EKS-GAG-00188

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-GAG-00188

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE7	392.2	1.2E-117	69	334	266

Status

Unreviewed

Ensembl Protein

ENSGALP00000001475

UniProt Accession

F1P3T1;

Protein Name

Protein Synonyms/Alias

Gene Name

MAP2K4

Gene Synonyms/Alias

MAP2K4;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGALG00000001001	ENSGALP00000001475	ENSGALT00000001477

Organism

Gallus gallus

Functional Description

Protein Length

366

Protein Sequence
(FASTA)

VRCLPGKRKA LKLNFANPPF KSTARFTLNT SGVPFQNPHI ERLRTHSIES SGKLKISPEQ 60

HWDFTAEDLK DLGEIGRGAY GSVNKMVHKP SGQIMAVKRI RSTVDEKEQK QLLMDLDVVM 120

RSSDCPYIVQ FYGALFREGD CWICMELMST SFDKFYKYVY SVLDDVIPEE ILGKITLATV 180

KALNHLKENL KIIHRDIKPS NILLDRNGNI KLCDFGISGQ LVDSIAKTRD AGCRPYMAPE 240

RIDPSASRQG YDVRSDVWSL GITLYELATG RFPYPKWNSV FDQLTQVVKG DPPQLSNSEE 300

REFSPSFINF VNLCLTKEES KRPKYKELLK HPFILMYEER TVDVACYVCK ILDQMPATPS 360

SPMYVD 366

Nucleotide Sequence
(FASTA)

GTCCGTTGTC TCCCAGGTAA ACGCAAAGCG CTGAAGTTAA ATTTTGCAAA TCCACCTTTC 60

AAGTCCACGG CAAGGTTTAC TCTGAACACC TCAGGAGTTC CTTTCCAAAA TCCACACATA 120

GAGAGACTGA GAACACACAG CATTGAATCA TCAGGAAAAT TGAAGATTTC CCCTGAACAG 180

CATTGGGATT TTACAGCAGA GGACTTGAAA GACCTTGGAG AAATTGGACG AGGCGCTTAT 240

GGTTCTGTCA ACAAAATGGT CCACAAACCA AGTGGGCAAA TTATGGCAGT TAAAAGAATT 300

CGATCGACAG TGGATGAAAA AGAACAGAAG CAGCTTCTGA TGGACCTTGA TGTAGTAATG 360

CGAAGCAGTG ACTGCCCATA TATTGTTCAG TTTTATGGTG CACTCTTCAG AGAGGGTGAC 420

TGTTGGATCT GTATGGAGCT CATGTCTACC TCGTTTGATA AGTTTTACAA ATATGTATAT 480

AGTGTATTAG ATGATGTTAT TCCAGAAGAA ATCCTAGGCA AAATCACTTT AGCTACTGTG 540

AAAGCACTAA ACCACTTAAA AGAAAACTTG AAAATCATTC ACAGAGATAT CAAACCTTCC 600

AATATTCTTC TGGACAGAAA TGGAAATATT AAACTCTGTG ACTTTGGCAT TAGTGGACAG 660

CTTGTGGACT CCATTGCCAA AACACGAGAT GCAGGGTGCC GGCCGTACAT GGCGCCGGAA 720

AGGATAGATC CCAGCGCATC CAGGCAAGGC TATGACGTCC GCTCAGACGT CTGGAGCTTG 780

GGGATTACAC TGTATGAGCT GGCCACAGGG CGATTCCCCT ACCCCAAATG GAACAGTGTG 840

TTTGACCAGT TGACGCAAGT AGTAAAAGGA GACCCACCAC AGCTGAGTAA CTCAGAGGAA 900

AGGGAATTCT CCCCAAGTTT CATCAACTTT GTCAACTTGT GCCTTACAAA GGAGGAGTCC 960

AAAAGGCCAA AGTACAAAGA GCTTCTGAAA CATCCCTTCA TTCTGATGTA TGAGGAACGC 1020

ACAGTGGATG TTGCATGCTA TGTTTGTAAA ATCCTGGATC AAATGCCAGC AACTCCCAGC 1080

TCTCCAATGT ATGTCGATTG A 1101

Domain Profile

S: 1     lekleelGaGnggvVekvlhkksgkilavKtirleikkeeqkqilrelevlkkssnspyi  60

         l++l+e+G+G++g+V+k++hk+sg+i+avK+ir++++++eqkq+l++l+v+++ss++pyi

Q: 69    LKDLGEIGRGAYGSVNKMVHKPSGQIMAVKRIRSTVDEKEQKQLLMDLDVVMRSSDCPYI  128

         68899*******************************************************

S: 61    vkfyGafvsegdvsicmelmdgtsldkvlkkvlek.kkripekvlgkiavavvkaleylk  119

         v+fyGa+++egd++icmelm+ ts+dk++k v+++ ++ ipe++lgki++a+vkal++lk

Q: 129   VQFYGALFREGDCWICMELMS-TSFDKFYKYVYSVlDDVIPEEILGKITLATVKALNHLK  187

         *********************.*************9************************

S: 120   eklkiiHRDvKPsNiLvnskGevKlCDFGvsgqlvdsiAksa.vGtksYmaPErieg...  175

         e+lkiiHRD+KPsNiL++++G++KlCDFG+sgqlvdsiAk++ +G+++YmaPEri++

Q: 188   ENLKIIHRDIKPSNILLDRNGNIKLCDFGISGQLVDSIAKTRdAGCRPYMAPERIDPsas  247

         *********************************************************999

S: 176   kkkYsvksdvWslGltlvelatgrypyeklkeilellkaivneeppklpee...efseef  232

         ++ Y+v+sdvWslG+tl+elatgr+py+k+++ +++l+++v+++pp+l+++   efs++f

Q: 248   RQGYDVRSDVWSLGITLYELATGRFPYPKWNSVFDQLTQVVKGDPPQLSNSeerEFSPSF  307

         9***********************************************988788******

S: 233   qefvskClkkdekeRpklkellkhafi  259

         ++fv+ Cl+k+e++Rpk+kellkh+fi

Q: 308   INFVNLCLTKEESKRPKYKELLKHPFI  334

         **************************7

Domain Sequence
(FASTA)

LKDLGEIGRG AYGSVNKMVH KPSGQIMAVK RIRSTVDEKE QKQLLMDLDV VMRSSDCPYI 60

VQFYGALFRE GDCWICMELM STSFDKFYKY VYSVLDDVIP EEILGKITLA TVKALNHLKE 120

NLKIIHRDIK PSNILLDRNG NIKLCDFGIS GQLVDSIAKT RDAGCRPYMA PERIDPSASR 180

QGYDVRSDVW SLGITLYELA TGRFPYPKWN SVFDQLTQVV KGDPPQLSNS EEREFSPSFI 240

NFVNLCLTKE ESKRPKYKEL LKHPFI 266

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0071260	; P:cellular response to mechanical stimulus
GO:0000165	; P:MAPK cascade

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013