EKS-GAG-00123
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-GAG-00123
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Csk353.94.0E-106195437243
StatusUnreviewed
Ensembl ProteinENSGALP00000039236
UniProt AccessionF1NMH8;
Protein Name
Protein Synonyms/Alias Tyrosine-protein kinase CSK;
Gene NameCSK
Gene Synonyms/Alias CSK;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSGALG00000001318ENSGALP00000039232ENSGALT00000040025
ENSGALG00000001318ENSGALP00000039236ENSGALT00000040029
ENSGALG00000001318ENSGALP00000002008ENSGALT00000002010
OrganismGallus gallus
Functional Description
Protein Length447
Protein Sequence
(FASTA)
MSGMQAVWPS GTECIAKYNF HGTAEQDLPF SKGDVLTIVA VTKDPNWYKA KNKVGREGII 60
PANYVQKREG VKAGIKLSLM PWFHGKITRE QAERLLYPPE TGLFLVREST NYPGDYTLCV 120
SCEGKVEHYR IIYSSSKLSI DEEVYFENLM QLVEHYTTDA DGLCTRLIKP KVMEGTVAAQ 180
DEFSRSGWAL NMKDLKLLQI IGKGEFGDVM LGDYRGNKVA VKCIKNDATA QAFLAEASVM 240
TELQQNNLGQ LLVSFYARVS GRRAPEKAGM LEYWCCSHGA DNQIPNASLP PARDVCEAME 300
YLEANNFVHR DLAARNVLVS EDNIAKVSDF GLTKEASSTQ DTGKLPVKWT APEALREKKF 360
STKSDVWSFG ILLWEIYSFG RVPYPRIPLK DVVPRVEKGY KMDPPDGCPA IVYEVKKKCW 420
TLDPGHPPSF HQLREQLVHI KEKELYL 447
Nucleotide Sequence
(FASTA)
ATGTCAGGGA TGCAGGCCGT TTGGCCATCC GGTACAGAAT GTATCGCCAA GTACAACTTC 60
CACGGTACGG CCGAGCAGGA CCTGCCGTTC AGCAAGGGAG ACGTCCTCAC CATCGTCGCC 120
GTCACCAAGG ACCCCAACTG GTACAAGGCG AAGAACAAGG TGGGCCGGGA GGGCATCATC 180
CCCGCTAACT ACGTGCAGAA GAGGGAAGGA GTGAAGGCTG GCATCAAGCT CAGCCTCATG 240
CCGTGGTTCC ATGGGAAGAT CACACGGGAG CAGGCAGAGA GGCTGCTGTA CCCACCCGAG 300
ACGGGGCTGT TCCTGGTGCG GGAGAGCACC AACTACCCTG GGGACTACAC CCTGTGTGTG 360
AGCTGTGAGG GCAAGGTGGA GCACTACCGC ATCATTTACT CCTCCAGCAA GCTGAGCATC 420
GATGAGGAGG TCTACTTCGA GAACCTGATG CAGCTTGTGG AGCATTACAC CACGGACGCC 480
GACGGGCTCT GCACGCGCCT CATCAAACCG AAGGTGATGG AGGGGACGGT GGCAGCTCAG 540
GACGAGTTCT CCCGCAGTGG CTGGGCCCTC AACATGAAGG ACCTCAAGCT GCTGCAAATC 600
ATTGGCAAAG GGGAATTTGG AGATGTGATG CTGGGTGATT ACCGGGGGAA CAAAGTCGCC 660
GTCAAGTGCA TTAAAAATGA CGCCACAGCG CAGGCTTTCC TGGCAGAAGC ATCCGTGATG 720
ACGGAGCTCC AACAAAACAA TCTGGGGCAA CTGCTGGTAT CGTTCTACGC GCGAGTTTCG 780
GGTCGGCGGG CGCCGGAAAA GGCCGGAATG TTGGAATATT GGTGTTGCAG CCACGGTGCT 840
GATAACCAAA TCCCTAACGC CTCTCTGCCT CCCGCCAGAG ATGTCTGTGA AGCCATGGAG 900
TACCTGGAAG CCAACAACTT CGTCCACCGG GACCTGGCGG CGAGGAATGT GTTGGTCTCA 960
GAGGACAACA TTGCCAAGGT CAGCGATTTC GGGCTGACAA AGGAAGCGTC GTCCACTCAG 1020
GACACGGGGA AGCTGCCTGT GAAGTGGACG GCACCCGAAG CACTTAGAGA AAAGAAATTC 1080
TCCACCAAAT CGGACGTGTG GAGCTTCGGG ATCCTCCTCT GGGAAATCTA CTCCTTCGGG 1140
CGAGTGCCTT ATCCGAGAAT CCCCCTGAAG GACGTGGTGC CCCGGGTGGA GAAGGGCTAT 1200
AAGATGGACC CTCCAGACGG CTGCCCGGCC ATCGTCTACG AGGTGAAGAA GAAGTGCTGG 1260
ACGCTGGACC CAGGGCACCC GCCGTCCTTC CACCAGCTCC GTGAACAGCT AGTGCATATC 1320
AAAGAGAAGG AGCTCTACCT GTGA 1344
Domain Profile
S: 1     lklgetigkgefgdvllgeyrgekvavkvikndataqafldeasvmtklehenlvkllgv  60
         lkl + igkgefgdv+lg+yrg+kvavk+ikndataqafl+easvmt+l+ +nl +ll  
Q: 195   LKLLQIIGKGEFGDVMLGDYRGNKVAVKCIKNDATAQAFLAEASVMTELQQNNLGQLLVS  254
         6899*****************************************************988
S: 61    ileekglylvteyvakgslvdylrsrgrallekkqllkfaldvaegmeyleskklvhrdl  120
             ++     e    g l  +  s g +    +  l  a dv+e+meyle++++vhrdl
Q: 255   FYARVSGRRAPE--KAGMLEYWCCSHGADNQIPNASLPPARDVCEAMEYLEANNFVHRDL  312
         888865554444..35666667889***9999999*************************
S: 121   aarnvlvsedlvakvsdfglakeeskdldsgklpvkwtapealkekkfstksdvwsfgil  180
         aarnvlvsed++akvsdfgl+ke+s+++d+gklpvkwtapeal+ekkfstksdvwsfgil
Q: 313   AARNVLVSEDNIAKVSDFGLTKEASSTQDTGKLPVKWTAPEALREKKFSTKSDVWSFGIL  372
         ************************************************************
S: 181   lweifsfgrvpypriplkdvvkavekgykmeapegcppevyelmkeaweleaakrpsfak  240
         lwei+sfgrvpypriplkdvv++vekgykm++p+gcp+ vye+ k++w l++ + psf++
Q: 373   LWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDPPDGCPAIVYEVKKKCWTLDPGHPPSFHQ  432
         ************************************************************
S: 241   lkekl  245
         l+e+l
Q: 433   LREQL  437
         **997
Domain Sequence
(FASTA)
LKLLQIIGKG EFGDVMLGDY RGNKVAVKCI KNDATAQAFL AEASVMTELQ QNNLGQLLVS 60
FYARVSGRRA PEKAGMLEYW CCSHGADNQI PNASLPPARD VCEAMEYLEA NNFVHRDLAA 120
RNVLVSEDNI AKVSDFGLTK EASSTQDTGK LPVKWTAPEA LREKKFSTKS DVWSFGILLW 180
EIYSFGRVPY PRIPLKDVVP RVEKGYKMDP PDGCPAIVYE VKKKCWTLDP GHPPSFHQLR 240
EQL 243
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00137
EKS-ANC-00139
EKS-BOT-00146
EKS-CAE-00119
EKS-CAJ-00150
EKS-CAF-00152
EKS-CAP-00145
EKS-CII-00089
EKS-CIS-00181
EKS-DAR-00430
EKS-EQC-00143
EKS-FEC-00136
EKS-GAM-00074
EKS-GAA-00170
EKS-GOG-00145
EKS-HOS-00150
EKS-ICT-00139
EKS-LAC-00154
EKS-LOA-00144
EKS-MAM-00143
EKS-MAE-00056
EKS-MEG-00113
EKS-MOD-00144
EKS-MUM-00149
EKS-MUP-00149
EKS-MYL-00155
EKS-ORN-00178
EKS-ORL-00167
EKS-OTG-00150
EKS-PAT-00135
EKS-POA-00141
EKS-PRC-00025
EKS-PTV-00137
EKS-RAN-00143
EKS-SAH-00139
EKS-SOA-00023
EKS-SUS-00127
EKS-TAR-00188
EKS-TEN-00180
EKS-TUT-00144
EKS-XET-00133
EKS-XIM-00172
Gene Ontology
GO:0005911; C:cell-cell junction
GO:0005813; C:centrosome
GO:0005794; C:Golgi apparatus
GO:0005886; C:plasma membrane
GO:0005524; F:ATP binding
GO:0004713; F:protein tyrosine kinase activity
GO:0008285; P:negative regulation of cell proliferation
GO:0042997; P:negative regulation of Golgi to plasma membrane protein transport
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980; SH2.
IPR001452; SH3_domain.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
Pfam
PF07714; Pkinase_Tyr; 1.
PF00017; SH2; 1.
PF00018; SH3_1; 1.
SMARTs
SM00252; SH2; 1.
SM00326; SH3; 1.
SM00219; TyrKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS50001; SH2; 1.
PS50002; SH3; 1.
Prints
PR00401; SH2DOMAIN.
PR00109; TYRKINASE.
Created Date20-Feb-2013