EKS-GAG-00190

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-GAG-00190

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE7	383.7	4.8E-115	71	367	297

Status

Unreviewed

Ensembl Protein

ENSGALP00000001932

UniProt Accession

F1NYZ2;

Protein Name

Protein Synonyms/Alias

Dual-specificity mitogen-activated protein kinase kinase 2;

Gene Name

MAP2K2

Gene Synonyms/Alias

MAP2K2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGALG00000001267	ENSGALP00000001932	ENSGALT00000001934

Organism

Gallus gallus

Functional Description

Protein Length

398

Protein Sequence
(FASTA)

MPAKRKPVLP ALTITPSPAE GPGPGGSAEA NLVDLQKKLE ELELDEQQKK RLEAFLTQKA 60

KVGELKDDDF ERISELGAGN GGVVTKVQHK PSGLIMARKL IHLEIKPAIR NQIIRELQVL 120

HECNSPYIVG FYGAFYSDGE ISICMEHMDG GSLDQVLKEA KRIPEEILGK VSIAVLRGLA 180

YLREKHQIMH RDVKPSNILV NSRGEIKLCD FGVSGQLIDS MANSFVGTRS YMSPERLQGT 240

HYSVQSDIWS MGLSLVELSI GRYPIPPPDS KELEAIFGRP VVDGAEGESH SVSPRARPPG 300

RPISGHGMDS RPAMAIFELL DYIVNEPPPK LPNGVFTQDF QEFVNKCLIK NPAERADLKM 360

LMNHTFIKRS EVEEVDFAGW LCKTLRLNQP STPTRAAV 398

Nucleotide Sequence
(FASTA)

ATGCCGGCCA AGAGGAAGCC GGTGCTGCCG GCCCTCACCA TCACTCCCAG CCCCGCCGAG 60

GGACCCGGGC CCGGCGGTTC CGCAGAGGCC AACCTGGTGG ACCTTCAGAA GAAGCTGGAG 120

GAGCTGGAGC TGGATGAGCA GCAGAAGAAG CGCTTGGAAG CTTTCCTCAC TCAGAAAGCC 180

AAAGTGGGAG AGCTGAAGGA CGATGACTTT GAGAGGATCT CCGAGCTGGG GGCTGGCAAC 240

GGTGGTGTGG TCACCAAAGT GCAACACAAA CCCTCAGGGC TCATTATGGC ACGGAAGCTG 300

ATTCATCTAG AAATCAAACC AGCCATCAGG AATCAGATTA TCCGAGAGCT GCAGGTGCTG 360

CATGAGTGTA ATTCCCCATA CATTGTGGGT TTCTATGGGG CCTTCTACAG CGATGGAGAG 420

ATTTCCATCT GCATGGAGCA CATGGATGGT GGCTCCCTGG ATCAAGTGTT GAAAGAAGCC 480

AAAAGAATCC CCGAGGAAAT ACTGGGGAAA GTCAGCATAG CGGTTCTGAG AGGTTTGGCC 540

TATCTGAGAG AGAAGCACCA AATCATGCAC AGAGATGTGA AGCCTTCCAA CATCCTGGTT 600

AACTCTCGAG GAGAGATTAA GCTGTGTGAT TTTGGGGTCA GTGGTCAACT CATTGACTCC 660

ATGGCAAACT CTTTTGTGGG AACTCGGTCC TACATGTCTC CTGAACGGTT GCAGGGCACC 720

CATTACTCAG TCCAGTCCGA CATCTGGAGC ATGGGTCTGT CACTGGTGGA GCTTTCTATT 780

GGAAGGTACC CCATACCCCC ACCAGACTCC AAGGAACTGG AAGCAATATT TGGCCGTCCC 840

GTGGTGGATG GGGCAGAGGG AGAATCTCAC AGCGTCTCGC CGCGGGCCAG ACCCCCAGGA 900

CGCCCCATCA GTGGCCATGG AATGGACAGC CGACCTGCAA TGGCCATCTT TGAACTGCTG 960

GACTATATCG TTAATGAGCC ACCTCCCAAG TTGCCAAATG GAGTTTTCAC GCAAGATTTC 1020

CAGGAGTTTG TAAATAAATG CTTAATTAAG AATCCAGCGG AACGGGCAGA TTTGAAGATG 1080

CTGATGAATC ACACCTTCAT CAAACGCTCC GAAGTGGAGG AGGTGGATTT CGCCGGCTGG 1140

CTGTGCAAAA CACTGAGGTT AAACCAGCCC AGCACACCCA CCCGTGCTGC CGTGTGA 1197

Domain Profile

S: 2     ekleelGaGnggvVekvlhkksgkilavKtirleikkeeqkqilrelevlkkssnspyiv  61

         e+++elGaGnggvV+kv+hk+sg i+a+K i+leik+++++qi+rel+vl+++ nspyiv

Q: 71    ERISELGAGNGGVVTKVQHKPSGLIMARKLIHLEIKPAIRNQIIRELQVLHEC-NSPYIV  129

         789**************************************************.******

S: 62    kfyGafvsegdvsicmelmdgtsldkvlkkvlekkkripekvlgkiavavvkaleylkek  121

         +fyGaf+s+g++sicme+mdg+sld+vlk+    +kripe++lgk+++av+++l+yl+ek

Q: 130   GFYGAFYSDGEISICMEHMDGGSLDQVLKE----AKRIPEEILGKVSIAVLRGLAYLREK  185

         *****************************9....79************************

S: 122   lkiiHRDvKPsNiLvnskGevKlCDFGvsgqlvdsiAksavGtksYmaPEriegkkkYsv  181

         ++i+HRDvKPsNiLvns+Ge+KlCDFGvsgql+ds+A+s+vGt+sYm+PEr++g ++Ysv

Q: 186   HQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQG-THYSV  244

         ******************************************************.*****

S: 182   ksdvWslGltlvelatgrypyeklke..................................  207

         +sd+Ws+Gl+lvel +gryp++++++

Q: 245   QSDIWSMGLSLVELSIGRYPIPPPDSkeleaifgrpvvdgaegeshsvsprarppgrpis  304

         ************************999*********************************

S: 208   ...........ilellkaivneeppklpeeefseefqefvskClkkdekeRpklkellkh  256

                    i+ell++ivne+ppklp+  f+++fqefv+kCl+k+++eR++lk+l++h

Q: 305   ghgmdsrpamaIFELLDYIVNEPPPKLPNGVFTQDFQEFVNKCLIKNPAERADLKMLMNH  364

         ************************************************************

S: 257   afi  259

+fi

Q: 365   TFI  367

*97

Domain Sequence
(FASTA)

ERISELGAGN GGVVTKVQHK PSGLIMARKL IHLEIKPAIR NQIIRELQVL HECNSPYIVG 60

FYGAFYSDGE ISICMEHMDG GSLDQVLKEA KRIPEEILGK VSIAVLRGLA YLREKHQIMH 120

RDVKPSNILV NSRGEIKLCD FGVSGQLIDS MANSFVGTRS YMSPERLQGT HYSVQSDIWS 180

MGLSLVELSI GRYPIPPPDS KELEAIFGRP VVDGAEGESH SVSPRARPPG RPISGHGMDS 240

RPAMAIFELL DYIVNEPPPK LPNGVFTQDF QEFVNKCLIK NPAERADLKM LMNHTFI 297

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Xiphophorus maculatus"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005778	; C:peroxisomal membrane
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:2000147	; P:positive regulation of cell motility

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013