

CTGTTCCTGG AGTACTGCAG CGGCGGGGAG CTCTTCGACC GCATCGAGCC GGACATTGGG 240

ATGCCGGAGC CGGAGGCGCA GCGCTTCTTC CAGCAGCTGA TTGCTGGTGT GGTGTACCTG 300

CACAGCATGG GCATCACGCA CCGCGACCTC AAGCCGGAGA ACCTGCTGCT GGATGAGCGA 360

GACAACCTGA AGATCTCCGA TTTCGGCCTG GCCACCGTCT TCAAGCACAA CGGGCGCGAG 420

CGGCTGCTGA ACAAGATGTG TGGCACACTG CCCTACGTGG CCCCCGAGCT GCTGCGGCGC 480

CCCGAGTTCC GTGCAGAGCC CGTGGACGTG TGGGCCTGCG GCGTGGTGCT GACCGCCATG 540

CTGGCGGGAG AGCTACCCTG GGATCAGCCC AGCGACAGCT GCCAGGAGTA CAGCGACTGG 600

AAGGAGAGGA AGACCTACCT GGCGCCCTGG AGGAAGATCG ACTCTGCACC ATTAGCACTG 660

CTGCACAAGA TCCTGACCGA GAACCCCACG GCGCGCATCA CCATCCCCGA CATAAAAAAA 720

AAAAGAAGAA AAAAAAGAAA ACTAAAAAAA GGAGCAAAGC AA 762

Domain Profile

S: 15    VklakhketkekvavKiikkkklseeslekikrEieilkklkhpniikllevietkkkly  74

         V+la++++t+e+vavKi++ k++  +  e+ik+Ei i k+l+h+n++k++   ++  + y

Q: 2     VQLAVNRRTEEAVAVKIVDMKRAA-DCPENIKKEICINKMLNHENVVKFYGHRREGATQY  60

         99******************7765.5579*******************************

S: 75    lvleyasggeLfdyieekgrlkekearklfkqlvsavkYlhskgivHrDlKpeNllldkk  134

         l+ley+sggeLfd+ie +  ++e ea+++f+ql+++v Ylhs gi+HrDlKpeNllld++

Q: 61    LFLEYCSGGELFDRIEPDIGMPEPEAQRFFQQLIAGVVYLHSMGITHRDLKPENLLLDER  120

         ************************************************************

S: 135   enikiaDFGlanlfkeg...klletfcGsppYaaPellkgkkYegpkvDvWslGvvLyal  191

         +n+ki+DFGla++fk++   +ll+++cG++pY+aPell++ ++++++vDvW++GvvL a+

Q: 121   DNLKISDFGLATVFKHNgreRLLNKMCGTLPYVAPELLRRPEFRAEPVDVWACGVVLTAM  180

         ************999988889***************************************

S: 192   vtgklPfdee..nlkellekilkgkleipkk.lskelesLlrklLvvdpekRatieeilk  248

         ++g+lP+d++  +++e++++ +++++  p   +++    Ll+k+L+++p+ R+ti +i+k

Q: 181   LAGELPWDQPsdSCQEYSDWKERKTYLAPWRkIDSAPLALLHKILTENPTARITIPDIKK  240

         *********97679999999999999999888**************************98

S: 249   h  249

Q: 241   K  241

Domain Sequence
(FASTA)

VQLAVNRRTE EAVAVKIVDM KRAADCPENI KKEICINKML NHENVVKFYG HRREGATQYL 60

FLEYCSGGEL FDRIEPDIGM PEPEAQRFFQ QLIAGVVYLH SMGITHRDLK PENLLLDERD 120

NLKISDFGLA TVFKHNGRER LLNKMCGTLP YVAPELLRRP EFRAEPVDVW ACGVVLTAML 180

AGELPWDQPS DSCQEYSDWK ERKTYLAPWR KIDSAPLALL HKILTENPTA RITIPDIKKK 240

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005813	; C:centrosome
GO:0000785	; C:chromatin
GO:0000781	; C:chromosome, telomeric region
GO:0000794	; C:condensed nuclear chromosome
GO:0005657	; C:replication fork
GO:0005524	; F:ATP binding
GO:0035402	; F:histone kinase activity (H3-T11 specific)
GO:0071260	; P:cellular response to mechanical stimulus
GO:0048096	; P:chromatin-mediated maintenance of transcription
GO:0000077	; P:DNA damage checkpoint
GO:0006281	; P:DNA repair
GO:0000086	; P:G2/M transition of mitotic cell cycle
GO:0045839	; P:negative regulation of mitosis
GO:0010569	; P:regulation of double-strand break repair via homologous recombination
GO:2000615	; P:regulation of histone H3-K9 acetylation
GO:0046602	; P:regulation of mitotic centrosome separation
GO:0010767	; P:regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013